BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0011.p (596 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J240.1 D8J240_HERSS Choline dehydrogenase protein EC=1.1.99.1 1217 0.0 E3HMD0.1 E3HMD0_ACHXA Gluconate 2-dehydrogenase flavoprotein EC=... 943 0.0 D4XEG1.1 D4XEG1_9BURK Gluconate 2-dehydrogenase flavoprotein EC=... 941 0.0 E1TJN1.1 E1TJN1_BURSG Gluconate 2-dehydrogenase (Acceptor) EC=1.... 927 0.0 Q1LKE6.1 Q1LKE6_RALME Gluconate 2-dehydrogenase flavoprotein (GA... 917 0.0 E5U1I0.1 E5U1I0_ALCXX Glucose-methanol-choline oxidoreductase 916 0.0 E5YEI9.1 E5YEI9_9ENTR Gluconate 2-dehydrogenase subunit protein 794 0.0 A8GDC8.1 A8GDC8_SERP5 Gluconate 2-dehydrogenase (Acceptor) EC=1.... 793 0.0 E3A306.1 E3A306_PSEAE Gluconate dehydrogenase 755 0.0 Q9I1K8.1 Q9I1K8_PSEAE Gluconate dehydrogenase 755 0.0 >D8J240.1 D8J240_HERSS Choline dehydrogenase protein EC=1.1.99.1 Length = 593 Score = 1217 bits (3148), Expect = 0.0, Method: Compositional matrix adjust. Identities = 588/596 (98%), Positives = 590/596 (98%), Gaps = 3/596 (0%) Query: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS Sbjct: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 Query: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM Sbjct: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 Query: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL Sbjct: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 Query: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG Sbjct: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 Query: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR Sbjct: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 Query: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT Sbjct: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 Query: 361 QFNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 420 QFNPFIGTG +GMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV Sbjct: 361 QFNPFIGTG---AGGVGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 417 Query: 421 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENE 480 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTY+DANGQPLLRLTLNWKENE Sbjct: 418 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYRDANGQPLLRLTLNWKENE 477 Query: 481 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 540 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN Sbjct: 478 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 537 Query: 541 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA Sbjct: 538 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 593 >E3HMD0.1 E3HMD0_ACHXA Gluconate 2-dehydrogenase flavoprotein EC=1.1.99.3 Length = 591 Score = 943 bits (2437), Expect = 0.0, Method: Compositional matrix adjust. Identities = 452/596 (75%), Positives = 507/596 (85%), Gaps = 5/596 (0%) Query: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 MAIKKDKVD V+VG GWTG+I+G ELTEAGL VLALERG M+DT D YPK DEL YS Sbjct: 1 MAIKKDKVDAVLVGFGWTGAILGQELTEAGLHVLALERGAMQDTPKDAEYPKVADELAYS 60 Query: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 VRG LFQDLS+ETVTIRH + DVAVPYRQ+GSFLLG GVGGAGFHWNGM YR LPEELE+ Sbjct: 61 VRGKLFQDLSKETVTIRHGVDDVAVPYRQNGSFLLGTGVGGAGFHWNGMHYRVLPEELEL 120 Query: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 R+ +E +YGK FIPE MTIQD GVTY ELEP++ E V SGKAGNL GQIV GGNPL Sbjct: 121 RSRYETRYGKSFIPEGMTIQDFGVTYDELEPYFSKFEYVCGTSGKAGNLNGQIVAGGNPL 180 Query: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 EG+RS EFP PPL Y A L +KA R+VG+HPYPAPAANAS P+TNPYGVR+GPCN+CG Sbjct: 181 EGKRSKEFPLPPLTTTYGAQLFDKAAREVGFHPYPAPAANASGPYTNPYGVRLGPCNFCG 240 Query: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 FCENYGCYMYSKASPQTTILPVLLK+ NFE+RT++ VIKVNLD+SGK+A GVTYIDAQGR Sbjct: 241 FCENYGCYMYSKASPQTTILPVLLKKPNFELRTQSHVIKVNLDSSGKKAVGVTYIDAQGR 300 Query: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 E+EQPADLV+L+A+Q HNVRLLLLSGIGKPYDP T EGVVGKN+AYQ NGG++V++PKGT Sbjct: 301 EIEQPADLVILSAYQMHNVRLLLLSGIGKPYDPKTNEGVVGKNYAYQMNGGVSVLLPKGT 360 Query: 361 QFNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 420 Q NPF+GTG +GMDDLN DQFDHGPLGF+GGASIRHVRYGGRPIKQ TMPG Sbjct: 361 QLNPFVGTG---AGGVGMDDLNGDQFDHGPLGFLGGASIRHVRYGGRPIKQTPTMPG--T 415 Query: 421 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENE 480 PSWG+ WKA VQDAYQR +TIG+SGSVM+YRD YLSLDPTYKD+ GQPLLR+T +W +NE Sbjct: 416 PSWGTGWKAGVQDAYQRHMTIGISGSVMSYRDAYLSLDPTYKDSFGQPLLRMTFDWHDNE 475 Query: 481 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 540 ML Y+ +ME+V +AM PEK VRK G+ +DTRVYQSTH TGGAIMGT PK SVVN Sbjct: 476 FDMLGYMGKRMEEVAKAMKPEKYAVGVRKKGARYDTRVYQSTHNTGGAIMGTNPKESVVN 535 Query: 541 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 KYLQSWDVPN+FV GACAFPQNMGYNPTGLV ALAY SA+AIR+QYLKNPGPLVQA Sbjct: 536 KYLQSWDVPNLFVMGACAFPQNMGYNPTGLVGALAYWSAQAIRDQYLKNPGPLVQA 591 >D4XEG1.1 D4XEG1_9BURK Gluconate 2-dehydrogenase flavoprotein EC=1.1.99.3 Length = 591 Score = 941 bits (2432), Expect = 0.0, Method: Compositional matrix adjust. Identities = 452/596 (75%), Positives = 506/596 (84%), Gaps = 5/596 (0%) Query: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 MAIKKDKVD V+VG GWTG+I+G ELTEAGL VLALERG M+DT D YPK +DEL YS Sbjct: 1 MAIKKDKVDAVLVGFGWTGAILGQELTEAGLQVLALERGAMQDTPKDAEYPKVIDELAYS 60 Query: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 VRG LFQDLS+ETVTIRH + DVAVPYRQ+GSFLLG GVGGAGFHWNGM YR LPEELE+ Sbjct: 61 VRGKLFQDLSKETVTIRHGVDDVAVPYRQNGSFLLGTGVGGAGFHWNGMHYRVLPEELEL 120 Query: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 RT +E +YGKKFIPE MTIQD GVTY ELEP++ E V SGKAGNL G+IV GGNPL Sbjct: 121 RTRYETRYGKKFIPEGMTIQDFGVTYDELEPYFSKFEYVCGTSGKAGNLNGKIVEGGNPL 180 Query: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 