BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0144.p (161 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IYI7.1 D8IYI7_HERSS 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 315 2e-84 E8TSE2.1 E8TSE2_ALIDB 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 176 1e-42 B5WRB4.1 B5WRB4_9BURK 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 174 3e-42 D5WC56.1 D5WC56_BURSC 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 173 6e-42 B2T062.1 B2T062_BURPP 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 173 9e-42 Q145E6.1 Q145E6_BURXL 7,8-Dihydro-6-hydroxymethylpterin-pyrophos... 171 3e-41 D5NN86.1 D5NN86_9BURK 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 169 1e-40 E1T7T5.1 E1T7T5_BURSG 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 169 1e-40 B1FWD6.1 B1FWD6_9BURK 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 168 2e-40 C9YG38.1 C9YG38_9BURK 2-amino-4-hydroxy-6-hydroxymethyldihydropt... 168 3e-40 >D8IYI7.1 D8IYI7_HERSS 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase protein EC=2.7.6.3 Length = 161 Score = 315 bits (806), Expect = 2e-84, Method: Compositional matrix adjust. Identities = 159/161 (98%), Positives = 160/161 (99%) Query: 1 MEPASTLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNA 60 MEPASTLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNA Sbjct: 1 MEPASTLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNA 60 Query: 61 VALVSTTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPR 120 VALVSTTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPR Sbjct: 61 VALVSTTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPR 120 Query: 121 MAQRAFVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 M QRAFVLAPLLEIDENAVIPGVGAARPL+DAITDQPIRRI Sbjct: 121 MVQRAFVLAPLLEIDENAVIPGVGAARPLLDAITDQPIRRI 161 >E8TSE2.1 E8TSE2_ALIDB 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC=2.7.6.3 Length = 172 Score = 176 bits (445), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 95/158 (60%), Positives = 113/158 (71%), Gaps = 6/158 (3%) Query: 4 ASTLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVAL 63 A+ AWIG+G NLGDARA + A+ + ALP T++LR SSLYR+APVDA G DY+NAVA Sbjct: 13 AAVTAWIGLGANLGDARAALRGAVWAMGALPDTRVLRVSSLYRSAPVDAGGPDYLNAVAE 72 Query: 64 VSTTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQ 123 + T L L LLHALQAIE GRERPYRNAPRTLDLD+L+YGE R+ ELTVPHPRM + Sbjct: 73 LRTCLAPLRLLHALQAIEQAAGRERPYRNAPRTLDLDLLLYGEQRLGGAELTVPHPRMWE 132 Query: 124 RAFVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 RAFVL PL E+ V P AR + A+ Q I R+ Sbjct: 133 RAFVLLPLAELRPGWVAP----AR--LQAVAAQRIERV 164 >B5WRB4.1 B5WRB4_9BURK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC=2.7.6.3 Length = 180 Score = 174 bits (442), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 84/156 (53%), Positives = 109/156 (69%) Query: 6 TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVS 65 T+A++G+G NLGDAR T++ A+ LA +L SSLYRTAP+DA GDDY N V + Sbjct: 2 TVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKLE 61 Query: 66 TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125 TTLP LL IE Q GRERP+RNAPRTLDLD+L+YG+ I + +L VPHPR+ +RA Sbjct: 62 TTLPVRQLLALCHKIEHQFGRERPFRNAPRTLDLDILLYGDQSIDEADLIVPHPRLVERA 121 Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 F L PL+EID VIP G A L+D+++DQ I ++ Sbjct: 122 FALVPLVEIDAAIVIPQHGRAAALLDSVSDQRIEKV 157 >D5WC56.1 D5WC56_BURSC 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC=2.7.6.3 Length = 180 Score = 173 bits (439), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 84/156 (53%), Positives = 109/156 (69%) Query: 6 TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVS 65 T+A++G+G NLGDAR T++ A+ LA +L SSLYRTAP+DA GDDY N V + Sbjct: 2 TVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKLE 61 Query: 66 TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125 TTLP LL IE Q GRERP+RNAPRTLDLD+L+YG+ I + +L VPHPR+ +RA Sbjct: 62 TTLPVRHLLALCHKIEHQFGRERPFRNAPRTLDLDILLYGDQSIDEADLIVPHPRLVERA 121 Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 F L PL+EID VIP G A L+D+++DQ I ++ Sbjct: 122 FALVPLVEIDAAIVIPQHGRAAALLDSVSDQRIEKV 157 >B2T062.1 B2T062_BURPP 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC=2.7.6.3 Length = 182 Score = 173 bits (438), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 82/156 (52%), Positives = 109/156 (69%) Query: 6 TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVS 65 T+A++G+G NLGDAR T++ A+ LA +L SSLYRTAP+DA GDDY N V + Sbjct: 2 TVAYLGLGANLGDARQTLKDAVVCLAQQHTISVLAKSSLYRTAPIDAGGDDYFNCVVKID 61 Query: 66 TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125 TTLP LL IE Q GRERP+RNAPRTLDLD+L++G+ I + +L VPHPR+ +RA Sbjct: 62 TTLPVRHLLALCHKIEHQFGRERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLVERA 121 Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 F L PL+EID + VIP G A L+ ++DQ I+++ Sbjct: 122 FALVPLVEIDPSLVIPQHGRAEALLSGVSDQRIKKV 157 >Q145E6.1 Q145E6_BURXL 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK EC=2.7.6.3 Length = 182 Score = 171 bits (433), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 82/156 (52%), Positives = 107/156 (68%) Query: 6 TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVS 65 T+A++G+G NLGDAR T++ A+ LA +L SSLYRTAP+DA GDDY N V V Sbjct: 2 TVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKVD 61 Query: 66 TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125 TTLP LL IE Q GRERP+RNAPRTLDLD+L++G+ I + +L VPHPR+ +RA Sbjct: 62 TTLPVRHLLALCHKIEHQFGRERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLIERA 121 Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 F L PL+EID +IP G A L+ ++DQ I ++ Sbjct: 122 FALVPLVEIDSALIIPQHGRAEALLSKVSDQRIEKV 157 >D5NN86.1 D5NN86_9BURK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC=2.7.6.3 Length = 182 Score = 169 bits (428), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 81/156 (51%), Positives = 106/156 (67%) Query: 6 TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVS 65 T+A++G+G NLGDAR T++ A+ LA +L SSLYRTAP+DA GDDY N V V Sbjct: 2 TVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKVD 61 Query: 66 TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125 TTLP LL IE Q GRERP+RNAPRTLDLD+L++G+ I + +L VPHPR+ +RA Sbjct: 62 TTLPVRHLLALCHKIEHQFGRERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLIERA 121 Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 F L PL+EID +IP G L+ ++DQ I ++ Sbjct: 122 FALVPLVEIDSALIIPQHGRVEALLSKVSDQRIEKV 157 >E1T7T5.1 E1T7T5_BURSG 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC=2.7.6.3 Length = 177 Score = 169 bits (428), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 84/156 (53%), Positives = 106/156 (67%) Query: 6 TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVS 65 T+A++G+G NLGDAR T++ A+ LA +L SSLYRTAP+DA GDDY N V + Sbjct: 2 TVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKID 61 Query: 66 TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125 TTLP LL IE Q GRERP+RNAPRTLDLD+L+YG+ I + +L VPHPR+ +RA Sbjct: 62 TTLPVRHLLALCHKIEHQFGRERPFRNAPRTLDLDILLYGDQSIDEADLIVPHPRLVERA 121 Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 F L PL+EID VIP G A L+D + Q I +I Sbjct: 122 FALVPLVEIDAALVIPRHGRADALLDGVRAQRIEKI 157 >B1FWD6.1 B1FWD6_9BURK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC=2.7.6.3 Length = 177 Score = 168 bits (426), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 81/156 (51%), Positives = 107/156 (68%) Query: 6 TLAWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVS 65 T+A++G+G NLGDAR T++ A+ LA +L SSLYRTAP+DA GDDY N V + Sbjct: 2 TVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKID 61 Query: 66 TTLPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRA 125 TTLP LL IE Q GRERP+RNAPRTLDLD+L++G+ I + +L VPHPR+ +RA Sbjct: 62 TTLPVRHLLALCHKIEHQFGRERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLVERA 121 Query: 126 FVLAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 F L PL+EID +IP G A L+D + +Q I ++ Sbjct: 122 FALVPLVEIDAALIIPRHGRADALLDGVREQRIEKV 157 >C9YG38.1 C9YG38_9BURK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Length = 158 Score = 168 bits (425), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 89/154 (57%), Positives = 108/154 (70%), Gaps = 6/154 (3%) Query: 8 AWIGIGGNLGDARATVETAIARLAALPQTQLLRSSSLYRTAPVDASGDDYVNAVALVSTT 67 A+IG+G NLGD + TA+ L LP T+L+R+S + + PVD++G DYVNAVA +ST Sbjct: 9 AYIGLGANLGDPMVALRTALVGLERLPATRLVRASGFFGSTPVDSTGPDYVNAVAEISTC 68 Query: 68 LPALDLLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEARIADQELTVPHPRMAQRAFV 127 L A DLL ALQ ELQ GRERPYRNAPRTLDLD+L+YG ARIA LTVPHPRM +RAFV Sbjct: 69 LSAPDLLSALQKQELQAGRERPYRNAPRTLDLDILLYGSARIASPALTVPHPRMRERAFV 128 Query: 128 LAPLLEIDENAVIPGVGAARPLMDAITDQPIRRI 161 L PL E+D V P +DA+ DQ I R+ Sbjct: 129 LMPLAELDPERVKPAE------LDAVRDQGIWRL 156