BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0019.0009.p (399 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IVA3.1 D8IVA3_HERSS Non-ribosomal peptide synthetase protein 676 0.0 A4BRH6.1 A4BRH6_9GAMM Amino acid adenylation 325 8e-87 Q3KF66.1 Q3KF66_PSEPF Putative non-ribosomal peptide synthetase 324 2e-86 A5W123.1 A5W123_PSEP1 Amino acid adenylation domain 312 6e-83 E2XU32.1 E2XU32_PSEFL Amino acid adenylation 305 1e-80 F2KJT3.1 F2KJT3_PSEBR Amino acid adenylation domain-containing p... 304 2e-80 B1JBV2.1 B1JBV2_PSEPW Amino acid adenylation domain protein 293 3e-77 Q0K0K3.1 Q0K0K3_CUPNH Non-ribosomal peptide synthetase 289 5e-76 B3RAA2.1 B3RAA2_CUPTR Non ribosomal peptide synthase, antibiotic... 285 7e-75 F0E8A7.1 F0E8A7_9PSED Amino acid adenylation 280 3e-73 >D8IVA3.1 D8IVA3_HERSS Non-ribosomal peptide synthetase protein Length = 9160 Score = 676 bits (1744), Expect = 0.0, Method: Compositional matrix adjust. Identities = 389/399 (97%), Positives = 393/399 (98%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 VASAEDMRDGERFA FLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA Sbjct: 4775 VASAEDMRDGERFAKFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 4834 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 120 RIRALAPQCR+FNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD Sbjct: 4835 RIRALAPQCRVFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 4894 Query: 121 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGG 180 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGG Sbjct: 4895 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGG 4954 Query: 181 VRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGALAACLAADHGQALPA 240 VRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGALAACLAADHGQALPA Sbjct: 4955 VRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGALAACLAADHGQALPA 5014 Query: 241 WRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAVVAQAQGALA 300 WRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGR DSGTP VVAQAQGALA Sbjct: 5015 WRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRQDSGTPDVVAQAQGALA 5074 Query: 301 ALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPALVFDHPNAIA 360 ALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPALVFDHPNAIA Sbjct: 5075 ALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPALVFDHPNAIA 5134 Query: 361 LAAALQAAAPDPDALERLAQSRLESAAPAQDAAMTAMSA 399 LAAALQAAAPDPDALERLAQSRLESAAPAQ +M A++A Sbjct: 5135 LAAALQAAAPDPDALERLAQSRLESAAPAQADSMNALTA 5173 Score = 211 bits (538), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 160/368 (43%), Positives = 199/368 (54%), Gaps = 31/368 (8%) Query: 9 DGERFANFLRQHGIDALKIVPSHLDALLET--PAPYLP-ATLVLGGEATAPAQLARIRAL 65 D + FA +L +H +D LKIVPSHL ALL P LP TLVLGGEAT L RI AL Sbjct: 1365 DPDGFAAYLHEHAVDVLKIVPSHLQALLHAARPEQVLPRHTLVLGGEATGWPLLERIAAL 1424 Query: 66 APQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLDAQLRP 125 P CR+ NHYGP+E TVGVLV EA + + A LP+ AL VLD QLR Sbjct: 1425 