BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0006.0017.p (567 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IPL5.1 D8IPL5_HERSS 2-isopropylmalate synthase 2 EC=2.3.3.13 1169 0.0 A6SX91.1 A6SX91_JANMA 2-isopropylmalate synthase EC=2.3.3.13 885 0.0 A4G3X8.2 A4G3X8_HERAR 2-isopropylmalate synthase EC=2.3.3.13 874 0.0 Q0K537.1 Q0K537_CUPNH 2-Isopropylmalate synthase EC=2.3.3.13 854 0.0 B2AHM5.1 LEU1_CUPTR 2-isopropylmalate synthase EC=2.3.3.13 844 0.0 A9HW07.1 LEU1_BORPD 2-isopropylmalate synthase EC=2.3.3.13 829 0.0 E5U8H2.1 E5U8H2_ALCXX 2-isopropylmalate synthase EC=2.3.3.13 829 0.0 E3HPC1.1 E3HPC1_ACHXA 2-isopropylmalate synthase EC=2.3.3.13 825 0.0 Q7W2R5.1 Q7W2R5_BORPA 2-isopropylmalate synthase EC=2.3.3.13 825 0.0 Q7WDR3.1 Q7WDR3_BORBR 2-isopropylmalate synthase EC=2.3.3.13 825 0.0 >D8IPL5.1 D8IPL5_HERSS 2-isopropylmalate synthase 2 EC=2.3.3.13 Length = 567 Score = 1169 bits (3025), Expect = 0.0, Method: Compositional matrix adjust. Identities = 566/567 (99%), Positives = 567/567 (100%) Query: 1 MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60 MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE Sbjct: 1 MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60 Query: 61 LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEG 120 LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSR+ELIRRTIESLEG Sbjct: 61 LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSREELIRRTIESLEG 120 Query: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF Sbjct: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180 Query: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST Sbjct: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240 Query: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL Sbjct: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300 Query: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY Sbjct: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360 Query: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK Sbjct: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420 Query: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG Sbjct: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480 Query: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK Sbjct: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540 Query: 541 AVLSAVNRQIAISESANQAGSSQAKAA 567 AVLSAVNRQIAISESANQAGSSQAKAA Sbjct: 541 AVLSAVNRQIAISESANQAGSSQAKAA 567 >A6SX91.1 A6SX91_JANMA 2-isopropylmalate synthase EC=2.3.3.13 Length = 552 Score = 885 bits (2288), Expect = 0.0, Method: Compositional matrix adjust. Identities = 421/553 (76%), Positives = 488/553 (88%), Gaps = 2/553 (0%) Query: 1 MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60 MML+NPAAKYR FP + L DRTWP++VI+TPPIWMSTDLRDGNQALIEPMN E+KLRFF+ Sbjct: 1 MMLTNPAAKYRAFPPVQLKDRTWPNRVISTPPIWMSTDLRDGNQALIEPMNHEKKLRFFD 