BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0013.0040.p (168 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J0Q1.1 LEU1_HERSS 2-isopropylmalate synthase EC=2.3.3.13 291 2e-77 C6CD53.1 C6CD53_DICDC Pyruvate carboxyltransferase 251 2e-65 Q2L077.1 Q2L077_BORA1 2-isopropylmalate synthase EC=2.3.3.13 245 1e-63 C6DJY7.1 C6DJY7_PECCP 2-isopropylmalate synthase 243 5e-63 E0SKU8.1 E0SKU8_DICD3 2-isopropylmalate synthase EC=2.3.3.13 243 5e-63 D2BRQ8.1 D2BRQ8_DICD5 Pyruvate carboxyltransferase 241 4e-62 A9BNM7.1 A9BNM7_DELAS 2-isopropylmalate synthase EC=2.3.3.13 235 1e-60 D8D9J8.1 D8D9J8_COMTE 2-isopropylmalate synthase EC=2.3.3.13 233 1e-59 B7WWN3.1 B7WWN3_COMTE 2-isopropylmalate synthase EC=2.3.3.13 231 4e-59 Q4K963.1 Q4K963_PSEF5 2-isopropylmalate synthase 226 9e-58 >D8J0Q1.1 LEU1_HERSS 2-isopropylmalate synthase EC=2.3.3.13 Length = 575 Score = 291 bits (745), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 140/149 (93%), Positives = 143/149 (95%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 MLTDPSQKYRAIAPVDLP+RRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE Sbjct: 1 MLTDPSQKYRAIAPVDLPDRRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA Sbjct: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASILN 149 RRVIVHFYNAIAPAWREIVF + I+ Sbjct: 121 RRVIVHFYNAIAPAWREIVFGMSVPQIIT 149 >C6CD53.1 C6CD53_DICDC Pyruvate carboxyltransferase Length = 558 Score = 251 bits (642), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 120/149 (80%), Positives = 130/149 (87%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 MLTDPSQKYR ++PV+L +R WPSRTL QAP WLSTD+RDGNQALFEPMNRERKLRLFHE Sbjct: 1 MLTDPSQKYRPLSPVNLADREWPSRTLTQAPIWLSTDMRDGNQALFEPMNRERKLRLFHE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LVRIGFKEIEVGFPAASR DFE VRHLID IP+DVTPMVMTQLR DLITETV+SVAGA Sbjct: 61 LVRIGFKEIEVGFPAASRTDFEIVRHLIDADQIPEDVTPMVMTQLRDDLITETVRSVAGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASILN 149 RRVIVH YNAIAP WRE VF + I++ Sbjct: 121 RRVIVHVYNAIAPVWRERVFGMSVPQIID 149 >Q2L077.1 Q2L077_BORA1 2-isopropylmalate synthase EC=2.3.3.13 Length = 558 Score = 245 bits (626), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 118/149 (79%), Positives = 127/149 (85%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 MLTDPSQKYR +APVDL +R+WPSR L QAP WLSTDLRDGNQALFEPMN ERKLRLFHE Sbjct: 1 MLTDPSQKYRPMAPVDLADRQWPSRLLTQAPIWLSTDLRDGNQALFEPMNCERKLRLFHE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 L+RIGFKEIEVGFPAASR DFE VR LID IP+DVTPMVMT LR DLI ETV++VAGA Sbjct: 61 LLRIGFKEIEVGFPAASRTDFEIVRQLIDAGQIPEDVTPMVMTPLREDLIAETVRAVAGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASILN 149 RRVIVH YNAIAPAWREIVF + I+ Sbjct: 121 RRVIVHCYNAIAPAWREIVFGMSVPQIIE 149 >C6DJY7.1 C6DJY7_PECCP 2-isopropylmalate synthase Length = 558 Score = 243 bits (621), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 118/148 (79%), Positives = 126/148 (85%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 MLTDPSQKYR VDL +R+WPSRTL +AP WLSTDLRDGNQALFEPMN ERKL LF E Sbjct: 1 MLTDPSQKYRPFPAVDLVDRQWPSRTLTRAPVWLSTDLRDGNQALFEPMNHERKLHLFQE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LVRIGFKEIEVGFP+ASR DFE VRHLID LIPDDVTPMV+TQLR DLI ETV+SVAGA Sbjct: 61 LVRIGFKEIEVGFPSASRTDFEVVRHLIDADLIPDDVTPMVITQLRDDLIEETVRSVAGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASIL 148 RRVIVHFYNAIAP WREIVF + I+ Sbjct: 121 RRVIVHFYNAIAPVWREIVFGMSVEQII 148 >E0SKU8.1 E0SKU8_DICD3 2-isopropylmalate synthase EC=2.3.3.13 Length = 567 Score = 243 bits (621), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 117/149 (78%), Positives = 126/149 (84%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 ML DPSQKYR V+L +R+WPSRTL QAP WLSTDLRDGNQALFEPMNRERKLRLFHE Sbjct: 4 MLIDPSQKYRPAPLVNLVDRQWPSRTLTQAPIWLSTDLRDGNQALFEPMNRERKLRLFHE 63 