BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0121.p (572 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IQ51.1 D8IQ51_HERSS Chloride channel EriC protein 1100 0.0 Q1LQV6.1 Q1LQV6_RALME Putative CBS:Cl-channel, voltage gated 690 0.0 Q46XU8.1 Q46XU8_CUPPJ CBS:Cl-channel, voltage gated 660 0.0 E6V8I8.1 E6V8I8_VARPD Cl-channel voltage-gated family protein 659 0.0 B1FLV6.1 B1FLV6_9BURK Chloride channel core 653 0.0 B4ELA3.1 B4ELA3_BURCJ Putative voltage-gated clc-type chloride c... 652 0.0 B1YX23.1 B1YX23_BURA4 Chloride channel core 651 0.0 Q0B8K2.1 Q0B8K2_BURCM Cl-channel, voltage-gated family protein 650 0.0 B1TDN6.1 B1TDN6_9BURK Chloride channel core 650 0.0 Q1BNT8.1 Q1BNT8_BURCA Cl-channel, voltage gated 650 0.0 >D8IQ51.1 D8IQ51_HERSS Chloride channel EriC protein Length = 572 Score = 1100 bits (2846), Expect = 0.0, Method: Compositional matrix adjust. Identities = 570/572 (99%), Positives = 570/572 (99%) Query: 1 MKHKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATH 60 MKHKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATH Sbjct: 1 MKHKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATH 60 Query: 61 TLGWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSG 120 TLGWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSG Sbjct: 61 TLGWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSG 120 Query: 121 IVIGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAV 180 IVIGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAV Sbjct: 121 IVIGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAV 180 Query: 181 LLAVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGL 240 LLAVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGL Sbjct: 181 LLAVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGL 240 Query: 241 ASGVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLL 300 ASGVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLL Sbjct: 241 ASGVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLL 300 Query: 301 HQHMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWP 360 HQHMLLSAAL LLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWP Sbjct: 301 HQHMLLSAALALLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWP 360 Query: 361 LVCMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIA 420 LVCMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIA Sbjct: 361 LVCMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIA 420 Query: 421 RRGLHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQAHVHRYYPVTDGV 480 RRGLHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQ HVHRYYPVTDGV Sbjct: 421 RRGLHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQEHVHRYYPVTDGV 480 Query: 481 HLVGMLALRALEHADASQPCDTLAQGHEHYLLPHMSARSAAGMMARLGVARLPVVAGPER 540 HLVGMLALRALEHADASQPCDTLAQGHEHYLLPHMSARSAAGMMARLGVARLPVVAGPER Sbjct: 481 HLVGMLALRALEHADASQPCDTLAQGHEHYLLPHMSARSAAGMMARLGVARLPVVAGPER 