BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0394.p (892 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IY21.1 D8IY21_HERSS DNA topoisomerase EC=5.99.1.2 1836 0.0 A4G1G3.1 A4G1G3_HERAR DNA topoisomerase EC=5.99.1.2 1509 0.0 A6SU82.1 A6SU82_JANMA DNA topoisomerase EC=5.99.1.2 1505 0.0 F1W3L6.1 F1W3L6_9BURK DNA topoisomerase III 1504 0.0 C3X5C0.1 C3X5C0_OXAFO DNA topoisomerase EC=5.99.1.2 1361 0.0 D5W9E3.1 D5W9E3_BURSC DNA topoisomerase EC=5.99.1.2 1356 0.0 C3XBJ5.1 C3XBJ5_OXAFO DNA topoisomerase EC=5.99.1.2 1355 0.0 E1T4K8.1 E1T4K8_BURSG DNA topoisomerase EC=5.99.1.2 1352 0.0 D5NM09.1 D5NM09_9BURK DNA topoisomerase EC=5.99.1.2 1352 0.0 Q147A8.1 Q147A8_BURXL DNA topoisomerase EC=5.99.1.2 1351 0.0 >D8IY21.1 D8IY21_HERSS DNA topoisomerase EC=5.99.1.2 Length = 892 Score = 1836 bits (4755), Expect = 0.0, Method: Compositional matrix adjust. Identities = 888/892 (99%), Positives = 889/892 (99%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK Sbjct: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY Sbjct: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA Sbjct: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK Sbjct: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA Sbjct: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS Sbjct: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA Sbjct: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT Sbjct: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL Sbjct: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM Sbjct: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP Sbjct: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQA+ Sbjct: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAE 720 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE Sbjct: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKVPAKGKAAAADA 840 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAK PAKGKAAAADA Sbjct: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKAPAKGKAAAADA 840 Query: 841 DDGADEAVAKPAAKKTAPKTAAKTTATKTKAAAAKKPALRKATPKKAAAPDA 892 DDGADEAVAKPAAKKTA KTAAKTTATK KAAAAKKPALRKATPKKAAAPDA Sbjct: 841 DDGADEAVAKPAAKKTATKTAAKTTATKAKAAAAKKPALRKATPKKAAAPDA 892 >A4G1G3.1 A4G1G3_HERAR DNA topoisomerase EC=5.99.1.2 Length = 878 Score = 1509 bits (3907), Expect = 0.0, Method: Compositional matrix adjust. Identities = 718/835 (85%), Positives = 770/835 (92%), Gaps = 4/835 (0%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 M+KTLIIAEKPSVANDIAKTLGGFTKHD+YFESD+Y+LSSAVGHL+EI+VPEEYDVKRGK Sbjct: 1 MTKTLIIAEKPSVANDIAKTLGGFTKHDDYFESDEYVLSSAVGHLVEISVPEEYDVKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSF HLPMIPP+FALNPIAKTESRLKVL+KLIKRKDVT LINACDAGREGELIFRLIAQY Sbjct: 61 WSFAHLPMIPPYFALNPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQY 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 KAKQP+KRLWLQSMTPGAIRE F +LR DEEML LA+AAR RSEADWLIGINGTRAMTA Sbjct: 121 AKAKQPIKRLWLQSMTPGAIREAFKNLRSDEEMLSLADAARSRSEADWLIGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEV AEF+CAAGIY+GRWLD Sbjct: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVRAEFICAAGIYQGRWLDT 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACR-DKPGNVTEESKPTTQMSPGLFDLTSLQRE 299 KKDE DPE+RPERLWSKAAA+SIVAACR KPGNVTEESKPTT M+P LFDLTSLQRE Sbjct: 241 AFKKDETDPERRPERLWSKAAAESIVAACRGGKPGNVTEESKPTTSMAPALFDLTSLQRE 300 Query: 300 ANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQF 359 AN+RFGFSAKNTLGLAQALYE+HKVLTYPRTDSRHLPEDY+ TV +T+E +AENNNYHQF Sbjct: 301 ANARFGFSAKNTLGLAQALYERHKVLTYPRTDSRHLPEDYLPTVLETLEVVAENNNYHQF 360 Query: 360 SKQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPP 419 +KQIL