BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0144.p (295 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8ITH9.1 D8ITH9_HERSS Permease of the drug/metabolite transporte... 555 e-156 E6V189.1 E6V189_VARPD Putative uncharacterized protein 208 8e-52 D6CKM3.1 D6CKM3_THIS3 Putative Permease of the drug/metabolite t... 202 7e-50 D5X5U9.1 D5X5U9_THIK1 Putative uncharacterized protein 196 4e-48 C5CX86.1 C5CX86_VARPS Putative uncharacterized protein 186 4e-45 A2SLS8.1 A2SLS8_METPP Putative transmembrane protein 186 4e-45 E6PLN8.1 E6PLN8_9ZZZZ Putative Permease of the drug/metabolite t... 181 1e-43 A9BR00.1 A9BR00_DELAS Putative uncharacterized protein 179 3e-43 B1Y2H8.1 B1Y2H8_LEPCP Putative uncharacterized protein 176 4e-42 D0IWC2.1 D0IWC2_COMT2 Hypothetical transmembrane protein 171 9e-41 >D8ITH9.1 D8ITH9_HERSS Permease of the drug/metabolite transporter (DMT) superfamily protein Length = 295 Score = 555 bits (1429), Expect = e-156, Method: Compositional matrix adjust. Identities = 290/295 (98%), Positives = 292/295 (98%) Query: 1 MQALPKSAVAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLP 60 MQ LPKSAVAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCT+LLVALRYRDLP Sbjct: 1 MQVLPKSAVAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTLLLVALRYRDLP 60 Query: 61 QLWRHPALLWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPR 120 QLWRHPALLWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPR Sbjct: 61 QLWRHPALLWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPR 120 Query: 121 SLTRVALGLSGAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARA 180 SLTRVALGLSGAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARA Sbjct: 121 SLTRVALGLSGAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARA 180 Query: 181 VAMLAGSGLLAGVLGVMLALAGAIAWPLHVPATAWPLVGVWALLFLVSNLCLQYGVARLP 240 VAMLAGSGLLAGVLGVMLALAGAIAWPLHVPATAWPLVGVWALLFLVSNLCLQYGVARLP Sbjct: 181 VAMLAGSGLLAGVLGVMLALAGAIAWPLHVPATAWPLVGVWALLFLVSNLCLQYGVARLP 240 Query: 241 ATITSVIMLAEILVASLSAWWFGAAELRPQDLIGGLLIIAAPWLVRDPRPVAQGA 295 ATITSVIMLAEILVASLSAWWFGAAELRPQDLIGG+LIIAAPWLVRD RPVAQ A Sbjct: 241 ATITSVIMLAEILVASLSAWWFGAAELRPQDLIGGILIIAAPWLVRDSRPVAQSA 295 >E6V189.1 E6V189_VARPD Putative uncharacterized protein Length = 296 Score = 208 bits (529), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 126/273 (46%), Positives = 170/273 (62%), Gaps = 8/273 (2%) Query: 11 ALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLPQLWRHPALLW 70 AL+ N +WGLSW R +E GLHP+WTT I+ ++ +R +P L Sbjct: 5 ALIFNAFVWGLSWFPFRHIESHGLHPLWTTCLIYLAIATVMGIVRRHAWKSFTAYPMLAV 