BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0021.0008.p (276 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IQG3.1 D8IQG3_HERSS Zn-dependent beta-lactamase domain hydrola... 555 e-156 D1RPW2.1 D1RPW2_SEROD Beta-lactamase domain protein 401 e-110 Q0BE74.1 Q0BE74_BURCM Beta-lactamase domain protein 388 e-106 D4XCW8.1 D4XCW8_9BURK Metallo-beta-lactamase 383 e-104 Q0BSY8.1 Q0BSY8_GRABC Metal-dependent hydrolase EC=3.-.-.- 370 e-100 F2KGJ4.1 F2KGJ4_PSEBR Putative uncharacterized protein 369 e-100 B2IKZ1.1 B2IKZ1_BEII9 Beta-lactamase domain protein 365 3e-99 F0GDX8.1 F0GDX8_9BURK Beta-lactamase domain-containing protein 359 3e-97 Q219A1.1 Q219A1_RHOPB Beta-lactamase-like 353 2e-95 Q39MN8.1 Q39MN8_BURS3 Beta-lactamase-like protein 351 8e-95 >D8IQG3.1 D8IQG3_HERSS Zn-dependent beta-lactamase domain hydrolase protein EC=3.5.2.6 Length = 276 Score = 555 bits (1431), Expect = e-156, Method: Compositional matrix adjust. Identities = 273/276 (98%), Positives = 273/276 (98%) Query: 1 MHFPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRS 60 MHFPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRS Sbjct: 1 MHFPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRS 60 Query: 61 PTQTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAF 120 PTQTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAF Sbjct: 61 PTQTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAF 120 Query: 121 PDAELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISA 180 PDAELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYR RLRTFAGGEVLPGISA Sbjct: 121 PDAELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRDRLRTFAGGEVLPGISA 180 Query: 181 QPLPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL 240 Q LPGHT GHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL Sbjct: 181 QLLPGHTDGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL 240 Query: 241 DMVSADQLLIAGMHLGEEGFVQIVRTGKSYRVVGKR 276 DMVSADQLLIAGMHLGEEGFVQIVRTGKSYRVVGKR Sbjct: 241 DMVSADQLLIAGMHLGEEGFVQIVRTGKSYRVVGKR 276 >D1RPW2.1 D1RPW2_SEROD Beta-lactamase domain protein Length = 276 Score = 401 bits (1031), Expect = e-110, Method: Compositional matrix adjust. Identities = 187/272 (68%), Positives = 223/272 (81%) Query: 1 MHFPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRS 60 M FPT+Q+G FS+TAISDG+LS L+ LSNIDP +A+ LQ AG+ DPS+IHINCYL+R Sbjct: 1 MAFPTRQVGAFSITAISDGYLSTGLDSLSNIDPMDASTLQQNAGVKDPSSIHINCYLVRG 60 Query: 61 PTQTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAF 120 P +T+L+DAGAGGFKQWGG+L+ NL AGV P DIDT+LLTHAHPDHIGGL++S+G+ AF Sbjct: 61 PGRTILIDAGAGGFKQWGGKLKANLALAGVRPCDIDTILLTHAHPDHIGGLVESSGEAAF 120 Query: 121 PDAELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISA 180 PDAELVV E+ FWE+D N RASERARGNF+FAR+VF KYR R+R F EVLPGISA Sbjct: 121 PDAELVVHQHEVSFWEDDGNLSRASERARGNFLFARKVFDKYRQRIRRFTDNEVLPGISA 180 Query: 181 QPLPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL 240 PLPGHTAGH GY + S+ LLIWGDIVHFPH+QIARPDVSIAFD DP ++ TR LL Sbjct: 181 LPLPGHTAGHSGYRLESDSSSLLIWGDIVHFPHIQIARPDVSIAFDQDPRVSAETRSKLL 240 Query: 241 DMVSADQLLIAGMHLGEEGFVQIVRTGKSYRV 272 