BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0255.p (240 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IQX7.1 D8IQX7_HERSS Pseudouridine synthase EC=5.4.99.- 489 e-136 A4G5R7.1 A4G5R7_HERAR Putative 16S rRNA uridine-516 pseudouridyl... 397 e-108 A6SZE3.1 A6SZE3_JANMA Ribosomal small subunit pseudouridine synt... 395 e-108 D5CRA1.1 D5CRA1_SIDLE Pseudouridine synthase EC=5.4.99.- 360 1e-97 F1VVR1.1 F1VVR1_9BURK 16S rRNA pseudouridylate 516 synthase 345 3e-93 D9SCG3.1 D9SCG3_GALCS Pseudouridine synthase EC=5.4.99.- 326 2e-87 Q474U7.1 Q474U7_CUPPJ Pseudouridine synthase EC=5.4.99.- 277 9e-73 Q0K7M8.1 Q0K7M8_CUPNH Pseudouridine synthase EC=5.4.99.- 273 1e-71 B3R607.1 B3R607_CUPTR Pseudouridine synthase EC=5.4.99.- 268 3e-70 Q1LJQ9.1 Q1LJQ9_RALME Pseudouridine synthase EC=5.4.99.- 257 1e-66 >D8IQX7.1 D8IQX7_HERSS Pseudouridine synthase EC=5.4.99.- Length = 240 Score = 489 bits (1258), Expect = e-136, Method: Compositional matrix adjust. Identities = 237/240 (98%), Positives = 238/240 (99%) Query: 1 MAKLTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEY 60 MAKLTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIF EEWEY Sbjct: 1 MAKLTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFEEEWEY 60 Query: 61 REHVYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGA 120 REHVYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGA Sbjct: 61 REHVYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGA 120 Query: 121 FIHAQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEI 180 FIHAQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEI Sbjct: 121 FIHAQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEI 180 Query: 181 VLEQGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALLVPDAE 240 VLEQGKYHQVKRMLAAAGNHCSAL+RTAIGGLQLE LALEEGEWTYLDAEQMALLVPDAE Sbjct: 181 VLEQGKYHQVKRMLAAAGNHCSALQRTAIGGLQLEALALEEGEWTYLDAEQMALLVPDAE 240 >A4G5R7.1 A4G5R7_HERAR Putative 16S rRNA uridine-516 pseudouridylate synthase EC=4.2.1.70 Length = 244 Score = 397 bits (1019), Expect = e-108, Method: Compositional matrix adjust. Identities = 189/239 (79%), Positives = 203/239 (84%) Query: 1 MAKLTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEY 60 M+KLTLDRILQSQGFG+RKYCR LIEDGEV ING VVD+++ DT DL TIF E W Y Sbjct: 1 MSKLTLDRILQSQGFGTRKYCRGLIEDGEVSINGVVVDNFKTAVDTTDLEFTIFDEVWRY 60 Query: 61 REHVYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGA 120 REHVYI +NKP N ECSRKPSHHPGVLTLLPEQFTWRD+QPVGRLDHDTTG+LLMSDDG Sbjct: 61 REHVYIVLNKPANFECSRKPSHHPGVLTLLPEQFTWRDLQPVGRLDHDTTGMLLMSDDGP 120 Query: 121 FIHAQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEI 180 FIHAQSSPKRH+PK+Y ATT +PVT LIAQL GVQLHDEPAPLAA CR L E+ +EI Sbjct: 121 FIHAQSSPKRHIPKIYVATTHDPVTPELIAQLLGGVQLHDEPAPLAAQTCRMLAEHQIEI 180 Query: 181 VLEQGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALLVPDA 239 VLEQGKYHQVKRMLAAAGNHCSAL R IG L LE L LEEGEWTYLDAEQ+ALL P A Sbjct: 181 VLEQGKYHQVKRMLAAAGNHCSALNRAEIGELTLESLGLEEGEWTYLDAEQLALLRPSA 239 >A6SZE3.1 A6SZE3_JANMA Ribosomal small subunit pseudouridine synthase A protein EC=4.2.1.70 Length = 238 Score = 395 bits (1015), Expect = e-108, Method: Compositional matrix adjust. Identities = 189/237 (79%), Positives = 200/237 (84%) Query: 1 MAKLTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEY 60 M+KLTLDRILQSQGFG+RKYCR LIEDGEV INGE V DYRA DT DL TIF E W Y Sbjct: 1 MSKLTLDRILQSQGFGTRKYCRNLIEDGEVSINGESVTDYRAAFDTSDLEFTIFDEVWRY 60 Query: 61 REHVYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGA 120 R+HVYI +NKP N ECSRKPSHHPGVLTLLPEQFTWR++QPVGRLDHDTTG+LLMSDDG Sbjct: 61 RQHVYIVLNKPANFECSRKPSHHPGVLTLLPEQFTWRELQPVGRLDHDTTGMLLMSDDGP 120 Query: 121 FIHAQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEI 180 FIHAQSSPKRH+PKVY ATT +PVT LIAQL GVQLHDEPAPLAA CR LG N LEI Sbjct: 121 FIHAQSSPKRHIPKVYVATTHDPVTPELIAQLLGGVQLHDEPAPLAAQTCRMLGANELEI 180 Query: 181 VLEQGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALLVP 237 VLEQGKYHQVKRMLAAAGNHCSALRR AIG L LE L L+EGEW YL Q+ALL P Sbjct: 181 VLEQGKYHQVKRMLAAAGNHCSALRRVAIGALTLESLELDEGEWAYLTDAQLALLAP 237 >D5CRA1.1 D5CRA1_SIDLE Pseudouridine synthase EC=5.4.99.- Length = 241 Score = 360 bits (924), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 170/235 (72%), Positives = 196/235 (83%) Query: 1 MAKLTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEY 60 M+KL LDRILQSQGFG+RK+CRELIEDGEV++ G+ + DYR +T +L +++GE W + Sbjct: 1 MSKLPLDRILQSQGFGTRKWCRELIEDGEVLVAGDSITDYRHAFETDNLEFSVYGESWRF 60 Query: 61 REHVYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGA 120 REHVYIA+NKP + ECSRKPSHHPGVL+LLPEQF RDVQPVGRLDHDTTGLLLMSDDGA Sbjct: 61 REHVYIALNKPADYECSRKPSHHPGVLSLLPEQFALRDVQPVGRLDHDTTGLLLMSDDGA 120 Query: 121 FIHAQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEI 180 FIHAQSSPKRH+PKVY ATT +PVT L+ QL +GV+LHDEPAPLAA C L L+I Sbjct: 121 FIHAQSSPKRHIPKVYVATTHDPVTPQLVRQLMSGVKLHDEPAPLAAVVCNMLDTCQLKI 180 Query: 181 VLEQGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALL 235 VLEQGKYHQVKRMLAAAGNHC+ALRRT IG L+LE L L EGEW YL ++ALL Sbjct: 181 VLEQGKYHQVKRMLAAAGNHCTALRRTEIGKLRLEALGLAEGEWCYLGEAELALL 235 >F1VVR1.1 F1VVR1_9BURK 16S rRNA pseudouridylate 516 synthase Length = 239 Score = 345 bits (885), Expect = 3e-93, Method: Compositional matrix adjust. Identities = 169/236 (71%), Positives = 196/236 (83%) Query: 1 MAKLTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEY 60 M KLTLDR+LQSQGFG+RK+CR+LI+DGEV + G VV DYR + L +F E+W++ Sbjct: 1 MKKLTLDRLLQSQGFGTRKWCRQLIDDGEVSVAGTVVTDYRTAFEPDGLTFRLFDEDWDF 60 Query: 61 REHVYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGA 120 EHV++A++KPPN ECSRKPSHHPGVL++LPE