BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0006.0027.p (261 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IPM5.1 D8IPM5_HERSS Short chain dehydrogenase protein 525 e-147 A1WRZ2.1 A1WRZ2_VEREI Short-chain dehydrogenase/reductase SDR 397 e-109 E3HRU9.1 E3HRU9_ACHXA Short chain dehydrogenase family protein 2 311 4e-83 E5U551.1 E5U551_ALCXX Short-chain dehydrogenase/reductase SDR 295 4e-78 Q6SEY2.1 Q6SEY2_9BACT Oxidoreductase, short chain dehydrogenase/... 276 2e-72 B1G5Y8.1 B1G5Y8_9BURK Short-chain dehydrogenase/reductase SDR 261 5e-68 E2CL20.1 E2CL20_9RHOB Granaticin polyketide synthase putative ke... 261 5e-68 E8TC90.1 E8TC90_MESCW Short-chain dehydrogenase/reductase SDR 261 6e-68 Q1BN84.1 Q1BN84_BURCA Short-chain dehydrogenase/reductase SDR 261 1e-67 A0B092.1 A0B092_BURCH Short-chain dehydrogenase/reductase SDR 261 1e-67 >D8IPM5.1 D8IPM5_HERSS Short chain dehydrogenase protein Length = 261 Score = 525 bits (1353), Expect = e-147, Method: Compositional matrix adjust. Identities = 259/261 (99%), Positives = 260/261 (99%) Query: 1 MDLNLKDQKVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSR 60 MDLNLKDQKVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSR Sbjct: 1 MDLNLKDQKVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSR 60 Query: 61 TDVSSEREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPF 120 TDVSSEREVDAMFADLAQRWSGRLDVL+NNAGIAGPT PVEEVALSDWDQTLAVNLTGPF Sbjct: 61 TDVSSEREVDAMFADLAQRWSGRLDVLINNAGIAGPTSPVEEVALSDWDQTLAVNLTGPF 120 Query: 121 LCTRRAVPLLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIR 180 LCTRRAVPLLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIR Sbjct: 121 LCTRRAVPLLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIR 180 Query: 181 VNAVLPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCS 240 VNAVLPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCS Sbjct: 181 VNAVLPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCS 240 Query: 241 PAGASISGQSLSVCGNVEVLG 261 PAGASISGQSLSVCGNVEVLG Sbjct: 241 PAGASISGQSLSVCGNVEVLG 261 >A1WRZ2.1 A1WRZ2_VEREI Short-chain dehydrogenase/reductase SDR Length = 258 Score = 397 bits (1020), Expect = e-109, Method: Compositional matrix adjust. Identities = 195/261 (74%), Positives = 226/261 (86%), Gaps = 3/261 (1%) Query: 1 MDLNLKDQKVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSR 60 MD+ L ++V+VTAGAQGIGLAIT AFV AGA VHICDV E FLA A + + +SR Sbjct: 1 MDIGLNGKRVLVTAGAQGIGLAITEAFVAAGAQVHICDVDEGFLAQATRQLPQ--LCHSR 58 Query: 61 TDVSSEREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPF 120 TDVS +VDAMFA +A+RW GRLDVLVNNAGIAGPT VE+ AL+DW+QT+AVNLTGPF Sbjct: 59 TDVSDAAQVDAMFAGIAERW-GRLDVLVNNAGIAGPTSAVEDTALADWEQTIAVNLTGPF 117 Query: 121 LCTRRAVPLLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIR 180 LCTRRAVPLLK GGG+IVN+SS AGRLGF LRTPYSASK+GVIGLTE+WA+ELGPS IR Sbjct: 118 LCTRRAVPLLKAAGGGSIVNLSSAAGRLGFPLRTPYSASKFGVIGLTESWAMELGPSRIR 177 Query: 181 VNAVLPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCS 240 VNA+LPGIV GARQER++AA+AA+YGI HE MR+RLLS+VSLR MVTA+DIANQ++F+CS Sbjct: 178 