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LVR+GFKEIEVGFPAASR DFE VRHLID IP+DVTPMVMTQLR DLI ETV+ VAGA Sbjct: 64 LVRLGFKEIEVGFPAASRTDFEIVRHLIDTEQIPEDVTPMVMTQLREDLIAETVRCVAGA 123 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASILN 149 RRVIVHFYNAIAP WRE VF + I++ Sbjct: 124 RRVIVHFYNAIAPVWRETVFGMSVPQIID 152 >D2BRQ8.1 D2BRQ8_DICD5 Pyruvate carboxyltransferase Length = 561 Score = 241 bits (614), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 116/149 (77%), Positives = 125/149 (83%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 MLTDPSQKYR V+L +R+WPSRTL AP WLSTDLRDGNQALFEPMNRERKLRLFHE Sbjct: 1 MLTDPSQKYRPAPLVNLVDRQWPSRTLTHAPIWLSTDLRDGNQALFEPMNRERKLRLFHE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LVR+GFKEIEVGFPAASR DFE VRHLID IP+DVTPMVMT LR DLI ETV+ VAGA Sbjct: 61 LVRLGFKEIEVGFPAASRTDFEIVRHLIDTEQIPEDVTPMVMTPLREDLIAETVRCVAGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASILN 149 RRVIVHFYNAIAP WRE VF + I++ Sbjct: 121 RRVIVHFYNAIAPVWRETVFGMSVPQIID 149 >A9BNM7.1 A9BNM7_DELAS 2-isopropylmalate synthase EC=2.3.3.13 Length = 566 Score = 235 bits (600), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 112/148 (75%), Positives = 123/148 (83%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 ML +P+ +Y VDLPER+WPSR L QAP WLSTDLRDGNQALFEPMNRERKLRLFHE Sbjct: 1 MLKNPASRYLTFPSVDLPERQWPSRQLSQAPVWLSTDLRDGNQALFEPMNRERKLRLFHE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LVRIGFKEIEVGFP+AS+ D+ VRHLID LIP DVTPMV+TQLR DLI TV SVAGA Sbjct: 61 LVRIGFKEIEVGFPSASQTDYGIVRHLIDNGLIPGDVTPMVITQLREDLIRATVDSVAGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASIL 148 RR IVHFYNAIAPAWREIVF ++ I+ Sbjct: 121 RRAIVHFYNAIAPAWREIVFGMQVPEII 148 >D8D9J8.1 D8D9J8_COMTE 2-isopropylmalate synthase EC=2.3.3.13 Length = 559 Score = 233 bits (593), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 111/148 (75%), Positives = 124/148 (83%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 ML DPS KYRA VDLP R+WP+RTL QAP WLSTDLRDGNQALFEPMNRERKLRLF E Sbjct: 1 MLADPSTKYRAFPVVDLPTRQWPARTLTQAPVWLSTDLRDGNQALFEPMNRERKLRLFEE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LV IGFKEIE+GFP+AS+ DF+ VRHLI+ LIP DVTPMV+TQLR DLI TV+SVAGA Sbjct: 61 LVAIGFKEIEIGFPSASQTDFDIVRHLIEAQLIPHDVTPMVITQLREDLIATTVRSVAGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASIL 148 RRVIVH YNA+APA+REIVF + I+ Sbjct: 121 RRVIVHLYNAVAPAFREIVFGMEVPQII 148 >B7WWN3.1 B7WWN3_COMTE 2-isopropylmalate synthase EC=2.3.3.13 Length = 563 Score = 231 bits (588), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 110/148 (74%), Positives = 120/148 (81%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 ML DPS KYRA VDLP R+WP RTL QAP WLSTDLRDGNQALFEPMN ERKLRLF E Sbjct: 1 MLADPSTKYRAFPVVDLPNRQWPGRTLTQAPVWLSTDLRDGNQALFEPMNHERKLRLFQE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LV IGFKEIE+GFP+AS+ DF+ VRHLID LIP DVTPMV+TQLR DLI TV SV GA Sbjct: 61 LVAIGFKEIEIGFPSASQTDFDIVRHLIDAQLIPQDVTPMVITQLREDLIATTVHSVTGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFSSRIASIL 148 RRVIVH YNA+APA+REIVF + I+ Sbjct: 121 RRVIVHLYNAVAPAFREIVFGMEVPQII 148 >Q4K963.1 Q4K963_PSEF5 2-isopropylmalate synthase Length = 571 Score = 226 bits (576), Expect = 9e-58, Method: Compositional matrix adjust. Identities = 108/141 (76%), Positives = 116/141 (82%) Query: 1 MLTDPSQKYRAIAPVDLPERRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHE 60 ML P KYR PVDL R+WPSRT+ QAP WLSTDLRDGNQALFEPMNRERKLRLF E Sbjct: 1 MLAHPHTKYRPFTPVDLDSRQWPSRTITQAPIWLSTDLRDGNQALFEPMNRERKLRLFEE 60 Query: 61 LVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGA 120 LVR+GFKEIEVGFPAASR DFE VR L+++ IP DVTPMVMTQLR DLI ETV+SV GA Sbjct: 61 LVRLGFKEIEVGFPAASRTDFEVVRELVEQQRIPADVTPMVMTQLREDLIRETVRSVQGA 120 Query: 121 RRVIVHFYNAIAPAWREIVFS 141 RRVIVH YNAIAP WR +VF Sbjct: 121 RRVIVHLYNAIAPVWRRVVFG 141