QPACRVLNHYGPSETTVGVLVQ------EAASASRRAAVLPVGSALVGVQAWVLDRQLRR 1478 Query: 126 TPAGAIGQLWLGGAQLARGYLD-AQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGGVRLA 184 P GA+G+L+LGGA LARGY A E F+ P+ G+RLYRSGD A L G + Sbjct: 1479 APVGAVGELYLGGAGLARGYHGRAALTAERFVAHPFASGQRLYRSGDRARYLGDGSIEFL 1538 Query: 185 GRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGALAACLAADHGQALPA---- 240 GR D QVK+RG R+EPGE+ L GV A VLA P A L HG + A Sbjct: 1539 GRIDDQVKIRGHRVEPGEVRQQLLRLAGVVDAAVLALPAADDAQRLQL-HGFIVCAAGAV 1597 Query: 241 -----WRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAVVAQA 295 WRA LA LP + P+ V P LP NGK+DR+AL + + V Q Sbjct: 1598 ADPAGWRATLAADLPDYLLPTLTPV-PALPLTANGKLDRQALAGLMAGAMAAPQQQVPQV 1656 Query: 296 ---------QGALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALE 346 QG L LA A++L+ P + ++FFELG S+L +K++AR R+ L Sbjct: 1657 QQAHQAGAPQGELEHKLAAIWAEVLKLPQVGREDNFFELGGDSILTLKIVARARKE-GLR 1715 Query: 347 AAPALVFD 354 AP + + Sbjct: 1716 IAPKAMME 1723 Score = 173 bits (438), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 128/312 (41%), Positives = 169/312 (54%), Gaps = 27/312 (8%) Query: 48 VLGGEATAPAQLARIR-ALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLP 106 V GGEA A R+R LAP+ + N YGPTE V L+ + + A + + G +P Sbjct: 8531 VFGGEAMPRASFERVRRHLAPRL-LINGYGPTETVVTPLIWKGTSAAGVDFD---GPFVP 8586 Query: 107 LTEALPHAYVRVLDAQLRPTPAGAIGQLWLGGAQLARGYLDA-QQDREAFIDDPW-LPGR 164 + + + +LDA L+P G G+L++GG LARGYL+ Q E F+ DP+ PG Sbjct: 8587 IGKPVGRRNAYILDACLQPVAPGEAGELYIGGDGLARGYLERPAQSAERFVADPFGEPGA 8646 Query: 165 RLYRSGDLAVLLPQGGVRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDG 224 R+YR+GDLA LP G V GR DHQVK+RGFRIE GEIEA LR QPGV +A V+ DG Sbjct: 8647 RMYRTGDLARWLPDGNVEYLGRLDHQVKIRGFRIELGEIEALLRRQPGVAEAAVVVRSDG 8706 Query: 225 -------ALAACLAADHGQALP---------AWRAALAEVLPAQMQPSRWLVLPELPRLG 268 L A + A A P + RAAL LP M P+ +++L LP Sbjct: 8707 QGEETVRQLVAYVGAPQAVAAPETAQRDFSDSLRAALRAGLPEYMLPAHFVLLAALPVTH 8766 Query: 269 NGKVDRKALLEQLGRPDSGTPAVVAQAQGALAALLAQQMAQLLERPAIAANEDFFELGAH 328 NGK+DRKAL P A A ALA + +L+R + ++FFELG Sbjct: 8767 NGKLDRKALPAPQAAPARSYVAPATPAAQALAEI----WQTVLKRERVGQEDNFFELGGD 8822 Query: 329 SLLVIKLIARIR 340 SLL +++IAR R Sbjct: 8823 SLLCLQVIARAR 8834 Score = 170 bits (431), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 152/409 (37%), Positives = 198/409 (48%), Gaps = 27/409 (6%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATL---VLGGEATAPA 57 +A+ ++ RD A +R+H +D L VPS L + P +L + GEA PA Sbjct: 7413 LAAPDEHRDPALLAARIRRHAVDTLHFVPSMLQGFVAHPDSAQCHSLRQVICSGEAL-PA 7471 Query: 58 QL-ARIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYV 116 +L + A PQ + N YGPTE + V H E S+P+ + H Sbjct: 7472 ELQEQAFARLPQIALHNLYGPTEAAIDV-THWTCRPGER--------SVPIGRPISHTAA 7522 Query: 117 RVLDAQLRPTPAGAIGQLWLGGAQLARGYLDAQQ-DREAFIDDPWL-PGRRLYRSGDLAV 174 VLD L P P G G+L+LGG LARGYL E F+ DP+ G R+YR+GDL Sbjct: 7523 YVLDGGLNPLPHGIAGELYLGGIGLARGYLGRPGLSAERFVADPFAADGSRMYRTGDLVR 7582 Query: 175 LLPQGGVRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGALAACL---A 