D+VS+D+ LIAGMHLGE GF +I R GKSY++ Sbjct: 241 DIVSSDKTLIAGMHLGELGFARIERAGKSYKI 272 >Q0BE74.1 Q0BE74_BURCM Beta-lactamase domain protein Length = 279 Score = 388 bits (997), Expect = e-106, Method: Compositional matrix adjust. Identities = 183/272 (67%), Positives = 221/272 (81%) Query: 1 MHFPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRS 60 M FP ++IG+FS+TAISDG+LSA L+LLSNIDP EA++LQ AG+SDPS+IHINCYL+R Sbjct: 4 MKFPGQRIGEFSITAISDGYLSASLDLLSNIDPMEASKLQQDAGVSDPSSIHINCYLVRG 63 Query: 61 PTQTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAF 120 +T+L+DAGAGGFKQWGG+L NL AGV PSDIDT+LLTHAHPDH+GGLLDS+G+ AF Sbjct: 64 RGRTILIDAGAGGFKQWGGKLMANLALAGVQPSDIDTILLTHAHPDHVGGLLDSSGEAAF 123 Query: 121 PDAELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISA 180 PDAELVV +E+ FW++D N RASERARGNF+ AR+VF +YR + RTF EVLPGISA Sbjct: 124 PDAELVVHQREVSFWKDDGNLSRASERARGNFLLARKVFDQYREKTRTFTDSEVLPGISA 183 Query: 181 QPLPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL 240 PL GHTAGH GY I S+ + LL+WGDIVHFP +QIARP+VSIAFD DP L+ TR LL Sbjct: 184 MPLLGHTAGHSGYRIESDDRSLLVWGDIVHFPQIQIARPEVSIAFDQDPILSAETRSKLL 243 Query: 241 DMVSADQLLIAGMHLGEEGFVQIVRTGKSYRV 272 +VS+D++LIAGMHLGE GF I R G Y + Sbjct: 244 GVVSSDKILIAGMHLGELGFGHIKRKGTLYEI 275 >D4XCW8.1 D4XCW8_9BURK Metallo-beta-lactamase Length = 279 Score = 383 bits (984), Expect = e-104, Method: Compositional matrix adjust. Identities = 183/272 (67%), Positives = 219/272 (80%) Query: 1 MHFPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRS 60 M FP +QIG+FSVTAISDG+L A L++LSNID EA++LQ AG+S+PS+IHINCYL+R Sbjct: 4 MKFPGQQIGEFSVTAISDGYLFASLDILSNIDSMEASKLQQDAGVSEPSSIHINCYLVRG 63 Query: 61 PTQTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAF 120 +T+L+DAGAGGFKQWGG+L NL AGV PSDIDT+LLTHAHPDH+GGLLD +G+ AF Sbjct: 64 RGRTILIDAGAGGFKQWGGKLIANLALAGVQPSDIDTILLTHAHPDHVGGLLDPSGEAAF 123 Query: 121 PDAELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISA 180 PDAELVV +E+ FW++D N RASERARGNF+FAR+VF +YR ++RTF EVLPGI A Sbjct: 124 PDAELVVHQREVSFWKDDGNLSRASERARGNFLFARKVFDQYREKMRTFTDREVLPGIGA 183 Query: 181 QPLPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL 240 LPGHTAGH GY I S+ + LLIWGDIVHFP +QIARPDVSIAFD DP L+ TR LL Sbjct: 184 VSLPGHTAGHSGYRIESDDRSLLIWGDIVHFPQIQIARPDVSIAFDQDPILSAETRSKLL 243 Query: 241 DMVSADQLLIAGMHLGEEGFVQIVRTGKSYRV 272 D+VS+D+ LIAGMHLGE GF I R G Y + Sbjct: 244 DVVSSDKTLIAGMHLGELGFGHIKRKGALYEI 275 >Q0BSY8.1 Q0BSY8_GRABC Metal-dependent hydrolase EC=3.-.-.- Length = 406 Score = 370 bits (950), Expect = e-100, Method: Compositional matrix adjust. Identities = 175/271 (64%), Positives = 213/271 (78%) Query: 3 FPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRSPT 62 FP++ +GD ++TAISDG+L A LLSNID +A+++Q AG+ D +AIHINCYL+R Sbjct: 125 FPSQTVGDLTLTAISDGYLHASFGLLSNIDADDASQMQENAGIQDHTAIHINCYLVRGGG 184 Query: 63 QTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAFPD 122 +TVL+DAGAGGFKQWGGRL+DNL +AG+ P+ ID +LLTHAHPDH+GGLLD G+ AFP+ Sbjct: 185 RTVLIDAGAGGFKQWGGRLKDNLAQAGIQPAAIDAILLTHAHPDHVGGLLDPTGEAAFPN 244 Query: 123 AELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISAQP 182 AEL+V QE FW++D N A ERA