VNAILPGIVAGARQERVIAARAASYGIDHEAMRERLLSKVSLRSMVTAQDIANQIVFICS 237 Query: 241 PAGASISGQSLSVCGNVEVLG 261 PAGA+ISGQSLSVCGNVE LG Sbjct: 238 PAGATISGQSLSVCGNVEHLG 258 >E3HRU9.1 E3HRU9_ACHXA Short chain dehydrogenase family protein 2 Length = 258 Score = 311 bits (798), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 164/261 (62%), Positives = 206/261 (78%), Gaps = 3/261 (1%) Query: 1 MDLNLKDQKVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSR 60 M +L+ ++V++TAGAQGIGLAI F+EAGA VH+CDV E +A A H + S Sbjct: 1 MSNSLQGKRVLITAGAQGIGLAIARRFLEAGAEVHVCDVDEAACKAAAAE--HPRLGVSV 58 Query: 61 TDVSSEREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPF 120 TDVSSE +V AMF +L ++W G+LD LVNNAG++GPT +EE L W +TL VNLTG F Sbjct: 59 TDVSSEAQVQAMFGELTEKW-GKLDALVNNAGVSGPTNRLEETTLDAWQRTLDVNLTGTF 117 Query: 121 LCTRRAVPLLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIR 180 LC R AVPLL+ GGGAIVNISSVAGRLGF+LRTPYSASK+G+ GLT+TWA+ELGPS+IR Sbjct: 118 LCARSAVPLLRAAGGGAIVNISSVAGRLGFSLRTPYSASKFGLAGLTQTWAMELGPSNIR 177 Query: 181 VNAVLPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCS 240 VN+VLPG+V G R ERI+AA+AAA G+ ++ MR++L+ +VSLR+M + +DIANQV +LCS Sbjct: 178 VNSVLPGVVSGDRVERIIAARAAASGVSNDAMREQLVDKVSLRRMTSPQDIANQVAYLCS 237 Query: 241 PAGASISGQSLSVCGNVEVLG 261 GA ISGQS+SVCGNVE LG Sbjct: 238 DEGAIISGQSISVCGNVEYLG 258 >E5U551.1 E5U551_ALCXX Short-chain dehydrogenase/reductase SDR Length = 258 Score = 295 bits (756), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 164/258 (63%), Positives = 205/258 (79%), Gaps = 3/258 (1%) Query: 4 NLKDQKVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSRTDV 63 +LK ++V++TAGA GIGLAI F+ AGA VHICDV+ + + +A HA +S S TDV Sbjct: 4 SLKGKRVLITAGAGGIGLAIARKFLAAGARVHICDVAAEAVQAAVQA--HAGLSGSVTDV 61 Query: 64 SSEREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPFLCT 123 + E +V AMFA+LA+RW G+LD LVNNAG++GPT +E+ L+ W TL VNLTG FLC Sbjct: 62 ADEAQVLAMFAELAERW-GKLDALVNNAGVSGPTSRLEDTDLAAWQATLDVNLTGTFLCA 120 Query: 124 RRAVPLLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIRVNA 183 R AVPLL++ GGGAI+NISSVAGRLGF+LR+PYSASK+G+ GLT+TWA+ELGPS IRVN+ Sbjct: 121 RSAVPLLREAGGGAIINISSVAGRLGFSLRSPYSASKFGLAGLTQTWAMELGPSGIRVNS 180 Query: 184 VLPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCSPAG 243 VLPG+V G R ERI+AA+AAA G+ ++ MR +L+ +VSLRKM EDIANQV FLCS G Sbjct: 181 VLPGVVAGDRVERIIAARAAAGGVSNDAMRAQLVEKVSLRKMTQPEDIANQVAFLCSDEG 240 Query: 244 ASISGQSLSVCGNVEVLG 261 A ISGQS+SVCGNVE LG Sbjct: 241 AMISGQSISVCGNVEYLG 258 >Q6SEY2.1 Q6SEY2_9BACT Oxidoreductase, short chain dehydrogenase/reductase family Length = 260 Score = 276 bits (706), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 135/252 (53%), Positives = 182/252 (72%), Gaps = 3/252 (1%) Query: 9 KVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSRTDVSSERE 68 +V+VTAGA GIG I +F + GA +HICD+++ L A+ H SR DVS + Sbjct: 12 RVLVTAGASGIGRVIAESFAQTGARLHICDIADAALGEAKKT--HPTWGVSRCDVSQSDQ 69 Query: 69 VDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPFLCTRRAVP 128 V +F ++ G LDVL+NNAGIAGPT VEE+ DW +T+ +NL G F C RAVP Sbjct: 70 VARLFEEVGNNLGG-LDVLINNAGIAGPTGGVEEITADDWRRTVDINLNGQFYCANRAVP 