FTWRDVQPVGRLDHDTTGLLLMSD G Sbjct: 61 HEHVFVALHKPPNFECSRKPSHHPGVLSILPENFTWRDVQPVGRLDHDTTGLLLMSDHGP 120 Query: 121 FIHAQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEI 180 FIHAQSSPK H+PKVY ATTAE VT L+A L AGVQLHDEPAPLAA RC + + +EI Sbjct: 121 FIHAQSSPKSHIPKVYIATTAEAVTPELVALLLAGVQLHDEPAPLAAVRCSMVDSHRIEI 180 Query: 181 VLEQGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALLV 236 VLEQGKYHQVKRMLAAAGNHC+AL+R AIG L LE L LEEGEW YLDA ++ALL+ Sbjct: 181 VLEQGKYHQVKRMLAAAGNHCAALQRVAIGQLTLEGLGLEEGEWCYLDAAELALLI 236 >D9SCG3.1 D9SCG3_GALCS Pseudouridine synthase EC=5.4.99.- Length = 241 Score = 326 bits (835), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 158/237 (66%), Positives = 184/237 (77%) Query: 1 MAKLTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEY 60 M+KLTLDRIL +QGFG+RKYCR+LI G + I G+ + D +T L ++ E Y Sbjct: 1 MSKLTLDRILHTQGFGTRKYCRQLIAAGAIRIGGDTITDTNTPIETDGLEFSVDDEHCIY 60 Query: 61 REHVYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGA 120 RE +Y+A+NKP NIECSRKPSHHPGVL++LP+QFT RDVQPVGRLDHDTTGLLLMSDDGA Sbjct: 61 RERIYVALNKPANIECSRKPSHHPGVLSILPDQFTRRDVQPVGRLDHDTTGLLLMSDDGA 120 Query: 121 FIHAQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEI 180 FIH QSSPK HVPKVY ATT PVT LI +L AGV+LHDEP LAA CR + ++ LEI Sbjct: 121 FIHTQSSPKHHVPKVYVATTYAPVTGELIERLLAGVKLHDEPGTLAAEICRMIDDHHLEI 180 Query: 181 VLEQGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALLVP 237 VLEQGKYHQVKRMLAAA NHC+AL R+ IG L+L LAL GEW YL+ Q+ALL P Sbjct: 181 VLEQGKYHQVKRMLAAADNHCTALNRSQIGNLKLAELALAPGEWCYLNDAQLALLKP 237 >Q474U7.1 Q474U7_CUPPJ Pseudouridine synthase EC=5.4.99.- Length = 251 Score = 277 bits (708), Expect = 9e-73, Method: Compositional matrix adjust. Identities = 137/233 (58%), Positives = 168/233 (72%) Query: 4 LTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEYREH 63 +TLDRILQSQGFG+R+YC +LI G V +NGE+ +D RA + L LT+ GEEW Sbjct: 16 MTLDRILQSQGFGTRRYCGDLIAAGLVEVNGELCEDPRAQFEVDGLRLTVDGEEWLACTK 75 Query: 64 VYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGAFIH 123 Y+ +NKP ECS++P HHP V LLP R+VQ VGRLDHDTTGLLL++DDG FIH Sbjct: 76 AYLMLNKPAGYECSQRPRHHPSVYNLLPVPLRQREVQAVGRLDHDTTGLLLLTDDGQFIH 135 Query: 124 AQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEIVLE 183 AQ+SPKR VPKVY TTAEPVT+ + L+ GV+L DEP P+AA C GE L + L Sbjct: 136 AQTSPKRKVPKVYEVTTAEPVTQEQVDALRTGVKLDDEPVPIAAEGCEITGECSLRLTLL 195 Query: 184 QGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALLV 236 QGKYHQVKRM+AAAGNH +AL R+A+GGL+L+ AL EGEW +L AE +A L Sbjct: 196 QGKYHQVKRMVAAAGNHVNALHRSAVGGLRLDPAALPEGEWRWLTAEDLAALT 248 >Q0K7M8.1 Q0K7M8_CUPNH Pseudouridine synthase EC=5.4.99.