BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0070.p (204 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IXN8.1 D8IXN8_HERSS Bifunctional enzyme: cobinamide kinase/cob... 409 e-112 A6SWZ0.1 A6SWZ0_JANMA Cobinamide kinase / conamide phosphate gua... 217 9e-55 A4G3R2.1 A4G3R2_HERAR Bifunctional adenosylcobalamin biosynthesi... 202 2e-50 D8N8F2.1 D8N8F2_RALSO Bifunctional cobinamide kinase and cobinam... 188 4e-46 D8NQY6.1 D8NQY6_RALSO Bifunctional cobinamide kinase and cobinam... 187 9e-46 B5RV91.1 B5RV91_RALSO Cobalamin biosynthesis bifunctional protei... 186 2e-45 D8P065.1 D8P065_RALSO Bifunctional cobinamide kinase and cobinam... 185 3e-45 B5SHY8.1 B5SHY8_RALSO Cobalamin biosynthesis bifunctional protei... 185 3e-45 A3RRV2.1 A3RRV2_RALSO Cobinamide kinase / cobinamide phosphate g... 185 3e-45 Q8XWS9.1 Q8XWS9_RALSO Probable cobalamin biosynthesis bifunction... 184 4e-45 >D8IXN8.1 D8IXN8_HERSS Bifunctional enzyme: cobinamide kinase/cobinamide phosphate guanylyltransferase protein EC=2.7.-.- Length = 204 Score = 409 bits (1051), Expect = e-112, Method: Compositional matrix adjust. Identities = 204/204 (100%), Positives = 204/204 (100%) Query: 1 MNTAPTRRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQ 60 MNTAPTRRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQ Sbjct: 1 MNTAPTRRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQ 60 Query: 61 RIDQHQQRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFP 120 RIDQHQQRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFP Sbjct: 61 RIDQHQQRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFP 120 Query: 121 DAGPIVPPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQA 180 DAGPIVPPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQA Sbjct: 121 DAGPIVPPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQA 180 Query: 181 VAAQCERVQWVAAGLPLSLKDLPC 204 VAAQCERVQWVAAGLPLSLKDLPC Sbjct: 181 VAAQCERVQWVAAGLPLSLKDLPC 204 >A6SWZ0.1 A6SWZ0_JANMA Cobinamide kinase / conamide phosphate guanylyltransferase EC=2.7.1.- Length = 182 Score = 217 bits (552), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 114/193 (59%), Positives = 139/193 (72%), Gaps = 14/193 (7%) Query: 8 RSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQQ 67 R+L+ GGARSGKSAHAE LA A+ G ++Y+ATA DAEMQ RI H+ Sbjct: 3 RTLVIGGARSGKSAHAEALATAS-------GKPVVYIATAQ----AGDAEMQLRIAHHRA 51 Query: 68 RRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIVP 127 RR G+W+TVEE LALG A++ +++ ++LVDCLTVWL+NLLF++ EFP+ G I Sbjct: 52 RRD---GQWQTVEETLALGDAIQQYSREDNLILVDCLTVWLSNLLFSENREFPEVGTIAA 108 Query: 128 PPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCER 187 P FT QR FL AL + G++ILVSNEVG GIVPQGAISRWFVDEAGRLNQ+VAA CER Sbjct: 109 PAYFTEQRAAFLQALTQAAGDIILVSNEVGQGIVPQGAISRWFVDEAGRLNQSVAATCER 168 Query: 188 VQWVAAGLPLSLK 200 V AGLPL+LK Sbjct: 169 AVLVVAGLPLTLK 181 >A4G3R2.1 A4G3R2_HERAR Bifunctional adenosylcobalamin biosynthesis protein cobU EC=2.7.1.156 EC=2.7.7.62 Length = 182 Score = 202 bits (515), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 113/193 (58%), Positives = 131/193 (67%), Gaps = 14/193 (7%) Query: 8 RSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQQ 67 R+L+ GGARSGKSA A A AG ++Y+ATA DAEMQ RI H+ Sbjct: 