540 Query: 541 RKLVGVLSLSDLARASAAHAEEESVRERLLGG 572 RKLVGVLSLSDLARASAAHAEEESVRERLLGG Sbjct: 541 RKLVGVLSLSDLARASAAHAEEESVRERLLGG 572 >Q1LQV6.1 Q1LQV6_RALME Putative CBS:Cl-channel, voltage gated Length = 637 Score = 690 bits (1780), Expect = 0.0, Method: Compositional matrix adjust. Identities = 401/579 (69%), Positives = 452/579 (78%), Gaps = 10/579 (1%) Query: 3 HKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTL 62 KRDY + RLP L AIAL IG +STGAA++L+ LI FTNLF+FQ LS A +PA HTL Sbjct: 49 EKRDYAVNGRLPMLAAIALGIGAISTGAAYVLVNLIHFFTNLFFFQTLSFADRSPAGHTL 108 Query: 63 GWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIV 122 G ++P GGLIVGLMARYGSDKIRGHGIPEAIEA+LFGKS+MSPKVA+LKPLSSGIV Sbjct: 109 GPWVIVVPAIGGLIVGLMARYGSDKIRGHGIPEAIEAVLFGKSKMSPKVAVLKPLSSGIV 168 Query: 123 IGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVLL 182 IGSGGPFGAEGPIIMTGGSI SLLAQ LHLTAAERKTLLV+GACAGMTAIFGTP+AAVLL Sbjct: 169 IGSGGPFGAEGPIIMTGGSIASLLAQYLHLTAAERKTLLVSGACAGMTAIFGTPVAAVLL 228 Query: 183 AVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLAS 242 A+ELLLFEL+PRSLLPVALACAVAGF+RP++ EAGPLFPL A + +AL SC++AGL Sbjct: 229 AIELLLFELRPRSLLPVALACAVAGFLRPFVFEAGPLFPLQTAPASTLALGSCVLAGLLC 288 Query: 243 GVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLHQ 302 G L A LTLALYR ED F LRLHWMWWPA+GG+ VG+GG +PRALGVGYDVIGDLL+ Sbjct: 289 GALGAGLTLALYRTEDAFDHLRLHWMWWPAIGGLVVGIGGYFEPRALGVGYDVIGDLLNN 348 Query: 303 HMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPLV 362 +L+ AA+ LL VKAVIW+ ALGSGTSGGVLAPLLMLGAGLG+VL+P LPGGS GLW LV Sbjct: 349 RLLVEAAVALLAVKAVIWIAALGSGTSGGVLAPLLMLGAGLGVVLAPMLPGGSPGLWALV 408 Query: 363 CMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIARR 422 CMAGVLGSVLGAPLTAIVFAFGLTH S+ALLPL+ TTAVAYG +VL MKRSIMTEKIARR Sbjct: 409 CMAGVLGSVLGAPLTAIVFAFGLTHDSEALLPLLLTTAVAYGFSVLTMKRSIMTEKIARR 468 Query: 423 GLHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQAHVHRYYPVTDGVHL 482 GLH++REYGVDPLER HV ELMT + +LP EAL HR YPV + Sbjct: 469 GLHIYREYGVDPLERAHVGELMTRDVVWIDASLPVTEALPRYFGDHAAHRAYPVLRDGRV 528 Query: 483 VGMLALRAL--EHA--DASQPC-DTLAQGHE-----HYLLPHMSARSAAGMMARLGVARL 532 +GML A+ HA DA C D LA G LLP + R+AAG MA L VARL Sbjct: 529 IGMLQRAAIVAAHAGDDAGLTCGDLLADGANPNAGPAVLLPAQTGRAAAGRMAELSVARL 588 Query: 533 PVVAGPERRKLVGVLSLSDLARASAAHAEEESVRERLLG 571 PVV +LVG++SL DL S+ EE+ RERL G Sbjct: 589 PVVEDEITMRLVGIVSLRDLMAPSSHVLHEETQRERLRG 627 >Q46XU8.1 Q46XU8_CUPPJ CBS:Cl-channel, voltage gated Length = 584 Score = 660 bits (1703), Expect = 0.0, Method: Compositional matrix adjust. Identities = 394/574 (68%), Positives = 448/574 (78%), Gaps = 5/574 (0%) Query: 3 HKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTL 62 K DY +RL LC IAL IG++ST AA +LLKLI FTNLF++Q LSLA +PA HTL Sbjct: 4 EKSDYAVSQRLLLLCGIALLIGVVSTLAADVLLKLIRFFTNLFFYQTLSLAERSPAHHTL 63 Query: 63 GWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIV 122 G ++P+ GGLIVGLMARYGSDKIRGHGIPEAIEA+LFGKS+MSP+VA+LKPLSSGIV Sbjct: 64 GAWVIVVPVLGGLIVGLMARYGSDKIRGHGIPEAIEAVLFGKSKMSPRVAVLKPLSSGIV 123 Query: 123 IGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVLL 182 IGSGGPFGAEGPIIMTGGS+ SLLAQ LHLTA ERK+LLVAGACAGMTAIFGTP+AAVLL Sbjct: 124 IGSGGPFGAEGPIIMTGGSLASLLAQYLHLTAGERKSLLVAGACAGMTAIFGTPVAAVLL 183 Query: 183 AVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLAS 242 A+ELLLFEL+PRSLLPVALACAVAGF+RP+ EAGPLFPL A PVAL SC+VAGL Sbjct: 184 AIELLLFELRPRSLLPVALACAVAGFLRPFFFEAGPLFPLQTAPAGPVALGSCVVAGLLC 243 Query: 243 GVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLHQ 302 G L AALTLALYR ED F RL LHWMWWPA+GG+ VG+GG +PRALGVGYDVIGDLL+ Sbjct: 244 GALGAALTLALYRTEDAFSRLPLHWMWWPAIGGLLVGIGGYFEPRALGVGYDVIGDLLNN 303 Query: 303 HMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPLV 362 H+ +S A+ LL+VKA+IW+ ALGSGTSGGVLAPLLMLGAGLG VL+PWLPGGS LW LV Sbjct: 304 HLAISVAVALLVVKALIWIAALGSGTSGGVLAPLLMLGAGLGTVLAPWLPGGSPQLWALV 363 Query: 363 CMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIARR 422 CMAGVLGSVLGAPLTAIVFAFGLTH ++ALLPL+ TTAVAYG +VL MKRSIMTEKIARR Sbjct: 364 CMAGVLGSVLGAPLTAIVFAFGLTHNTEALLPLLLTTAVAYGFSVLTMKRSIMTEKIARR 423 Query: 423 GLHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQAHVHRYYPVTDGVHL 482 GLH++REY VDPLER HV ELMT T+ L +EA A + HR YPV G + Sbjct: 424 GLHIYREYSVDPLERAHVAELMTRDVITIDADLGVSEATARYFGEHAAHRAYPVVSGDRV 483 Query: 483 VGMLALRALEHADA-SQP----CDTLAQGHEHYLLPHMSARSAAGMMARLGVARLPVVAG 537 +GML + A A S P C L L+P +AR+AAG MA VARLPVV Sbjct: 484 LGMLDRATVRGAAAGSAPANLRCRDLLVAQAQVLMPAQTARAAAGSMAASSVARLPVVES 543 Query: 538 PERRKLVGVLSLSDLARASAAHAEEESVRERLLG 571 + +LVG++SL DL + S EE RERL G Sbjct: 544 LDTMRLVGIVSLRDLLQPSGQVFHEEFRRERLRG 577 >E6V8I8.1 E6V8I8_VARPD Cl-channel voltage-gated family protein Length = 581 Score = 659 bits (1699), Expect = 0.0, Method: Compositional matrix adjust. Identities = 359/568 (63%), Positives = 434/568 (76%) Query: 4 KRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTLG 63 + D+ + RL + A+A+ IG +ST AA +LL LI FTNLF+FQ SLA +PA HTLG Sbjct: 9 RGDFALNARLLRITAMAIVIGAISTVAARVLLDLIRFFTNLFFFQTFSLADRSPAEHTLG 68 Query: 64 WIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIVI 123 ++P+ GGLIVGL+ARYGSDKIRGHGIPEAIEAILFGKS+MSPKVA+LKPLSSGIVI Sbjct: 69 AWVIVVPVIGGLIVGLVARYGSDKIRGHGIPEAIEAILFGKSKMSPKVAVLKPLSSGIVI 128 Query: 124 GSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVLLA 183 GSGGPFGAEGPIIMTGG+IGSL+AQ HLTAAERK LLVAGA AGMTA+FGTP+AAVLLA Sbjct: 129 GSGGPFGAEGPIIMTGGAIGSLIAQYFHLTAAERKALLVAGATAGMTAVFGTPVAAVLLA 188 Query: 184 VELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLASG 243 VELLLFEL+PRSLLPVA+ACAVAGF RP L++AGPLFPL A P P+A+LSC+VAGL G Sbjct: 189 VELLLFELRPRSLLPVAVACAVAGFTRPLLMDAGPLFPLQTAVPGPLAMLSCIVAGLLCG 248 Query: 244 VLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLHQH 303 VL+A+L+++LY++ED F +L +HWMWWPA+GG+AVG+GG +PRALGVGYDVIGDLLH H Sbjct: 249 VLSASLSISLYKVEDLFGKLPIHWMWWPAIGGLAVGIGGYFEPRALGVGYDVIGDLLHNH 308 Query: 304 MLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPLVC 363 + L LL VKA+IW+++LGSGTSGGVLAPLLM+GAGLG+VLS LPG LWPLVC Sbjct: 309 LALGVVAALLAVKAIIWIISLGSGTSGGVLAPLLMMGAGLGVVLSHVLPGNDPILWPLVC 368 Query: 364 MAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIARRG 423 MA LG V+ APLTA +FAFGLTH S ALLPL+ T+AVAYG VL M+RSI+TEKIARRG Sbjct: 369 MAATLGGVMRAPLTATIFAFGLTHDSNALLPLLTTSAVAYGFTVLTMRRSILTEKIARRG 428 Query: 424 LHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQAHVHRYYPVTDGVHLV 483 H++REYG+DPLER VEE+MT +++ ALP AEALA + +HR YPV G ++ Sbjct: 429 YHIYREYGIDPLERHSVEEVMTREVRSIDAALPVAEALAQYFGEGQMHRAYPVLRGNAVI 488 Query: 484 GMLALRALEHADASQPCDTLAQGHEHYLLPHMSARSAAGMMARLGVARLPVVAGPERRKL 543 GM L D + L + R A +AR + RLPVV + L Sbjct: 489 GMADRAMLAAFSVGTVGDACEGSAPLFALAGENCRVVATRLARHRLERLPVVKDAQSLAL 548 Query: 544 VGVLSLSDLARASAAHAEEESVRERLLG 571 VG+++ SDL + S AH +EE RER+ G Sbjct: 549 VGLVARSDLIKPSLAHFDEEEKRERMRG 576 >B1FLV6.1 B1FLV6_9BURK Chloride channel core Length = 595 Score = 653 bits (1685), Expect = 0.0, Method: Compositional matrix adjust. Identities = 371/581 (63%), Positives = 439/581 (75%), Gaps = 21/581 (3%) Query: 3 HKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTL 62 HKRD++ + RLP + +A IGLLST AA++LL LI LFTNLF+FQ+ S A +PA HTL Sbjct: 5 HKRDFSTNERLPRIALLAAGIGLLSTLAAFVLLSLIHLFTNLFFFQQFSFADRSPANHTL 64 Query: 63 GWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIV 122 G ++P+ GGLIVGLMAR+GS+KIRGHGIPEAIEAILFGKSRMSPKVA+LKPLSSG+V Sbjct: 65 GAWVIVVPVIGGLIVGLMARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAILKPLSSGVV 124 Query: 123 IGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVLL 182 IGSGGPFGAEGPIIMTGG++GSL+AQ +H+TAAERKTLLVAGA AGMTA+FGTP+AAVLL Sbjct: 125 IGSGGPFGAEGPIIMTGGALGSLIAQCVHVTAAERKTLLVAGAAAGMTAVFGTPVAAVLL 184 Query: 183 AVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLAS 242 AVELLLFE +PRS LPVALACAVAGF R PLFPL A+PTPVALLSC+VAGL S Sbjct: 185 AVELLLFEWRPRSFLPVALACAVAGFARAVFFGVEPLFPLTTASPTPVALLSCIVAGLLS 244 Query: 243 GVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLHQ 302 G+LA L+ ALYR+ED F +L +HWMWWPALG +A+G+GG L+PRALGVGYDVIGDLLHQ Sbjct: 245 GMLACGLSAALYRVEDTFAKLPVHWMWWPALGAVAIGIGGWLEPRALGVGYDVIGDLLHQ 304 Query: 303 HMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPLV 362 H+ L AL LL+VKAV+W++ALGSGTSGGVLAPLLMLGAGLG VLSP LPGG LWPLV Sbjct: 305 HIALKIALALLIVKAVMWVIALGSGTSGGVLAPLLMLGAGLGTVLSPVLPGGDPALWPLV 364 Query: 363 CMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIARR 422 CMA LG+ LGAPLTAIVFAFGLTH + ALLPL+A T VA+G ++MKRSIMTEKIARR Sbjct: 365 CMAATLGATLGAPLTAIVFAFGLTHDANALLPLLAATLVAHGFATIVMKRSIMTEKIARR 424 Query: 423 GLHVHREYGVDPLERMHVEELMTAAPQTLA--GALPAAEALAWCRAQAHVHRYYPVTDGV 480 G H++REYGVDPLER V E+MT+A +A GA P + HR YPV Sbjct: 425 GYHIYREYGVDPLERHDVAEVMTSADALVAIDGATPLDAVESQYFGAKQTHRAYPVVQHG 