WVKPNKRIFDNTKISDHFAIIPTT PKNLSEPEQKLYDLVTRRFMA+FFP Sbjct: 361 AKQILNSKWVKPNKRIFDNTKISDHFAIIPTTLAPKNLSEPEQKLYDLVTRRFMAIFFPA 420 Query: 420 AEFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVK 479 AEFQVTTR+TEVSGHQFK+EGKVM NPGWLA+YGK+V D+KD E G LV VA GEKV+ Sbjct: 421 AEFQVTTRFTEVSGHQFKTEGKVMTNPGWLAVYGKEV-IDEKDPENSGTLVPVAKGEKVQ 479 Query: 480 TDKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGL 539 T+ V ANGLVTKPPARYTEATLLSAMEGAGKL+D +LR AM GKGLGTPATRAAIIEGL Sbjct: 480 TESVVANGLVTKPPARYTEATLLSAMEGAGKLIDDSDLRVAMTGKGLGTPATRAAIIEGL 539 Query: 540 LNEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEF 599 L EKYL+REGREMMPTAKAFQLMTLL GLGV+ELT PELTGEWE+KL++MERGKISR+EF Sbjct: 540 LTEKYLLREGREMMPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSEMERGKISREEF 599 Query: 600 MREIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKV 659 MREIAQMTQ+IVKRAKEYDNDTIPGDYATLKTPCPNCG VVKENYRRFACTKCEFSMSK Sbjct: 600 MREIAQMTQVIVKRAKEYDNDTIPGDYATLKTPCPNCGSVVKENYRRFACTKCEFSMSKT 659 Query: 660 PGGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQA 719 PG RQFE+AEVEELL N+TIGPLQGFRSKMGRPFAA+LKISRDEEIKN+KLEFDFGQ+ Sbjct: 660 PGSRQFEVAEVEELLTNKTIGPLQGFRSKMGRPFAAVLKISRDEEIKNYKLEFDFGQN-- 717 Query: 720 DGEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILP 779 D E EPVDFS+QTPLG CPKC GVYEM L+YVCE +VAKPK CDFRS RIILQQEILP Sbjct: 718 DDENAEPVDFSDQTPLGPCPKCAGGVYEMPLSYVCENSVAKPKTCDFRSGRIILQQEILP 777 Query: 780 EQMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKVPAKGK 834 EQM+KLLN+GKTDLLPGF+SQRTRR FKA+LVRGKDGK SFEFE RK KVP KGK Sbjct: 778 EQMSKLLNEGKTDLLPGFVSQRTRRAFKAYLVRGKDGKTSFEFEPRKEKVPGKGK 832 >A6SU82.1 A6SU82_JANMA DNA topoisomerase EC=5.99.1.2 Length = 881 Score = 1505 bits (3896), Expect = 0.0, Method: Compositional matrix adjust. Identities = 714/825 (86%), Positives = 765/825 (92%), Gaps = 2/825 (0%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 M+KTLIIAEKPSVANDIAKTLGGFTKHDEYFESD+Y+LSSAVGHL+EI VPEEYDVKRGK Sbjct: 1 MTKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDEYVLSSAVGHLVEITVPEEYDVKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 W+FTHLPMIPPHFALNPIAKTESRLKVL+KLIKRKDVT LINACDAGREGELIFRLIAQY Sbjct: 61 WTFTHLPMIPPHFALNPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQY 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 TKAKQP+KRLWLQSMTPGAIRE F +LR D+EMLPLA+AARCRSEADWLIGINGTRAMTA Sbjct: 121 TKAKQPIKRLWLQSMTPGAIREAFKNLRSDDEMLPLADAARCRSEADWLIGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEV AEF+CAAGIY+GRWLD Sbjct: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVRAEFICAAGIYQGRWLDT 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 KKDE DPE+R ERLWSKAAA+SIVAACR K GNVTEESKPTT M+P LFDLTSLQREA Sbjct: 241 AFKKDETDPERRAERLWSKAAAESIVAACRGKQGNVTEESKPTTSMAPALFDLTSLQREA 300 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 N+RFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDY+ TV T++ +AENNNYHQF+ Sbjct: 301 NARFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYLPTVLQTLDVIAENNNYHQFA 360 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 KQI WVKPNKRIFDNTKISDHFAIIPTTQ PKNLSEPEQKLYDLVTRRFMA+FFP A Sbjct: 361 KQITDNKWVKPNKRIFDNTKISDHFAIIPTTQAPKNLSEPEQKLYDLVTRRFMAIFFPAA 420 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 EFQVTTR+TEVSGHQFK+EGKVM NPGWLA+YGK+V D+KD E G LV VA GEKVKT Sbjct: 421 EFQVTTRFTEVSGHQFKTEGKVMTNPGWLAVYGKEV-IDEKDPENSGTLVPVAKGEKVKT 479 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 + V ANGLVTKPPARY+EATLLSAMEGAGKL+D+D LR+AMAGKGLGTPATRAAIIEGLL Sbjct: 480 ESVVANGLVTKPPARYSEATLLSAMEGAGKLIDNDGLRDAMAGKGLGTPATRAAIIEGLL 539 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 