BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0087.p (261 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J1X2.1 D8J1X2_HERSS Metal-dependent hydrolases of the beta-lac... 527 e-148 A6SXH7.1 A6SXH7_JANMA Metallo-beta-lactamase superfamily protein 357 8e-97 A4G722.1 A4G722_HERAR Putative metallo-hydrolase/oxidoreductase ... 356 1e-96 F1VXD1.1 F1VXD1_9BURK Putative Metallo-beta-lactamase family pro... 334 8e-90 B2SXT5.1 B2SXT5_BURPP Beta-lactamase domain protein 301 6e-80 E8YIB8.1 E8YIB8_9BURK Beta-lactamase domain protein 299 2e-79 D5NFB8.1 D5NFB8_9BURK Beta-lactamase domain protein 297 1e-78 C3X4S3.1 C3X4S3_OXAFO Metallo-beta-lactamase superfamily protein 296 2e-78 Q13X21.1 Q13X21_BURXL Putative metallo-beta-lactamase family pro... 296 3e-78 B1G5U7.1 B1G5U7_9BURK Beta-lactamase domain protein 293 2e-77 >D8J1X2.1 D8J1X2_HERSS Metal-dependent hydrolases of the beta-lactamase superfamily I protein Length = 261 Score = 527 bits (1357), Expect = e-148, Method: Compositional matrix adjust. Identities = 258/261 (98%), Positives = 259/261 (99%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI Sbjct: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS Sbjct: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS Sbjct: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLK VIGAHLSQQNNTPELARAALEGVL Sbjct: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKRVIGAHLSQQNNTPELARAALEGVL 240 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 G TFG+IGIACQAEGFGWLDV Sbjct: 241 GMTFGNIGIACQAEGFGWLDV 261 >A6SXH7.1 A6SXH7_JANMA Metallo-beta-lactamase superfamily protein Length = 259 Score = 357 bits (916), Expect = 8e-97, Method: Compositional matrix adjust. Identities = 173/261 (66%), Positives = 206/261 (78%), Gaps = 5/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 MKFASLGSGSEGNALLIS +G R TT+MLDCGF ++E ERR+ RL + P+D+S I Sbjct: 1 MKFASLGSGSEGNALLISTQSGSTR----TTLMLDCGFGIKETERRLARLQMLPTDLSGI 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 +VTHEH DHV GVFKFARR+++PVWL+YGT+QAV D+ V + FC D ++ AIGDLEL Sbjct: 57 IVTHEHQDHVGGVFKFARRHKLPVWLTYGTYQAVHDKCDGVQLHFCRDNERFAIGDLELL 116 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREP+QYVA DG RRLGVLTDAG TAH+V ALG CDAL+LECNHDR ML S Sbjct: 117 PYTVPHDAREPVQYVASDGTRRLGVLTDAGHGTAHMVAALGGCDALMLECNHDRQMLVNS 176 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP LK+RIGG+YGHL+N A+ EIL LDKSRL+ ++GAHLS +NNTPELARAAL V+ Sbjct: 177 TYPPSLKQRIGGEYGHLSNHAAGEILAALDKSRLQRIVGAHLSLKNNTPELARAALMQVV 236 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 ++ IACQ EGF W+ V Sbjct: 237 ADR-AEVLIACQEEGFDWVAV 256 >A4G722.1 A4G722_HERAR Putative metallo-hydrolase/oxidoreductase superfamily protein Length = 261 Score = 356 bits (914), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 176/261 (67%), Positives = 205/261 (78%), Gaps = 5/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 +KFASLGSGSEGNALLIS +G R TTVMLDCGF +RE ERR+ RL L P+D++ I Sbjct: 3 LKFASLGSGSEGNALLISTQSGTTR----TTVMLDCGFGIRETERRLERLQLLPADLAGI 58 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 +VTHEH DHV GVFKFARR+R+PVWL++GT+QA D+ DV++ C DG AIGDLELS Sbjct: 59 IVTHEHQDHVGGVFKFARRHRLPVWLTFGTYQATRDRCDDVEIHICRDGAVFAIGDLELS 118 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREP+QYVA DG RLGVLTDAG TAHL++AL ACDAL+LECNHD ML S Sbjct: 119 PYTVPHDAREPVQYVASDGALRLGVLTDAGHATAHLIEALAACDALMLECNHDIQMLRDS 178 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP LK+RIGGDYGHL+N + EIL LDKSRLK V+GAHLS +NNTPELARAAL + Sbjct: 179 AYPPSLKQRIGGDYGHLSNQMAGEILSGLDKSRLKRVVGAHLSLKNNTPELARAALTDAV 238 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 T ++ IACQ EGF WL+V Sbjct: 239 -TERIEVMIACQEEGFAWLEV 258 >F1VXD1.1 F1VXD1_9BURK Putative Metallo-beta-lactamase family protein Length = 258 Score = 334 bits (856), Expect = 8e-90, Method: Compositional matrix adjust. Identities = 175/261 (67%), Positives = 203/261 (77%), Gaps = 4/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 MKFASLGSGSEGNALLI+AA+G R TTVMLDCGF+++E ERRM R+G+ +++SAI Sbjct: 1 MKFASLGSGSEGNALLITAASGMTR----TTVMLDCGFSVKETERRMARIGMAAAELSAI 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 V+THEHSDHVSG KFARRY +PVWLSYGT+QAV VDV+FC DG + IGDLEL Sbjct: 57 VITHEHSDHVSGALKFARRYHVPVWLSYGTFQAVQGDCKGVDVRFCRDGIAIPIGDLELM 116 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREP+QYVA DG RLGVLTDAG T HLV AL CDAL+LECNHD+ ML S Sbjct: 117 PYTVPHDAREPVQYVASDGRMRLGVLTDAGHSTPHLVGALDGCDALVLECNHDKLMLANS 176 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP LKRRIGG YGHL+ND+S +IL LD+SRL+ VIGAHLSQQNNT LA AAL L Sbjct: 177 VYPPSLKRRIGGVYGHLSNDSSTQILAALDRSRLRMVIGAHLSQQNNTAALAAAALTRGL 236 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 + IACQ++GF W+D+ Sbjct: 237 EGDAVQVSIACQSDGFDWIDL 257 >B2SXT5.1 B2SXT5_BURPP Beta-lactamase domain protein Length = 257 Score = 301 bits (771), Expect = 6e-80, Method: Compositional matrix adjust. Identities = 147/261 (56%), Positives = 187/261 (71%), Gaps = 4/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 M+FASLGSGSEGNALL+ A +G ++ T V+LDCGF+ +E ERR+ RLG + AI Sbjct: 1 MRFASLGSGSEGNALLVEAQSG----ATTTRVLLDCGFSAKEVERRLTRLGASAEGLDAI 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 ++THEHSDH+ AR++ IP+++S+GT +AV DVD+Q + +AIGDL + Sbjct: 57 LITHEHSDHIGSALTLARKWSIPLYMSWGTARAVGADEADVDLQVLWGDEAVAIGDLSIL 116 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREP+QYV +G RLGVLTD G T H+ L CDAL+LECNHD ML S Sbjct: 117 PYTVPHDAREPLQYVLSNGASRLGVLTDVGTSTPHISSVLSGCDALVLECNHDVRMLAGS 176 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP LK RIGG++GHL NDA+AEIL LD+SRL+ ++ AHLSQQNN PELA+AA+ GVL Sbjct: 177 RYPQSLKARIGGNHGHLNNDAAAEILASLDRSRLRHLVAAHLSQQNNLPELAQAAMAGVL 236 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 GT ++ +A Q EGF WL V Sbjct: 237 GTAPTEVVVASQDEGFAWLSV 257 >E8YIB8.1 E8YIB8_9BURK Beta-lactamase domain protein Length = 257 Score = 299 bits (766), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 147/261 (56%), Positives = 187/261 (71%), Gaps = 4/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 M+FASLGSGSEGNALL+ A +G ++ T V+LDCGF+ +E ERR+ RLG + AI Sbjct: 1 MRFASLGSGSEGNALLVEAQSG----ATTTRVLLDCGFSAKEVERRLARLGSSAEGLDAI 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 ++THEHSDH+ AR++ IP+++S+GT +AV DVD+Q + +AIGDL + Sbjct: 57 LITHEHSDHIGSALTLARKWSIPLYMSWGTARAVGADDADVDLQVLWGDEAVAIGDLSVL 116 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREP+QYV +G RLGVLTD G T H+ L CDAL+LECNHD ML S Sbjct: 117 PYTVPHDAREPLQYVFSNGASRLGVLTDVGTSTPHISAVLSGCDALVLECNHDVRMLAGS 176 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP LK RIGG++GHL NDA+AEIL LD+SRL+ ++ AHLSQQNN PELA+AA+ GVL Sbjct: 177 RYPQSLKARIGGNHGHLNNDAAAEILASLDRSRLRHLVAAHLSQQNNLPELAQAAMAGVL 236 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 G D+ +A QAEGF WL + Sbjct: 237 GAASTDVVVASQAEGFEWLSL 257 >D5NFB8.1 D5NFB8_9BURK Beta-lactamase domain protein Length = 257 Score = 297 bits (760), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 145/261 (55%), Positives = 187/261 (71%), Gaps = 4/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 M+FASLGSGSEGNALL+ A +G ++ T V+LDCGF+ +E ERR+ RLG + AI Sbjct: 1 MRFASLGSGSEGNALLVEAQSG----ATTTRVLLDCGFSAKEVERRLTRLGASVEGLDAI 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 ++THEHSDH+ AR++ IP+++S+GT +AV D+D+Q + +AIGDL + Sbjct: 57 