231 G + GR DHQVK+RG RIE GEIEA L QPGV A+V+A + A L A Sbjct: 7583 RRADGEIEYLGRTDHQVKIRGLRIELGEIEAQLLAQPGVAAAVVVALVEPGRPARLVGYA 7642 Query: 232 ADHGQAL--PAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTP 289 AD G L A RAAL + LP M P R ++LP LP NGKVDRKA L RPD Sbjct: 7643 ADPGGMLEAEALRAALLQSLPDYMVPQRLILLPALPLNANGKVDRKA----LPRPDFNEQ 7698 Query: 290 AVVAQAQGALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAP 349 QG LA A++L + +++FFELG S+L ++++AR + P Sbjct: 7699 GGYEAPQGQTEIGLAAIWAEVLRLQRVGRHDNFFELGGDSILSLQIVARAHEQ-GWPLTP 7757 Query: 350 ALVFDHPNAIALAAAL-QAAAPDPDALERLAQSRLESAAPAQDAAMTAM 397 +F LA Q P P A+ RLE A A A+ Sbjct: 7758 RQLFQSQTVAELAQQCDQLQPPAPTQAVTAARGRLEDYLSAAQTAQLAL 7806 Score = 164 bits (416), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 139/357 (38%), Positives = 181/357 (50%), Gaps = 32/357 (8%) Query: 8 RDGERFANFLRQHGIDALKIVPSHLDALLETPA-PYLPA------TLVLGGEATAPAQLA 60 R E F L + + L PS LL+ PA LP+ T++ GGEA P L Sbjct: 5882 RSPEDFLALLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALRTVIFGGEALEPEMLR 5941 Query: 61 -RIRALAPQC-RIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRV 118 I Q + N YG TE TV V R A+ D S P+ A+P + V Sbjct: 5942 PWITQFGDQRPALINMYGITETTVHVTYRRLL-----RADLDASRS-PIGAAIPDLGLYV 5995 Query: 119 LDAQLRPTPAGAIGQLWLGGAQLARGYLD-AQQDREAFIDDPWL----PGRRLYRSGDLA 173 LD QL PAG G+L++ GA LARGYL+ A E F+ +P+ G RLYR+GDL Sbjct: 5996 LDQQLNLAPAGVPGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEGSRLYRTGDLV 6055 Query: 174 VLLPQGGVRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGA---LAACL 230 G + GR D QVK+RGFRIE GEIEA L QPGV A V+ D A L L Sbjct: 6056 RWRHDGQMDYLGRIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQDAATPRLVGYL 6115 Query: 231 AADHGQA-----LPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPD 285 + G A A R AL VLP M P+ ++LP LP NGKVDRKAL P+ Sbjct: 6116 SPQAGIAPEALDTGALRTALGAVLPDYMVPAALVMLPALPLNINGKVDRKALPA----PE 6171 Query: 286 SGTPAVVAQAQGALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQS 342 A QGAL LA ++L+ A+ +++FFELG S+L +++++R R++ Sbjct: 6172 LAARTAYAAPQGALEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVSRARRA 6228 Score = 159 bits (403), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 147/398 (36%), Positives = 190/398 (47%), Gaps = 29/398 (7%) Query: 8 RDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATL---VLGGEATAPAQLARIRA 64 RD A +R+HG+ L VPS L A L + +L + GEA + A Sbjct: 2871 RDPAELAALIREHGVSTLHFVPSMLQAFLASGQAAACTSLRQVICSGEALPAEARDQFFA 2930 Query: 65 LAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLDAQLR 124 L PQ + N YGPTE + V H + +P+ + + VLDA L Sbjct: 2931 LLPQAALHNLYGPTEAAIDV-THWTCQHGDR-------GPVPIGQPISGLRAVVLDADLN 2982 Query: 125 PTPAGAIGQLWLGGAQLARGYLDAQQ-DREAFIDDPWLPGRRLYRSGDLAVLLPQGGVRL 183 P G G+L+LGG LARGYL E F+ P+ G RLYR+GDL G + Sbjct: 2983 VLPCGVAGELYLGGIGLARGYLGRPGLTAERFVASPFGQGERLYRTGDLVRWREDGQIDY 3042 Query: 184 AGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGA---LAACLAADHGQALPA 240 GR