EG+RS EFP PPL Y A L EKA R+VG++PYPAPAANAS P+TNPYGVR+GPCN+CG Sbjct: 181 EGKRSKEFPLPPLTTTYGAQLFEKAAREVGFNPYPAPAANASGPYTNPYGVRLGPCNFCG 240 Query: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 FCENYGCYMYSKASPQTTILPVLLK+ NFE+RT +QVIKVNLD++GK+A GVTYIDAQG Sbjct: 241 FCENYGCYMYSKASPQTTILPVLLKKPNFELRTHSQVIKVNLDSTGKKAIGVTYIDAQGN 300 Query: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 EV+QPADLV+L+A+Q HNVRLLLLSGIGKPYDP T EGVVGKN+AYQ NG +NV++PKGT Sbjct: 301 EVDQPADLVILSAYQMHNVRLLLLSGIGKPYDPKTNEGVVGKNYAYQMNGAVNVLLPKGT 360 Query: 361 QFNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 420 Q NPF+GTG +GMDDLN DQFDHGPLGF+GGASIRHVRYGGRPIKQ T PG Sbjct: 361 QLNPFVGTG---AGGVGMDDLNGDQFDHGPLGFVGGASIRHVRYGGRPIKQTPTTPG--T 415 Query: 421 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENE 480 PSWG+ WKA VQDAYQR +TIG+SGSVM+YRD YLSLDPTYKDA GQPLLR+T +W +NE Sbjct: 416 PSWGTAWKAGVQDAYQRFMTIGISGSVMSYRDAYLSLDPTYKDAYGQPLLRMTFDWHDNE 475 Query: 481 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 540 ML Y+ +ME V +AMNPEK AVRK G+ +DTRVYQSTH TGGAIMG+ PK SVVN Sbjct: 476 FDMLGYMGKRMETVAKAMNPEKHFVAVRKKGAHYDTRVYQSTHNTGGAIMGSNPKESVVN 535 Query: 541 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 KYLQSWDVPNVFV GAC FPQNMGYNPTGLV ALAY +A+AIR+QYLKNPGPLVQA Sbjct: 536 KYLQSWDVPNVFVMGACVFPQNMGYNPTGLVGALAYWAAQAIRDQYLKNPGPLVQA 591 >E1TJN1.1 E1TJN1_BURSG Gluconate 2-dehydrogenase (Acceptor) EC=1.1.99.3 Length = 591 Score = 927 bits (2396), Expect = 0.0, Method: Compositional matrix adjust. Identities = 436/596 (73%), Positives = 502/596 (84%), Gaps = 5/596 (0%) Query: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 MAIKK+KVD V+VG GWTG+I+ ELT+AGL+V+ALERG MRDT TD YPK VDELKY+ Sbjct: 1 MAIKKNKVDCVVVGFGWTGAILAQELTDAGLNVVALERGAMRDTPTDANYPKVVDELKYA 60 Query: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 VRG LFQDLS ETVTIRH + D+AVPYRQH SFLLG+GVGGAGFHWNGM YR LPEEL++ Sbjct: 61 VRGELFQDLSSETVTIRHGVDDLAVPYRQHASFLLGNGVGGAGFHWNGMHYRMLPEELQL 120 Query: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 RT +E++YGKKFIPE M +QD GVTY E+EPF+DF+EKV SGKAGNL G + GGNPL Sbjct: 121 RTRYEERYGKKFIPEGMQVQDFGVTYDEMEPFFDFAEKVFGTSGKAGNLNGDLQAGGNPL 180 Query: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 EG RS EFPTPPL+ ASL EKA R+VG HPYPAPAANAS P+TNPYGVR+GPCN+CG Sbjct: 181 EGRRSSEFPTPPLKNSLGASLFEKAAREVGLHPYPAPAANASTPYTNPYGVRLGPCNFCG 240 Query: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 FCE++GCYMYSKASPQTTILPVLLK+ NFE+RTK+ V +V L KRATGVTYIDAQGR Sbjct: 241 FCEDFGCYMYSKASPQTTILPVLLKKPNFELRTKSYVTRVLLSPDKKRATGVTYIDAQGR 300 Query: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 EVEQPAD+V++ AFQ HNVRLLLLSGIGKPYDP TGEGVVG+N+AYQ NGGINV++PKGT Sbjct: 301 EVEQPADMVIVAAFQMHNVRLLLLSGIGKPYDPKTGEGVVGRNYAYQMNGGINVLLPKGT 360 Query: 361 QFNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 