60 Query: 61 LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEG 120 +LLK GLKEIEV FPSASQTDFDFVRKLI E RIPDDVTI VLTQ+R++LIRRT++S+ G Sbjct: 61 MLLKIGLKEIEVAFPSASQTDFDFVRKLIDEKRIPDDVTIEVLTQAREDLIRRTVDSVVG 120 Query: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180 +++AIVH+YN+ APAFR+IVFNMS+EE+K +AV GT+L++ELTDA P TEW F+YSPE+F Sbjct: 121 SRRAIVHMYNATAPAFRRIVFNMSKEEVKALAVAGTKLIRELTDAHPETEWVFQYSPETF 180 Query: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240 S TELDF+KE+CDAV E W +PERK+I+NLP TVE +TPNVYADQ+EWM RNL R S Sbjct: 181 SMTELDFAKEVCDAVSEAWQPTPERKMIINLPGTVEASTPNVYADQVEWMHRNLARRDSI 240 Query: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300 I+SVHPHNDRG AVA+AELAVMAGADR+EGCLFGNGERTGNVDLVTLALNLY+QG+NPGL Sbjct: 241 ILSVHPHNDRGCAVAAAELAVMAGADRIEGCLFGNGERTGNVDLVTLALNLYSQGINPGL 300 Query: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360 DFSDID +RQ VEECNQIPVHPRHPYVGDLV+TAFSGSHQDAIKKGFAKQ+PD IWEVPY Sbjct: 301 DFSDIDEIRQCVEECNQIPVHPRHPYVGDLVYTAFSGSHQDAIKKGFAKQKPDEIWEVPY 360 Query: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420 +P+DPADLGRSYDAVIRVNSQSGKGGM YLLEQEYGL LPRRLQIEFSRA+QR D TG Sbjct: 361 MPVDPADLGRSYDAVIRVNSQSGKGGMTYLLEQEYGLVLPRRLQIEFSRAVQRITDETGG 420 Query: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480 E+AA+DIH IF EYL V PY YR H + D SK + I+V++ ++G+PV+++G GNG Sbjct: 421 EVAANDIHTIFNSEYLNAVTPYHYRNHHI--DDSKDGEVQIKVELEKDGKPVSMQGVGNG 478 Query: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540 PIDAF++ALGL+IKLMDFHEHAIGAGA A AASY+ELR+N T FGVGID NIVTASF+ Sbjct: 479 PIDAFINALGLNIKLMDFHEHAIGAGASANAASYVELRVNNGVTRFGVGIDGNIVTASFR 538 Query: 541 AVLSAVNRQIAIS 553 AVLSAVNR IA++ Sbjct: 539 AVLSAVNRDIALA 551 >A4G3X8.2 A4G3X8_HERAR 2-isopropylmalate synthase EC=2.3.3.13 Length = 553 Score = 874 bits (2257), Expect = 0.0, Method: Compositional matrix adjust. Identities = 416/553 (75%), Positives = 482/553 (87%), Gaps = 1/553 (0%) Query: 1 MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE 60 MMLSNP KYR FP + L DR WP++VI+ PIWMSTDLRDGNQ+LIEPMN ++KLRFF+ Sbjct: 1 MMLSNPEQKYRAFPPVRLTDRNWPNQVISKAPIWMSTDLRDGNQSLIEPMNHDKKLRFFD 60 Query: 61 LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEG 120 +L+K GLKEIEV FPSASQTDFDFVR+LI E RIPDDVTI VLT +R++LIRRT+ES+ G Sbjct: 61 MLVKIGLKEIEVAFPSASQTDFDFVRRLIEEKRIPDDVTIEVLTPAREDLIRRTVESVVG 120 Query: 121 AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF 180 A++AI+HLYN+ APAFR+IVFNMSR+E+K +AV G +LV+ELTDA P TEW F+YSPE+F Sbjct: 121 ARRAIIHLYNATAPAFRRIVFNMSRDEVKALAVAGAKLVRELTDAHPETEWVFQYSPEAF 180 Query: 181 STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST 240 S TEL+FSKEICDAV TW +PERK+I NLP TVE +TPNVYADQ+EWM RNL R S Sbjct: 181 SMTELEFSKEICDAVSATWQPTPERKMIFNLPGTVEASTPNVYADQVEWMHRNLARRDSI 240 Query: 241 IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL 300 +ISVHPHNDRG