NEKYL+REGREM+PTAKAFQLMTLL GLGV+ELT PELTGEWE+KL++MERGKISR+EFM Sbjct: 540 NEKYLLREGREMIPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSEMERGKISREEFM 599 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 REIAQMTQ+IVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSK P Sbjct: 600 REIAQMTQVIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKTP 659 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 G RQFEIAEVEELL N+TIGPLQGFRSKMGRPFAA+LKISRDEEIKN+KLEFDFGQ+ D Sbjct: 660 GSRQFEIAEVEELLTNKTIGPLQGFRSKMGRPFAAVLKISRDEEIKNYKLEFDFGQND-D 718 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 E E VDFS QT LG CPKC GVYE+ L+YVCE +VAKPK CDFRS RIILQQEILPE Sbjct: 719 DENAEAVDFSGQTSLGPCPKCAGGVYELPLSYVCENSVAKPKTCDFRSGRIILQQEILPE 778 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEER 825 QM+KLLN+GKTDLLPGF+SQRTRR FKA+LVRGKDGK SFEFE R Sbjct: 779 QMSKLLNEGKTDLLPGFVSQRTRRAFKAYLVRGKDGKTSFEFEPR 823 >F1W3L6.1 F1W3L6_9BURK DNA topoisomerase III Length = 884 Score = 1504 bits (3895), Expect = 0.0, Method: Compositional matrix adjust. Identities = 732/884 (82%), Positives = 796/884 (90%), Gaps = 2/884 (0%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 M+KTLIIAEKPSVANDIAKTLGGFTKHDEYFESD+Y+LSSAVGHLLEIAVPEE+D+KRGK Sbjct: 1 MTKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDEYVLSSAVGHLLEIAVPEEFDIKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSF HLPMIPP+FAL PIAKTE+RLKVL++LIKRKDVT LINACDAGREGELIFRLIAQ Sbjct: 61 WSFAHLPMIPPYFALTPIAKTEARLKVLNRLIKRKDVTALINACDAGREGELIFRLIAQN 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 KAKQP+KRLWLQSMTPGAIRE F +LRDD EMLPLA+AARCRSEADWLIGINGTRAMTA Sbjct: 121 AKAKQPIKRLWLQSMTPGAIREAFTNLRDDAEMLPLADAARCRSEADWLIGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSKEGGFYLTTVGRVQTPTLSIVV REEKIKKFV RD+WEV A+FVCAAG+Y+GRWLD Sbjct: 181 FNSKEGGFYLTTVGRVQTPTLSIVVLREEKIKKFVARDFWEVRADFVCAAGVYEGRWLDT 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 KKDE DPEKR ERLWSKAAA+SIVAACR K GNVTEESKPTT M+PGLFDLTSLQREA Sbjct: 241 KFKKDETDPEKRAERLWSKAAAESIVAACRTKQGNVTEESKPTTSMAPGLFDLTSLQREA 300 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 N+RFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYI+TVK+T+E ++ENNNY+QF+ Sbjct: 301 NARFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYISTVKETLETVSENNNYYQFA 360 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 QIL WVKPNKRIFDNTKISDHFAIIPTTQ PKNLSEPEQKLYDLVTRRF+A+FFP A Sbjct: 361 AQILNGNWVKPNKRIFDNTKISDHFAIIPTTQAPKNLSEPEQKLYDLVTRRFLAIFFPAA 420 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 EFQVTTR+TEVSGHQFK+EGKVM+NPGWLA+YGK V D K +G G LVAVA GEKV+T Sbjct: 421 EFQVTTRFTEVSGHQFKTEGKVMVNPGWLAVYGKDV-VDPKAADGDGTLVAVAKGEKVQT 479 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 D + ANGLVTKPPARYTEATLLSAMEGAGKL+D +ELR+AMAGKGLGTPATRAA IEGL+ Sbjct: 480 DTIVANGLVTKPPARYTEATLLSAMEGAGKLIDDEELRDAMAGKGLGTPATRAATIEGLI 539 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 NE+YL+REGREM+PTAKAFQLMTLL GLGV+ELT PELTGEWE+KL+QMERGKISR+EFM Sbjct: 540 NERYLLREGREMIPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSQMERGKISREEFM 599 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 REIAQMTQIIVKRAKEYDN TIPGDY TLKTPCPNCG VVKENYRRFACTKCEFSMSK P Sbjct: 600 REIAQMTQIIVKRAKEYDNVTIPGDYTTLKTPCPNCGAVVKENYRRFACTKCEFSMSKTP 659 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 G RQFEI EVEELL NRTIGPLQGFRSKMGRPFAAILKISRDEEIKN KLEFDFGQ+ + Sbjct: 660 GSRQFEIPEVEELLTNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNCKLEFDFGQNDEE 719 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 GE GE VDF+ QT LG CPKC +GV+E+GLAYVCEK+VAKPK CDFRS RIILQQEILPE Sbjct: 720 GENGEGVDFTGQTALGPCPKCANGVFELGLAYVCEKSVAKPKECDFRSGRIILQQEILPE 