420 Q NPF+G+G +G+DD N DQFDHGPLGF+GGASIRH+R GGRPIKQA T+PG Sbjct: 361 QLNPFVGSG---AGGVGLDDFNGDQFDHGPLGFVGGASIRHIRTGGRPIKQAATVPG--T 415 Query: 421 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENE 480 P+WGS WKA V DAYQR +TIG+SGSVM YRD YL LDP Y+DA G PLLR+T +W +NE Sbjct: 416 PTWGSAWKAGVTDAYQRYMTIGISGSVMPYRDAYLDLDPIYRDAYGLPLLRMTFDWHDNE 475 Query: 481 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 540 ML +I ++ME+V +AMNPEK +A+RK G +DTRVYQSTH TGGA+MG +P SVVN Sbjct: 476 YTMLDHIGTRMEEVAKAMNPEKYFRAIRKKGQHYDTRVYQSTHTTGGAVMGASPATSVVN 535 Query: 541 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 KYLQSWDVPNVFV GA AFPQNMGYNPTG+V ALA+HSAKAIREQYLK+P PLVQA Sbjct: 536 KYLQSWDVPNVFVMGASAFPQNMGYNPTGIVAALAFHSAKAIREQYLKDPAPLVQA 591 >Q1LKE6.1 Q1LKE6_RALME Gluconate 2-dehydrogenase flavoprotein (GADH dehydrogenase subunit) (GA 2-DH dehydrogenase subunit) EC=1.1.99.3 Length = 591 Score = 917 bits (2370), Expect = 0.0, Method: Compositional matrix adjust. Identities = 432/596 (72%), Positives = 501/596 (84%), Gaps = 5/596 (0%) Query: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 MAIKKDKVD V++GLGWTG+I+ ELT+AGL V+ALERG MRDT TD YPK VDELKY Sbjct: 1 MAIKKDKVDCVVIGLGWTGAILAQELTDAGLDVVALERGAMRDTPTDAEYPKVVDELKYV 60 Query: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 VRG LFQDLSRETVTIRH + D+AVPYRQ+GSFLLG+GVGGAGFHWNGM YR LPEEL++ Sbjct: 61 VRGELFQDLSRETVTIRHGVDDLAVPYRQNGSFLLGNGVGGAGFHWNGMHYRVLPEELQL 120 Query: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 R+ + +YGKKFIPE M +QD GVTY ELEP +DF+EKV SG AGNL G+I PGGNPL Sbjct: 121 RSRYVDRYGKKFIPEGMQVQDFGVTYDELEPHFDFAEKVFGTSGTAGNLNGKIQPGGNPL 180 Query: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 EG RS E+PTP L+ A L EKA R+ G+HPYPAPAAN S+P+TNPYGVR+GPCN+CG Sbjct: 181 EGHRSSEYPTPALKNSLGAQLFEKAAREAGFHPYPAPAANTSEPYTNPYGVRLGPCNFCG 240 Query: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 FCE++GCYMYSKASPQTTILPVLLK+ NFE+RTKAQV ++ LD+ KRATGV YIDAQGR Sbjct: 241 FCEDFGCYMYSKASPQTTILPVLLKKPNFELRTKAQVTRILLDSDKKRATGVLYIDAQGR 300 Query: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 EVEQPADLV++ A+Q HNVRLLLLSGIG PYDP TG+GVVG+N+AYQ NG +NV++PKGT Sbjct: 301 EVEQPADLVIVAAYQLHNVRLLLLSGIGTPYDPKTGKGVVGRNYAYQMNGAVNVMLPKGT 360 Query: 361 QFNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 420 NPFIGTG +G+DDLN DQFDHGPLGF+GGASIRH+RYGGRPIKQ T+PG Sbjct: 361 LLNPFIGTG---AGGVGLDDLNGDQFDHGPLGFLGGASIRHIRYGGRPIKQTPTVPG--T 415 Query: 421 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENE 480 P+WGS+WKA V DAYQR +TIG+SGSVM YRD YL LDPTY+DANG PL+R+T +W +NE Sbjct: 416 PAWGSKWKAGVVDAYQRYMTIGISGSVMPYRDAYLDLDPTYRDANGLPLMRMTFDWHDNE 475 Query: 481 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 540 ML Y+ ++ME+V +AM PE KA+RK G +DTRVYQSTH TGGA+MG++P+ SVVN Sbjct: 476 YAMLDYMGTRMEEVAKAMKPEAYYKAIRKKGQHYDTRVYQSTHTTGGAVMGSSPETSVVN 535 Query: 