DHQVK+RG RIE GEIEA L V +A+V+A GA LA +A+ Q A Sbjct: 3043 LGRLDHQVKIRGLRIELGEIEAQLLALDEVEEAVVVAHEHGAGPVLAGYVASRRWQRQDA 3102 Query: 241 --WRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKAL-LEQLGRPDSGTPAVVAQAQG 297 + ALA LP M P+ +LP LP NGK+DRKAL +L D A QG Sbjct: 3103 ATLKQALAARLPDYMVPAVLTLLPTLPLNANGKIDRKALPAPRLHSEDF----AYAAPQG 3158 Query: 298 ALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQ----SLALEAAPALVF 353 + LAQ LL + + FFELG HSLL L+AR+R + + LVF Sbjct: 3159 QVEQRLAQIWQALLGLERVGRFDHFFELGGHSLLAASLVARLRYQGEAGVGVALPLRLVF 3218 Query: 354 DHPNAIALAAALQAAAPDPDALERLAQSR---LESAAP 388 +P +AA ++A P P + RL R L S AP Sbjct: 3219 AYPRLHEMAACIEARPPLPPSSWRLHLRRCCNLASGAP 3256 >A4BRH6.1 A4BRH6_9GAMM Amino acid adenylation Length = 1076 Score = 325 bits (833), Expect = 8e-87, Method: Compositional matrix adjust. Identities = 195/404 (48%), Positives = 254/404 (62%), Gaps = 19/404 (4%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 VA AEDM+D FA F+ + ID LKIVPSHL+ALL+T + LP TL+LGGEAT A + Sbjct: 669 VADAEDMQDAASFARFMLEQDIDCLKIVPSHLEALLDTESATLPRTLILGGEATPRALVE 728 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 120 R+ LAP CRI NHYGPTE TVGV+ H + +A G +LPL++ L + V +LD Sbjct: 729 RLVKLAPDCRIHNHYGPTETTVGVMAHTFDPQ-----DAWCGDALPLSQPLANCSVYLLD 783 Query: 121 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGG 180 R P GA+G+L+LGGAQ+ RGYL+ D + FIDDP+ PG RLYRSGDL LP G Sbjct: 784 EARRLVPTGALGELYLGGAQVCRGYLNRPAD-DVFIDDPFRPGERLYRSGDLGRYLPGGS 842 Query: 181 VRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDG------ALAACLAADH 234 ++LAGR D Q+K+RGFRIEP E+E AL T PG+RQA V A +G A + A+ Sbjct: 843 LQLAGRTDDQLKIRGFRIEPAEVELALLTVPGIRQAAVRAWGEGEQRQLFAYVVAVRAEG 902 Query: 235 GQALP--AWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAVV 292 G L A + L + L + M P+ VLP+LPRL NGK DR+AL D + Sbjct: 903 GGELDEAALKQELKKHLASAMLPAHVFVLPQLPRLANGKTDRQAL---PAPTDLSKRSAY 959 Query: 293 AQAQGALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPALV 352 + A+ A+LA A+LL+R ++ + FF+LG HSLLVIKL+ARIR+ L +E P LV Sbjct: 960 VAPRDAVEAVLANVWAELLKREKVSVTDSFFDLGGHSLLVIKLVARIRKLLQVEILPGLV 1019 Query: 353 FDHPNAIALAAALQAAAPDPDALERLA--QSRLESAAPAQDAAM 394 FDHP+ ALA AL +P LE++A + RL S P + A+ Sbjct: 1020 FDHPSIEALAQALPRFESEPGQLEQVAALRQRLMSLNPEEHKAL 1063 >Q3KF66.1 Q3KF66_PSEPF Putative non-ribosomal peptide synthetase Length = 1070 Score = 324 bits (830), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 190/400 (47%), Positives = 250/400 (62%), Gaps = 18/400 (4%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 VAS M+D + FA +++ H ID LKIVPSHL ALL++ P+LP TLVLGGEA A + Sbjct: 669 VASDAQMQDAQAFAGYVQAHAIDCLKIVPSHLAALLDSETPHLPRTLVLGGEAIAAPLIQ 728 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLP-LTEALPHAYVRVL 119 RI + C++FNHYGPTE TVGV+VH+ A PG L++ L + V VL Sbjct: 729 RIAQVRSDCQVFNHYGPTETTVGVMVHKVA----------PGQGAGWLSQVLDNNQVYVL 778 Query: 120 DAQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQG 179 DAQ + P G +G+L++GGAQL RGY++ + ID P++ G RLYR+GDLA LP+G Sbjct: 779 