779 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKVPAKGKAAAADA 840 QM KLLN+GKTDL+PGF+SQRTRRPFKAFLV+GKDGK+SFEFEERKAK PAKGKAAA DA Sbjct: 780 QMVKLLNEGKTDLMPGFVSQRTRRPFKAFLVKGKDGKVSFEFEERKAKAPAKGKAAAVDA 839 Query: 841 DDG-ADEAVAKPAAKKTAPKTAAKTTATKTKAAAAKKPALRKAT 883 D+G A E+ A K A +KPA++KA+ Sbjct: 840 DEGDATESTKVVKLAAKPVAKKAAPKKVAAKKPAVRKPAVKKAS 883 >C3X5C0.1 C3X5C0_OXAFO DNA topoisomerase EC=5.99.1.2 Length = 872 Score = 1361 bits (3523), Expect = 0.0, Method: Compositional matrix adjust. Identities = 661/875 (75%), Positives = 740/875 (84%), Gaps = 11/875 (1%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 M+KTLIIAEKPSVANDIAK+LGGFTK +YFESDQY+L+SAVGHLLEI PEEY+VKRGK Sbjct: 1 MTKTLIIAEKPSVANDIAKSLGGFTKQGDYFESDQYVLTSAVGHLLEIRAPEEYEVKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSF +LP+IPP FAL PIAKTE RLK+LS+LI+RKD+T ++NACDAGREGELIFRLIAQY Sbjct: 61 WSFANLPVIPPSFALEPIAKTEPRLKMLSRLIRRKDITAIVNACDAGREGELIFRLIAQY 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 TKAKQP+KRLWLQSMTP AIR+GF LRDDEEMLPLA AAR RSEADWLIGINGTRAMTA Sbjct: 121 TKAKQPIKRLWLQSMTPAAIRDGFKRLRDDEEMLPLARAARSRSEADWLIGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSKEGGF+LTTVGRVQTPTLSIVV+REEKIK FV RDYWEV AEFVCA G+Y+GRWLD Sbjct: 181 FNSKEGGFFLTTVGRVQTPTLSIVVQREEKIKSFVSRDYWEVRAEFVCAKGVYEGRWLDS 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 KKD ADPEKRPERLWS+AAA+SIV AC K G VTEESKPTT +SP LFDLTSLQREA Sbjct: 241 HFKKDGADPEKRPERLWSRAAAESIVTACLGKDGKVTEESKPTTSLSPALFDLTSLQREA 300 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 N+RFGFSAKNTL LAQALYEKHKVLTYPRTDSRHLPEDY+ T T+E+L EN NY F+ Sbjct: 301 NARFGFSAKNTLSLAQALYEKHKVLTYPRTDSRHLPEDYLQTSMQTLESLKENANYQTFA 360 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 QIL+ WV+PNKRIFDN KISDHFAIIPTTQ+PKNLSEPEQKLYDLVTRRFMAVFFP A Sbjct: 361 SQILESRWVRPNKRIFDNKKISDHFAIIPTTQLPKNLSEPEQKLYDLVTRRFMAVFFPAA 420 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 EF VTTR+TEV+GH+FKSEG+VM +PGWLAIYGK++ K+ + LV V+PGE V T Sbjct: 421 EFLVTTRFTEVAGHRFKSEGRVMTSPGWLAIYGKEMPAAGKNADNDRLLVPVSPGETVLT 480 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 DKV + + TKPPARYTEATLLSAMEGAGKLV+ DELREAM KGLGTPATRAAIIEGLL Sbjct: 481 DKVLIDDMATKPPARYTEATLLSAMEGAGKLVE-DELREAMKDKGLGTPATRAAIIEGLL 539 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 +EKYL+REGRE++PT KAFQLMTLL GLGV ELT PELTGEWE KL+QME+G+ISR+EFM Sbjct: 540 SEKYLLREGRELIPTPKAFQLMTLLKGLGVKELTLPELTGEWEFKLSQMEKGQISREEFM 599 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 ++IA+M Q+IVKRAKEYD DTIPGDYA L+TPCP CGG V+ENYRRFACT+C+FS+SK P Sbjct: 600 QQIARMAQVIVKRAKEYDEDTIPGDYAILQTPCPKCGGEVRENYRRFACTQCDFSISKTP 659 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 G RQF I EVEELL N IGPLQGFRSKMGRPFAAILKI D + NFKLEFDFGQ Q + Sbjct: 660 GSRQFSIPEVEELLGNGQIGPLQGFRSKMGRPFAAILKIVPDADKDNFKLEFDFGQPQEE 719 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 G DFS + P+G CPKC +YE GL+Y+CE TVA+PK+CDFRS RIILQQEI+PE Sbjct: 720 EAG--TADFSGKIPVGNCPKCAGKIYESGLSYICENTVAQPKSCDFRSGRIILQQEIVPE 777 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKV-PAKGKAAAA- 838 QMAKLLNDG+TDLL GF+SQRT RPFKA+L GK+GK+SF+FEE K AK KA A Sbjct: 778 QMAKLLNDGQTDLLTGFVSQRTHRPFKAYLALGKEGKVSFKFEETAVKASSAKKKATTAS 837 Query: 839 ---DADDGADEAVAKPAAKKTAPKTAAKTTATKTK 870 + AD A K A KKTA A KT+A K K Sbjct: 838 KTKSSAKAADTAREKTAVKKTA---ARKTSARKAK 869 >D5W9E3.1 D5W9E3_BURSC DNA topoisomerase EC=5.99.1.2 Length = 905 Score = 1356 bits (3509), Expect = 0.0, Method: Compositional matrix adjust. Identities = 653/860 (75%), Positives = 734/860 (85%), Gaps = 13/860 (1%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 