64 Query: 71 VGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRSLTRVALGLS 130 +GLA G TN FN AV GDVVRV+LLFYLMP+W+V+L L+L E T +L RVAL L+ Sbjct: 65 LGLAAGFTNVGFNWAVTQGDVVRVVLLFYLMPLWSVLLGWLLLGERPTGGALARVALALT 124 Query: 131 GAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARAVAMLAGSGLL 190 G +VL P P+P SLPDW+ +AAG FA+TN++LR L+ +RA+AM G + Sbjct: 125 GVVVVLKAPGTDWPVPSSLPDWLGLAAGFSFAVTNIVLRHLRPAPGESRALAMFCGCTFV 184 Query: 191 AGVLGVMLALAGAIAWPLHVPATAWPLVGVWALL----FLVSNLCLQYGVARLPATITSV 246 AG+ ++ GAIA PL A P WA+L F++ N+CLQYG ARL A+ TSV Sbjct: 185 AGIAALVGTSLGAIASPLQ----ATPGWLGWAVLLGAGFVIGNVCLQYGAARLAASATSV 240 Query: 247 IMLAEILVASLSAWWFGAAELRPQDLIGGLLII 279 IML+E+L AS+S+ GA+ + P+ L GG LI+ Sbjct: 241 IMLSEVLFASVSSVALGASTMDPRILTGGALIV 273 >D6CKM3.1 D6CKM3_THIS3 Putative Permease of the drug/metabolite transporter (DMT) superfamily Length = 312 Score = 202 bits (513), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 127/276 (46%), Positives = 176/276 (63%), Gaps = 4/276 (1%) Query: 2 QALPKSAVAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLPQ 61 A+ +A+ L++N +WG+SW R G+GL+P+W TAA++ + T+++VA R + Sbjct: 5 SAITLAAIGGLMLNAFVWGVSWWPFRHFNGLGLNPLWATAAMYAVSTLIIVAARPSAVRA 64 Query: 62 LWRHPALLWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRS 121 LWRHP L + +A+G TN+ FN V GDVVRV+LLFYLMPVW +LAR +L+E +T Sbjct: 65 LWRHPPLWGILIASGATNAAFNWGVTEGDVVRVVLLFYLMPVWATLLARWLLNEKLTRLV 124 Query: 122 LTRVALGLSGAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARAV 181 R+ L L+GA +VL+ GLPLPQ DW+ V G+ FA+ NVLLR+ AR + Sbjct: 125 GLRLTLALAGAMVVLWPQGGGLPLPQHPADWLGVIGGMFFALNNVLLRKYAHTPPEARGL 184 Query: 182 AMLAGSGLLAGVLGVMLALAGAIAWPLHVPATAWPLVGV--WALLFLVSNLCLQYGVARL 239 AM AG ++AG + +L +GA+A P+ PA W L+GV AL FL +NL LQYG RL Sbjct: 185 AMFAGGVIVAGGVAALLTASGAVA-PMPAPAPGW-LMGVVLMALAFLAANLGLQYGAERL 242 Query: 240 PATITSVIMLAEILVASLSAWWFGAAELRPQDLIGG 275 P+T+T+V+M EI+ AS SA G L Q L GG Sbjct: 243 PSTLTAVVMTVEIVFASGSAVLLGVERLSAQALWGG 278 >D5X5U9.1 D5X5U9_THIK1 Putative uncharacterized protein Length = 312 Score = 196 bits (498), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 128/276 (46%), Positives = 175/276 (63%), Gaps = 4/276 (1%) Query: 2 QALPKSAVAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLPQ 61 A+ +A+ L++N +WG+SW R G+GL+P+W TAA++ + T+++VA R L Sbjct: 5 SAITLAAIGGLMLNAFVWGVSWWPFRHFNGLGLNPLWATAAMYAVSTLIIVAARPSALRA 64 Query: 62 LWRHPALLWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRS 121 LWRHP L + +A+G TN+ FN V GDVVRV+LLFYLMPVW +LAR +L+E +T Sbjct: 65 LWRHPPLWGILIASGATNAAFNWGVTEGDVVRVVLLFYLMPVWATLLARWLLNEKLTRLV 