DAQQQLAPVGVVGELYVGGAQLFRGYVNVDAEAGLLIDSPFISGERLYRTGDLARYLPEG 838 Query: 180 GVRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLA--APDGALAACLAADHGQA 237 + L GR DHQ+KVRGFRIE E+EA L QP V++A V+A +P+ L A + A A Sbjct: 839 AIVLHGRRDHQIKVRGFRIELTEVEAQLLRQPSVQEAAVVAGDSPEQGLQAFVVARESLA 898 Query: 238 LPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAVVAQAQG 297 + R LA+ LPA M P + + LPRL NGK+DRKA L+QL D G + Sbjct: 899 ADSLREQLAQQLPAVMVPQQIRFIERLPRLANGKIDRKA-LQQLA--DQGVDDDYVAPRD 955 Query: 298 ALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPALVFDHPN 357 AL LLA +MAQLL + ++ + DFF G HSLLVIKL+A IR+ L E P +VFDHP Sbjct: 956 ALETLLAGRMAQLLGQDRLSIDRDFFAAGGHSLLVIKLVAGIRKLLQCEIHPGVVFDHPT 1015 Query: 358 AIALAAALQAAAPDPDALERLAQS--RLESAAPAQDAAMT 395 LA AL+ P L++LAQ+ RLES +P + A +T Sbjct: 1016 VAGLAQALRGQEASPGQLDKLAQARVRLESMSPEEKALLT 1055 >A5W123.1 A5W123_PSEP1 Amino acid adenylation domain Length = 1058 Score = 312 bits (799), Expect = 6e-83, Method: Compositional matrix adjust. Identities = 190/403 (47%), Positives = 244/403 (60%), Gaps = 17/403 (4%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 VA+ E M+D E FA +L Q ID LKIVPSHL ALLE+ AP +PAT++LGGEA + A L Sbjct: 667 VAADEVMKDAELFAAYLEQQAIDCLKIVPSHLSALLESKAPAVPATVILGGEAPSAALLQ 726 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 120 R+ + P C++FNHYGPTE TVGV+VH A P +L L++ LP+ V VLD Sbjct: 727 RLLQIRPDCKLFNHYGPTETTVGVMVH--------PVRAVPTGTLGLSQVLPNNQVYVLD 778 Query: 121 AQLRPTPAGAIGQLWLGGAQLARGYL-DAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQG 179 L+ G +G+L++GG Q+ RGYL D Q D AF++ P++ G RLYR+GDLA P G Sbjct: 779 QHLQLAVTGVLGELYVGGQQVCRGYLQDVQSDPPAFVESPFVAGERLYRTGDLARYRPDG 838 Query: 180 GVRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGALAACLAADHGQ--A 237 + L GR DHQVK+RGFRIE EIEA L P V +A VL + A D A Sbjct: 839 AIELQGRRDHQVKIRGFRIELAEIEAQLSGAPQVVEAAVLCDGEALSAYVSLRDEATAAA 898 Query: 238 LPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAVVAQAQG 297 L A R LA LPA M P LP LPRLGNGK+DR+AL + P +G A + Sbjct: 899 LDAVREYLARQLPAVMLPRTLQALPRLPRLGNGKLDRQALRQVGKEPAAGLLA----PRD 954 Query: 298 ALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPALVFDHPN 357 AL ++AQ+MAQLL + +DFF LG HSLLVIKL A IR+ L + P ++FDH Sbjct: 955 ALETVIAQRMAQLLGLEQVGIEQDFFALGGHSLLVIKLAAGIRKLLQCDINPGVIFDHAT 1014 Query: 358 AIALAAALQAAAPDPDALERLAQS--RLESAAPAQDAAMTAMS 398 LA AL+ +P L +LAQ+ RL+S +P + A + S Sbjct: 1015 VATLAQALREREANPGQLLKLAQARLRLDSMSPEEKARLLEKS 1057 >E2XU32.1 E2XU32_PSEFL Amino acid adenylation Length = 1048 Score = 305 bits (780), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 198/398 (49%), Positives = 246/398 (61%), Gaps = 29/398 (7%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 +A+ +D+ DG F FL + D K VPSHL ALLE AP LP TL+LGGEAT + Sbjct: 641 IAAQDDLADGAAFRRFLLRERPDVAKFVPSHLAALLEGDAPLLPGTLILGGEATPRRLVE 700 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 120 ++ A AP R+FNHYGPTE TVGVL H+ +A D +PL+ L V +LD Sbjct: 701 QLFAQAPTLRLFNHYGPTETTVGVLFHQLRADA-----PDRDDRVPLSRVLAGNRVYLLD 