MSK LIIAEKPSVANDIA+ LGGFTKHDEY+ESD Y+LSSAVGHLLEIA P+EY+VKRGK Sbjct: 18 MSKALIIAEKPSVANDIARALGGFTKHDEYYESDDYVLSSAVGHLLEIAAPDEYEVKRGK 77 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSF +LP+IPPHF LNPIAK+ESRLKVL+KL+KRKD+ LINACDAGREGELIFRLIAQ+ Sbjct: 78 WSFANLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDIDRLINACDAGREGELIFRLIAQH 137 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 KAKQPV+RLWLQSMT G+IREGFA LR DEEM PLA+AARCRSEADWL+GINGTRAMTA Sbjct: 138 AKAKQPVQRLWLQSMTAGSIREGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTA 197 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSK GGF+LTTVGRVQTPTLSIVVEREEKI++FVPRDYWEV AEFVCAAG Y+GRW D Sbjct: 198 FNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCAAGFYEGRWFDP 257 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 K+DE DPEKR RLWS AA++IVAACR + G VTEESKP+TQ+SP LFDLTSLQREA Sbjct: 258 KFKRDEFDPEKRDSRLWSLPAAETIVAACRGQMGVVTEESKPSTQLSPALFDLTSLQREA 317 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 N RFGFSAKNTLGLAQALYEKHKVLTYPRTD+R LPEDY++TVK T+ L E+NNY F+ Sbjct: 318 NGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLDTVKQTLGMLKESNNYLPFA 377 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 KQ+L +GWVKPNKRIFDN+KISDHFAIIPT Q PKNLSEPEQKLYDLV +RF++VFFP A Sbjct: 378 KQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLSVFFPAA 437 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 E++VTTR TEV GH FK+EGKV++ PGWL IYG++ DD NLV V EKVKT Sbjct: 438 EYRVTTRITEVVGHHFKTEGKVLVEPGWLQIYGRETSGDD------ANLVPVQKDEKVKT 491 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 DK+ A LVTKPPARY EATLLSAMEGAGKLV+ DELREAMA KGLGTPATRAAIIEGLL Sbjct: 492 DKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLL 551 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 EKYLIREGR+++P AKAFQLMTLL GLGV ELT PELTGEWE+KL+QMERG + RD FM Sbjct: 552 TEKYLIREGRDLIPAAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFM 611 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 +EIA+MTQ IVKRAKEYD+DTIPGDYATL+TPCPNCGG VKENYRRFAC+KCEFS+SK+P Sbjct: 612 QEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACSKCEFSISKIP 671 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 GGRQFEIAEVEELLQN+TIGPL GFRSKMGRPF+AILK+S D+EIKN+KLEFDFGQD A Sbjct: 672 GGRQFEIAEVEELLQNKTIGPLSGFRSKMGRPFSAILKLSLDDEIKNYKLEFDFGQDAA- 730 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 GE GEP DFS+Q P+GACPKC V+E G++YVCE +VA PK+CDFRS ++ILQQEI E Sbjct: 731 GEDGEPPDFSDQQPVGACPKCQGRVFEHGMSYVCENSVANPKSCDFRSGKVILQQEIARE 790 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERK------AKVPAKGK 834 QMAKLL +G+TDLL F S RT R FKAFLV+ DGKI FEFE+++ A G Sbjct: 791 QMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPAAAKTAAAKTSGA 850 Query: 835 AAAADADDGADEAVAKPAAK 854 +AA A ADE A K Sbjct: 851 RSAAKAMPEADEGDTAVAVK 870 >C3XBJ5.1 C3XBJ5_OXAFO DNA topoisomerase EC=5.99.1.2 Length = 879 Score = 1355 bits (3506), Expect = 0.0, Method: Compositional matrix adjust. Identities = 654/838 (78%), Positives = 719/838 (85%), Gaps = 9/838 (1%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 M+KTLIIAEKPSVANDIAK+LGGFTK +YFESDQY+L+SAVGHLLEI PEEY+VKRGK Sbjct: 1 MTKTLIIAEKPSVANDIAKSLGGFTKQGDYFESDQYVLTSAVGHLLEIRAPEEYEVKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSF +LP+IPP FAL PIAKTESRLK+L+KLIKRKD++ +INACDAGREGELIFRLIAQY Sbjct: 61 WSFANLPVIPPDFALEPIAKTESRLKMLNKLIKRKDISEIINACDAGREGELIFRLIAQY 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 TKAKQPVKRLWLQSMTP AIREGF HLR DEEM PLA AAR RSEADWLIGINGTRAMTA Sbjct: 121 TKAKQPVKRLWLQSMTPNAIREGFKHLRGDEEMQPLAKAARSRSEADWLIGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSKEGGF+LTTVGRVQTPTLSIVV+REEKIK