124 Query: 122 LTRVALGLSGAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARAV 181 R+ L L+GA +VL+ GLPLPQ DW+ V G+ FA+ NVLLR+ AR + Sbjct: 125 GLRLTLALAGAMVVLWPQGGGLPLPQHPADWLGVIGGMFFALNNVLLRKYAHTPPEARGL 184 Query: 182 AMLAGSGLLAGVLGVMLALAGAIAWPLHVPATAWPLVGV--WALLFLVSNLCLQYGVARL 239 AM AG ++AG +L +GA+A P+ PA W L+GV AL FL +NL LQYG RL Sbjct: 185 AMFAGGVIVAGGAAALLTASGAVA-PMPAPAPGW-LMGVVLMALAFLAANLGLQYGAERL 242 Query: 240 PATITSVIMLAEILVASLSAWWFGAAELRPQDLIGG 275 P+T+T+V+M EI+ AS SA G L Q L GG Sbjct: 243 PSTLTAVVMTVEIVFASGSAVLLGVERLSAQALWGG 278 >C5CX86.1 C5CX86_VARPS Putative uncharacterized protein Length = 296 Score = 186 bits (472), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 129/287 (44%), Positives = 174/287 (60%), Gaps = 6/287 (2%) Query: 11 ALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLPQLWRHPALLW 70 AL+ N +WG+SW R +E GLHPVWTT I+ ++ + R +P L+ Sbjct: 5 ALIFNAFVWGVSWFPFRHIESHGLHPVWTTCIIYVAISLAMGFFRRHAWRGFAAYPMLVL 64 Query: 71 VGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRSLTRVALGLS 130 +GLA G TN FN AV GDVVRV+LLFYLMP+W+V+L VL E T +L RVAL L+ Sbjct: 65 LGLAAGFTNLGFNWAVTQGDVVRVVLLFYLMPLWSVLLGWAVLGERPTGGALARVALALT 124 Query: 131 GAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARAVAMLAGSGLL 190 G +VL P + P+P SLPDW+ +AAG FA+TN++LR L+ +RA+AM G + Sbjct: 125 GVAVVLKTPGVEWPVPSSLPDWLGLAAGFSFAVTNIVLRHLRDAPGESRALAMFCGCAAV 184 Query: 191 AGVLGVMLALAGAIAWPLHVPATAWPLVGVWALL---FLVSNLCLQYGVARLPATITSVI 247 AG+ L G PL W +G ALL F+++N+CLQYG ARL A+ T+VI Sbjct: 185 AGIAAAAGTLLGDFGSPL-AAEPGW--IGWAALLGTGFVLANICLQYGAARLAASATAVI 241 Query: 248 MLAEILVASLSAWWFGAAELRPQDLIGGLLIIAAPWLVRDPRPVAQG 294 ML+E+L AS+S+ GAA++ P+ L GG LI+ A R AQG Sbjct: 242 MLSEVLFASVSSVALGAAQMDPRILAGGALIVLAAVWSAFARTPAQG 288 >A2SLS8.1 A2SLS8_METPP Putative transmembrane protein Length = 304 Score = 186 bits (471), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 131/270 (48%), Positives = 168/270 (62%), Gaps = 4/270 (1%) Query: 3 ALPKSAVAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLP-Q 61 A+P AV AL++N +WG+SW R L GLHP+W TA ++GL ++V LR+ P Q Sbjct: 13 AVPLLAVLALMLNAFVWGVSWWPFRQLHSFGLHPLWATALVYGLAVAVIV-LRWPQAPGQ 71 Query: 62 LWRHPALLWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRS 121 L R P L + LA G TN+ FN AV GDVVRV+LLFYLMP+WT +LARL+L E +T + Sbjct: 72 LRRTPVLWVLVLAAGTTNAAFNWAVTIGDVVRVVLLFYLMPLWTALLARLLLQERLTRWA 131 Query: 122 LTRVALGLSGAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARAV 181 L RV L L+GA IVL G PLP SL D + + G FA+ NV+LRR RA+ Sbjct: 132 