BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0102.p (459 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IPF0.1 D8IPF0_HERSS Dihydrolipoamide acetyltransferase compone... 150 4e-34 A4G354.1 A4G354_HERAR Dihydrolipoyllysine-residue acetyltransfer... 140 6e-31 A6SVR7.1 A6SVR7_JANMA Pyruvate dehydrogenase E2 component (Dihyd... 139 1e-30 A4G355.1 A4G355_HERAR Dihydrolipoyl dehydrogenase (E3 component ... 135 1e-29 A6SVR9.1 A6SVR9_JANMA Dihydrolipoamide dehydrogenase EC=1.8.1.4 133 6e-29 D0IVR6.1 D0IVR6_COMT2 Pyruvate dehydrogenase complex dihydrolipo... 127 5e-27 D8D8H7.1 D8D8H7_COMTE Pyruvate dehydrogenase complex dihydrolipo... 127 5e-27 B7WUS1.1 B7WUS1_COMTE Pyruvate dehydrogenase complex dihydrolipo... 127 5e-27 Q2L1F1.1 Q2L1F1_BORA1 Dihydrolipoamide dehydrogenase EC=1.8.1.4 125 1e-26 E8U127.1 E8U127_ALIDB Dihydrolipoamide dehydrogenase 124 3e-26 >D8IPF0.1 D8IPF0_HERSS Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (E2) protein EC=2.3.1.12 Length = 554 Score = 150 bits (380), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 69/70 (98%), Positives = 69/70 (98%) Query: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK Sbjct: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 Query: 61 VKVGDKVAEA 70 VKVGDKVAE Sbjct: 61 VKVGDKVAEG 70 Score = 125 bits (313), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 54/67 (80%), Positives = 64/67 (95%) Query: 4 VEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIKVKV 63 VE++VPDIGDFKEVEVIEVMVKVGDT+K +QSL+TVESDKASMEIPSS AGV+KE+KVK+ Sbjct: 120 VEIEVPDIGDFKEVEVIEVMVKVGDTVKAEQSLLTVESDKASMEIPSSHAGVIKELKVKL 179 Query: 64 GDKVAEA 70 GDKV++ Sbjct: 180 GDKVSKG 186 >A4G354.1 A4G354_HERAR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (E2) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) EC=2.3.1.12 Length = 455 Score = 140 bits (352), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 62/70 (88%), Positives = 67/70 (95%) Query: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 MS VEVKVPDIGDFKEVE+IE++VKVGDTIK+DQSLITVESDKASMEIPSS AGVVKEIK Sbjct: 1 MSTVEVKVPDIGDFKEVEIIELLVKVGDTIKIDQSLITVESDKASMEIPSSHAGVVKEIK 60 Query: 61 VKVGDKVAEA 70 VK+GDKVAE Sbjct: 61 VKLGDKVAEG 70 >A6SVR7.1 A6SVR7_JANMA Pyruvate dehydrogenase E2 component (Dihydrolipoamide acetyltransferase) EC=2.3.1.12 Length = 458 Score = 139 bits (349), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 62/70 (88%), Positives = 66/70 (94%) Query: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 MS VEVKVPDIGDFKEVEVIE++VK GDTIKVDQSLITVESDKASMEIPSS AGVVKEIK Sbjct: 1 MSMVEVKVPDIGDFKEVEVIELLVKAGDTIKVDQSLITVESDKASMEIPSSHAGVVKEIK 60 Query: 61 VKVGDKVAEA 70 VK+GDK+AE Sbjct: 61 VKLGDKIAEG 70 >A4G355.1 A4G355_HERAR Dihydrolipoyl dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) EC=1.8.1.4 Length = 611 Score = 135 bits (341), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 60/70 (85%), Positives = 66/70 (94%) Query: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 MS +EVKVPDIGDFKEVE+IE++V VGDTIKVDQSLITVESDKASMEIPSS AGVVKE+K Sbjct: 1 MSTIEVKVPDIGDFKEVEIIEMLVNVGDTIKVDQSLITVESDKASMEIPSSHAGVVKELK 60 Query: 61 VKVGDKVAEA 70 VK+GDKVAE Sbjct: 61 VKLGDKVAEG 70 >A6SVR9.1 A6SVR9_JANMA Dihydrolipoamide dehydrogenase EC=1.8.1.4 Length = 603 Score = 133 bits (335), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 56/67 (83%), Positives = 65/67 (97%) Query: 4 VEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIKVKV 63 +EVKVPDIGDFKEVE+IE++VKVGDTIK+DQSLITVESDKASMEIPSS AGV+KE+K+K+ Sbjct: 2 