BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0157.p (250 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IW51.1 D8IW51_HERSS 2,4-dihydroxyhept-2-ene-1,7-dioic acid ald... 504 e-141 C1B6A3.1 C1B6A3_RHOOB Aldolase 233 1e-59 D2ZJ89.1 D2ZJ89_9ENTR 2,4-dihydroxyhept-2-ene-1,7-dioic acid ald... 229 3e-58 B3T178.1 B3T178_9ZZZZ Putative HpcH/HpaI aldolase family protein 229 4e-58 A2SEE7.1 A2SEE7_METPP 2-dehydro-3-deoxyglucarate aldolase EC=4.1... 223 1e-56 A8LLW9.1 A8LLW9_DINSH 2-dehydro-3-deoxyglucarate aldolase EC=4.1... 222 3e-56 D6V764.1 D6V764_9BRAD HpcH/HpaI aldolase 218 7e-55 B1Y3Z7.1 B1Y3Z7_LEPCP HpcH/HpaI aldolase 215 4e-54 B2JXI5.1 B2JXI5_BURP8 HpcH/HpaI aldolase 205 4e-51 A5VH82.1 A5VH82_SPHWW HpcH/HpaI aldolase 192 3e-47 >D8IW51.1 D8IW51_HERSS 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase protein EC=4.1.2.- Length = 250 Score = 504 bits (1299), Expect = e-141, Method: Compositional matrix adjust. Identities = 248/250 (99%), Positives = 248/250 (99%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA Sbjct: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG Sbjct: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 PARGFLYGGADY THANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL Sbjct: 121 PARGFLYGGADYFTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 Query: 181 APDAYDDVRLNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQIKA 240 APDAYDDVRLNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQIKA Sbjct: 181 APDAYDDVRLNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQIKA 240 Query: 241 EGARRVGALR 250 EGARRV ALR Sbjct: 241 EGARRVSALR 250 >C1B6A3.1 C1B6A3_RHOOB Aldolase Length = 263 Score = 233 bits (595), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 117/250 (46%), Positives = 159/250 (63%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MR N LR A +A + W+S AE ++H+G+D+VT+DLQHG F ID A+ +LQA Sbjct: 1 MRPNLLRAAMADGNVAANAWISSSGTYAAEALSHAGFDSVTIDLQHGMFGIDTAVALLQA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 +SS PAVP+VR S EI KLLDAGAYG+ICP I+ A FV AC Y G RS+G Sbjct: 61 VSSGPAVPMVRSSGADPAEIGKLLDAGAYGIICPSIDDAVTCADFVSACRYPGVGVRSFG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 P+RG LYGG DY+ HA+ T++ AMIE+ +N + I+ LDG++IGP+DLA+ LG Sbjct: 121 PSRGLLYGGPDYVAHADTTVVAWAMIESATALSNLDEIVAVDGLDGVYIGPNDLALSLGE 180 Query: 181 APDAYDDVRLNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQIKA 240 P + EAI ++ AR+ G YVG F G E A+++ +G+DLV PG DI ++ Sbjct: 181 RPGGSFSEPVLEAIVRVVEAARRRGIYVGAFCGGEETARQLVDLGLDLVTPGNDISLLRD 240 Query: 241 EGARRVGALR 250 RR+ A+R Sbjct: 241 AATRRIAAIR 250 >D2ZJ89.1 D2ZJ89_9ENTR 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Length = 263 Score = 229 bits (583), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 117/239 (48%), Positives = 157/239 (65%), Gaps = 1/239 (0%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MR+N L+T F ++GW+++ + AE++ G+DAVTVDLQHG +AL MLQA Sbjct: 1 MRKNTLKTAFQDNTPIINGWLAIPSGYSAEIVGQQGFDAVTVDLQHGMIDFASALTMLQA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 +S+TPAVPLVR ++N +I ++LDAGAYGVICP+I++A +A RFV AC Y P G RS+G Sbjct: 61 LSATPAVPLVRVADNDPAQIMRVLDAGAYGVICPMISSAEEARRFVAACRYPPLGVRSFG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIEL-G 179 PARG LYGG+DY HAN +LTLAMIETREG AN +AIL T LDG+FIGP+DL++ L G Sbjct: 121 PARGLLYGGSDYPQHANDEILTLAMIETREGLANLDAILDTDGLDGVFIGPNDLSLTLTG 180 Query: 180 LAPDAYDDVRLNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQI 238 A + A++ ++ R+ K GIF + A G V P D+ Q+ Sbjct: 181 NASAESQHPEMLAAVERVIDRCRQQQKIAGIFCTSGAAAAARIAQGFHFVTPANDVMQL 