BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0457.p (284 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IS14.1 D8IS14_HERSS Gluconolactonase protein 585 e-165 A4G1Q8.1 A4G1Q8_HERAR Putative gluconolactonase with senescence ... 380 e-103 Q6J687.1 Q6J687_9BURK Gluconolactonase 377 e-103 A6SUL2.1 A6SUL2_JANMA Gluconolactonase 356 2e-96 B1Y487.1 B1Y487_LEPCP SMP-30/Gluconolaconase/LRE domain protein 303 2e-80 C5CX79.1 C5CX79_VARPS SMP-30/Gluconolaconase/LRE domain protein 275 6e-72 A1WL09.1 A1WL09_VEREI Gluconolactonase EC=3.1.1.17 263 2e-68 A1VIG9.1 A1VIG9_POLNA Gluconolactonase EC=3.1.1.17 261 8e-68 B2JMN7.1 B2JMN7_BURP8 SMP-30/Gluconolaconase/LRE domain protein 261 1e-67 Q12H41.1 Q12H41_POLSJ Gluconolactonase EC=3.1.1.17 260 1e-67 >D8IS14.1 D8IS14_HERSS Gluconolactonase protein Length = 302 Score = 585 bits (1507), Expect = e-165, Method: Compositional matrix adjust. Identities = 282/284 (99%), Positives = 283/284 (99%) Query: 1 MLLGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAI 60 MLLGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAI Sbjct: 19 MLLGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAI 78 Query: 61 RTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCFE 120 RTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCFE Sbjct: 79 RTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCFE 138 Query: 121 RNALRDAHHAVVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNCRLLRQFDSD 180 RNALRDAHHAVVTSNGLAFS DQRLMYHANTPAHRINLYDYDLATGATSNCRLLRQFDSD Sbjct: 139 RNALRDAHHAVVTSNGLAFSSDQRLMYHANTPAHRINLYDYDLATGATSNCRLLRQFDSD 198 Query: 181 KSAPDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVAFGGDD 240 KSAPDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVAFGGDD Sbjct: 199 KSAPDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVAFGGDD 258 Query: 241 LRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPGQLEYSYRP 284 LRTLYITTGRNGRSPAELAQYPESGCVLAVRV+VPGQLEYSYRP Sbjct: 259 LRTLYITTGRNGRSPAELAQYPESGCVLAVRVDVPGQLEYSYRP 302 >A4G1Q8.1 A4G1Q8_HERAR Putative gluconolactonase with senescence marker Length = 296 Score = 380 bits (975), Expect = e-103, Method: Compositional matrix adjust. Identities = 176/282 (62%), Positives = 217/282 (76%), Gaps = 1/282 (0%) Query: 1 MLLGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAI 60 M LGE PLWHAQ+AALYWIDI G A+HR HP G H W +P EPG I +A GGL+VA+ Sbjct: 14 MQLGECPLWHAQQAALYWIDIDGCAIHRFHPAHGAHHVWTMPSEPGCIAINASGGLIVAL 73 Query: 61 RTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCFE 120 R+G+ L+TD G LT + AAPYD + RFNDGRCDA+GR W G+IYEPRD LYC E Sbjct: 74 