3 RTLVIGGARSGKSA-------HAEALATAAGKPVVYIATAQ----AGDAEMQARIAHHRA 51 Query: 68 RRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIVP 127 RR W TVEE L LGAA+ H+ P +V+VDCLTVWL+NLLFA+ +FP+ G I Sbjct: 52 RRDS---HWVTVEEVLTLGAAIEKHSTPDNLVMVDCLTVWLSNLLFAEKNQFPEIGAIDA 108 Query: 128 PPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCER 187 P FT QR L AL + RG+VILVSNEVG GIVPQGA+SRWFVDEAGRLNQAVAA CER Sbjct: 109 PACFTEQRAALLQALMQARGDVILVSNEVGQGIVPQGAVSRWFVDEAGRLNQAVAAACER 168 Query: 188 VQWVAAGLPLSLK 200 V AGLPL+LK Sbjct: 169 AVLVVAGLPLALK 181 >D8N8F2.1 D8N8F2_RALSO Bifunctional cobinamide kinase and cobinamide phosphate guanylyltransferase EC=2.7.1.156 EC=2.7.7.62 Length = 193 Score = 188 bits (477), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 103/194 (53%), Positives = 133/194 (68%), Gaps = 14/194 (7%) Query: 7 RRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQ 66 R +L+ GGARSGKS HAE+LAL Q G + Y+ATA S D EMQ RI H+ Sbjct: 4 RLTLVLGGARSGKSHHAEQLAL-------QCAGPVTYIATARES----DEEMQLRIALHR 52 Query: 67 QRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIV 126 RR E +W VEEP+ L L THA+ G VLVDCLT+WL NLLFA G ++P+ GPI Sbjct: 53 ARRPE---QWTIVEEPVRLAETLYTHARHGGCVLVDCLTLWLNNLLFAGGHDYPETGPIT 109 Query: 127 PPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCE 186 PP A++ + E L AL + GEVILVSNE+G+G+VP GA++R++VDE GRLNQ +AAQ + Sbjct: 110 PPEAWSAEIEALLTALPLLPGEVILVSNEIGLGVVPMGAVTRFYVDELGRLNQRLAAQAD 169 Query: 187 RVQWVAAGLPLSLK 200 RV + AG+P+ +K Sbjct: 170 RVHLLVAGIPMPVK 183 >D8NQY6.1 D8NQY6_RALSO Bifunctional cobinamide kinase and cobinamide phosphate guanylyltransferase EC=2.7.1.156 EC=2.7.7.62 Length = 193 Score = 187 bits (474), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 101/194 (52%), Positives = 132/194 (68%), Gaps = 14/194 (7%) Query: 7 RRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQ 66 R +L+ GGARSGKS HAE+LAL Q G I Y+ATA S D EMQ RI H+ Sbjct: 4 RLTLVLGGARSGKSHHAEQLAL-------QCAGPITYIATARES----DEEMQLRIALHR 52 Query: 67 QRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIV 126 RR E +W +EEP+ L L HA+ G VLVDCLT+WL NLLFA G ++P+ GPI Sbjct: 53 ARRPE---QWTVIEEPVRLAETLYAHARHGGCVLVDCLTLWLNNLLFAGGHDYPETGPIT 109 Query: 127 PPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCE 186 PP A++ + E L AL + GE+ILVSNE+G+G++P GAI+R++VDE GRLNQ +AAQ + Sbjct: 110 PPEAWSAETEALLTALPLLPGEIILVSNEIGLGVIPMGAITRFYVDELGRLNQRLAAQAD 169 Query: 187 RVQWVAAGLPLSLK 200 RV + AG+P+ +K Sbjct: 170 RVHLLVAGIPMPVK 183 >B5RV91.1 B5RV91_RALSO Cobalamin biosynthesis bifunctional protein: cobinamide kinase and cobinamide phosphate guanylyltransferase EC=2.-.-.- EC=2.7.-.- Length = 193 Score = 186 bits (471), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 100/194 (51%), Positives = 132/194 (68%), Gaps = 14/194 (7%) Query: 7 RRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQ 66 R +L+ GGARSGKS HAE+LAL Q G + Y+ATA S D EMQ RI H+ Sbjct: 4 RLTLVLGGARSGKSHHAEQLAL-------QCAGPVTYIATARES----DEEMQLRIALHR 52 Query: 67 QRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIV 126 RR + +W +EEP+ L L HA+ G VLVDCLT+WL NLLFA G ++P+ GPI Sbjct: 53 ARRPD---QWTVIEEPVRLAETLYAHARHGGCVLVDCLTLWLNNLLFAGGHDYPETGPIT 109 Query: 127 PPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCE 186 PP