BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0091.p (199 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value E3SJ83.1 E3SJ83_9CAUD Transketolase central region-containing pr... 137 9e-31 D1CDK6.1 D1CDK6_THET1 Pyruvate dehydrogenase (Acetyl-transferrin... 95 6e-18 B5EEC4.1 B5EEC4_GEOBB Pyruvate dehydrogenase complex, E1 protein... 94 1e-17 E8RB11.1 E8RB11_9DELT Pyruvate dehydrogenase (Acetyl-transferrin... 94 1e-17 E8WIT1.1 E8WIT1_GEOS8 Pyruvate dehydrogenase (Acetyl-transferrin... 93 2e-17 E8N8X4.1 E8N8X4_MICTS Pyruvate/2-oxoglutarate dehydrogenase comp... 93 2e-17 Q1BD30.1 Q1BD30_MYCSS Pyruvate dehydrogenase (Lipoamide) EC=1.2.4.1 93 2e-17 A3PVJ7.1 A3PVJ7_MYCSJ Pyruvate dehydrogenase (Acetyl-transferrin... 93 2e-17 A1UBW3.1 A1UBW3_MYCSK Pyruvate dehydrogenase (Acetyl-transferrin... 93 2e-17 C6E832.1 C6E832_GEOSM Pyruvate dehydrogenase (Acetyl-transferrin... 92 4e-17 >E3SJ83.1 E3SJ83_9CAUD Transketolase central region-containing protein Length = 402 Score = 137 bits (345), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 74/198 (37%), Positives = 110/198 (55%), Gaps = 13/198 (6%) Query: 2 TKDELIAFEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLL 61 T D L +F ++IA +AG++ +HL GNEEQ+ID+F I D+V + R+ Y LL Sbjct: 7 TPDGLRSFVDKIAEHHDAGRLPFALHLPGGNEEQLIDIFSNINEGDYVLSTHRNMYHALL 66 Query: 62 KGVPPQAVREEILAGRSISLCFPEQRIYSSAIVGGVLPIAVGTAMAIQRSGEDAKVYCFM 121 G+PP+ V E+IL GRS+ + E+ Y SAI+GG + IAVG A A++R G D +V+CF+ Sbjct: 67 HGLPPEEVEEKILNGRSMFMFDRERNFYVSAIIGGPVAIAVGIAWALKRKGSDQRVWCFL 126 Query: 122 GEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRLSYEEVNDDF--- 178 G+ T +TG E+++Y LP F++ED+ +V W N+D Sbjct: 127 GDGTEDTGHFAEAVRYVNGFDLPCTFIIEDDCMAVEAPKERRWG--------TNEDLEWP 178 Query: 179 --ITYYRYQTKYPHAGAG 194 + Y Y PH G Sbjct: 179 SCVIRYHYTKTRPHIRTG 196 >D1CDK6.1 D1CDK6_THET1 Pyruvate dehydrogenase (Acetyl-transferring) E1 component, alpha subunit EC=1.2.4.1 Length = 329 Score = 94.7 bits (234), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 56/171 (32%), Positives = 81/171 (47%), Gaps = 10/171 (5%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 FEE A + I HL G E ++ IR D+VF +R H L G P+A Sbjct: 27 FEERAAQLYTQAYIGGYCHLNVGEEATVVGALTSIREDDYVFTYYREHGHALTLGSDPKA 86 Query: 69 VREEILA---------GRSISLCFPEQRIYSS-AIVGGVLPIAVGTAMAIQRSGEDAKVY 118 V E+ G S+ L + R+Y IVGG LP+AVG AMAI+ GED+ V Sbjct: 87 VMAELCGKVTGLSKGRGGSMHLFDKKHRLYGGYGIVGGHLPLAVGAAMAIEYKGEDSIVM 146 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRL 169 C GE + G HE++ ++ + LP+ F +N+ ++ E P + Sbjct: 147 CLFGEGATNIGAFHEALNLAKVYHLPVLFFCVNNQYAMGARVDEDSAVPEM 197 >B5EEC4.1 B5EEC4_GEOBB Pyruvate dehydrogenase complex, E1 protein, alpha subunit Length = 325 Score = 93.6 bits (231), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 55/171 (32%), Positives = 82/171 (47%), Gaps = 10/171 (5%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 FEE A ++ G I +HLY G E + ++P D+V ++R H Q +++G P+ Sbjct: 