541 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 KYLQSWDV NVFV GA AFPQNMGYNPTGLV ALAYHSAKAIREQYLK+P PLVQA Sbjct: 536 KYLQSWDVHNVFVMGASAFPQNMGYNPTGLVAALAYHSAKAIREQYLKHPAPLVQA 591 >E5U1I0.1 E5U1I0_ALCXX Glucose-methanol-choline oxidoreductase Length = 591 Score = 916 bits (2368), Expect = 0.0, Method: Compositional matrix adjust. Identities = 445/596 (74%), Positives = 502/596 (84%), Gaps = 5/596 (0%) Query: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 MAIKKDKVD V+VG GWTG+IMG ELTEAGL VLALERG M+DT + YPK +DEL YS Sbjct: 1 MAIKKDKVDAVLVGFGWTGAIMGQELTEAGLHVLALERGAMQDTPKEAEYPKVLDELAYS 60 Query: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 VRG LFQDLS+ETVTIRH + DVAVPYRQ+GSFLLG GVGGAGFHWNGM YR LPEELE+ Sbjct: 61 VRGKLFQDLSKETVTIRHGVDDVAVPYRQNGSFLLGTGVGGAGFHWNGMHYRVLPEELEL 120 Query: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 RT +E +YGK FIPE MTIQD GVTY ELEP++ E V SGKAGNL GQIV GGNPL Sbjct: 121 RTRYETRYGKSFIPEGMTIQDFGVTYDELEPYFTKFEYVCGTSGKAGNLNGQIVEGGNPL 180 Query: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 EG+RS EFP PPL Y A L +KA R+VG+HPYPAPAANAS P+TNPYGVR+GPCN+CG Sbjct: 181 EGKRSKEFPLPPLATTYGAQLFDKAAREVGFHPYPAPAANASGPYTNPYGVRLGPCNFCG 240 Query: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 FCENYGCYMYSKASPQTTILPVLLK+ NFE+RT + VIKVNLD++GK+A GVTYIDAQGR Sbjct: 241 FCENYGCYMYSKASPQTTILPVLLKKPNFELRTHSHVIKVNLDSTGKKAVGVTYIDAQGR 300 Query: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 EVEQPADLV+L+A+Q HNVRLLLLSGIGKPYDP T EGVVGKN+AYQ NG +NV++PKGT Sbjct: 301 EVEQPADLVILSAYQMHNVRLLLLSGIGKPYDPKTNEGVVGKNYAYQMNGAVNVLLPKGT 360 Query: 361 QFNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 420 Q NPF+GTG +GMDDLN DQFDHGPLGF+GGASIRHVRYGGRPIK T PG Sbjct: 361 QLNPFVGTG---AGGVGMDDLNGDQFDHGPLGFLGGASIRHVRYGGRPIKMTPTTPGTPT 417 Query: 421 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENE 480 + WKA VQDAYQR +TIG+SGSVM+YRD YLSLDPTYKD+ GQPLLR+T +W +NE Sbjct: 418 WG--TAWKAGVQDAYQRFMTIGISGSVMSYRDAYLSLDPTYKDSFGQPLLRMTFDWHDNE 475 Query: 481 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 540 ML ++ ++ME+V +AM PEK AVRK G+ +DTRVYQSTH TGGAIMG+ P+ SVVN Sbjct: 476 FDMLGHMGNKMEEVAKAMKPEKHFVAVRKKGARYDTRVYQSTHNTGGAIMGSNPRESVVN 535 Query: 541 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 KYLQSWDVPNVFV GACAFPQNMGYNPTGLV ALA+ SA+AIR+QYLKNPGPLVQA Sbjct: 536 KYLQSWDVPNVFVMGACAFPQNMGYNPTGLVGALAFWSAQAIRDQYLKNPGPLVQA 591 >E5YEI9.1 E5YEI9_9ENTR Gluconate 2-dehydrogenase subunit protein Length = 592 Score = 794 bits (2051), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/594 (63%), Positives = 460/594 (77%), Gaps = 5/594 (0%) Query: 3 IKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYSVR 62 IKK+ VDVV+VG GWTG+IMGME+T+AGLSV+ALERG+ RDT D YP+ DEL Y +R Sbjct: 4 IKKEPVDVVIVGFGWTGAIMGMEMTDAGLSVVALERGEKRDTYPDFAYPRIADELTYGIR 63 Query: 63 GALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEMRT 122 LFQ+ S+ETVT+RH D AVPYRQ GSFL G+GVGGAG HWNGM +R LP +L+M T Sbjct: 64 LKLFQEASKETVTVRHNPGDYAVPYRQFGSFLPGNGVGGAGVHWNGMHWRALPSDLKMHT 123 Query: 123 HHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPLEG 182 ++YGK FIPE M +QD+ V+Y +LEPF+D EKV +GK+GNL+G+I+ GGNP EG Sbjct: 124 TVMERYGKSFIPEGMLLQDYPVSYDDLEPFFDKFEKVCGTAGKSGNLQGKIIDGGNPFEG 183 Query: 183 ERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCGFC 242 R E+PTPPL+ YS +L +A +++GYHP+ PAAN SQP+TNPYGV++GPCNYCGFC Sbjct: 184 PRMSEYPTPPLKQLYSGTLFSQAAKELGYHPFAIPAANCSQPYTNPYGVQLGPCNYCGFC 243 Query: 243 ENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGREV 302 E +GC+MYSK SPQ+TILPVL +RKNFE+R + VIKVNLD+SGK+ATGVTY+DAQGRE+ Sbjct: 244 ERFGCFMYSKGSPQSTILPVLTQRKNFELRANSMVIKVNLDSSGKKATGVTYVDAQGREI 303 Query: 303 EQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGTQF 362 EQPA +V+L+A+Q HNVRLLLLSGIG PY+P TGEG+VG+N+AYQ N GI+V K T F Sbjct: 304 EQPASIVILSAYQLHNVRLLLLSGIGTPYNPQTGEGMVGRNYAYQMNSGISVFFDKDTNF 363 Query: 363 NPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKVPS 422 NPFIG G +DD N+D FDH LGFIGGA I VR GGRPI+Q ++P E P+ Sbjct: 364 NPFIGAGAAGAV---IDDFNSDNFDHSDLGFIGGAYISAVRTGGRPIQQM-SLPAE-TPT 418 Query: 423 WGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENEGK 482 WG+ WK ++D Y +++IG GSVM Y++CYL LDP YKD GQPLLR+T +WK NE K Sbjct: 419 WGAGWKQGIKDNYLHSMSIGSEGSVMPYKECYLDLDPNYKDDFGQPLLRMTFDWKPNEIK 478 Query: 483 MLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVNKY 542 M +I S+M+ + AMNP+++ +V S +D R YQSTH TGGAIMG P NSV+NKY Sbjct: 479 MTQHITSKMQGIATAMNPKQMKISVMDMNSHYDVRPYQSTHTTGGAIMGDNPSNSVINKY 538 Query: 543 LQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 LQSWDVPNVFV GA AFPQNM YNPTGLV ALAY SA AIR QYL NPGPLVQA Sbjct: 539 LQSWDVPNVFVQGASAFPQNMAYNPTGLVGALAYWSAHAIRTQYLANPGPLVQA 592 >A8GDC8.1 A8GDC8_SERP5 Gluconate 2-dehydrogenase (Acceptor) EC=1.1.99.3 Length = 592 Score = 793 bits (2048), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/595 (63%), Positives = 459/595 (77%), Gaps = 5/595 (0%) Query: 2 AIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYSV 61 AIKK VDVV+VG GWTG+IMGMELTE+GLSVLALERG+ RDT D YP+ DEL Y + Sbjct: 3 AIKKPPVDVVIVGFGWTGAIMGMELTESGLSVLALERGEQRDTYPDFAYPRIADELTYGI 62 Query: 62 RGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEMR 121 R L Q ++ ETVT+RHT +D AVPYRQ GSFL G+GVGGAG HWNGM +R LP +L++ Sbjct: 63 RMKLMQAMANETVTVRHTPADFAVPYRQLGSFLPGNGVGGAGVHWNGMHWRALPSDLKLH 122 Query: 122 THHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPLE 181 T +KYG K+IPE MT+QD+ ++Y+ELEP++D EKV +GKAGNL+GQI+ GGNP E Sbjct: 123 TTLNEKYGAKWIPEGMTLQDYPLSYQELEPYFDKFEKVCGTAGKAGNLRGQIIKGGNPFE 182 Query: 182 GERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCGF 241 G R+ E+PTP L+ YS SL A +GYHP+ PAAN S+P+TNPYGV++GPCNYCG+ Sbjct: 183 