RSGLALLDTDNGQLTTIAAAPYDPASTRFNDGRCDAAGRLWVGSIYEPRDHPHAALYCIE 133 Query: 121 RNALRDAHHAVVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNCRLLRQFDSD 180 R +RD+ SNG+AFSPD + +YHA+T +HRI+ Y+YD+ATGA S RLL+QF +D Sbjct: 134 RGLIRDSGKRATVSNGVAFSPDNKTLYHADTTSHRISAYEYDVATGAISGTRLLKQFSTD 193 Query: 181 KSAPDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVAFGGDD 240 K +YGGRPDGAAVDS+GAYWCAM+EGG++LRLSP GE+L+EI LP RCPTM+AFGGDD Sbjct: 194 K-LNNYGGRPDGAAVDSEGAYWCAMYEGGKILRLSPDGEVLREIPLPVRCPTMLAFGGDD 252 Query: 241 LRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPGQLEYSY 282 LRTLYITT R AEL Q+P SGCVL++R++V G +E++Y Sbjct: 253 LRTLYITTVSKNRPAAELKQFPLSGCVLSLRIDVAGLVEHAY 294 >Q6J687.1 Q6J687_9BURK Gluconolactonase Length = 295 Score = 377 bits (969), Expect = e-103, Method: Compositional matrix adjust. Identities = 179/282 (63%), Positives = 214/282 (75%) Query: 1 MLLGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAI 60 M LGE PLWHA EAALYW+DI VHRL P G H W LP EPG I RHA GGLVVA+ Sbjct: 12 MQLGECPLWHAGEAALYWVDISAMQVHRLRPADGVHAMWQLPAEPGCIGRHAGGGLVVAM 71 Query: 61 RTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCFE 120 RTG+ HLNTD+G LT + APYD++ RFNDGRCDA+GRFW GTIYEPRD G LY E Sbjct: 72 RTGVVHLNTDSGELTHIADAPYDTATARFNDGRCDAAGRFWAGTIYEPRDHAGAQLYAIE 131 Query: 121 RNALRDAHHAVVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNCRLLRQFDSD 180 ++ +R A + V SNGL FS D R++YH++T AHRI Y++DL G R+L+QF D Sbjct: 132 KDKVRPAGNPVTVSNGLGFSGDSRILYHSDTTAHRICSYEFDLENGVIGAGRVLKQFAMD 191 Query: 181 KSAPDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVAFGGDD 240 KSA DYGGRPDGAAVDS+ AYWCAM+EGGR+LRLSP GE+LQE+ LP RCPTM+AFGG D Sbjct: 192 KSAADYGGRPDGAAVDSEDAYWCAMYEGGRLLRLSPSGEVLQEVLLPVRCPTMMAFGGAD 251 Query: 241 LRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPGQLEYSY 282 LRTLYIT+ RS AEL +YP SG +L++RV+VPG++E +Y Sbjct: 252 LRTLYITSVSEKRSAAELQKYPASGYILSLRVDVPGRIEPAY 293 >A6SUL2.1 A6SUL2_JANMA Gluconolactonase Length = 296 Score = 356 bits (914), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 167/282 (59%), Positives = 207/282 (73%), Gaps = 1/282 (0%) Query: 1 MLLGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAI 60 M LGE PLWH +EAALYWIDI G+AVHR P + H++WD+P EPG I +A GL+VA+ Sbjct: 14 MQLGECPLWHPEEAALYWIDIDGRAVHRFIPANDVHQQWDMPSEPGCIALNAGSGLLVAL 73 Query: 61 RTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCFE 120 R+G+ L+T +G LT + APYD + RFNDGRCDA+GR W G+IYEPRD LYC E Sbjct: 74 RSGLALLDTTSGQLTQIADAPYDPATTRFNDGRCDAAGRLWTGSIYEPRDHANAALYCVE 133 Query: 121 RNALRDAHHAVVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNCRLLRQFDSD 180 +RD+ SNG+AFSPD R MYHA+T