27 FEESCAEQYSKGHITGFLHLYSGQEAVAVGCTAGLQPADYVLSAYRDHAQAIVRGADPKR 86 Query: 69 VREEILA---------GRSISLCFPEQRIYSS-AIVGGVLPIAVGTAMAIQRSGEDAKVY 118 V E+ G S+ L PE AIVGG PIA+G A Q +D Sbjct: 87 VMAELFGKATGLCKGKGGSMHLFAPELNFMGGYAIVGGQFPIAIGLAWGSQLQEQDRITA 146 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRL 169 CF G+ + G HES+ ++R LP+ F+ E+N + T+ A Q L Sbjct: 147 CFFGDGSMNQGTFHESLNWARLWDLPVLFICENNFYGIGTEVHRASAQAAL 197 >E8RB11.1 E8RB11_9DELT Pyruvate dehydrogenase (Acetyl-transferring) E1 component, alpha subunit EC=1.2.4.1 Length = 324 Score = 93.6 bits (231), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 61/179 (34%), Positives = 85/179 (47%), Gaps = 19/179 (10%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 FEE+ A ++A KIR +HLY G E + V + P+D V ++R H Q L +G+ A Sbjct: 22 FEEKSAELYSAMKIRGFLHLYIGEEAVAVGVMAALSPEDAVVATYREHGQALARGMSANA 81 Query: 69 VREEILA---------GRSISLCFPEQRIY-SSAIVGGVLPIAVGTAMAIQRSGEDAKVY 118 + E+ G S+ L R Y +AIVGG LP+AVG A+A G Sbjct: 82 IMAEMYGKVEGCCRGRGGSMHLFDATTRFYGGNAIVGGGLPLAVGLALADHMQGRQRVTS 141 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRLSYEEVNDD 177 CF G+ G HES+ + LP+ FV E+N ++ T R Y E N D Sbjct: 142 CFFGDGAVAEGYFHESMNLAALWKLPVLFVCENNLYAMGTALR---------YTEANQD 191 >E8WIT1.1 E8WIT1_GEOS8 Pyruvate dehydrogenase (Acetyl-transferring) E1 component, alpha subunit EC=1.2.4.1 Length = 325 Score = 93.2 bits (230), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 57/171 (33%), Positives = 80/171 (46%), Gaps = 10/171 (5%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 FEE A ++ G I +HLY G E + + P+D+V ++R H Q +++G P Sbjct: 27 FEESCAEQYSKGHITGFLHLYTGQEAVAVGCTAGLLPKDYVLSAYRDHAQAIVRGADPNK 86 Query: 69 VREEILA---------GRSISLCFPEQRIYSS-AIVGGVLPIAVGTAMAIQRSGEDAKVY 118 V E+ G S+ L PE AIVGG PIA G A A Q ED Sbjct: 87 VMAELFGKATGLCKGKGGSMHLFAPELNFMGGYAIVGGQFPIATGLAWASQLLEEDRVTA 146 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRL 169 CF G+ G HES+ ++R LP+ F+ E+N + T+ A Q L Sbjct: 147 CFFGDGAMNQGTFHESLNWARLWELPVLFICENNFYGIGTEVHRASAQAAL 197 >E8N8X4.1 E8N8X4_MICTS Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Length = 365 Score = 92.8 bits (229), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 53/171 (30%), Positives = 84/171 (49%), Gaps = 10/171 (5%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 FEE A ++ KI HL G E ++ + + P D+++ ++R H L +G+ P+ Sbjct: 36 FEERAARAYSEAKIGGYCHLNLGEEATVVGLMAALEPGDYLYANYREHGYALARGISPER 95 Query: 69 VREEILA---------GRSISLCFPEQRIYSS-AIVGGVLPIAVGTAMAIQRSGEDAKVY 118 E+ G S+ + + R IVGG +P+A GTA+AI GED V Sbjct: 96 AMAELYGRTDGVSKGWGGSMHMFDLDARFMGGYGIVGGQVPLATGTALAIHYRGEDDVVM 155 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRL 169 C MG+ T+ G HES+ + LPI +VV +N + T ++ +P L Sbjct: 156 CLMGDGTTNIGAFHESLNIAALWNLPIVYVVNNNGLGMGTTVEQSSAEPEL 206 >Q1BD30.1 Q1BD30_MYCSS Pyruvate dehydrogenase (Lipoamide) EC=1.2.4.1 Length = 325 Score = 92.8 bits (229), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 