FV RDYWEVHAEFVCA G+Y+GRWLD Sbjct: 181 FNSKEGGFFLTTVGRVQTPTLSIVVQREEKIKNFVSRDYWEVHAEFVCAQGVYEGRWLDA 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 KKDEADPEKR ERLWS+AAADSIV AC K G VTEESKPTT +SP LFDLTSLQREA Sbjct: 241 AFKKDEADPEKRAERLWSRAAADSIVTACLGKQGTVTEESKPTTSISPALFDLTSLQREA 300 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 N+RFGFSAKNTL LAQALYEKHKVLTYPRTDSRHLPEDY+ T T+E L+EN NY F+ Sbjct: 301 NARFGFSAKNTLALAQALYEKHKVLTYPRTDSRHLPEDYLQTSMQTLECLSENANYQTFA 360 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 QILK WV PNKRIFDN KISDHFAIIPTTQ PKNLSEPEQKLYDLV +RFMAVFFP A Sbjct: 361 LQILKNRWVHPNKRIFDNKKISDHFAIIPTTQSPKNLSEPEQKLYDLVAKRFMAVFFPAA 420 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 EF VTTR+TEV+GH+FKSEG++M PGWLAIYG+++ K+ E LV V+ GEKV Sbjct: 421 EFLVTTRFTEVAGHRFKSEGRIMTKPGWLAIYGREMPASGKESENDRILVPVSQGEKVLA 480 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 DKV L TKPPARY+EATLLSAMEGAGK V+ DELREAM GKGLGTPATRAAIIEGLL Sbjct: 481 DKVLVEELATKPPARYSEATLLSAMEGAGKFVE-DELREAMQGKGLGTPATRAAIIEGLL 539 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 EKYL+REGRE++PT KAFQLMTLL GLGV ELT PELTGEWE KL+QME+G+ISR+EFM Sbjct: 540 TEKYLLREGRELIPTPKAFQLMTLLKGLGVKELTLPELTGEWEFKLSQMEKGQISREEFM 599 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 ++IAQMTQ+IVKRAKEYD DTIPGDYATL+T CP CGG +KENYRRFACTKCEFSM+K P Sbjct: 600 QQIAQMTQVIVKRAKEYDEDTIPGDYATLQTRCPKCGGEIKENYRRFACTKCEFSMTKTP 659 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 GGRQF IAEVEELLQ IGPLQGFRSKMGRPFAAILKI D E NFKLEFDFGQ + Sbjct: 660 GGRQFSIAEVEELLQKGEIGPLQGFRSKMGRPFAAILKIVPDTEKDNFKLEFDFGQPKE- 718 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 E E DF+ +TP+G CPKC VY+ GL+YVCE TVA+PK+CDFRS RIILQQEILPE Sbjct: 719 -EDTEAPDFTGKTPVGKCPKCQGSVYDSGLSYVCEHTVARPKSCDFRSGRIILQQEILPE 777 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKVPAKGKAAAA 838 QM KLL++G+TDLL GF+SQRT RPFKA+L GK+GKI F+FEE A GKAA A Sbjct: 778 QMTKLLSEGQTDLLTGFVSQRTHRPFKAYLALGKEGKIGFKFEE------ATGKAAGA 829 >E1T4K8.1 E1T4K8_BURSG DNA topoisomerase EC=5.99.1.2 Length = 890 Score = 1352 bits (3500), Expect = 0.0, Method: Compositional matrix adjust. Identities = 641/826 (77%), Positives = 723/826 (87%), Gaps = 7/826 (0%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 MSK LIIAEKPSVANDIA+ LGGFTKHDEY+ESD+Y+LSSAVGHLLEIA PEEY+VKRGK Sbjct: 1 MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSF +LP+IPPHF LNPIAK+ESRLKVL+KL+KRKD+ LINACDAGREGELIFRLIAQ+ Sbjct: 61 WSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDIDRLINACDAGREGELIFRLIAQH 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 KAKQPV+RLWLQSMTP AIR+GFA LR DEEM PLA+AARCRSEADWL+GINGTRAMTA Sbjct: 121 AKAKQPVQRLWLQSMTPAAIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSK GGF+LTTVGRVQTPTLSIVVEREEKI++FVPRDYWEV AEFVCAAG Y+GRW D Sbjct: 181 FNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCAAGFYEGRWFDP 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 K+DE DPEKR RLWS AA++IVAACR + G VTEESKP+TQ+SP LFDLTSLQREA Sbjct: 241 KFKRDEFDPEKRDSRLWSLPAAETIVAACRGQLGTVTEESKPSTQLSPALFDLTSLQREA 300 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 N RFGFSAKNTLGLAQALYEKHKVLTYPRTD+R LPEDY+ TVK T+ L E+NNY F+ Sbjct: 301 NGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMETVKQTLGMLKESNNYLPFA 360 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 KQ+L +GWVKPNKRIFDN+KISDHFAIIPT Q PKNLSEPEQKLYDLV +RF++VFFP A Sbjct: 361 KQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLSVFFPAA 420 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 E++VTTR TEV GH FK+EGKV++ PGWL +YG+++ +D NLV V EKVKT Sbjct: 421 EYRVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGED------ANLVPVQKDEKVKT 474 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 DK+ A LVTKPPARY EATLLSAMEGAGKLV+ DELREAMA KGLGTPATRAAIIEGLL Sbjct: 475 DKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLL 534 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 EKYLIREGR+++PTAKAFQLMTLL GLGV ELT PELTGEWE+KL+QMERG + RD FM Sbjct: 535 GEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFM 594 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 +EIA+MTQ IVKRAKEYD+DTIPGDYATL+TPCPNCGG VKENYRRFAC+KCEFS+SK+P Sbjct: 595 QEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACSKCEFSISKIP 654 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 GGRQFEI EVEELL+N+TIGPL GFRSKMGRPF+AILK+S D+EIKN+KLEFDFGQD A Sbjct: 655 GGRQFEIEEVEELLKNKTIGPLSGFRSKMGRPFSAILKLSLDDEIKNYKLEFDFGQD-AG 713 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 GE GEP DFS+Q P+GACPKC V+E G++YVCE +VA PK CDFRS ++ILQQEI E Sbjct: 714 GEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIARE 773 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERK 826 QMAKLL +G+TDLL F S RT R FKAFLV+ DGKI FEFE+++ Sbjct: 774 QMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKE 819 >D5NM09.1 D5NM09_9BURK DNA topoisomerase EC=5.99.1.2 Length = 888 Score = 1352 bits (3500), Expect = 0.0, Method: Compositional matrix adjust. Identities = 641/826 (77%), Positives = 725/826 (87%), Gaps = 7/826 (0%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 MSK LIIAEKPSVANDIA+ LGGFTKHDEY+ESD+Y+LSSAVGHLLEIA PE+Y+VKRGK Sbjct: 1 MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEDYEVKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSF +LP+IPPHF LNPIAK+ESRLKVL+KL+KRKDV LINACDAGREGELIFRLIAQ+ Sbjct: 61 WSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDVDRLINACDAGREGELIFRLIAQH 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 KAKQPV+RLWLQSMT GAIR+GFA LR DEEM PLA+AARCRSEADWL+GINGTRAMTA Sbjct: 121 AKAKQPVQRLWLQSMTAGAIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSK GGF+LTTVGRVQTPTLSIVVEREEKI++FVPRDYWEV AEFVC+AG Y+GRW D Sbjct: 181 FNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCSAGFYEGRWFDP 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 K+DE DPEKR RLWS AA++IVAACR + G VTEESKP+TQ+SP LFDLTSLQREA Sbjct: 241 KFKRDEFDPEKRDSRLWSLPAAETIVAACRGQIGTVTEESKPSTQLSPALFDLTSLQREA 300 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 N RFGFSAKNTLGLAQALYEKHKVLTYPRTD+R LPEDY++TVK+T+ L E+NNY F+ Sbjct: 301 NGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKETLGMLKESNNYLPFA 360 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 KQ+L +GWVKPNKRIFDN+KISDHFAIIPT Q PKNLSEPEQKLYDLV +RF++VFFP A Sbjct: 361 KQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLSVFFPAA 420 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 EF+VTTR TEV GH FK+EGKV++ PGWL +YG+++ +D NLV V EKVKT Sbjct: 421 EFKVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGED------ANLVPVQKDEKVKT 474 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 DK+ A LVTKPPARY EATLLSAMEGAGKLV+ DELREAMA KGLGTPATRAAIIEGLL Sbjct: 475 DKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLL 534 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 EKYLIREGR+++PTAKAFQLMTLL GLGV ELT PELTGEWE+KL+QMERG + RD FM Sbjct: 535 GEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFM 594 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 +EIA+MTQ IVKRAKEYD+DTIPGDYATL+TPCPNCGG VKENYRRFAC+KCEFS+SK+P Sbjct: 595 QEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACSKCEFSISKIP 654 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 GGRQFEI EVEELL+N+TIGPL GFRSKMGRPF+AILK+S D+EIKN+KLEFDFGQD A Sbjct: 655 