AVA+AELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLY+QG++PGL Sbjct: 241 LISVHPHNDRGCAVAAAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQGISPGL 300 Query: 301 DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY 360 DFSDID VRQ VEECNQIPVHPRHPYVGDLV+TAFSGSHQDAIKKGFA+QQPDAIWEVPY Sbjct: 301 DFSDIDAVRQCVEECNQIPVHPRHPYVGDLVYTAFSGSHQDAIKKGFAQQQPDAIWEVPY 360 Query: 361 LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK 420 +P+DPADLGRSYDAVIRVNSQSGKGGM YLLEQEYGL LPRRLQIEFSRA+QR D TG Sbjct: 361 MPVDPADLGRSYDAVIRVNSQSGKGGMTYLLEQEYGLVLPRRLQIEFSRAVQRITDETGG 420 Query: 421 EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG 480 E+AA+DIH IF EYL V PY YR+H + E AE + I V++ ++G+PVT++G+GNG Sbjct: 421 EVAANDIHTIFNNEYLNAVTPYQYRSHHIDESQGNAE-VRIRVELEKDGKPVTLQGAGNG 479 Query: 481 PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK 540 PIDAF++ALG+DI+LMDFHEHAIGAGA+A AASY+ELR+N T FGVGID NIVTAS + Sbjct: 480 PIDAFINALGMDIRLMDFHEHAIGAGANANAASYVELRVNNGSTRFGVGIDGNIVTASLR 539 Query: 541 AVLSAVNRQIAIS 553 AVLSAVNR IA++ Sbjct: 540 AVLSAVNRDIALA 552 >Q0K537.1 Q0K537_CUPNH 2-Isopropylmalate synthase EC=2.3.3.13 Length = 565 Score = 854 bits (2206), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/565 (70%), Positives = 467/565 (82%), Gaps = 2/565 (0%) Query: 2 MLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFEL 61 MLSNPA KY P +D+PDRTWP++ I P WMSTDLRDGNQALIEPMN RKLRFFE Sbjct: 1 MLSNPATKYHPAATVDIPDRTWPARTITRAPRWMSTDLRDGNQALIEPMNPARKLRFFEQ 60 Query: 62 LLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEGA 121 L+K GLKEIEV FP+ASQTDFDFVR LI E RIP+DV I+VLTQSR++LIRRT+ES+ GA Sbjct: 61 LVKIGLKEIEVAFPAASQTDFDFVRMLIEEQRIPEDVNIVVLTQSREDLIRRTVESVRGA 120 Query: 122 KKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESFS 181 +A VHLYN +APA+R+IVFN SREEIK +AV+GTRL++ LTDA PGT W +EYSPE+FS Sbjct: 121 ARATVHLYNPIAPAWRRIVFNASREEIKEVAVSGTRLIRSLTDAMPGTAWAYEYSPETFS 180 Query: 182 TTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRASTI 241 ELDFS E+ DAV W A P+R +ILNLP+TVEC+TPNV+ADQ+EWM R L R Sbjct: 181 LAELDFSLEVSDAVSAAWQAGPDRPMILNLPTTVECSTPNVFADQVEWMHRRLARREHIA 240 Query: 242 ISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGLD 301 +SVHPHNDRGTAVA+AELA+MAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGV PGLD Sbjct: 241 LSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVAPGLD 300 Query: 302 FSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPYL 361 FSDID VRQ VE CNQ+PVHPRHPYVGDLVFTAFSGSHQDAI+KGFA+QQPD IWEVPYL Sbjct: 301 FSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAQQQPDGIWEVPYL 360 Query: 362 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGKE 421 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQ +G+ +PRRLQIEFSRA+Q D TG E Sbjct: 361 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQVHGIYMPRRLQIEFSRAVQAMTDDTGLE 420 Query: 422 IAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNGP 481 +A D+H +FQREYL + P Y +H++ DS A IEV +VR+G+P +VRG+GNGP Sbjct: 421 ASADDLHGLFQREYLAQQTPLRYVSHQLVSDSGGA--TEIEVQMVRDGKPCSVRGTGNGP 478 Query: 482 IDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFKA 541 IDAFV+AL L +++MD+HEHA+ AGADA+AA Y+E+R+ ++PTGFG GIDAN+VTAS +A Sbjct: 479 IDAFVNALDLPVRVMDYHEHAMSAGADARAACYVEVRVGDSPTGFGAGIDANLVTASLRA 538 Query: 542 VLSAVNRQIAISESANQAGSSQAKA 566 V+S VNR + A QA S A Sbjct: 539 VISGVNRHLQAGFGAAQAPQSAEAA 563 >B2AHM5.1 LEU1_CUPTR 2-isopropylmalate synthase EC=2.3.3.13 Length = 569 Score = 844 bits (2181), Expect = 0.0, Method: Compositional matrix adjust. Identities = 394/549 (71%), Positives = 463/549 (84%), Gaps = 2/549 (0%) Query: 2 MLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFEL 61 ML NPA KYRP +D+PDRTWP + I P WMSTDLRDGNQALIEPMN RKLR FE Sbjct: 1 MLVNPATKYRPAATVDIPDRTWPGRTITRAPRWMSTDLRDGNQALIEPMNPARKLRLFEQ 60 Query: 62 LLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLEGA 121 L+K GLKEIEV FP+ASQTDFDFVR LI E RIPDDVTI+VLTQSR++LIRRT+ES+ GA Sbjct: 61 LVKIGLKEIEVAFPAASQTDFDFVRMLIEERRIPDDVTIVVLTQSREDLIRRTVESVRGA 120 Query: 122 KKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESFS 181 +A VHLYN +APA+R+IVFN SR+EIK +AV+GTRL+K LTDA P T W +EYSPE+FS Sbjct: 121 ARATVHLYNPIAPAWRRIVFNASRDEIKAVAVSGTRLIKALTDAMPETAWTYEYSPETFS 180 Query: 182 TTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRASTI 241 ELDFS E+ DAV W A P R +ILNLP+TVEC+TPNV+ADQIEWM R L RA + Sbjct: 181 LAELDFSLEVSDAVSAAWQAGPGRPMILNLPTTVECSTPNVFADQIEWMHRRLARRAHIV 240 Query: 242 ISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGLD 301 +SVHPHNDRGTAVA+AELA+MAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGV P LD Sbjct: 241 LSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVAPELD 300 Query: 302 FSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPYL 361 FSDID VRQ VE CNQ+PVHPRHPYVGDLVFTAFSGSHQDAI+KGFA+QQPDAIWEVPYL Sbjct: 301 FSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAQQQPDAIWEVPYL 360 Query: 362 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGKE 421 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQ +GL LPRRLQIEFSRA+Q D TG E Sbjct: 361 PIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQVHGLYLPRRLQIEFSRAVQAMTDDTGLE 420 Query: 422 IAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNGP 481 +A D++ +F+REYL R P Y +H+++ D++ A +I ++++ R+GQP TVRG+GNGP Sbjct: 421 ASADDLYGLFRREYLARETPLRYVSHQLASDATGATAITVQME--RDGQPCTVRGTGNGP 478 Query: 482 IDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFKA 541 IDAF+ AL L +++MD+HEHA+ AGADA+AA Y+E+R+ ++PTGFG GIDA++VTAS +A Sbjct: 479 IDAFIDALDLPVRVMDYHEHAMTAGADARAACYVEVRVGDSPTGFGAGIDASLVTASLRA 538 Query: 542 VLSAVNRQI 550 V+S VNR + Sbjct: 539 VVSGVNRHL 547 >A9HW07.1 LEU1_BORPD 2-isopropylmalate synthase EC=2.3.3.13 Length = 568 Score = 829 bits (2142), Expect = 0.0, Method: Compositional matrix adjust. Identities = 390/567 (68%), Positives = 471/567 (83%), Gaps = 4/567 (0%) Query: 2 MLSNPAAKYRPFP--AIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFF 59 ML+NPA KY PF A D +RTWPS+ I PPIWMSTDLRDGNQ+LIEPM+ ERKLRFF Sbjct: 1 MLANPATKYVPFAPFARDFSERTWPSRRITQPPIWMSTDLRDGNQSLIEPMSVERKLRFF 60 Query: 60 ELLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESLE 119 E L+K G KEIEVGFPSASQTDFDFVRKL+ E RIPDDVTIIVLTQSR++LI RT+E+ Sbjct: 61 EQLVKIGFKEIEVGFPSASQTDFDFVRKLVDEKRIPDDVTIIVLTQSREDLISRTVEAAA 120 Query: 120 GAKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPES 179 GAK+AIVHLYN+ APAFRK+VFNMS++EIK IA++GT+ VK+ P T+WR+EYSPE Sbjct: 121 GAKQAIVHLYNACAPAFRKVVFNMSKDEIKQIAISGTQWVKQYMAQHPETQWRYEYSPEV 180 Query: 180 FSTTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAS 239 FSTTE +F+ E+ +AV + W +PE K++LNLP+T+E TPN+YADQIEWM +NL R S Sbjct: 181 FSTTEPEFALEVSNAVADVWQPTPECKMVLNLPATIEATTPNLYADQIEWMHKNLARRDS 240 Query: 240 TIISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPG 299 ++SVHPHNDRGTAVA+AE AVMAGADR+EGCLFG+GERTGNVDLVTLALNLYTQGV+PG Sbjct: 241 IVLSVHPHNDRGTAVAAAEFAVMAGADRIEGCLFGSGERTGNVDLVTLALNLYTQGVHPG 300 Query: 300 LDFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVP 359 LDFSDID VR+ E CNQ+PVHPRHPY GDLVFTAFSGSHQDAIKKGFA+Q+PDA+WEVP Sbjct: 301 LDFSDIDEVRRCAEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGFAQQKPDAVWEVP 360 Query: 360 YLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATG 419 YLPIDPADLGRSYDAVIRVNSQSGKGG++YLLEQE+GL LPRRLQIEFSRAIQR D TG Sbjct: 361 YLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLEQEHGLVLPRRLQIEFSRAIQRVTDETG 420 Query: 420 KEIAASDIHAIFQREYLERVEPYVYRAHRMSEDSS--KAESINIEVDIVRNGQPVTVRGS 477 +E+ A D+H IF REYLE+ P+ HR+ D + + + +I+V++ NG+ V GS Sbjct: 421 REVTADDVHTIFNREYLEQHSPWKLVRHRIDGDPAGGQGKQFSIQVELDYNGERRVVTGS 480 Query: 478 GNGPIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTA 537 G+G I AFV ALG+ +++MD+HEHAIG G D +AASY+ELR+ ++ TGFGVGID +IVTA Sbjct: 481 GDGAISAFVAALGIPVRIMDYHEHAIGTGTDTRAASYVELRVGDSATGFGVGIDRDIVTA 540 Query: 538 SFKAVLSAVNRQIAISESANQAGSSQA 564 SF+AVLSAVNR +A + ++ ++QA Sbjct: 541 SFQAVLSAVNRHLANGVTVTESETAQA 567 >E5U8H2.1 E5U8H2_ALCXX 2-isopropylmalate synthase EC=2.3.3.13 Length = 569 Score = 829 bits (2141), Expect = 0.0, Method: Compositional matrix adjust. Identities = 394/568 (69%), Positives = 466/568 (82%), Gaps = 4/568 (0%) Query: 1 MMLSNPAAKYRPFP--AIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRF 58 MML+NPA KY PF A D +RTWPS+ I PPIWMSTDLRDGNQALIEPM+ ERKLRF Sbjct: 1 MMLANPATKYVPFTPFARDFSERTWPSRRITQPPIWMSTDLRDGNQALIEPMSVERKLRF 60 Query: 59 FELLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESL 118 FE L+K G KEIEVGFPSASQTDFDFVRKLI E RIPDDVTIIVLTQSR++LI RT+ES Sbjct: 61 FEQLVKIGFKEIEVGFPSASQTDFDFVRKLIDEKRIPDDVTIIVLTQSREDLISRTVESA 120 Query: 119 EGAKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPE 178 GAK+AIVHLYN+ APAFRK+VFNM+++EIKNIA TGTRLVK+ P T+WR++YSPE Sbjct: 121 AGAKQAIVHLYNACAPAFRKVVFNMTKDEIKNIATTGTRLVKQYMARHPETKWRYQYSPE 180 Query: 179 SFSTTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRA 238 FSTTE +F+ E+ +AV + W +P+ K++LNLP+T+E TPN+YADQIEWM +NL R Sbjct: 181 VFSTTEPEFALEVSNAVADVWEPTPDCKMVLNLPATIEATTPNMYADQIEWMHKNLARRD 240 Query: 239 STIISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNP 298 S ++SVHPHNDRGTAVA+AE AVMAGADR+EGCLFG+GERTGNVDLVTLALNLYTQGV+P Sbjct: 241 SIVLSVHPHNDRGTAVAAAEFAVMAGADRIEGCLFGSGERTGNVDLVTLALNLYTQGVHP 300 Query: 299 GLDFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEV 358 GLDFSDID VR+ E CNQ+PVHPRHPY GDLVFTAFSGSHQDAIKKGFA+QQPDA+WEV Sbjct: 301 GLDFSDIDEVRRCAEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGFAQQQPDAVWEV 360 Query: 359 PYLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADAT 418 PYLPIDPADLGRSYDAVIRVNSQSGKGG++YLLEQE+GL LPRRLQIEFSRAIQR D T Sbjct: 361 PYLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLEQEHGLVLPRRLQIEFSRAIQRVTDET 420 Query: 419 GKEIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAES--INIEVDIVRNGQPVTVRG 476 G+E+ A D+H IF REYLE+ P+ HR+ + + E +IE ++ NG+ V G Sbjct: 421 GREVTADDVHTIFNREYLEQKAPWKLVRHRIDGNPAAGEGQHFSIEAELEYNGERRIVTG 480 Query: 477 SGNGPIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVT 536 G+G I AFV AL + +++MD+HEHAIG G D +AASY+ELR+ ++ TGFGVGID +IVT Sbjct: 481 KGDGAISAFVAALDVPVRIMDYHEHAIGTGTDTRAASYVELRVGDSSTGFGVGIDRDIVT 540 Query: 537 ASFKAVLSAVNRQIAISESANQAGSSQA 564 ASF+AVLSAVNR I + ++QA Sbjct: 541 ASFQAVLSAVNRHINAGAVITEQEAAQA 568 >E3HPC1.1 E3HPC1_ACHXA 2-isopropylmalate synthase EC=2.3.3.13 Length = 570 Score = 825 bits (2131), Expect = 0.0, Method: Compositional matrix adjust. Identities = 390/554 (70%), Positives = 458/554 (82%), Gaps = 4/554 (0%) Query: 1 MMLSNPAAKYRPFPAI--DLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRF 58 MML+NPA KY PF D +RTWPS+ I PIWMSTDLRDGNQALIEPM+ ERK+RF Sbjct: 1 MMLANPATKYVPFAPFTRDFSERTWPSRRITKAPIWMSTDLRDGNQALIEPMSVERKVRF 60 Query: 59 FELLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESL 118 FE L+K G KEIEVGFPSASQTDFDFVRKLI E RIPDDVTIIVLTQSR++LI RT+ES Sbjct: 61 FEQLVKIGFKEIEVGFPSASQTDFDFVRKLIDEKRIPDDVTIIVLTQSREDLISRTVESA 120 Query: 119 EGAKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPE 178 GAK+AIVHLYN+ APAFRK+VFNMS++EIKNIA TGTRLVK+ P T+WR++YSPE Sbjct: 121 AGAKQAIVHLYNACAPAFRKVVFNMSKDEIKNIATTGTRLVKQYMAQHPETQWRYQYSPE 180 Query: 179 SFSTTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRA 238 FSTTE +F+ E+ +AV + W +P+ K++LNLP+T+E +PN+YADQIEWM +NL R Sbjct: 181 VFSTTEPEFALEVSNAVADVWQPTPDCKMVLNLPATIEATSPNLYADQIEWMHKNLARRD 240 Query: 239 STIISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNP 298 S ++SVHPHNDRGTAVA+AE AVMAGADR+EGCLFG+GERTGNVDLVTLALNLYTQGV+P Sbjct: 241 