128 Query: 129 LLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIRVNAVLPGI 188 LLK++ +I+ ISSVAGRLG+A RTPY+A+K+ +IGLT++ AIELGPS IRVNA+LPGI Sbjct: 129 LLKQSPNASIICISSVAGRLGYAYRTPYAATKWAIIGLTKSLAIELGPSGIRVNALLPGI 188 Query: 189 VEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCSPAGASISG 248 V G R E++++ +A G+ + +M Q + +VSLR+MVTA+D+ANQ +FLCSP G +ISG Sbjct: 189 VAGPRIEKVISDRAQTMGVSYGDMEQEYIDKVSLRRMVTAQDVANQAVFLCSPGGVNISG 248 Query: 249 QSLSVCGNVEVL 260 QS+S+CGNVEVL Sbjct: 249 QSISICGNVEVL 260 >B1G5Y8.1 B1G5Y8_9BURK Short-chain dehydrogenase/reductase SDR Length = 268 Score = 261 bits (668), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 132/256 (51%), Positives = 184/256 (71%), Gaps = 5/256 (1%) Query: 9 KVIVTAGAQGIGLAITAAFVEAGAHVHICDVSE---DFLASARARFGHAPVSYSRTDVSS 65 +V++T GA GIGL + AF+EAGA VH+CD S+ D L A+ ++ + DV+ Sbjct: 14 RVLITGGASGIGLVMAQAFIEAGARVHVCDASQQAIDALQKAQESVELNRITATLADVAD 73 Query: 66 EREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPFLCTRR 125 V+ +F D+ Q G LDVLVNNAGIAGPT V+E+ +W+ T+ VNL F RR Sbjct: 74 RAAVERVFVDV-QAELGGLDVLVNNAGIAGPTGGVDELDEQEWNNTVDVNLNAQFYFARR 132 Query: 126 AVPLLKK-NGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIRVNAV 184 AVPLL++ GG I+ +SSVAGRLG+A RTPY+A+K+ V+G+T++ AIELGPS+IRVNA+ Sbjct: 133 AVPLLRQARDGGTIIALSSVAGRLGYAFRTPYAATKWAVVGMTKSLAIELGPSNIRVNAI 192 Query: 185 LPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCSPAGA 244 PGIV+G R ER++AA+A + +EEM ++ L+++SLR+M T E++A +FLCSPAG+ Sbjct: 193 QPGIVKGPRIERVIAARAKQLKLSYEEMEKQYLAKISLRRMTTPEEVAATALFLCSPAGS 252 Query: 245 SISGQSLSVCGNVEVL 260 ISGQ++SVCGNVE L Sbjct: 253 GISGQAISVCGNVEFL 268 >E2CL20.1 E2CL20_9RHOB Granaticin polyketide synthase putative ketoacyl reductase 1 Length = 264 Score = 261 bits (668), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 138/244 (56%), Positives = 178/244 (72%), Gaps = 3/244 (1%) Query: 5 LKDQKVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSRTDVS 64 L ++++VTAGA GIGLAI A GA V ICDV E+ LA A + G+ R DVS Sbjct: 24 LMAKRIVVTAGAGGIGLAIAKALHAQGARVAICDVDENALALASGQLGNCLAI--RADVS 81 Query: 65 SEREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPFLCTR 124 E VD F + ++++G LD LVNNAGIAGPT VE++ SDW Q + V LTG FLC R Sbjct: 82 DEASVDRFFDAVQEQFNG-LDALVNNAGIAGPTGGVEDILPSDWRQCVDVCLTGQFLCAR 140 Query: 125 RAVPLLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIRVNAV 184 RAVPL+KK+GGGA+VN+SS AG+ G+A RTPYSA+K+GVIG T++ A ELGP +IRVNA+ Sbjct: 141 RAVPLMKKSGGGAMVNMSSAAGKHGYAYRTPYSAAKFGVIGFTQSLAKELGPDNIRVNAI 200 Query: 185 LPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCSPAGA 244 LPGIVEG R E ++ +AA G+ +E+M+ + LSR+SLRKMVTA+++A V FL S AGA Sbjct: 201 LPGIVEGPRIEGVIRDRAAVTGVSYEDMKDQYLSRISLRKMVTADEVAATVAFLISDAGA 260 Query: 245 SISG 248 +ISG Sbjct: 261 NISG 264 >E8TC90.1 E8TC90_MESCW Short-chain dehydrogenase/reductase SDR Length = 268 Score = 261 bits (668), Expect = 6e-68, Method: Compositional matrix adjust. Identities = 136/256 (53%), Positives = 182/256 (71%), Gaps = 3/256 (1%) Query: 5 LKDQKVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAPVSYSRTDVS 64 LK Q+V+VTAGA