755 Query: 121 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGG 180 LR P GA+G+L++GGAQL RGYL + + E F+DDP++PG+RLYRSGDL +GG Sbjct: 756 EHLRLVPTGALGELYIGGAQLCRGYL-GESNAERFVDDPFMPGQRLYRSGDLGRYRAEGG 814 Query: 181 VRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALV-LAAPDGALAACLA-------- 231 ++L GR D+QVK+RG RIE GE+EAAL T PGV QA+ L AP A+ +A Sbjct: 815 LQLVGRQDYQVKLRGQRIELGEVEAALLTLPGVDQAVARLWAPSEGAASLIAYVVLAQGV 874 Query: 232 ADHGQALPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAV 291 AD ALP ALAE LP P+R LVLP LPRL NGKVDR AL PD G A Sbjct: 875 AD--DALPPLSTALAERLPDASCPTRLLVLPSLPRLSNGKVDRHAL------PDPGQLAR 926 Query: 292 VAQAQ---GALAALLAQQMAQLLERP--AIAANEDFFELGAHSLLVIKLIARIRQSLALE 346 A+ L A L MA+LL P A+ ++DFF+ G HSLLVIKL+AR+R LE Sbjct: 927 RQPARAPTSELEASLRDAMAELLGCPPAALGVDDDFFDAGGHSLLVIKLLARLRTMFKLE 986 Query: 347 AAPALVFDHPNAIALAAALQAAAPDPDALERLAQSRLE 384 P +VFDHP+A ALA AL A DP LE++A+ R E Sbjct: 987 VPPGVVFDHPSAAALAVALGELA-DPARLEKVARLRRE 1023 >F2KJT3.1 F2KJT3_PSEBR Amino acid adenylation domain-containing protein Length = 1074 Score = 304 bits (778), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 192/402 (47%), Positives = 243/402 (60%), Gaps = 16/402 (3%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 VAS E M+DG FA +++Q ID LKIVPSHL ALL++ LP TL+LGGE + Sbjct: 667 VASDEQMQDGALFAQYVQQQRIDCLKIVPSHLAALLDSEQATLPLTLILGGEPIPATLIE 726 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 120 RI L CR+FNHYGPTE TVGV++H + A G LT+ L + V +LD Sbjct: 727 RIARLRSDCRVFNHYGPTEATVGVMIHPLSLHGAA------GDCAALTQVLGNNQVYLLD 780 Query: 121 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGG 180 A LR P G +G+++LGGAQL RGYL A+ D + FI P+ P +RLYR+GDLA P G Sbjct: 781 ADLRLAPVGVLGEVYLGGAQLCRGYLHAEADEQTFIQSPFDPAQRLYRTGDLARYHPNGA 840 Query: 181 VRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVL--AAPDGALAACLAADHGQA- 237 ++L GR D QVKVRGFRIE EIEA L P V +ALVL A+ + L A + A G A Sbjct: 841 IQLYGRRDQQVKVRGFRIELAEIEAVLLRMPQVAEALVLPAASVEQGLLAFIVAPAGSAT 900 Query: 238 --LPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAVVAQA 295 L A RA L+ LP+ M P ++ PRL NGK+DRKAL + G + T A Sbjct: 901 GVLDAARAGLSARLPSVMVPQHMQLIEAFPRLVNGKIDRKALQQLAG---AATDDKDAAP 957 Query: 296 QGALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPALVFDH 355 + AL LLA +MAQLL + + DFF G HSLLVIKL+A IR+ L E P LVFDH Sbjct: 958 RDALEQLLAARMAQLLGLERLGIDRDFFAAGGHSLLVIKLVAGIRKLLQCEIHPGLVFDH 1017 Query: 356 PNAIALAAALQAAAPDPDALERLAQSRL--ESAAPAQDAAMT 395 P +LA AL+A P LE++AQ RL E+ +P + +T Sbjct: 1018 PTVASLALALRALESSPGQLEKMAQVRLRMEAMSPEEKLRLT 1059 >B1JBV2.1 B1JBV2_PSEPW Amino acid adenylation domain protein Length = 1029 Score = 293 bits (750), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 201/406 (49%), Positives = 237/406 (58%), Gaps = 24/406 (5%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 VAS M+D FA F+R GID LKIVPSHL ALL++ P LPATLVLGGEA + LA Sbjct: 631 VASDAVMQDPAAFAAFVRDEGIDCLKIVPSHLAALLDSAQPSLPATLVLGGEAPSAQLLA 690 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 