HRI Y++D+ + R+L+QF +D Sbjct: 134 HGEIRDSDKRATVSNGVAFSPDNRTMYHADTTTHRIFAYEFDIGSATLGEGRVLKQFSTD 193 Query: 181 KSAPDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVAFGGDD 240 K +YGGRPDGAAVDS+G YWCAM+EGGR+LRLSP G+IL E+ LP RCPTM+AFGGDD Sbjct: 194 KQN-NYGGRPDGAAVDSEGNYWCAMYEGGRILRLSPAGDILSELALPVRCPTMMAFGGDD 252 Query: 241 LRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPGQLEYSY 282 LRTLYIT+ R AEL QYP SGCVL++RV+VPG E+ Y Sbjct: 253 LRTLYITSVSKNRPAAELEQYPLSGCVLSLRVDVPGLPEHFY 294 >B1Y487.1 B1Y487_LEPCP SMP-30/Gluconolaconase/LRE domain protein Length = 299 Score = 303 bits (776), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 149/279 (53%), Positives = 185/279 (66%), Gaps = 3/279 (1%) Query: 1 MLLGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAI 60 MLLGESP+WH QE LYW+DIPGK +HRL P SG + WD P EP + GGL++A+ Sbjct: 13 MLLGESPMWHPQEQLLYWVDIPGKRLHRLDPGSGAQRHWDFPCEPAACAPVLGGGLLLAM 72 Query: 61 RTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCFE 120 R G++ + +T +LL PYD S RFNDG+CD GRFW GTIYEPR+ LY + Sbjct: 73 RDGLWRFDPETSLRSLLCEPPYDPSSERFNDGKCDPLGRFWVGTIYEPREPARAALYRWH 132 Query: 121 RNALRDAHHAVVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNCRLLRQFDSD 180 L + SNGL +SPD R MY ++T AH + D+D+ GA S R+ F+ Sbjct: 133 ARKLDRMAGDITVSNGLGWSPDARTMYWSDTKAHTVYALDFDVGEGAVSQQRVFASFERK 192 Query: 181 KSAPD---YGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVAFG 237 + D YGGRPDGAAVD+QG YW AMFEG R+LRLSPQG +L+E+ LP RCPTM FG Sbjct: 193 RPDQDLRHYGGRPDGAAVDAQGCYWVAMFEGQRLLRLSPQGTVLRELALPVRCPTMPCFG 252 Query: 238 GDDLRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPG 276 G DLRTLYITT R R ELA+ P +GCVL++RV+VPG Sbjct: 253 GADLRTLYITTARENRPAPELAEQPLAGCVLSLRVDVPG 291 >C5CX79.1 C5CX79_VARPS SMP-30/Gluconolaconase/LRE domain protein Length = 311 Score = 275 bits (703), Expect = 6e-72, Method: Compositional matrix adjust. Identities = 138/292 (47%), Positives = 185/292 (63%), Gaps = 18/292 (6%) Query: 3 LGESPLWHAQEAALYWIDIPGKAVHR----LHPESGQHKRWDLPEEPGSIVRHAQGGLVV 58 LGESP WH +E ALYW+DIPG+AV R + +S + +RW L EPG + GGLV+ Sbjct: 12 LGESPFWHPRERALYWLDIPGRAVLRTRGDIGTDSAKVERWALSTEPGCMAPARNGGLVI 71 Query: 59 AIRTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYC 118 A+R G++ G L + +D +RFNDG+CDA GRFW G+I E +DR LYC Sbjct: 72 ALRDGIYRAREWGGELVAIARVDHDVRTMRFNDGKCDALGRFWSGSINEAKDRANAALYC 131 Query: 119 FERN-------ALRDAHHAVVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNC 171 + AL + V T+NGLAFSPD R +Y A+TPAH++ +++D A S Sbjct: 132 LDARPGSGVAPALTQMANQVTTANGLAFSPDARTLYWADTPAHQVRAWNWDAAANTLSQP 191 Query: 172 RLLRQFDS-------DKSAPDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEI 224 R+ QFD+ D A Y GRPDGA VD+QG YW AMFEG ++LRL+P GEI+ + Sbjct: 192 RVFHQFDAKPEGWTPDSLALRYEGRPDGATVDAQGHYWVAMFEGAQLLRLAPSGEIVAAV 251 Query: 225 RLPARCPTMVAFGGDDLRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPG 276 +PA+CPTM FGGDDL+TL++TT R GR AE+ + P SG V+++RV+ PG Sbjct: 252 PVPAQCPTMPCFGGDDLKTLFVTTARKGRPAAEIERLPASGTVISMRVDTPG 303 >A1WL09.1 A1WL09_VEREI Gluconolactonase EC=3.1.1.17 Length = 299 Score = 263 bits (672), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 136/289 (47%), Positives = 170/289 (58%), Gaps = 7/289 (2%) Query: 3 LGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAIRT 62 LGESP WH E LYW DI G A+H P +G+ RW++P EPG V+ +R Sbjct: 11 LGESPFWHPHEKRLYWCDIQGFALHAWEPATGRSWRWEMPAEPGCCAPAPDRHCVIGLRD 70 Query: 63 GMFHLNTDTGALTLLLAAP---YDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCF 119 G L+T +GAL L P +D R+R NDGRCD +GRFW G++ PR L+ Sbjct: 71 GFHLLDTASGALRCLAPLPAARHDPRRLRLNDGRCDTAGRFWAGSMVTPRTAPDAALWRL 130 Query: 120 ERNA----LRDAHHAVVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNCRLLR 175 A L T+NGLAFSPD R MY +NTP HRI+ +D+D ATGA + Sbjct: 131 SAGAGGYRLEQMAGDNFTANGLAFSPDDRFMYWSNTPEHRIDRFDFDAATGAIGKRQPWA 190 Query: 176 QFDSDKSAPDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVA 235 F + YGGRPDGAAVD QG YW AM+EG VL+L+P G +LQ I P +CPTMV Sbjct: 191 HFARKEPGQPYGGRPDGAAVDRQGNYWVAMYEGACVLQLAPTGAVLQRIATPVQCPTMVC 250 Query: 236 FGGDDLRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPGQLEYSYRP 284 FGG+DLRTLYIT+ R GR E P +GC+ + RVEVPG ++P Sbjct: 251 FGGEDLRTLYITSARAGRPEQERNASPAAGCLFSTRVEVPGLAVNFFKP 299 >A1VIG9.1 A1VIG9_POLNA Gluconolactonase EC=3.1.1.17 Length = 308 Score = 261 bits (667), Expect = 8e-68, Method: Compositional matrix adjust. Identities = 137/288 (47%), Positives = 180/288 (62%), Gaps = 14/288 (4%) Query: 3 LGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGG----LVV 58 LGESP WH E LYW+DI + R +G +RW +P EPG I GG LV+ Sbjct: 13 LGESPFWHPDEQRLYWVDITACQICRADAATGMVERWTVPSEPGCIAPARTGGQNSGLVM 72 Query: 59 AIRTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYC 118 A+R G++ G L LL A +D + +RFNDG+ DA GRFW GTIYEPR L+ Sbjct: 73 ALRDGIYRARQWGGELALLAPAQHDPATLRFNDGKADALGRFWAGTIYEPRGAARAQLFS 132 Query: 119 FE----RNALRDAHHA-VVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNCRL 173 + R + +A A T+NGLA+SPD +Y A+TP H + +D+D A S+ R+ Sbjct: 133 LDGRGGRAPVLEAKAADATTANGLAWSPDAATLYWADTPRHLVRAWDWDAAGNTLSHERV 192 Query: 174 LRQFDSDKSA-----PDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPA 228 RQ+ P YGGRPDGAAVDSQG Y+ AM+EG R+L+LSP GE+L E +PA Sbjct: 193 