239 >B3T178.1 B3T178_9ZZZZ Putative HpcH/HpaI aldolase family protein Length = 263 Score = 229 bits (583), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 112/249 (44%), Positives = 166/249 (66%), Gaps = 5/249 (2%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MR+N+L+ +F++ + ++GW+ + ++ AEV+AH G+D++T+D+QHG AL MLQA Sbjct: 1 MRKNKLKQIFSEGKAVVNGWLQIPSSFSAEVMAHQGWDSLTIDMQHGVIDYPNALQMLQA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 IS+T VP+ R + N G+I K+LDAG+YGVICP++N +AE+FV+AC Y P+G RS G Sbjct: 61 ISATDVVPMARVNWNEPGQIMKILDAGSYGVICPMVNNREEAEKFVQACLYPPKGYRSLG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 P RG LYGG+DY HA+ +L LAMIET+E + I+ TP LDGI+IGP+DL++ +G Sbjct: 121 PIRGLLYGGSDYAKHADKEILKLAMIETKEALDKLDKIMSTPGLDGIYIGPADLSLAIGT 180 Query: 181 APDAYDDVRLNEA---IDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQ 237 P +D + + A I+++L A+K GI T E A +M +G LV G+D Q Sbjct: 181 EP-GFDKEKSSPAFSVIENILKHAKKNNIVAGIHNATPEYATKMIEMGFQLVTAGSD-QS 238 Query: 238 IKAEGARRV 246 + GA+ V Sbjct: 239 YMSAGAKAV 247 >A2SEE7.1 A2SEE7_METPP 2-dehydro-3-deoxyglucarate aldolase EC=4.1.2.- Length = 262 Score = 223 bits (569), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 117/252 (46%), Positives = 157/252 (62%), Gaps = 3/252 (1%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MR NRLR ++ AL+GW+++ N+ AE +AH G+DA+T+DLQHG A +PMLQA Sbjct: 1 MRPNRLREIWKSGGAALNGWLAIPNSFSAETMAHQGWDALTIDLQHGVVDYQAMVPMLQA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 +S+T VP+VR G + K LDAGAYGVICP++NT DA++ V HY+PRG RS+G Sbjct: 61 LSTTATVPVVRVPWLEPGILMKTLDAGAYGVICPMVNTREDAQKLVAYTHYAPRGTRSFG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 P R LYGGADY HAN T++T AMIET + N + IL LD I+IGPSDL++ LG Sbjct: 121 PVRALLYGGADYAQHANDTIVTFAMIETAQALDNLDDILSVEGLDAIYIGPSDLSLALGC 180 Query: 181 APDAYDDVR--LNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQI 238 P +DDV + +AIDH+LA A+ G I G+ E A G V +D + + Sbjct: 181 TP-TFDDVDPPVAQAIDHILARAKAHGVVAAIHNGSPEAALARIAKGFQFVTVSSDARLM 239 Query: 239 KAEGARRVGALR 250 A + V +R Sbjct: 240 AAGAQQVVAKMR 251 >A8LLW9.1 A8LLW9_DINSH 2-dehydro-3-deoxyglucarate aldolase EC=4.1.2.20 Length = 253 Score = 222 bits (566), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 118/237 (49%), Positives = 150/237 (63%), Gaps = 1/237 (0%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MR N+LRTL AQ ++ W+S+ + +AE H G+D+VTVDLQHG + A+ MLQA Sbjct: 1 MRPNKLRTLLAQDTPIVNAWLSIPSGYVAEGAGHQGFDSVTVDLQHGLIGFETAVSMLQA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 IS+T AVPLVR + I LLDAGAYGVICP+I+T +A FV AC Y P+G RS+G Sbjct: 61 ISATEAVPLVRSPSKAPEVIMHLLDAGAYGVICPMISTPEEAAAFVAACRYPPQGSRSFG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 PARG LYGG DY ANA +L + MIET E EAIL P +D I++GP+DLA++LG Sbjct: 121 PARGKLYGGPDYFEAANAEILAIPMIETAEAVDRIEAILAVPGVDMIYVGPNDLALDLGE 180 Query: 181 APDAYDDVR-LNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQ 236 P A R +AI H+L AR G GIF G ++++ G DLV PG D Sbjct: 181 GPGAEWHPRATTDAIAHVLDRARAAGVATGIFCGDGALSRQRLAEGFDLVTPGNDFN 237 >D6V764.1 D6V764_9BRAD HpcH/HpaI aldolase Length = 262 Score = 218 bits (554), Expect = 7e-55, Method: Compositional matrix adjust. Identities = 117/248 (47%), Positives = 160/248 (64%), Gaps = 4/248 (1%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MREN++R+++ ++GW+++ ++ AEV+AH G+D +TVDLQHG +A+ M A Sbjct: 1 MRENKIRSIWKSGGAVVNGWLAIPSSFSAEVMAHQGWDTLTVDLQHGVTDYASAVAMFTA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 IS+TP VP+ R G I K LDAGAYG+ICP++N DAE+FVRAC Y P GGRS G Sbjct: 61 