120 RI LAPQ R+FNHYGPTE TVGVLV EA P ASL A Y+ Sbjct: 691 RIARLAPQARVFNHYGPTEATVGVLVQPLRAEA-------PMASLGQVLAGNRVYLLTPA 743 Query: 121 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGG 180 QL G +G+L + G QL RGYL +Q FID+P G RLYRSGDLA G Sbjct: 744 GQL--AGVGELGELHVAGRQLCRGYLGGEQGASRFIDNPLQAGERLYRSGDLARYQADGS 801 Query: 181 VRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDG----ALAACLAADHGQ 236 + L GR DHQVK+RGFR+E E+EA L GV Q VLA L AC A HG+ Sbjct: 802 ILLQGRQDHQVKIRGFRVELAEVEARLLEIDGVAQGAVLAIETQPGQLELLACYAV-HGE 860 Query: 237 A----LPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAVV 292 A + RA LAE LPA M P++ LP LPRL NGK+DR+ALL+ Sbjct: 861 AEGLDEASLRARLAECLPAAMVPTQLRCLPSLPRLANGKLDRRALLQL----PQQQGGQQ 916 Query: 293 AQAQGALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPALV 352 Q AL LLAQ+MAQLL R +I + DFF G HSLL+IKL+A IR+ L E APALV Sbjct: 917 DAPQDALQTLLAQRMAQLLGRDSIGIHTDFFAAGGHSLLIIKLVAGIRKLLNCEVAPALV 976 Query: 353 FDHPNAIALAAALQAAAPDPDALERLAQSR--LESAAPAQDAAMTA 396 F+HP LA ALQA + L ++AQ+R LE +P + M A Sbjct: 977 FEHPTVAGLAEALQANEANRGHLLKIAQARLQLERMSPEEKEQMLA 1022 >Q0K0K3.1 Q0K0K3_CUPNH Non-ribosomal peptide synthetase Length = 1031 Score = 289 bits (740), Expect = 5e-76, Method: Compositional matrix adjust. Identities = 194/376 (51%), Positives = 236/376 (62%), Gaps = 15/376 (3%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 VAS +DM FA +LR +DA+KIVPSHL ALLET AP +PAT++LGGE + + Sbjct: 634 VASDDDMAHPAAFARYLRGREVDAIKIVPSHLAALLETDAPAVPATVILGGEPLPASLVQ 693 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 120 +R AP CRIFNHYGPTE T+GV+VH AE A P + PL+ AL VR+LD Sbjct: 694 GLRRHAPDCRIFNHYGPTETTIGVMVHAVG----AEDPAWPAGTAPLSRALGATRVRLLD 749 Query: 121 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQ-DREAFIDDPWLPGRRLYRSGDLAVLLPQG 179 LRP PAG GQL++GG QLA GYL D AF+DDP+ G+RLYR+GDLA P Sbjct: 750 DALRPVPAGVAGQLYVGGPQLAHGYLGRPDLDAAAFVDDPFAAGQRLYRTGDLARATP-A 808 Query: 180 GVRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAPDGALAACLA-----ADH 234 G++L GRAD QVK+RG R+EP E+EAAL QP V QA V AAP AA L A Sbjct: 809 GLQLLGRADQQVKIRGIRVEPAEVEAALLAQPAVAQAAVCAAPGPGAAAVLCAFIVPASA 868 Query: 235 GQA-LPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDS---GTPA 290 G A A R ALA +LP M PSR + LP LPRL NGK DR AL PD P Sbjct: 869 GSADTDALRRALAAMLPDAMVPSRLIALPALPRLPNGKTDRTALRTLAASPDDIAAAAPQ 928 Query: 291 VVAQAQGALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPA 350 + A+ L+ MA+LLE+ + + DFF LG HSLLVIKL+AR+R+ L +E AP Sbjct: 929 AATASADAVETLVCALMAELLEQERVDPHADFFALGGHSLLVIKLVARLRRRLQVEIAPG 988 Query: 351 LVFDHPNAIALAAALQ 366 +VFD P A ALAAA++ Sbjct: 989 VVFDRPTAHALAAAVR 1004 >B3RAA2.1 B3RAA2_CUPTR Non ribosomal peptide synthase, antibiotic synthesis; contains 1 condensation domain, 1 AMP-acid ligases II domain EC=5.1.1.11 Length = 1059 Score = 285 bits (730), Expect = 7e-75, Method: Compositional matrix adjust. Identities = 213/416 (51%), Positives = 253/416 (60%), Gaps = 27/416 (6%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLP----ATLVLGGEATAP 