FRQWPVKPEGWQAGMPGYGGRPDGAAVDSQGNYYVAMYEGARLLKLSPAGELLAEFAVPA 252 Query: 229 RCPTMVAFGGDDLRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPG 276 +CPTM FGG DL+TLY+TT R+GR AEL +P+SGC+ ++RV+VPG Sbjct: 253 QCPTMPCFGGADLKTLYLTTARHGRPAAELQAWPDSGCIFSMRVDVPG 300 >B2JMN7.1 B2JMN7_BURP8 SMP-30/Gluconolaconase/LRE domain protein Length = 296 Score = 261 bits (666), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 129/277 (46%), Positives = 171/277 (61%), Gaps = 3/277 (1%) Query: 3 LGESPLWHAQEAALYWIDIPGKAVHRLHPESGQHKRWDLPEEPGSIVRHAQGGLVVAIRT 62 LGE P W + A L+W+DI A+H P++GQ +PE G G + +RT Sbjct: 14 LGECPRWDERRAKLWWVDIQAPALHAFDPKTGQDTMLPMPENIGCFSLTEDDGFIAGMRT 73 Query: 63 GMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGTLYCFERN 122 G+F L+ + L A P + + RFNDGRCDA GRFW GT+ EP+ + LYC+ Sbjct: 74 GIFLLDAKGQVVRKLCANPENPATSRFNDGRCDAHGRFWLGTLDEPKAGNAAALYCYGNG 133 Query: 123 ALRDAHHAVVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSNCRLLRQFDSDKS 182 AL ++TSNG+AFSPD R YH++TP I + YD+ +G +F+ Sbjct: 134 ALTKVDAGLLTSNGMAFSPDYRWCYHSDTPRFTIYRHSYDVDSGEVGPREEWVKFE---P 190 Query: 183 APDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIRLPARCPTMVAFGGDDLR 242 P GRPDGA+VDS+G YW A++EGGRV+R+SP G++++ L ARCPTM FGGDDLR Sbjct: 191 TPTDRGRPDGASVDSEGFYWAALYEGGRVVRISPDGKVVETHPLAARCPTMCTFGGDDLR 250 Query: 243 TLYITTGRNGRSPAELAQYPESGCVLAVRVEVPGQLE 279 TLY+TT R GRS EL QYP+SG V A+RV VPG +E Sbjct: 251 TLYVTTARQGRSAEELEQYPQSGAVFAMRVSVPGLIE 287 >Q12H41.1 Q12H41_POLSJ Gluconolactonase EC=3.1.1.17 Length = 311 Score = 260 bits (665), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 138/291 (47%), Positives = 181/291 (62%), Gaps = 17/291 (5%) Query: 3 LGESPLWHAQEAALYWIDIPGKAVHRLHP---ESGQHKRWDLPEEPGSIVRHAQGG---- 55 LGESP WH +E +LYW+DIPG+ +HR +G + W +P EPGSI GG Sbjct: 13 LGESPFWHPEEQSLYWVDIPGRQIHRCKVGDVSNGPVQSWAMPTEPGSIAPARTGGRASG 72 Query: 56 LVVAIRTGMFHLNTDTGALTLLLAAPYDSSRIRFNDGRCDASGRFWCGTIYEPRDRDGGT 115 LV+A+R G++ G L L+ A +D++ RFNDG+ D GRFW GT+YEPRD Sbjct: 73 LVIALRDGIYRARQWGGELEQLVRAGHDTATTRFNDGKADPVGRFWAGTMYEPRDARQAQ 132 Query: 116 LY---CFERNALRDAHHA--VVTSNGLAFSPDQRLMYHANTPAHRINLYDYDLATGATSN 170 L+ C E A A + +NGLA+SPD +Y +TP+H I +D+D + S Sbjct: 133 LFSVDCREGRAPLVELKAGDAIIANGLAWSPDAATVYWTDTPSHTIRAWDWDGQSNVMSR 192 Query: 171 CRLLRQFDSDKSA-----PDYGGRPDGAAVDSQGAYWCAMFEGGRVLRLSPQGEILQEIR 225 R+ RQ+ P YGGRPDGAAVD +G Y+ AMFEGGR+L+LSP GE+L +I Sbjct: 193 GRVFRQWPGKPEGWQPGMPGYGGRPDGAAVDVEGNYYVAMFEGGRLLKLSPAGELLADIA 252 Query: 226 LPARCPTMVAFGGDDLRTLYITTGRNGRSPAELAQYPESGCVLAVRVEVPG 276 +PARCPTM FGG DLRTLY+TT R R EL +P+SGCV ++RV+VPG Sbjct: 253 VPARCPTMPCFGGADLRTLYLTTARYKRPDEELQTWPDSGCVFSMRVDVPG 303