ISTTPTVPIARVPWLDPGIIMKTLDAGAYGIICPMVNCREDAEKFVRACRYPPDGGRSLG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 P R LY GADY AN T++TLAMIET++ + IL LD ++IGP+DL++ LG Sbjct: 121 PIRATLYAGADYPQKANETIVTLAMIETQQALDKLDEILSVKGLDAVYIGPADLSLSLGC 180 Query: 181 APDAYDDVR--LNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQI 238 AP +DDV + EAID +LA A + G I GT EMA + G LV G+D + + Sbjct: 181 AP-TFDDVDKPVAEAIDMVLAKANEHGVIPCIHNGTPEMALKRIERGFRLVTIGSDSRLM 239 Query: 239 KAEGARRV 246 A GA++V Sbjct: 240 TA-GAQQV 246 >B1Y3Z7.1 B1Y3Z7_LEPCP HpcH/HpaI aldolase Length = 265 Score = 215 bits (548), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 114/248 (45%), Positives = 157/248 (63%), Gaps = 4/248 (1%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MRENRLRTL+ Q A++GW+++ ++ AEV+AH G+D +T+DLQHG A + MLQA Sbjct: 1 MRENRLRTLWRNDQAAVNGWLAIPDSFSAEVMAHQGWDTLTIDLQHGVVDYPAMVTMLQA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 IS+T VP+VR G I K LDAGAYG+ICP++N+ DA++ V HY+PRG RS+G Sbjct: 61 ISTTATVPIVRVPWLEPGIIGKTLDAGAYGIICPMVNSREDAQKLVAYSHYAPRGTRSFG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 P R LY GADY HAN T++T AMIET + ++IL LD I+IGPSDL++ +G Sbjct: 121 PVRATLYAGADYPQHANDTIVTFAMIETAQALDKLDSILSVEGLDAIYIGPSDLSLSMGC 180 Query: 181 APDAYDDVR--LNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQI 238 P +DDV + +AI+H+L A G GI G E A G V +D ++ Sbjct: 181 RP-VFDDVDPPVAQAIEHILERATAHGLKAGIHNGVPEGALARVAKGFRFVTVSSD-ARL 238 Query: 239 KAEGARRV 246 A G+++V Sbjct: 239 MAAGSQQV 246 >B2JXI5.1 B2JXI5_BURP8 HpcH/HpaI aldolase Length = 263 Score = 205 bits (522), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 110/247 (44%), Positives = 149/247 (60%), Gaps = 2/247 (0%) Query: 1 MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA 60 MRENR+R+++ ++ +++ + AE +AH G+D++TVDLQHG A+ M A Sbjct: 1 MRENRIRSIWKSGGAVVNCSLTIPSTFSAETMAHQGWDSLTVDLQHGVGDYQKAVDMFTA 60 Query: 61 ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG 120 IS+T VP+ R N G + K+LDAGAYGVICP++N DAE+ V HY PRG RS+G Sbjct: 61 ISTTNTVPMARVPWNEPGILMKVLDAGAYGVICPMVNCREDAEKLVAFTHYPPRGSRSFG 120 Query: 121 PARGFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL 180 P R LYGGADY T AN T++ A IETR+ N + IL P LD I+I PSDL++ LG Sbjct: 121 PVRALLYGGADYPTQANDTVVVFATIETRQALDNLDEILSVPGLDAIYICPSDLSLALGF 180 Query: 181 APDAYD-DVRLNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQIK 239 P D D + EAIDH++A A+ G G GT E A G V +D ++ Sbjct: 181 TPTLDDVDATVAEAIDHVIARAKAHGVVAGSNQGTPEKALERIAKGCQFVNISSDT-RLM 239 Query: 240 AEGARRV 246 A GA++V Sbjct: 240 AAGAQQV 246 >A5VH82.1 A5VH82_SPHWW HpcH/HpaI aldolase Length = 251 Score = 192 bits (488), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 108/244 (44%), Positives = 145/244 (59%), Gaps = 2/244 (0%) Query: 4 NRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQAISS 63 N++RT + + + AL+GW+ + L AE +A YDAV +D+QH P PML AI Sbjct: 2 NKVRTCWNEGRPALAGWLQLPGTLHAEALARLDYDAVVIDMQHSPIDFGQVAPMLIAIEL 61 Query: 64 TPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYGPAR 123 A P VR N +I KLLDAGAYG+I P++NT A+A+ A HYSPRG RS+GP R Sbjct: 62 GGAEPFVRTQVNDPSDIMKLLDAGAYGIIAPMVNTRAEAQTLASALHYSPRGLRSFGPRR 121 Query: 124 GFLYGGADYLTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGLAPD 183 L G+ YL A+ T++ LAMIETRE AN + IL +DG+FIGP+DLA++LG AP Sbjct: 122 PSLRYGSGYLAQASETVVGLAMIETREALANIDEILSVDGIDGVFIGPTDLALDLGHAPL 181 Query: 184 A-YDDVRLNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQIKAEG 242 ++ + AI H+ A GK VGIF G+ A+ G D V D+ + A Sbjct: 182 VDTEEAEVVSAIAHVRERAHAAGKRVGIFCGSGGFARVKLAEGFDFVTAAPDLAMLSA-A 240 Query: 243 ARRV 246 AR+V Sbjct: 241 ARQV 244