GGRQFEIPEVEELLRNKTIGPLSGFRSKMGRPFSAILKLSFDDEIKNYKLEFDFGQD-AG 713 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 GE GEP DFS+Q P+GACPKC V+E G++YVCE +VA PK CDFRS ++ILQQEI E Sbjct: 714 GEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIARE 773 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERK 826 QMAKLL +G+TDLL F S RT R FKAFLV+ DGKI FEFE+++ Sbjct: 774 QMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKE 819 >Q147A8.1 Q147A8_BURXL DNA topoisomerase EC=5.99.1.2 Length = 888 Score = 1351 bits (3496), Expect = 0.0, Method: Compositional matrix adjust. Identities = 640/826 (77%), Positives = 725/826 (87%), Gaps = 7/826 (0%) Query: 1 MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGK 60 MSK LIIAEKPSVANDIA+ LGGFTKHDEY+ESD+Y+LSSAVGHLLEIA PE+Y+VKRGK Sbjct: 1 MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEDYEVKRGK 60 Query: 61 WSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQY 120 WSF +LP+IPPHF LNPIAK+ESRLKVL+KL+KRKDV LINACDAGREGELIFRLIAQ+ Sbjct: 61 WSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDVDRLINACDAGREGELIFRLIAQH 120 Query: 121 TKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTA 180 KA+QPV+RLWLQSMT GAIR+GFA LR DEEM PLA+AARCRSEADWL+GINGTRAMTA Sbjct: 121 AKARQPVQRLWLQSMTAGAIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTA 180 Query: 181 FNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDK 240 FNSK GGF+LTTVGRVQTPTLSIVVEREEKI++FVPRDYWEV AEFVC+AG Y+GRW D Sbjct: 181 FNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCSAGFYEGRWFDP 240 Query: 241 GHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREA 300 K+DE DPEKR RLWS AA++IVAACR + G VTEESKP+TQ+SP LFDLTSLQREA Sbjct: 241 KFKRDEFDPEKRDSRLWSLPAAETIVAACRGQIGTVTEESKPSTQLSPALFDLTSLQREA 300 Query: 301 NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFS 360 N RFGFSAKNTLGLAQALYEKHKVLTYPRTD+R LPEDY++TVK+T+ L E+NNY F+ Sbjct: 301 NGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKETLGMLKESNNYLPFA 360 Query: 361 KQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPA 420 KQ+L +GWVKPNKRIFDN+KISDHFAIIPT Q PKNLSEPEQKLYDLV +RF++VFFP A Sbjct: 361 KQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLSVFFPAA 420 Query: 421 EFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKT 480 EF+VTTR TEV GH FK+EGKV++ PGWL +YG+++ +D NLV V EKVKT Sbjct: 421 EFKVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGED------ANLVPVQKDEKVKT 474 Query: 481 DKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLL 540 D++ A LVTKPPARY EATLLSAMEGAGKLV+ DELREAMA KGLGTPATRAAIIEGLL Sbjct: 475 DRIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLL 534 Query: 541 NEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFM 600 EKYLIREGR+++PTAKAFQLMTLL GLGV ELT PELTGEWE+KL+QMERG + RD FM Sbjct: 535 GEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFM 594 Query: 601 REIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVP 660 +EIA+MTQ IVKRAKEYD+DTIPGDYATL+TPCPNCGG VKENYRRFAC+KCEFS+SK+P Sbjct: 595 QEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACSKCEFSISKIP 654 Query: 661 GGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAD 720 GGRQFEI EVEELLQN+TIGPL GFRSKMGRPF+AILK+S D+EIKN+KLEFDFGQD A Sbjct: 655 GGRQFEIPEVEELLQNKTIGPLSGFRSKMGRPFSAILKLSFDDEIKNYKLEFDFGQD-AG 713 Query: 721 GEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPE 780 GE GEP DFS+Q P+GACPKC V+E G++YVCE +VA PK CDFRS ++ILQQEI E Sbjct: 714 GEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIARE 773 Query: 781 QMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERK 826 QMAKLL +G+TDLL F S RT R FKAFLV+ DGKI FEFE+++ Sbjct: 774 QMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKE 819