58/172 (33%), Positives = 82/172 (47%), Gaps = 10/172 (5%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 EEE A + GKIR +HLY G E R +RP D V ++R H LL+GVP + Sbjct: 20 MEEECAKLYGDGKIRGFLHLYVGEEAVAAGSLRALRPDDAVVGTYREHAHALLRGVPMTS 79 Query: 69 VREEILA---------GRSISLCFPEQRIY-SSAIVGGVLPIAVGTAMAIQRSGEDAKVY 118 + E+ G S+ L R Y +AIVGG LP+A G A+A + Sbjct: 80 IMAEMFGKQEGCSGGRGGSMHLFDAGTRFYGGNAIVGGGLPLATGLALADAQQRRRRITA 139 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRLS 170 CF G+ G+ HES+ + LP+ F E+N ++ T A +Q L+ Sbjct: 140 CFFGDGAVAEGVFHESLNMAALWRLPVLFCCENNLYAMGTALERAQSQTDLA 191 >A3PVJ7.1 A3PVJ7_MYCSJ Pyruvate dehydrogenase (Acetyl-transferring) EC=1.2.4.1 Length = 325 Score = 92.8 bits (229), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 58/172 (33%), Positives = 82/172 (47%), Gaps = 10/172 (5%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 EEE A + GKIR +HLY G E R +RP D V ++R H LL+GVP + Sbjct: 20 MEEECAKLYGDGKIRGFLHLYVGEEAVAAGSLRALRPDDAVVGTYREHAHALLRGVPMTS 79 Query: 69 VREEILA---------GRSISLCFPEQRIY-SSAIVGGVLPIAVGTAMAIQRSGEDAKVY 118 + E+ G S+ L R Y +AIVGG LP+A G A+A + Sbjct: 80 IMAEMFGKQEGCSGGRGGSMHLFDAGTRFYGGNAIVGGGLPLATGLALADAQQRRRRITA 139 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRLS 170 CF G+ G+ HES+ + LP+ F E+N ++ T A +Q L+ Sbjct: 140 CFFGDGAVAEGVFHESLNMAALWRLPVLFCCENNLYAMGTALERAQSQTDLA 191 >A1UBW3.1 A1UBW3_MYCSK Pyruvate dehydrogenase (Acetyl-transferring) EC=1.2.4.1 Length = 325 Score = 92.8 bits (229), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 58/172 (33%), Positives = 82/172 (47%), Gaps = 10/172 (5%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 EEE A + GKIR +HLY G E R +RP D V ++R H LL+GVP + Sbjct: 20 MEEECAKLYGDGKIRGFLHLYVGEEAVAAGSLRALRPDDAVVGTYREHAHALLRGVPMTS 79 Query: 69 VREEILA---------GRSISLCFPEQRIY-SSAIVGGVLPIAVGTAMAIQRSGEDAKVY 118 + E+ G S+ L R Y +AIVGG LP+A G A+A + Sbjct: 80 IMAEMFGKQEGCSGGRGGSMHLFDAGTRFYGGNAIVGGGLPLATGLALADAQQRRRRITA 139 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRLS 170 CF G+ G+ HES+ + LP+ F E+N ++ T A +Q L+ Sbjct: 140 CFFGDGAVAEGVFHESLNMAALWRLPVLFCCENNLYAMGTALERAQSQTDLA 191 >C6E832.1 C6E832_GEOSM Pyruvate dehydrogenase (Acetyl-transferring) E1 component, alpha subunit EC=1.2.4.1 Length = 325 Score = 92.0 bits (227), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 54/171 (31%), Positives = 81/171 (47%), Gaps = 10/171 (5%) Query: 9 FEEEIAATFNAGKIRAPVHLYYGNEEQIIDVFRQIRPQDWVFCSWRSHYQCLLKGVPPQA 68 FEE A ++ G I +HLY G E + ++P D++ ++R H Q +++G P+ Sbjct: 27 FEESCAEQYSKGHITGFLHLYSGQEAVAVGCSAGLQPADYILSAYRDHAQAIVRGADPKR 86 Query: 69 VREEILA---------GRSISLCFPEQRIYSS-AIVGGVLPIAVGTAMAIQRSGEDAKVY 118 V E+ G S+ L PE AIVGG PIA G A Q +D Sbjct: 87 VMAELFGKATGLCKGKGGSMHLFAPELNFMGGYAIVGGQFPIATGLAWGSQLQEQDRITA 146 Query: 119 CFMGEMTSETGIAHESIKYSRNHGLPIHFVVEDNEKSVCTDTREAWNQPRL 169 CF G+ + G HES+ ++R LP+ F+ E+N + T+ A Q L Sbjct: 147 CFFGDGSMNQGTFHESLNWARLWDLPVLFICENNFYGIGTEVHRASAQAAL 197