GIG AI GA + +CDVS++ LA+A ++ V+ + DVS Sbjct: 16 LKGQRVLVTAGAGGIGFAIADTLSRLGARIVVCDVSDEALAAAPSKIDL--VAAVKADVS 73 Query: 65 SEREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPFLCTR 124 +++VD +F + ++ G LD L+NNAGIAGPT V+E+ +DW + + + LTG FLC R Sbjct: 74 RDQDVDRLFEAVEKKLGG-LDALINNAGIAGPTGGVDEIDPADWRRCIDICLTGQFLCAR 132 Query: 125 RAVPLLKKNGGGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIRVNAV 184 RAVPL+K GGG+IV++SS AGR G+A RTPYSA+K+GVIG T++ A ELGP IRVNA+ Sbjct: 133 RAVPLIKAAGGGSIVSMSSAAGRHGYAFRTPYSAAKFGVIGFTQSLAKELGPHAIRVNAI 192 Query: 185 LPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCSPAGA 244 LPGI+EG R E +++A+A GI HEEM R L +SLR+M + D+A+ V FL S AG Sbjct: 193 LPGIIEGPRIEGVISARAKQVGISHEEMTGRYLQNISLRRMTSPYDVASMVAFLLSDAGI 252 Query: 245 SISGQSLSVCGNVEVL 260 +ISGQSL V GNVE L Sbjct: 253 NISGQSLGVDGNVETL 268 >Q1BN84.1 Q1BN84_BURCA Short-chain dehydrogenase/reductase SDR Length = 268 Score = 261 bits (666), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 136/256 (53%), Positives = 180/256 (70%), Gaps = 5/256 (1%) Query: 9 KVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAP---VSYSRTDVSS 65 +V+VT GA GIGL I AF E GA VH+CD S+ +A+ R A +S + DVS Sbjct: 14 RVLVTGGASGIGLEIADAFAECGARVHVCDASQASIAALADRPPRAATGAISATLADVSD 73 Query: 66 EREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPFLCTRR 125 V+ +FAD++ R G LDVLVNNAGIAGPT ++E+ W+QT+A+NL F RR Sbjct: 74 PAAVERVFADVSTRLGG-LDVLVNNAGIAGPTGGIDEIDPVQWEQTVAINLNAQFQFARR 132 Query: 126 AVPLLKKNG-GGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIRVNAV 184 AVPLL+++ GGAI+ +SSVAGRLG+A RTPY+A+K+ V+GL ++ AIELGP IRVNA+ Sbjct: 133 AVPLLRESKPGGAIIALSSVAGRLGYAFRTPYAATKWAVVGLVKSLAIELGPLGIRVNAI 192 Query: 185 LPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCSPAGA 244 PGIV G R R++ A+A GIG++EM QR L ++SLR+M +IA +FLCSP G Sbjct: 193 QPGIVRGPRMRRVIEARAQQLGIGYDEMEQRYLEKISLRRMTDPAEIAATALFLCSPGGH 252 Query: 245 SISGQSLSVCGNVEVL 260 I+GQ++SVCGNVEVL Sbjct: 253 GITGQAISVCGNVEVL 268 >A0B092.1 A0B092_BURCH Short-chain dehydrogenase/reductase SDR Length = 268 Score = 261 bits (666), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 136/256 (53%), Positives = 180/256 (70%), Gaps = 5/256 (1%) Query: 9 KVIVTAGAQGIGLAITAAFVEAGAHVHICDVSEDFLASARARFGHAP---VSYSRTDVSS 65 +V+VT GA GIGL I AF E GA VH+CD S+ +A+ R A +S + DVS Sbjct: 14 RVLVTGGASGIGLEIADAFAECGARVHVCDASQASIAALADRPPRAATGAISATLADVSD 73 Query: 66 EREVDAMFADLAQRWSGRLDVLVNNAGIAGPTLPVEEVALSDWDQTLAVNLTGPFLCTRR 125 V+ +FAD++ R G LDVLVNNAGIAGPT ++E+ W+QT+A+NL F RR Sbjct: 74 PAAVERVFADVSTRLGG-LDVLVNNAGIAGPTGGIDEIDPVQWEQTVAINLNAQFQFARR 132 Query: 126 AVPLLKKNG-GGAIVNISSVAGRLGFALRTPYSASKYGVIGLTETWAIELGPSHIRVNAV 184 AVPLL+++ GGAI+ +SSVAGRLG+A RTPY+A+K+ V+GL ++ AIELGP IRVNA+ Sbjct: 133 AVPLLRESKPGGAIIALSSVAGRLGYAFRTPYAATKWAVVGLVKSLAIELGPLGIRVNAI 192 Query: 185 LPGIVEGARQERIVAAKAAAYGIGHEEMRQRLLSRVSLRKMVTAEDIANQVIFLCSPAGA 244 PGIV G R R++ A+A GIG++EM QR L ++SLR+M +IA +FLCSP G Sbjct: 193 QPGIVRGPRMRRVIEARAQQLGIGYDEMEQRYLEKISLRRMTDPAEIAATALFLCSPGGH 252 Query: 245 SISGQSLSVCGNVEVL 260 I+GQ++SVCGNVEVL Sbjct: 253 GITGQAISVCGNVEVL 268