56 VA DMR F FL + +D LKIVPSHLDALL+ LP AT+VLGGEA A Sbjct: 643 VADEADMRHAAAFTAFLAREHVDCLKIVPSHLDALLDGDTAPLPLPPHATIVLGGEAAAT 702 Query: 57 AQLARIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPH--A 114 A L R+ A PQ R+ NHYGPTE TVG+L H A A+A A LPLT+ L + A Sbjct: 703 ALLQRLHARMPQARLCNHYGPTETTVGILFHDAGRAADAV-----DAPLPLTQVLANCEA 757 Query: 115 YVRVLDAQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAV 174 YVR L AG G+LWLGGAQL GYL + AF+ P PG+RLYRSGDLA Sbjct: 758 YVRTATGNL--AAAGETGELWLGGAQLCAGYLGGEVSGTAFVAHPERPGQRLYRSGDLAR 815 Query: 175 LLPQGGVRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALV-LAAPDGA---LAACL 230 LP GG+ L GRADHQ+KVRGFRIE GE+E AL PGVRQA+V LAAP G LA + Sbjct: 816 YLPSGGIELVGRADHQIKVRGFRIECGEVEQALAVLPGVRQAVVMLAAPAGGAPQLATWI 875 Query: 231 A------ADHGQALPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRP 284 D A R ALAE LP M P+ W +P LPRL NGKVDR+AL + Sbjct: 876 VPDDATATDAAAVRNALRYALAERLPEAMIPALWFAVPALPRLPNGKVDRRALAQAAAAS 935 Query: 285 DSGTPAVVAQAQGA--LAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQS 342 + + + A + A L ALL Q+ LL P +A +D FE G HSLLVIKL+ARIR+ Sbjct: 936 PAPSASAGAAREPASELEALLLDQLRDLLGAPDLAVRDDLFEAGGHSLLVIKLVARIRKL 995 Query: 343 LALEAAPALVFDHPNAIALAAALQAAAPDPDALERLA--QSRLESAAPAQDAAMTA 396 L LE APA+VFD P+A ALA AL+ A+ DPD LE LA Q +L + +P AA+ A Sbjct: 996 LKLEIAPAMVFDAPDAAALARALRNASADPDGLETLAGLQRQLAAMSPEARAALRA 1051 >F0E8A7.1 F0E8A7_9PSED Amino acid adenylation Length = 1064 Score = 280 bits (715), Expect = 3e-73, Method: Compositional matrix adjust. Identities = 186/406 (45%), Positives = 235/406 (57%), Gaps = 24/406 (5%) Query: 1 VASAEDMRDGERFANFLRQHGIDALKIVPSHLDALLETPAPYLPATLVLGGEATAPAQLA 60 VA + +RD ERF ++L +D LKIVPSHL ALLE P LP TLVLGGEA AP L Sbjct: 659 VADEDTLRDPERFRDYLVAGEVDCLKIVPSHLGALLEAEQPRLPGTLVLGGEAPAPGLLQ 718 Query: 61 RIRALAPQCRIFNHYGPTECTVGVLVHRAATEAEAEAEADPGASLPLTEALPHAYVRVLD 120 R+ L CR+FNHYGPTE TVGV+V E G+ LP + V VLD Sbjct: 719 RVFQLRADCRVFNHYGPTEATVGVMVQVLTPEPLGHGPVGLGSVLPGNQ------VYVLD 772 Query: 121 AQLRPTPAGAIGQLWLGGAQLARGYLDAQQDREAFIDDPWLPGRRLYRSGDLAVLLPQGG 180 A+ R P G +G+L++ G QL RGYL+ EAF+D P+ PG RLYR+GDLA G Sbjct: 773 ARHRLVPPGVLGELYISGRQLCRGYLN--DAGEAFVDHPFAPGERLYRTGDLARYRVDGS 830 Query: 181 VRLAGRADHQVKVRGFRIEPGEIEAALRTQPGVRQALVLAAP--------DGALAACLAA 232 + L GR D QVK+ GFR+E E+EA L+ VR+A V+A P A + A Sbjct: 831 LALHGRRDQQVKLNGFRVELAELEAELQRVACVREAAVVAVPAEDAQAGLQPAAFVVVQA 890 Query: 233 DHGQALPAWRAALAEVLPAQMQPSRWLVLPELPRLGNGKVDRKALLEQLGRPDSGTPAVV 292 D + R LA LP + P R V+ +LPRL NGKVDR+ L + P Sbjct: 891 DEQNPQASIRRDLALRLPEPLLPRRIQVVAQLPRLANGKVDRQG----LAKLAPQAPQTE 946 Query: 293 AQ-AQGALAALLAQQMAQLLERPAIAANEDFFELGAHSLLVIKLIARIRQSLALEAAPAL 351 Q A+ AL LLA++M QLLE+PA+ ++DFF G HSLL IKL+A IR L E +PA+ Sbjct: 947 QQPARTALERLLAKRMGQLLEQPALGLHQDFFAAGGHSLLAIKLVAGIRNVLRREVSPAM 1006 Query: 352 VFDHPNAIALAAALQAA-APDPDALERLAQS--RLESAAPAQDAAM 394 VFD+P LA AL A D ALE LA++ +LE+ P Q AA+ Sbjct: 1007 VFDNPTVAELAQALGALPGSDAQALEALARAHLQLEALPPEQRAAL 1052