- Length = 235 Score = 273 bits (699), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 139/233 (59%), Positives = 168/233 (72%), Gaps = 1/233 (0%) Query: 4 LTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEYREH 63 +TLDRILQSQGFG+R+YC +LI G V +NGE+ +D RA + L LT+ GEEW Sbjct: 1 MTLDRILQSQGFGTRRYCGDLIAAGLVEVNGELCEDPRAQFEVDGLRLTVDGEEWLACTK 60 Query: 64 VYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGAFIH 123 Y+ +NKP ECS++P HHP V LLP R+VQ VGRLDHDTTGLLL++DDG FIH Sbjct: 61 AYLMLNKPTGYECSQRPRHHPSVYNLLPVPLRQREVQAVGRLDHDTTGLLLLTDDGQFIH 120 Query: 124 AQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEIVLE 183 AQ+SPKR VPK+Y TTAEPVT L +GVQL DEPAP+AA C GE L + L Sbjct: 121 AQTSPKRKVPKIYEVTTAEPVTPEQAEALCSGVQLLDEPAPIAAEACEITGERSLRLTLV 180 Query: 184 QGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALLV 236 QGKYHQVKRM+AAAGNH SAL R+AIGGL+L+ AL EGEW +L A+++A L Sbjct: 181 QGKYHQVKRMVAAAGNHVSALHRSAIGGLRLDP-ALAEGEWRWLTAQELAALT 232 >B3R607.1 B3R607_CUPTR Pseudouridine synthase EC=5.4.99.- Length = 235 Score = 268 bits (686), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 136/233 (58%), Positives = 165/233 (70%), Gaps = 1/233 (0%) Query: 4 LTLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEYREH 63 +TLDRILQSQGFG+R+YC +LI G V +NGE+ +D RA + L LT+ GEEW Sbjct: 1 MTLDRILQSQGFGTRRYCGDLIAAGLVEVNGELCEDPRAQFEVDGLRLTVDGEEWLACTK 60 Query: 64 VYIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGAFIH 123 Y+ +NKP ECS++P HHP V LLP R+VQ VGRLDHDTTGLLL++DDG FIH Sbjct: 61 AYLMLNKPAGYECSQRPRHHPSVYNLLPVPLRQREVQAVGRLDHDTTGLLLLTDDGQFIH 120 Query: 124 AQSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEIVLE 183 AQ+SPKR VPK+Y TTAEPVT L++GVQL DEPAP+AA C GE L + L Sbjct: 121 AQTSPKRKVPKIYEVTTAEPVTPEQAEALRSGVQLLDEPAPIAAEACEITGERSLRLTLV 180 Query: 184 QGKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALLV 236 QGKYHQVKRM+ AAGNH AL R+AIG L L+ AL EGEW +L A+++A L Sbjct: 181 QGKYHQVKRMVVAAGNHVDALHRSAIGSLPLDP-ALAEGEWRWLTAQELAALT 232 >Q1LJQ9.1 Q1LJQ9_RALME Pseudouridine synthase EC=5.4.99.- Length = 238 Score = 257 bits (656), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 129/231 (55%), Positives = 160/231 (69%), Gaps = 1/231 (0%) Query: 5 TLDRILQSQGFGSRKYCRELIEDGEVVINGEVVDDYRATPDTKDLVLTIFGEEWEYREHV 64 TLDRILQSQGFG+R+YC +L+ G V +NGE+ +D A + L L + GEEW Sbjct: 4 TLDRILQSQGFGTRRYCGDLVAAGLVEVNGELCEDPGARFEVDGLRLMVDGEEWLACTKA 63 Query: 65 YIAINKPPNIECSRKPSHHPGVLTLLPEQFTWRDVQPVGRLDHDTTGLLLMSDDGAFIHA 124 Y+ +NKP ECS++P HHP V LLP R+VQ VGRLDHDTTGLLL++DDG FIHA Sbjct: 64 YVMLNKPTGYECSQRPRHHPSVYNLLPVPLRQREVQAVGRLDHDTTGLLLLTDDGQFIHA 123 Query: 125 QSSPKRHVPKVYAATTAEPVTEALIAQLKAGVQLHDEPAPLAATRCRQLGENLLEIVLEQ 184 Q+SPK+ VPK+Y TT +PVT + L+ GV+L DEPAP+AA C GE L + L Q Sbjct: 124 QTSPKKQVPKIYEVTTFDPVTPEQVEALRTGVKLDDEPAPIAADACEATGERSLRLTLLQ 183 Query: 185 GKYHQVKRMLAAAGNHCSALRRTAIGGLQLEVLALEEGEWTYLDAEQMALL 235 GKYHQVKRM+AA GNH +AL R+AIGGL L+ AL GEW +L E +A L Sbjct: 184 GKYHQVKRMVAAVGNHVTALHRSAIGGLVLDP-ALGPGEWRWLTPEDLAAL 233