GPRNSEYPTPALKRLYSGSLFAPAAESLGYHPFSVPAANCSEPYTNPYGVQLGPCNYCGY 242 Query: 242 CENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGRE 301 CE +GC+MYSKASPQ+TILPVL +RKNFE+RT++QVIKVNLD++GK+ATGVTYI+AQG+E Sbjct: 243 CERFGCFMYSKASPQSTILPVLTQRKNFELRTQSQVIKVNLDSTGKKATGVTYINAQGQE 302 Query: 302 VEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGTQ 361 VEQPADLV+L+AFQ HNVRLLLLSGIGKPY+PVTGEGVVGKN+AYQ N I++ K Sbjct: 303 VEQPADLVILSAFQLHNVRLLLLSGIGKPYNPVTGEGVVGKNYAYQMNSNISLFYDKDIH 362 Query: 362 FNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKVP 421 FNPFIG G +DDLN + FDH LGFIGGA I R GGRP++Q M P Sbjct: 363 FNPFIGAGAAGTV---IDDLNGENFDHADLGFIGGAYISATRTGGRPLQQ--MMLPAGTP 417 Query: 422 SWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENEG 481 +WGS WK ++D Y +++I GSVM YRDCYL LDPTYKD G PLLR+T +WK+NE Sbjct: 418 TWGSGWKQGIKDNYLHSMSINSEGSVMPYRDCYLDLDPTYKDGYGLPLLRMTFDWKDNEI 477 Query: 482 KMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVNK 541 KM +I +M + + M P+++ +V K G +D R YQSTH TGGAI G P SVVNK Sbjct: 478 KMTQHITGKMVDIAKVMKPKQMSVSVMKAGDHYDVRPYQSTHTTGGAITGDNPATSVVNK 537 Query: 542 YLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 YLQ WDVPNVFV GACAFPQN+ YNPTG+V ALAY+SA+AIR QYLKNPGPLVQA Sbjct: 538 YLQCWDVPNVFVTGACAFPQNLAYNPTGIVGALAYYSAEAIRTQYLKNPGPLVQA 592 >E3A306.1 E3A306_PSEAE Gluconate dehydrogenase Length = 593 Score = 755 bits (1949), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/596 (61%), Positives = 446/596 (74%), Gaps = 5/596 (0%) Query: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 MA VD V+VG GWTG+I+ ELTEAGL+V+ALERG+ RDT D YP +DEL Y+ Sbjct: 3 MATTLKPVDAVVVGFGWTGAILAKELTEAGLNVVALERGENRDTYPDGAYPNTLDELTYN 62 Query: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 RG LFQ+LS+ TV+IRH ++D A+PYRQ +FL GDGVGGAG HW+G+ +R +PEEL + Sbjct: 63 TRGKLFQNLSKSTVSIRHGINDTALPYRQLSAFLPGDGVGGAGLHWSGVHFRIMPEELRL 122 Query: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 R+H+E++YGKKFIPE MTIQD+GV+Y+ELEP +DF+EKV SG A +KGQ+V GNP Sbjct: 123 RSHYEERYGKKFIPEGMTIQDYGVSYEELEPHFDFAEKVFGTSGTAHTVKGQVVGKGNPF 182 Query: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 +RSD+FP P L+ YSA L KA ++G HPY PAANAS P+TNPYGV++GPCN+CG Sbjct: 183 AADRSDDFPLPALRQVYSAQLFRKAAEELGLHPYDLPAANASGPWTNPYGVQMGPCNFCG 242 Query: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 FC Y CYMYSKASP ILP L + FE+R V+KVNLD+ G++ATGVTY+DAQGR Sbjct: 243 FCSGYACYMYSKASPNLNILPALRQTPLFELRANCNVLKVNLDSDGRQATGVTYVDAQGR 302 Query: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 E+ QPA LV+++AFQ HNVRLLLLSGIGKPYDP TGEGVVGKNFAYQ I K Sbjct: 303 EIVQPAKLVIISAFQFHNVRLLLLSGIGKPYDPRTGEGVVGKNFAYQNMATIKAFFDKDV 362 Query: 361 QFNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 420 NPF+GTG + +DD NAD FDHGPLGF+GG+ + + G +PI PG Sbjct: 363 HTNPFVGTG---GGGVAVDDFNADNFDHGPLGFVGGSPMWVNQAGSKPIGGLAVPPG--T 417 Query: 421 