IEVKVPDIGDFKEVEIIELLVKVGDTIKIDQSLITVESDKASMEIPSSHAGVIKELKIKL 61 Query: 64 GDKVAEA 70 GDKVAE Sbjct: 62 GDKVAEG 68 >D0IVR6.1 D0IVR6_COMT2 Pyruvate dehydrogenase complex dihydrolipoamide Length = 563 Score = 127 bits (318), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 58/70 (82%), Positives = 63/70 (90%) Query: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 M+ E+KVPDIGDF EV VIEV+VKVGDTIKV+QSLITVESDKASMEIPSSQAGVVKEIK Sbjct: 1 MALTEIKVPDIGDFSEVGVIEVLVKVGDTIKVEQSLITVESDKASMEIPSSQAGVVKEIK 60 Query: 61 VKVGDKVAEA 70 V +GDKV E Sbjct: 61 VALGDKVKEG 70 Score = 93.6 bits (231), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 42/66 (63%), Positives = 54/66 (81%) Query: 2 SQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIKV 61 S V++K+PDIGDFK+V VIE++VKVGDT+ +QSL TVESDKASMEIPS AG + + + Sbjct: 117 STVDLKIPDIGDFKDVAVIEMLVKVGDTVTAEQSLFTVESDKASMEIPSPSAGTITALTI 176 Query: 62 KVGDKV 67 K+GD V Sbjct: 177 KLGDTV 182 >D8D8H7.1 D8D8H7_COMTE Pyruvate dehydrogenase complex dihydrolipoamide Length = 563 Score = 127 bits (318), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 58/70 (82%), Positives = 63/70 (90%) Query: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 M+ E+KVPDIGDF EV VIEV+VKVGDTIKV+QSLITVESDKASMEIPSSQAGVVKEIK Sbjct: 1 MALTEIKVPDIGDFSEVGVIEVLVKVGDTIKVEQSLITVESDKASMEIPSSQAGVVKEIK 60 Query: 61 VKVGDKVAEA 70 V +GDKV E Sbjct: 61 VALGDKVKEG 70 Score = 93.6 bits (231), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 42/66 (63%), Positives = 54/66 (81%) Query: 2 SQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIKV 61 S V++K+PDIGDFK+V VIE++VKVGDT+ +QSL TVESDKASMEIPS AG + + + Sbjct: 117 STVDLKIPDIGDFKDVAVIEMLVKVGDTVTAEQSLFTVESDKASMEIPSPSAGTITALTI 176 Query: 62 KVGDKV 67 K+GD V Sbjct: 177 KLGDTV 182 >B7WUS1.1 B7WUS1_COMTE Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase EC=2.3.1.61 Length = 561 Score = 127 bits (318), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 58/70 (82%), Positives = 63/70 (90%) Query: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 M+ E+KVPDIGDF EV VIEV+VKVGDTIKV+QSLITVESDKASMEIPSSQAGVVKEIK Sbjct: 1 MALTEIKVPDIGDFSEVGVIEVLVKVGDTIKVEQSLITVESDKASMEIPSSQAGVVKEIK 60 Query: 61 VKVGDKVAEA 70 V +GDKV E Sbjct: 61 VALGDKVKEG 70 Score = 96.3 bits (238), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 43/66 (65%), Positives = 55/66 (83%) Query: 2 SQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIKV 61 S V++K+PDIGDFK+V VIE++VKVGDT+ V+QSL TVESDKASMEIPS AG + + + Sbjct: 118 STVDLKIPDIGDFKDVAVIEMLVKVGDTVAVEQSLFTVESDKASMEIPSPSAGTITALTI 177 Query: 62 KVGDKV 67 K+GD V Sbjct: 178 KLGDTV 183 >Q2L1F1.1 Q2L1F1_BORA1 Dihydrolipoamide dehydrogenase EC=1.8.1.4 Length = 590 Score = 125 bits (314), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 57/71 (80%), Positives = 64/71 (90%), Gaps = 1/71 (1%) Query: 1 MSQV-EVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEI 59 MS + E+KVPDIGDFKEVEVIEV+V VGDTIK DQSLITVESDKASMEIP+S+ GVVK + Sbjct: 1 MSNLKEIKVPDIGDFKEVEVIEVLVAVGDTIKADQSLITVESDKASMEIPASEGGVVKSL 60 Query: 60 KVKVGDKVAEA 70 K+KVGDKVAE Sbjct: 61 KIKVGDKVAEG 71 >E8U127.1 E8U127_ALIDB Dihydrolipoamide dehydrogenase Length = 609 Score = 124 bits (311), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 54/70 (77%), Positives = 64/70 (91%) Query: 1 MSQVEVKVPDIGDFKEVEVIEVMVKVGDTIKVDQSLITVESDKASMEIPSSQAGVVKEIK 60 M+ +++KVPDIGDF EV VIEV+V+VGDTIK +QSL+TVESDKASMEIPSS AGVVKE+K Sbjct: 1 MAVIDIKVPDIGDFAEVGVIEVLVQVGDTIKAEQSLVTVESDKASMEIPSSHAGVVKELK 60 Query: 61 VKVGDKVAEA 70 VK+GDKVAE Sbjct: 61 VKLGDKVAEG 70