LITHEHSDHIGSALTLARKWSIPLYMSWGTARAVGADKADIDLQVLWGDEAVAIGDLSIL 116 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREP+QYV +G RLGVLTD G T H+ L CDAL+LECNHD ML S Sbjct: 117 PYTVPHDAREPLQYVFSNGASRLGVLTDVGTSTPHISAMLSGCDALVLECNHDVRMLAGS 176 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP LK RIGG++GHL NDA+A+IL LD+SRL+ ++ AHLSQQNN PELA+AA+ GVL Sbjct: 177 RYPQSLKARIGGNHGHLNNDAAAQILASLDRSRLRHLVAAHLSQQNNLPELAQAAMAGVL 236 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 GT D+ +A Q +GF WL V Sbjct: 237 GTAPTDVVVASQDDGFAWLSV 257 >C3X4S3.1 C3X4S3_OXAFO Metallo-beta-lactamase superfamily protein Length = 260 Score = 296 bits (758), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 139/261 (53%), Positives = 187/261 (71%), Gaps = 4/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 MK SLGSGS+GN+LL+SA G + T VM+DCGF RE RR+ R+G PSD+SA+ Sbjct: 1 MKLTSLGSGSKGNSLLVSAKDG----LTTTFVMVDCGFGTRETVRRLERVGCSPSDLSAL 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 +VTHEHSDH GV FARR+RIPVW+SYGT+QA+ +++D+ FC DG +GDL++S Sbjct: 57 IVTHEHSDHAGGVLAFARRHRIPVWMSYGTFQALGKDFSEIDLSFCRDGDCFNVGDLQIS 116 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 +TV HDA+EP+Q+ DG + G+LTD GQ T H++ AL CDAL++ECN+D ML S Sbjct: 117 AFTVSHDAKEPLQFHMTDGAVKFGMLTDTGQTTPHILNALSGCDALMVECNYDDLMLKNS 176 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP +LK+RIG YGHL+N + E L +D+SRLK VIGAHLSQ NN PELA+ A++ + Sbjct: 177 SYPFYLKKRIGSIYGHLSNHCAGEFLAQIDQSRLKKVIGAHLSQNNNFPELAKQAIDASV 236 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 T ++ +A Q +GF W++V Sbjct: 237 DTKKIEVIVAGQNDGFEWVEV 257 >Q13X21.1 Q13X21_BURXL Putative metallo-beta-lactamase family protein Length = 257 Score = 296 bits (757), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 144/261 (55%), Positives = 186/261 (71%), Gaps = 4/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 M+FASLGSGSEGNALL+ A +G ++ T V+LDCGF+ +E ERR+ RLG + AI Sbjct: 1 MRFASLGSGSEGNALLVEAQSG----ATTTRVLLDCGFSAKEVERRLTRLGASVEGLDAI 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 ++THEHSDH+ AR++ IP+++S+GT +AV D+D+Q + +AIGDL + Sbjct: 57 LITHEHSDHIGSALTLARKWSIPLYMSWGTARAVGADEADIDLQVLWGDEAVAIGDLSIL 116 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREP+QYV +G RLGVLTD G T H+ L CDAL+LECNHD ML S Sbjct: 117 PYTVPHDAREPLQYVLSNGASRLGVLTDVGTSTPHISAVLSGCDALVLECNHDVRMLAGS 176 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP LK RIGG++GHL N+A+AEIL LD+SRL+ ++ AHLSQQNN PELA+AA+ GVL Sbjct: 177 RYPQSLKARIGGNHGHLNNEAAAEILASLDRSRLRHLVAAHLSQQNNLPELAQAAMAGVL 236 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 G D+ +A Q +GF WL V Sbjct: 237 GAAPTDVVVASQDDGFAWLSV 257 >B1G5U7.1 B1G5U7_9BURK Beta-lactamase domain protein Length = 257 Score = 293 bits (750), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 143/261 (54%), Positives = 185/261 (70%), Gaps = 4/261 (1%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 M+FASLGSGSEGNALL+ A +G + T V+LDCGF+ +E ERR+ RLG + A+ Sbjct: 1 MRFASLGSGSEGNALLVEAQSG----VTTTRVLLDCGFSAKEVERRLNRLGSSAEALDAV 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 ++THEHSDH+ AR++ IP+++S+GT +AV DVD+Q + +AIGDL + Sbjct: 57 LITHEHSDHIGSALTLARKWSIPLYMSWGTARAVGADEADVDLQVLWGDEAVAIGDLSVL 116 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 PYTVPHDAREP+QYV +G RLGVLTD G T H+ L CDAL+LECNHD ML S Sbjct: 117 PYTVPHDAREPLQYVFSNGASRLGVLTDVGTSTPHISTVLSGCDALVLECNHDVRMLAGS 176 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 YP LK RIGG++GHL NDA+AEIL LD+SRL+ ++ AHLSQQNN PELA+AA+ VL Sbjct: 177 RYPQSLKARIGGNHGHLNNDAAAEILASLDRSRLRHLVAAHLSQQNNLPELAQAAMASVL 236 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 G ++ +A QA+GF WL + Sbjct: 237 GAAATEVVVASQADGFEWLSL 257