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENE 480 PSWGS WK +V+DAY T+++ GS M YRD YL LDPTYKDA GQPLLR+T +WK+NE Sbjct: 418 PSWGSGWKQAVKDAYTHTVSMDAHGSNMTYRDNYLDLDPTYKDAYGQPLLRMTFDWKDNE 477 Query: 481 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 540 +M Y+ M K+ +AMNP+ + +V+ G ++TRVYQ+THL GGAIMG+ PK SV+N Sbjct: 478 IRMSRYVTEHMRKIAEAMNPKAISVSVKNFGDHFNTRVYQTTHLLGGAIMGSDPKTSVLN 537 Query: 541 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 +YLQSWDV NVFV GA AFPQ GYNPTGLV ALAY SAKAIREQYLKNPGPLVQA Sbjct: 538 RYLQSWDVHNVFVMGASAFPQGTGYNPTGLVAALAYWSAKAIREQYLKNPGPLVQA 593 >Q9I1K8.1 Q9I1K8_PSEAE Gluconate dehydrogenase Length = 591 Score = 755 bits (1949), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/596 (61%), Positives = 446/596 (74%), Gaps = 5/596 (0%) Query: 1 MAIKKDKVDVVMVGLGWTGSIMGMELTEAGLSVLALERGDMRDTNTDTPYPKAVDELKYS 60 MA VD V+VG GWTG+I+ ELTEAGL+V+ALERG+ RDT D YP +DEL Y+ Sbjct: 1 MATTLKPVDAVVVGFGWTGAILAKELTEAGLNVVALERGENRDTYPDGAYPNTLDELTYN 60 Query: 61 VRGALFQDLSRETVTIRHTLSDVAVPYRQHGSFLLGDGVGGAGFHWNGMMYRNLPEELEM 120 RG LFQ+LS+ TV+IRH ++D A+PYRQ +FL GDGVGGAG HW+G+ +R +PEEL + Sbjct: 61 TRGKLFQNLSKSTVSIRHGINDTALPYRQLSAFLPGDGVGGAGLHWSGVHFRIMPEELRL 120 Query: 121 RTHHEQKYGKKFIPEDMTIQDHGVTYKELEPFYDFSEKVMAVSGKAGNLKGQIVPGGNPL 180 R+H+E++YGKKFIPE MTIQD+GV+Y+ELEP +DF+EKV SG A +KGQ+V GNP Sbjct: 121 RSHYEERYGKKFIPEGMTIQDYGVSYEELEPHFDFAEKVFGTSGTAHTVKGQVVGKGNPF 180 Query: 181 EGERSDEFPTPPLQYQYSASLVEKAMRDVGYHPYPAPAANASQPFTNPYGVRIGPCNYCG 240 +RSD+FP P L+ YSA L KA ++G HPY PAANAS P+TNPYGV++GPCN+CG Sbjct: 181 AADRSDDFPLPALRQVYSAQLFRKAAEELGLHPYDLPAANASGPWTNPYGVQMGPCNFCG 240 Query: 241 FCENYGCYMYSKASPQTTILPVLLKRKNFEVRTKAQVIKVNLDASGKRATGVTYIDAQGR 300 FC Y CYMYSKASP ILP L + FE+R V+KVNLD+ G++ATGVTY+DAQGR Sbjct: 241 FCSGYACYMYSKASPNLNILPALRQTPLFELRANCNVLKVNLDSDGRQATGVTYVDAQGR 300 Query: 301 EVEQPADLVLLTAFQTHNVRLLLLSGIGKPYDPVTGEGVVGKNFAYQYNGGINVIMPKGT 360 E+ QPA LV+++AFQ HNVRLLLLSGIGKPYDP TGEGVVGKNFAYQ I K Sbjct: 301 EIVQPAKLVIISAFQFHNVRLLLLSGIGKPYDPRTGEGVVGKNFAYQNMATIKAFFDKDV 360 Query: 361 QFNPFIGTG*KPDFFLGMDDLNADQFDHGPLGFIGGASIRHVRYGGRPIKQAGTMPGEKV 420 NPF+GTG + +DD NAD FDHGPLGF+GG+ + + G +PI PG Sbjct: 361 HTNPFVGTG---GGGVAVDDFNADNFDHGPLGFVGGSPMWVNQAGSKPIGGLAVPPG--T 415 Query: 421 PSWGSEWKASVQDAYQRTLTIGMSGSVMAYRDCYLSLDPTYKDANGQPLLRLTLNWKENE 480 PSWGS WK +V+DAY T+++ GS M YRD YL LDPTYKDA GQPLLR+T +WK+NE Sbjct: 416 PSWGSGWKQAVKDAYTHTVSMDAHGSNMTYRDNYLDLDPTYKDAYGQPLLRMTFDWKDNE 475 Query: 481 GKMLTYIASQMEKVGQAMNPEKVVKAVRKTGSSWDTRVYQSTHLTGGAIMGTTPKNSVVN 540 +M Y+ M K+ +AMNP+ + +V+ G ++TRVYQ+THL GGAIMG+ PK SV+N Sbjct: 476 IRMSRYVTEHMRKIAEAMNPKAISVSVKNFGDHFNTRVYQTTHLLGGAIMGSDPKTSVLN 535 Query: 541 KYLQSWDVPNVFVYGACAFPQNMGYNPTGLVTALAYHSAKAIREQYLKNPGPLVQA 596 +YLQSWDV NVFV GA AFPQ GYNPTGLV ALAY SAKAIREQYLKNPGPLVQA Sbjct: 536 RYLQSWDVHNVFVMGASAFPQGTGYNPTGLVAALAYWSAKAIREQYLKNPGPLVQA 591