LFRVLLALAGAAIVLKPAGAGWPLPSSLADLLGIVGGFSFALNNVMLRRESRRPPEGRAL 191 Query: 182 AMLAGSGLLAGVLGVMLALAGAIAWPLHVPATAW-PLVGVWALLFLVSNLCLQYGVARLP 240 AM G L+AG L + L+ A ++AWP P W + + AL FL +NL LQYG ARL Sbjct: 192 AMFLGGVLVAGALALSLSTASSVAWP-PAPQPFWLLPLAMLALAFLAANLALQYGAARLR 250 Query: 241 ATITSVIMLAEILVASLSAWWFGAAELRPQ 270 A +TSV+ML EI+ AS+SA G PQ Sbjct: 251 ANVTSVVMLTEIVFASVSAVLLGDQVPSPQ 280 >E6PLN8.1 E6PLN8_9ZZZZ Putative Permease of the drug/metabolite transporter (DMT) superfamily Length = 309 Score = 181 bits (458), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 127/270 (47%), Positives = 168/270 (62%), Gaps = 2/270 (0%) Query: 7 SAVAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLPQLWRHP 66 +A++ L++N +WG+SW R L +GL+P+W TAAI+GL T ++ R R L L R+P Sbjct: 9 AAISGLMLNAFVWGVSWWPFRDLHALGLNPLWATAAIYGLSTAAILLARPRALGALLRNP 68 Query: 67 ALLWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRSLTRVA 126 AL + L++G TN+ FN V GDVVRV+LLFYLMPVW +LAR +L E +TP R+ Sbjct: 69 ALWLILLSSGATNAAFNWGVTEGDVVRVVLLFYLMPVWAALLARWLLQERLTPLVGLRLV 128 Query: 127 LGLSGAFIVLYQPRLGLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARAVAMLAG 186 L L+GA +VL+ P GLPLPQ DW+ V G+ FA+ NVLLR+ AR +AM AG Sbjct: 129 LALAGAMVVLWPPGGGLPLPQHPADWLGVVGGMTFALNNVLLRKYAHTPPEARGLAMFAG 188 Query: 187 SGLLAGVLGVMLALAGAIAWPLHVPA-TAWPLVGVWALLFLVSNLCLQYGVARLPATITS 245 G L A +A L VP VG+ AL FL +NL LQYG RLP+++T+ Sbjct: 189 -GTLVAGGLAAALAAAGVASGLPVPTLPLVLAVGLLALAFLAANLGLQYGAERLPSSLTA 247 Query: 246 VIMLAEILVASLSAWWFGAAELRPQDLIGG 275 V+M EI+ AS SA GA +L Q LIGG Sbjct: 248 VVMTVEIVFASGSAVLLGAEQLSVQALIGG 277 >A9BR00.1 A9BR00_DELAS Putative uncharacterized protein Length = 299 Score = 179 bits (455), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 124/281 (44%), Positives = 165/281 (58%), Gaps = 14/281 (4%) Query: 9 VAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLPQLWRHPAL 68 V ALL NT +WGL+W RA+ GLHP+W TA ++ L LVALR L Q ++P L Sbjct: 7 VLALLFNTLVWGLAWWPFRAMHEAGLHPLWATALMYALVLAGLVALRPASLRQALQYPVL 66 Query: 69 LWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRSLTRVALG 128 + +G G N FN AV GDVVRV+LLFYLMP W+V+LA +L E TP +LTR+ L Sbjct: 67 ILLGACAGSNNIAFNWAVTIGDVVRVVLLFYLMPAWSVLLAWKILGERPTPAALTRLLLA 126 Query: 129 LSGAFIVLYQPRL------GLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARAVA 182 G +VL GL SL D +A+ G FA+TNVLLRRLQ + AR +A Sbjct: 127 FGGVALVLVPEGTFSGGSPGLLRGLSLADGLALFGGFTFALTNVLLRRLQAVPAQARMLA 186 Query: 183 MLAGSGLLAGVLGVMLALAGA---IAWPLHVPATAWPLVGV-WALLFLVSNLCLQYGVAR 238 M SG +A +G+ A AG+ + P+ P W L+ A+L ++ N LQ+G AR Sbjct: 187 MF--SGCMA--MGLASAFAGSSVGLVPPMPAPQAGWMLIAAGLAVLLMLGNWALQFGAAR 