SIVLSVHPHNDRGTAVAAAEFAVMAGADRIEGCLFGSGERTGNVDLVTLALNLYTQGVHP 300 Query: 299 GLDFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEV 358 GLDFSDID VR+ E CNQ+PVHPRHPY GDLVFTAFSGSHQDAIKKGFA+QQ DA+WEV Sbjct: 301 GLDFSDIDEVRRCAEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGFAQQQADAVWEV 360 Query: 359 PYLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADAT 418 PYLPIDPADLGRSYDAVIRVNSQSGKGG++YLLEQE+GL LPRRLQIEFSRAIQR D T Sbjct: 361 PYLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLEQEHGLVLPRRLQIEFSRAIQRVTDET 420 Query: 419 GKEIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAES--INIEVDIVRNGQPVTVRG 476 G+E+ A D+H IF REYLE+ P+ HR+ + S E +IE ++ NG+ V G Sbjct: 421 GREVTADDVHTIFNREYLEQKSPWKLVRHRIDGNPSAGEGQHFSIEAELEYNGERRIVTG 480 Query: 477 SGNGPIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVT 536 G+G I AFV AL + +++MD+HEHAIG G D +AASY+ELR+ E+ TGFGVGID +IVT Sbjct: 481 KGDGAISAFVAALDVPVRIMDYHEHAIGTGTDTRAASYVELRVGESSTGFGVGIDRDIVT 540 Query: 537 ASFKAVLSAVNRQI 550 ASF+AVLSAVNR I Sbjct: 541 ASFQAVLSAVNRHI 554 >Q7W2R5.1 Q7W2R5_BORPA 2-isopropylmalate synthase EC=2.3.3.13 Length = 568 Score = 825 bits (2130), Expect = 0.0, Method: Compositional matrix adjust. Identities = 392/571 (68%), Positives = 471/571 (82%), Gaps = 7/571 (1%) Query: 1 MMLSNPAAKYRPFP--AIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRF 58 MML+NPA KY PF A D +RTWPS+ I PPIWMSTDLRDGNQ+LIEPM+ ERK+RF Sbjct: 1 MMLANPATKYVPFQPFARDFAERTWPSRRITQPPIWMSTDLRDGNQSLIEPMSVERKVRF 60 Query: 59 FELLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESL 118 FE L+K G KEIEVGFPSASQTDFDFVRKLI E RIPDDVTIIVLTQSR++LI RT+E+ Sbjct: 61 FEQLVKIGFKEIEVGFPSASQTDFDFVRKLIDEKRIPDDVTIIVLTQSREDLISRTVEAA 120 Query: 119 EGAKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPE 178 GA++A++HLYN+ APAFRKIVFNMSR+EIKNIAVTGTR+VK+ P T+WR+EYSPE Sbjct: 121 AGARQAMIHLYNACAPAFRKIVFNMSRDEIKNIAVTGTRMVKQYMAKYPQTQWRYEYSPE 180 Query: 179 SFSTTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRA 238 FSTTE +F+ ++ +AV + W A+P+RK++LNLP+T+E +PN+YADQIEWM +NL R Sbjct: 181 VFSTTEPEFALDVSNAVADEWYATPQRKMVLNLPATIEATSPNMYADQIEWMHKNLARRD 240 Query: 239 STIISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNP 298 S ++SVHPHNDRGTAVA+AE AVMAGADR+EGCLFG+GERTGNVDLVTLALNLYTQGV+P Sbjct: 241 SIVLSVHPHNDRGTAVAAAEFAVMAGADRIEGCLFGSGERTGNVDLVTLALNLYTQGVHP 300 Query: 299 GLDFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEV 358 GLDFSDID VR+ E CNQ+PVHPRHPY GDLVFTAFSGSHQDAIKKGFA+QQ DA WEV Sbjct: 301 GLDFSDIDEVRRCAEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGFAQQQADAPWEV 360 Query: 359 PYLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADAT 418 PYLPIDPADLGRSYDAVIRVNSQSGKGG++YLLEQE+GL LPRRLQIEFSRAIQR D T Sbjct: 361 PYLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLEQEHGLVLPRRLQIEFSRAIQRVTDET 420 Query: 419 GKEIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAES--INIEVDIVRNGQPVTVRG 476 G+E+++ D++ IF EYL + +P+ HR+ D S E +IE ++ NG+ V+G Sbjct: 421 GREVSSDDVYTIFDSEYLAQQQPWQLVRHRIDGDPSAGEGKHFSIEAELSFNGERRIVKG 480 Query: 477 SGNGPIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVT 536 SG+G I AFV AL + +++MD+HEHAIG G D +AA Y+E+R+ ++PTGFGVGID +IVT Sbjct: 481 SGDGAISAFVAALDVPVRIMDYHEHAIGTGTDTRAACYVEVRVGDSPTGFGVGIDRDIVT 540 Query: 537 ASFKAVLSAVNRQIAISESANQAGSSQAKAA 567 ASFKAVL AVNR +A QA ++A AA Sbjct: 541 ASFKAVLGAVNRHHV---AATQATETEAVAA 568 >Q7WDR3.1 Q7WDR3_BORBR 2-isopropylmalate synthase EC=2.3.3.13 Length = 568 Score = 825 bits (2130), Expect = 0.0, Method: Compositional matrix adjust. Identities = 392/571 (68%), Positives = 471/571 (82%), Gaps = 7/571 (1%) Query: 1 MMLSNPAAKYRPFP--AIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRF 58 MML+NPA KY PF A D +RTWPS+ I PPIWMSTDLRDGNQ+LIEPM+ ERK+RF Sbjct: 1 MMLANPATKYVPFQPFARDFAERTWPSRRITQPPIWMSTDLRDGNQSLIEPMSVERKVRF 60 Query: 59 FELLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSRDELIRRTIESL 118 FE L+K G KEIEVGFPSASQTDFDFVRKLI E RIPDDVTIIVLTQSR++LI RT+E+ Sbjct: 61 FEQLVKIGFKEIEVGFPSASQTDFDFVRKLIDEKRIPDDVTIIVLTQSREDLISRTVEAA 120 Query: 119 EGAKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPE 178 GA++A++HLYN+ APAFRKIVFNMSR+EIKNIAVTGTR+VK+ P T+WR+EYSPE Sbjct: 121 AGARQAMIHLYNACAPAFRKIVFNMSRDEIKNIAVTGTRMVKQYMAKYPQTQWRYEYSPE 180 Query: 179 SFSTTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRA 238 FSTTE +F+ ++ +AV + W A+P+RK++LNLP+T+E +PN+YADQIEWM +NL R Sbjct: 181 VFSTTEPEFALDVSNAVADEWDATPQRKMVLNLPATIEATSPNMYADQIEWMHKNLARRD 240 Query: 239 STIISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNP 298 S ++SVHPHNDRGTAVA+AE AVMAGADR+EGCLFG+GERTGNVDLVTLALNLYTQGV+P Sbjct: 241 SIVLSVHPHNDRGTAVAAAEFAVMAGADRIEGCLFGSGERTGNVDLVTLALNLYTQGVHP 300 Query: 299 GLDFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEV 358 GLDFSDID VR+ E CNQ+PVHPRHPY GDLVFTAFSGSHQDAIKKGFA+QQ DA WEV Sbjct: 301 GLDFSDIDEVRRCAEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGFAQQQADAPWEV 360 Query: 359 PYLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADAT 418 PYLPIDPADLGRSYDAVIRVNSQSGKGG++YLLEQE+GL LPRRLQIEFSRAIQR D T Sbjct: 361 PYLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLEQEHGLVLPRRLQIEFSRAIQRVTDET 420 Query: 419 GKEIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAES--INIEVDIVRNGQPVTVRG 476 G+E+++ D++ IF EYL + +P+ HR+ D S E +IE ++ NG+ V+G Sbjct: 421 GREVSSDDVYTIFDSEYLAQQQPWQLVRHRIDGDPSAGEGKHFSIEAELSFNGERRIVKG 480 Query: 477 SGNGPIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVT 536 SG+G I AFV AL + +++MD+HEHAIG G D +AA Y+E+R+ ++PTGFGVGID +IVT Sbjct: 481 SGDGAISAFVAALDVPVRIMDYHEHAIGTGTDTRAACYVEVRVGDSPTGFGVGIDRDIVT 540 Query: 537 ASFKAVLSAVNRQIAISESANQAGSSQAKAA 567 ASFKAVL AVNR +A QA ++A AA Sbjct: 541 ASFKAVLGAVNRHHV---AATQATETEAVAA 568