484 Query: 481 HLVGML------ALRALEHADAS------QPCDTLAQGHEHYLLPHMSARSAAGMMARLG 528 L+G++ A RA DAS +AQ HE + R A +A LG Sbjct: 485 RLLGLIDRATLDAHRAQAGPDASLASAFADRAPAVAQAHE-------TCRVVASRLAMLG 537 Query: 529 VARLPVVAGPERRKLVGVLSLSDLARASAAHAEEESVRERL 569 + RLPVV P+ +L G++S SDL + + H ++E RER Sbjct: 538 LERLPVVDDPQSLRLAGIVSRSDLIKPALQHFDDEQKRERF 578 >B4ELA3.1 B4ELA3_BURCJ Putative voltage-gated clc-type chloride channel Length = 595 Score = 652 bits (1681), Expect = 0.0, Method: Compositional matrix adjust. Identities = 368/577 (63%), Positives = 436/577 (75%), Gaps = 13/577 (2%) Query: 3 HKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTL 62 HKRD++ + RLP + +A IGLLST AA++LL LI LFTNLF+FQ+ S A +PA +TL Sbjct: 5 HKRDFSTNERLPRIALLAAVIGLLSTLAAFVLLSLIHLFTNLFFFQQFSFADHSPANNTL 64 Query: 63 G-WIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGI 121 G W+ A+ P+ GGLIVGLMAR+GS+KIRGHGIPEAIEAILFGKSRMSPKVA+LKPLSSG+ Sbjct: 65 GAWVIAV-PVIGGLIVGLMARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAILKPLSSGV 123 Query: 122 VIGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVL 181 VIGSGGPFGAEGPIIMTGG++GSL+AQ +H+TAAERKTLLVAGA AGMTA+FGTP+AAVL Sbjct: 124 VIGSGGPFGAEGPIIMTGGALGSLIAQCVHVTAAERKTLLVAGAAAGMTAVFGTPVAAVL 183 Query: 182 LAVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLA 241 LAVELLLFE +PRS LPVALACAVAGF R PLFPL AAPTPVALLSC+VAGL Sbjct: 184 LAVELLLFEWRPRSFLPVALACAVAGFARAVFFGVDPLFPLTTAAPTPVALLSCIVAGLL 243 Query: 242 SGVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLH 301 SG LA L+ ALYR+ED F +L +HWMWWPALG I +G+GG L+PRALGVGYDVIGDLLH Sbjct: 244 SGALACGLSAALYRVEDTFAKLPVHWMWWPALGAIVIGVGGWLEPRALGVGYDVIGDLLH 303 Query: 302 QHMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPL 361 QH++L AL LL+VKAV+W++ALGSGTSGGVLAPLLMLGAGLG VLSP LPGG LWPL Sbjct: 304 QHIVLKIALALLIVKAVMWVIALGSGTSGGVLAPLLMLGAGLGTVLSPVLPGGDPALWPL 363 Query: 362 VCMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIAR 421 VCMA LG+ LGAPLTAIVFAFGLTH + ALLPL+A T VA+G ++MKRSIMTEKIAR Sbjct: 364 VCMAATLGATLGAPLTAIVFAFGLTHDTNALLPLLAATLVAHGFATIVMKRSIMTEKIAR 423 Query: 422 RGLHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQ----AHVHRYYPVT 477 RG H++REYGVDPLER + E+MT+A L A+ L Q HR YPV Sbjct: 424 RGYHIYREYGVDPLERHDIGEVMTSA--DLLVAIDGTATLDTVETQYFGAKQTHRAYPVV 481 Query: 478 DGVHLVGMLALRALEHADASQPCDT-----LAQGHEHYLLPHMSARSAAGMMARLGVARL 532 L+G++ L+ A DT A L H + R A +A LG+ RL Sbjct: 482 QNGRLLGLVDRATLDAQRAQAGADTPISAAFADRAPAVALAHETCRVVASRLAMLGLERL 541 Query: 533 PVVAGPERRKLVGVLSLSDLARASAAHAEEESVRERL 569 PVVA + ++ G++S SDL + + H ++E RER Sbjct: 542 PVVADEQSLRITGIVSRSDLIKPALQHFDDEHKRERF 578 >B1YX23.1 B1YX23_BURA4 Chloride channel core Length = 595 Score = 651 bits (1679), Expect = 0.0, Method: Compositional matrix adjust. Identities = 368/581 (63%), Positives = 437/581 (75%), Gaps = 21/581 (3%) Query: 3 HKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTL 62 HKRD++ + RLP + +A IGLLST AA++LL LI LFTNLF+FQ+ S +PA HTL Sbjct: 5 HKRDFSTNERLPRIALLAAGIGLLSTLAAFVLLSLIHLFTNLFFFQQFSFTERSPANHTL 64 Query: 63 GWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIV 122 G ++P+ GGLIVGLMAR+GS+KIRGHGIPEAIEAILFGKSRMSPKVA+LKPLSSG+V Sbjct: 65 GAWVIVVPVIGGLIVGLMARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAILKPLSSGVV 124 Query: 123 IGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVLL 182 IGSGGPFGAEGPIIMTGG++GSL+AQ +H+TAAERKTLLVAGA AGMTA+FGTP+AAVLL Sbjct: 125 IGSGGPFGAEGPIIMTGGALGSLIAQCVHVTAAERKTLLVAGAAAGMTAVFGTPVAAVLL 184 Query: 183 AVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLAS 242 AVELLLFE +PRS LPVALACAVAGF R PLFPL A+PTPVALLSC+VAGL S Sbjct: 185 AVELLLFEWRPRSFLPVALACAVAGFARAVFFGVEPLFPLTTASPTPVALLSCIVAGLLS 244 Query: 243 GVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLHQ 302 G+LA L+ ALYR+ED F +L +HWMWWPALG + +G+GG L+PRALGVGYDVIGDLLHQ Sbjct: 245 GMLACGLSAALYRVEDTFAKLPVHWMWWPALGAVVIGIGGWLEPRALGVGYDVIGDLLHQ 304 Query: 303 HMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPLV 362 H+ L AL LL+VKAV+W++ALGSGTSGGVLAPLLMLGAGLG VLSP LPGG LWPLV Sbjct: 305 HIALKIALALLIVKAVMWVIALGSGTSGGVLAPLLMLGAGLGTVLSPVLPGGDPALWPLV 364 Query: 363 CMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIARR 422 CMA LG+ LGAPLTAIVFAFGLTH + ALLPL+A T VA+G ++MKRSIMTEKIARR Sbjct: 365 CMAATLGATLGAPLTAIVFAFGLTHDANALLPLLAATLVAHGFATIVMKRSIMTEKIARR 424 Query: 423 GLHVHREYGVDPLERMHVEELMTAAPQTLA--GALPAAEALAWCRAQAHVHRYYPVTDGV 480 G H++REYGVDPLER V E+MT+A +A GA P + HR YPV Sbjct: 425 GYHIYREYGVDPLERHDVAEVMTSADALVAIDGATPLDAVESQYFGAKQTHRAYPVVQNG 484 Query: 481 HLVGML------ALRALEHADAS------QPCDTLAQGHEHYLLPHMSARSAAGMMARLG 528 L+G++ A RA DAS +AQ HE + R A +A LG Sbjct: 485 RLLGLVDRATLDAHRAQAGPDASIASAFAGRAPAVAQAHE-------TCRVVASRLAMLG 537 Query: 529 VARLPVVAGPERRKLVGVLSLSDLARASAAHAEEESVRERL 569 + RLPVV P+ ++ G++S SDL + + H ++E RER Sbjct: 538 LERLPVVDDPQSLRVTGIVSRSDLIKPALQHFDDEQKRERF 578 >Q0B8K2.1 Q0B8K2_BURCM Cl-channel, voltage-gated family protein Length = 595 Score = 650 bits (1677), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/574 (63%), Positives = 433/574 (75%), Gaps = 7/574 (1%) Query: 3 HKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTL 62 HKRD++ + RLP + +A IGLLST AA++LL LI LFTNLF+FQ+ S +PA HTL Sbjct: 5 HKRDFSTNERLPRIALLAAGIGLLSTLAAFVLLSLIHLFTNLFFFQQFSFTERSPANHTL 64 Query: 63 GWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIV 122 G ++P+ GGLIVGLMAR+GS+KIRGHGIPEAIEAILFGKSRMSPKVA+LKPLSSG+V Sbjct: 65 GAWVIVVPVIGGLIVGLMARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAILKPLSSGVV 124 Query: 123 IGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVLL 182 IGSGGPFGAEGPIIMTGG++GSL+AQ +H+TAAERKTLLVAGA AGMTA+FGTP+AAVLL Sbjct: 125 IGSGGPFGAEGPIIMTGGALGSLIAQCVHVTAAERKTLLVAGAAAGMTAVFGTPVAAVLL 184 Query: 183 AVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLAS 242 AVELLLFE +PRS LPVALACAVAGF R PLFPL A+PTPVALLSC+VAGL S Sbjct: 185 AVELLLFEWRPRSFLPVALACAVAGFARAVFFGVEPLFPLTTASPTPVALLSCIVAGLLS 244 Query: 243 GVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLHQ 302 G+LA L+ ALYR+ED F +L +HWMWWPALG I +G+GG L+PRALGVGYDVIGDLLHQ Sbjct: 245 GMLACGLSAALYRVEDTFAKLPVHWMWWPALGAIVIGIGGWLEPRALGVGYDVIGDLLHQ 304 Query: 303 HMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPLV 362 H+ L AL LL+VKAV+W++ALGSGTSGGVLAPLLMLGAGLG VLSP LPGG LWPLV Sbjct: 305 HIALKIALALLIVKAVMWVIALGSGTSGGVLAPLLMLGAGLGTVLSPVLPGGDPALWPLV 364 Query: 363 CMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIARR 422 CMA LG+ LGAPLTAIVFAFGLTH + ALLPL+A T VA+G ++MKRSIMTEKIARR Sbjct: 365 CMAATLGATLGAPLTAIVFAFGLTHDANALLPLLAATLVAHGFATIVMKRSIMTEKIARR 424 Query: 423 GLHVHREYGVDPLERMHVEELMTAAPQTLA--GALPAAEALAWCRAQAHVHRYYPVTDGV 480 G H++REYGVDPLER V E+MT A +A GA P + HR YPV Sbjct: 425 GYHIYREYGVDPLERHDVTEVMTPADALVAIDGATPLDAVESQYFGAKQTHRAYPVVQNG 484 Query: 481 HLVGMLALRALE-HADASQPCDTLAQGHEH----YLLPHMSARSAAGMMARLGVARLPVV 535 L+G++ L+ H + P LA H + R A +A LG+ RLPVV Sbjct: 485 RLLGLVDRATLDAHRAQAGPDAPLASAFADRAPAVAQAHETCRVVASRLAMLGLERLPVV 544 Query: 536 AGPERRKLVGVLSLSDLARASAAHAEEESVRERL 569 P+ ++ G++S SDL + + H ++E RER Sbjct: 545 DDPQSLRVTGIVSRSDLIKPALQHFDDEQKRERF 578 >B1TDN6.1 B1TDN6_9BURK Chloride channel core Length = 595 Score = 650 bits (1676), Expect = 0.0, Method: Compositional matrix adjust. Identities = 364/574 (63%), Positives = 437/574 (76%), Gaps = 7/574 (1%) Query: 3 HKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTL 62 HKRD++ + RLP + +A IGLLST AA++LL LI LFTNLF+FQ+ S A +PA HTL Sbjct: 5 HKRDFSINERLPRIALLAAGIGLLSTLAAFVLLSLIHLFTNLFFFQQFSFADRSPANHTL 64 Query: 63 GWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIV 122 G ++P+ GGLIVGLMAR+GS+KIRGHGIPEAIEAILFGKSRMSPKVA+LKPLSSG+V Sbjct: 65 GAWVIVVPVIGGLIVGLMARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAILKPLSSGVV 124 Query: 123 IGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVLL 182 IGSGGPFGAEGPIIMTGG++GSL+AQ +H+TAAERKTLLVAGA AGMTA+FGTP+AAVLL Sbjct: 125 IGSGGPFGAEGPIIMTGGALGSLIAQCVHVTAAERKTLLVAGAAAGMTAVFGTPVAAVLL 184 Query: 183 AVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLAS 242 AVELLLFE +PRS LPVALACAVAGF R PLF L A+PTPVALLSC+VAGL S Sbjct: 185 AVELLLFEWRPRSFLPVALACAVAGFARAVFFGVEPLFALTTASPTPVALLSCIVAGLLS 244 Query: 243 GVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLHQ 302 G+LA L+ ALYR+ED F +L +HWMWWPALG + +G+GG L+PRALGVGYDVIGDLLHQ Sbjct: 245 GMLACGLSAALYRVEDAFAKLPVHWMWWPALGAVVIGIGGWLEPRALGVGYDVIGDLLHQ 304 Query: 303 HMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPLV 362 H+ L+ AL LL+VKAV+W++ALGSGTSGGVLAPLLMLGAGLG VLSP LPGG LWPLV Sbjct: 305 HIALTIALALLIVKAVMWVIALGSGTSGGVLAPLLMLGAGLGTVLSPVLPGGDPALWPLV 364 Query: 363 CMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIARR 422 CMA LG+ LGAPLTAIVFAFGLTH + ALLPL+A T VA+G ++MKRSIMTEKIARR Sbjct: 365 CMAATLGATLGAPLTAIVFAFGLTHDANALLPLLAATLVAHGFATIVMKRSIMTEKIARR 424 Query: 423 GLHVHREYGVDPLERMHVEELMTAAPQTLA--GALPAAEALAWCRAQAHVHRYYPVTDGV 480 G H++REYGVDPLER V E+MT+A +A GA P + HR YPV Sbjct: 425 GYHIYREYGVDPLERHDVAEVMTSADALVAIDGATPLDAVESQYFGAKQTHRAYPVVQNG 484 Query: 481 HLVGMLALRALE-HADASQPCDTLAQGHEH----YLLPHMSARSAAGMMARLGVARLPVV 535 L+G++ L+ H + P +LA H + R A +A LG+ RLPVV Sbjct: 485 RLLGLVDRATLDTHRAQAGPDASLASAFADRAPAVAHAHETCRVVASRLAMLGLERLPVV 544 Query: 536 AGPERRKLVGVLSLSDLARASAAHAEEESVRERL 569 P+ +++G++S SDL + + H ++E RER Sbjct: 545 DDPQSLRVIGIVSRSDLIKPALQHFDDEQKRERF 578 >Q1BNT8.1 Q1BNT8_BURCA Cl-channel, voltage gated Length = 595 Score = 650 bits (1676), Expect = 0.0, Method: Compositional matrix adjust. Identities = 368/577 (63%), Positives = 438/577 (75%), Gaps = 13/577 (2%) Query: 3 HKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATHTL 62 HKRD++ + RLP + +A IGLLST AA++LL LI LFTNLF+F++ S A +PAT+TL Sbjct: 5 HKRDFSTNARLPRIALLAAGIGLLSTLAAFVLLSLIRLFTNLFFFRQFSFAEHSPATNTL 64 Query: 63 G-WIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGI 121 G W+ A+ P+ GGLIVGLMAR+GS+KIRGHGIPEAIEAILFGKSRMSPKVA+LKPLSSG+ Sbjct: 65 GAWVIAV-PVIGGLIVGLMARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAILKPLSSGV 123 Query: 122 VIGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAVL 181 VIGSGGPFGAEGPIIMTGG++GSL+AQ +H+TAAERKTLLVAGA AGMTA+FGTP+AAVL Sbjct: 124 VIGSGGPFGAEGPIIMTGGALGSLIAQCVHVTAAERKTLLVAGAAAGMTAVFGTPVAAVL 183 Query: 182 LAVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGLA 241 LAVELLLFE +PRS LPVALACAVAGF R PLFPL AAPTPVALLSC+VAGL Sbjct: 184 LAVELLLFEWRPRSFLPVALACAVAGFARTVFFGVDPLFPLTTAAPTPVALLSCIVAGLL 243 Query: 242 SGVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLLH 301 SG+LA L+ ALYR+ED F +L +HWMWWPALG I +G+GG L+PRALGVGYDVIGDLLH Sbjct: 244 SGMLACGLSAALYRVEDTFAKLPVHWMWWPALGAIVIGIGGWLEPRALGVGYDVIGDLLH 303 Query: 302 QHMLLSAALTLLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWPL 361 QH+ L AL LL+VKAV+W++ALGSGTSGGVLAPLLMLGAGLG VLSP LPGG LWPL Sbjct: 304 QHIALKIALALLIVKAVMWVIALGSGTSGGVLAPLLMLGAGLGTVLSPVLPGGDPALWPL 363 Query: 362 VCMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIAR 421 VCMA LG+ LGAPLTAIVFAFGLTH + ALLPL+A T VA+G ++MKRSIMTEKIAR Sbjct: 364 VCMAATLGATLGAPLTAIVFAFGLTHDANALLPLLAATLVAHGFATVVMKRSIMTEKIAR 423 Query: 422 RGLHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQ----AHVHRYYPVT 477 RG H++REYGVDPLER + E+MT+A + + A+ A L Q HR YPV Sbjct: 424 RGYHIYREYGVDPLERHDIGEVMTSADRLV--AIDGAATLDTVETQYFGATQTHRAYPVV 481 Query: 478 DGVHLVGMLALRALEHADASQPCDT-----LAQGHEHYLLPHMSARSAAGMMARLGVARL 532 L+G++ L+ A DT A L H R A +A LG+ RL Sbjct: 482 QNGRLLGLVDRATLDAQRARAGADTPISAAFADRAPAVALAHEPCRVVASRLAMLGLERL 541 Query: 533 PVVAGPERRKLVGVLSLSDLARASAAHAEEESVRERL 569 PVVA + ++ G++S SDL + + H ++E RER Sbjct: 542 PVVADEQSLRITGIVSRSDLIKPALQHFDDEHKRERF 578