242 Query: 239 LPATITSVIMLAEILVASLSAWWFGAAELRPQDLIGGLLII 279 LPA +T+V+MLAE++ AS S+ L P+ L+GG II Sbjct: 243 LPAGVTAVVMLAEVVFASASSVLIAGEVLTPRTLLGGACII 283 >B1Y2H8.1 B1Y2H8_LEPCP Putative uncharacterized protein Length = 309 Score = 176 bits (446), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 126/296 (42%), Positives = 166/296 (56%), Gaps = 20/296 (6%) Query: 4 LPKS--AVAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLPQ 61 LP S AV ALL N WGLSW R L+ GLH +W+T I+G +++ R R Q Sbjct: 7 LPGSGLAVLALLFNALTWGLSWWPFRELQAAGLHSLWSTVLIYGAAALVVGLWRPRAWGQ 66 Query: 62 LWRHPALLWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRS 121 L R PAL + LA+G TN FN V GDV RV+LLFYL P+WT++LAR +L E Sbjct: 67 LARSPALWLIMLASGCTNLGFNWGVTVGDVARVVLLFYLTPLWTLLLARWLLGEHADAAV 126 Query: 122 LTRVALGLSGAFIVLYQPRL-----GLPLPQSLP---DWMAVAAGLLFAITNVLLRRLQG 173 RVA+ L GA +VL G S+P D +A+ G FA+ NV+LRR Sbjct: 127 WLRVAMALGGAVLVLTSSHAAESADGAARAVSMPLLADVLAIGGGFFFALNNVMLRRAAH 186 Query: 174 LSDSARAVAMLAGSGLLA------GVLGVMLALAGAIAWPLHVPATAW--PLVGVWALLF 225 D RA+AM G L++ G V + I WP +PA +W P +G+ A+ F Sbjct: 187 HPDEGRALAMFVGGTLVSLLVATLGAADVGVMALSRIDWP-PMPAASWVLPALGL-AVAF 244 Query: 226 LVSNLCLQYGVARLPATITSVIMLAEILVASLSAWWFGAAELRPQDLIGGLLIIAA 281 L +NL LQYG RLPA +TSV+M +EIL A++SA W+ + P L+GG LI+ A Sbjct: 245 LFANLALQYGATRLPANVTSVVMPSEILFAAVSAAWWAGEVMTPMLLVGGALILGA 300 >D0IWC2.1 D0IWC2_COMT2 Hypothetical transmembrane protein Length = 294 Score = 171 bits (434), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 123/288 (42%), Positives = 168/288 (58%), Gaps = 8/288 (2%) Query: 9 VAALLVNTTIWGLSWTATRALEGMGLHPVWTTAAIFGLCTMLLVALRYRDLPQLWRHPAL 68 V ALL+N IWGLSW R + GLHP+W TAA++ L L+ LR L Q W++P L Sbjct: 7 VFALLLNALIWGLSWWPFRLMHEAGLHPLWATAAMYALVLAGLLILRPASLRQAWQYPVL 66 Query: 69 LWVGLATGLTNSTFNVAVAYGDVVRVILLFYLMPVWTVILARLVLHEAITPRSLTRVALG 128 L + ++GL N FN AV GDVVRVILLFYLMP W V+LA +L E TP +L R+ L Sbjct: 67 LLLAASSGLNNVAFNWAVTVGDVVRVILLFYLMPAWAVLLAWKLLGEKPTPMALLRLLLA 126 Query: 129 LSGAFIVLYQPRL---GLPLPQSLPDWMAVAAGLLFAITNVLLRRLQGLSDSARAVAMLA 185 G +VL GL +L D +AV G +FA+TNVLLRR QG+ AR +AM A Sbjct: 127 FGGVVLVLLPADASLSGLFAGLTLADALAVFGGFMFALTNVLLRRFQGIPAQARMLAMFA 186 Query: 186 GSGLLAGVLGVMLALAGAIAWPLHVPATAWPLVGV-WALLFLVSNLCLQYGVARLPATIT 244 G + G+L + A + + ++W + V A++ + N LQ+G ARLP+ +T Sbjct: 187 GC-MSMGLLTALSASSAGMVPGFPAFDSSWAFLAVGLAVVLMFGNWALQFGAARLPSGVT 245 Query: 245 SVIMLAEILVASLSAWWFGAAELRPQDLIGGLLIIAAPWLV---RDPR 289 SV+ML+E++ AS+S+ +L + L GG LI+ A L R PR Sbjct: 246 SVVMLSEVVFASISSVLIAHEQLSARTLAGGALIMGAALLATLGRAPR 293