GNFIFAR+ F YR RLR F G+VLPG++A P Sbjct: 245 AELIVSQQEAAFWQDDGNLSHAPERAHGNFIFARQAFAAYRSRLRMFETGDVLPGMTAVP 304 Query: 183 LPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLLDM 242 LPGHTAGH GY + S GQ LL+WGDIVHFP +QI RPDVSIAFD D HLA ATR LLDM Sbjct: 305 LPGHTAGHTGYRLESGGQNLLVWGDIVHFPQIQIRRPDVSIAFDQDTHLAAATRSRLLDM 364 Query: 243 VSADQLLIAGMHLGEEGFVQIVRTGKSYRVV 273 VS+++LLIAGMHLGE GF +I RTG +Y V Sbjct: 365 VSSERLLIAGMHLGELGFARIERTGGNYHVA 395 >F2KGJ4.1 F2KGJ4_PSEBR Putative uncharacterized protein Length = 281 Score = 369 bits (947), Expect = e-100, Method: Compositional matrix adjust. Identities = 172/270 (63%), Positives = 210/270 (77%) Query: 3 FPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRSPT 62 P++QIG+FS+TAISDG+L A L+ L+NI P EA RLQ AAG+S+P++IHINCYL+R Sbjct: 8 LPSQQIGEFSITAISDGYLGASLDFLANIAPTEAARLQLAAGISEPASIHINCYLVRGRG 67 Query: 63 QTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAFPD 122 +T+L+DAGAGGF QWGG L NL AGV P +IDT+LLTHAHPDHIGGLL++ G+ AF + Sbjct: 68 RTILIDAGAGGFNQWGGELLANLALAGVQPGEIDTILLTHAHPDHIGGLLNAVGEMAFTN 127 Query: 123 AELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISAQP 182 AELVV +EL FWE+D + +ASERARGNF+FARRVF +YR LR F +VLPGISA P Sbjct: 128 AELVVHQRELAFWEDDGHLGQASERARGNFLFARRVFERYRQNLRPFTANDVLPGISAMP 187 Query: 183 LPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLLDM 242 LPGHT GHCGY S LL+WGDIVHFP +QIARPDV+IAFD DP L+ ATR LLD+ Sbjct: 188 LPGHTVGHCGYRFESAASSLLVWGDIVHFPQIQIARPDVTIAFDQDPLLSAATRTRLLDV 247 Query: 243 VSADQLLIAGMHLGEEGFVQIVRTGKSYRV 272 S+D L++AGMHL GF I R+G SY + Sbjct: 248 ASSDNLMVAGMHLAALGFAHIKRSGNSYTI 277 >B2IKZ1.1 B2IKZ1_BEII9 Beta-lactamase domain protein Length = 279 Score = 365 bits (938), Expect = 3e-99, Method: Compositional matrix adjust. Identities = 172/270 (63%), Positives = 215/270 (79%) Query: 3 FPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRSPT 62 FP++Q+GD ++TAISDG+L A L+ LSNIDPA+A+R+Q AG+ D S+IHINCYL+R Sbjct: 6 FPSQQVGDLTITAISDGYLHASLDFLSNIDPADASRMQENAGVKDYSSIHINCYLVRGGG 65 Query: 63 QTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAFPD 122 + VL+DAGAGGFKQWGG L+ NL AGV PS++D +LLTHAHPDH+GGL+D++G+ F + Sbjct: 66 RAVLIDAGAGGFKQWGGHLKTNLLLAGVQPSEVDAILLTHAHPDHVGGLMDASGEAVFLN 125 Query: 123 AELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISAQP 182 AELVV +E+ FW++D N RA ERARGNF+ AR+ F YR RLRTF GEVLPG++A P Sbjct: 126 AELVVHHREVAFWQDDGNLSRAPERARGNFLVARQAFDGYRDRLRTFDAGEVLPGMTAVP 185 Query: 183 LPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLLDM 242 LPGHT GH GY + S G+ LL+WGDIVHFP +QI RPDVSIAFD D HLA ATR LLD+ Sbjct: 186 LPGHTDGHTGYRLESGGRNLLVWGDIVHFPQIQIPRPDVSIAFDQDSHLAAATRSRLLDL 245 Query: 243 VSADQLLIAGMHLGEEGFVQIVRTGKSYRV 272 VS+++LLIAGMHL E GF +I RTG +Y V Sbjct: 246 VSSERLLIAGMHLSELGFARIERTGGNYGV 275 >F0GDX8.1 F0GDX8_9BURK Beta-lactamase domain-containing protein Length = 281 Score = 359 bits (921), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 170/270 (62%), Positives = 206/270 (76%) Query: 1 MHFPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRS 60 + FP +Q+GD+++TA+SDG+L+A L+ LSNI+ +EA+R+Q AG P A+HINCY++R Sbjct: 4 LAFPGQQVGDYTITALSDGYLTASLDFLSNIETSEASRMQREAGQQAPDAVHINCYVVRG 63 Query: 61 PTQTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAF 120 +TVLVD GAGG +QWGGRL+ NL AG+ P+ IDT+LLTHAHPDH+GGLLD AG AF Sbjct: 64 AGRTVLVDGGAGGIRQWGGRLKANLALAGIEPAAIDTILLTHAHPDHVGGLLDHAGQAAF 123 Query: 121 PDAELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISA 180 P+AELV G+E+ FW +D N RASERARGNF ARRVF YR LRTF G+VLPGI A Sbjct: 124 PNAELVAHGREVRFWRDDGNLARASERARGNFQIARRVFDAYRDTLRTFDDGQVLPGIHA 183 Query: 181 QPLPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL 240 PLPGHT GH GY + S QGLL+WGD+VHFPH+QI RPDVSIAFD D A ATR +L Sbjct: 184 MPLPGHTDGHTGYVLESGDQGLLVWGDVVHFPHIQIRRPDVSIAFDQDGTAAAATRSRIL 243 Query: 241 DMVSADQLLIAGMHLGEEGFVQIVRTGKSY 270 D S+D LLIAGMHLGE GF +I RT Y Sbjct: 244 DRASSDGLLIAGMHLGEAGFARIGRTKDGY 273 >Q219A1.1 Q219A1_RHOPB Beta-lactamase-like Length = 287 Score = 353 bits (906), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 166/273 (60%), Positives = 215/273 (78%) Query: 1 MHFPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRS 60 + FP++++G++++TAISDG L+A L+LLS+IDPAEA R+Q AG++ PSAI INCYL+R Sbjct: 12 LSFPSRRVGEYTITAISDGSLAASLDLLSDIDPAEAGRIQRDAGVAQPSAIDINCYLVRG 71 Query: 61 PTQTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAF 120 +TVL+DAGAG + GGRL NL+ AG+ PSDIDT+LLTHAHPDH+GGLLD +G+ AF Sbjct: 72 AGRTVLIDAGAGALRPGGGRLAANLRLAGIAPSDIDTILLTHAHPDHVGGLLDGSGEIAF 131 Query: 121 PDAELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTFAGGEVLPGISA 180 P+AELV +E+DFW++D N RASER RGNF AR+VF Y RLR FA GE +PGISA Sbjct: 132 PNAELVANRREVDFWQDDGNLSRASERGRGNFQIARQVFDGYGARLRRFAHGEPVPGISA 191 Query: 181 QPLPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL 240 PLPGHT GH GY ++S Q LL+WGDIVHFPH+QIARP+VSIAFD D +A ATR +L Sbjct: 192 MPLPGHTDGHTGYRVHSGDQSLLVWGDIVHFPHIQIARPEVSIAFDQDRSVAAATRSQIL 251 Query: 241 DMVSADQLLIAGMHLGEEGFVQIVRTGKSYRVV 273 D+V +++LL+AGMHLGE GF +++ SY ++ Sbjct: 252 DLVVSEKLLVAGMHLGEFGFAHVIQNNGSYALL 284 >Q39MN8.1 Q39MN8_BURS3 Beta-lactamase-like protein Length = 283 Score = 351 bits (900), Expect = 8e-95, Method: Compositional matrix adjust. Identities = 170/270 (62%), Positives = 208/270 (77%), Gaps = 2/270 (0%) Query: 3 FPTKQIGDFSVTAISDGFLSAPLELLSNIDPAEATRLQHAAGMSDPSAIHINCYLIRSPT 62 FP +Q+GD ++TAISDG+L+A L+ LSNID +A+++Q AG +P+A+HINCY++R Sbjct: 6 FPVQQVGDVTITAISDGYLTASLDFLSNIDSDDASKIQRDAGQKEPAAVHINCYVVRGAG 65 Query: 63 QTVLVDAGAGGFKQWGGRLQDNLKRAGVLPSDIDTVLLTHAHPDHIGGLLDSAGDRAFPD 122 +TVL+D GAGGFKQWGG+L+ NL AG+ P IDT+LLTHAHPDH+GGL+D AG AFP+ Sbjct: 66 RTVLIDGGAGGFKQWGGQLRTNLVLAGIEPVAIDTILLTHAHPDHVGGLVDGAGQVAFPN 125 Query: 123 AELVVQGQELDFWENDANFCRASERARGNFIFARRVFVKYRYRLRTF--AGGEVLPGISA 180 AELVV +E+ FW++D N RASERARGNF AR+VF Y RLR F A G VLPGISA Sbjct: 126 AELVVHQREVRFWQDDGNLSRASERARGNFAKARQVFDAYGDRLRMFADADGHVLPGISA 185 Query: 181 QPLPGHTAGHCGYHINSNGQGLLIWGDIVHFPHLQIARPDVSIAFDLDPHLATATRVHLL 240 PLPGHT GH GY I + +GLL+WGD+VHFPH+QI RPDVSIAFD D LA ATR LL Sbjct: 186 LPLPGHTDGHTGYVIEARDRGLLVWGDVVHFPHIQIQRPDVSIAFDHDASLAVATRARLL 245 Query: 241 DMVSADQLLIAGMHLGEEGFVQIVRTGKSY 270 D VS++ LLIAGMHLGE GF +I RT Y Sbjct: 246 DQVSSEGLLIAGMHLGELGFARIKRTSGGY 275