A++ + E L AL + GE+ILVSNE+G+G+VP GAI+R++VDE GRLNQ +AAQ + Sbjct: 110 PPEAWSAETEALLTALPLLPGEIILVSNEIGLGVVPMGAITRFYVDELGRLNQRLAAQAD 169 Query: 187 RVQWVAAGLPLSLK 200 RV + AG+P+ +K Sbjct: 170 RVHLLVAGIPMPVK 183 >D8P065.1 D8P065_RALSO Bifunctional cobinamide kinase and cobinamide phosphate guanylyltransferase EC=2.7.1.156 EC=2.7.7.62 Length = 193 Score = 185 bits (470), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 101/194 (52%), Positives = 132/194 (68%), Gaps = 14/194 (7%) Query: 7 RRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQ 66 R +L+ GGARSGKS HAE+LAL Q G + Y+ATA S D EMQ RI H+ Sbjct: 4 RLTLVLGGARSGKSHHAEQLAL-------QCAGPVTYIATARES----DEEMQLRIALHR 52 Query: 67 QRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIV 126 RR E +W +EEP+ L L HA+ G VLVDCLT+WL NLLFA G ++P+ GPI Sbjct: 53 ARRPE---QWIVIEEPVRLAETLYAHARHGGCVLVDCLTLWLNNLLFASGHDYPETGPIT 109 Query: 127 PPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCE 186 PP A++ + E L AL + GEVILVSNE+G+G+VP GA++R++VDE GRLNQ +AAQ + Sbjct: 110 PPEAWSAEIEALLTALPLLPGEVILVSNEIGLGVVPMGAVTRFYVDELGRLNQRLAAQAD 169 Query: 187 RVQWVAAGLPLSLK 200 RV + AG+P+ +K Sbjct: 170 RVHLLVAGIPMPVK 183 >B5SHY8.1 B5SHY8_RALSO Cobalamin biosynthesis bifunctional protein: cobinamide kinase and cobinamide phosphate guanylyltransferase EC=2.-.-.- EC=2.7.-.- Length = 193 Score = 185 bits (470), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 100/194 (51%), Positives = 132/194 (68%), Gaps = 14/194 (7%) Query: 7 RRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQ 66 R +L+ GGARSGKS HAE+LAL Q G + Y+ATA S D EMQ RI H+ Sbjct: 4 RLTLVLGGARSGKSHHAEQLAL-------QCAGPVTYIATARES----DEEMQLRIALHR 52 Query: 67 QRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIV 126 RR + +W +EEP+ L L HA+ G VLVDCLT+WL NLLFA G ++P+ GPI Sbjct: 53 ARRPD---QWTVIEEPVRLAETLYAHARHGGCVLVDCLTLWLNNLLFAGGHDYPETGPIT 109 Query: 127 PPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCE 186 PP A++ + E L AL + GE+ILVSNE+G+G+VP GAI+R++VDE GRLNQ +AAQ + Sbjct: 110 PPEAWSAETEALLTALPLLPGEIILVSNEIGLGVVPMGAITRFYVDELGRLNQRLAAQAD 169 Query: 187 RVQWVAAGLPLSLK 200 RV + AG+P+ +K Sbjct: 170 RVHLLVAGIPMPVK 183 >A3RRV2.1 A3RRV2_RALSO Cobinamide kinase / cobinamide phosphate guanylyltransferase EC=2.7.1.- EC=2.7.7.- Length = 193 Score = 185 bits (470), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 100/194 (51%), Positives = 132/194 (68%), Gaps = 14/194 (7%) Query: 7 RRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQ 66 R +L+ GGARSGKS HAE+LAL Q G + Y+ATA S D EMQ RI H+ Sbjct: 4 RLTLVLGGARSGKSHHAEQLAL-------QCAGPVTYIATARES----DEEMQLRIALHR 52 Query: 67 QRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIV 126 RR + +W +EEP+ L L HA+ G VLVDCLT+WL NLLFA G ++P+ GPI Sbjct: 53 ARRPD---QWTVIEEPVRLAETLYAHARHGGCVLVDCLTLWLNNLLFAGGHDYPETGPIT 109 Query: 127 PPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCE 186 PP A++ + E L AL + GE+ILVSNE+G+G+VP GAI+R++VDE GRLNQ +AAQ + Sbjct: 110 PPEAWSAETEALLTALPLLPGEIILVSNEIGLGVVPMGAITRFYVDELGRLNQRLAAQAD 169 Query: 187 RVQWVAAGLPLSLK 200 RV + AG+P+ +K Sbjct: 170 RVHLLVAGIPMPVK 183 >Q8XWS9.1 Q8XWS9_RALSO Probable cobalamin biosynthesis bifunctional protein: cobinamide kinase and cobinamide phosphate guanylyltransferase EC=2.-.-.- EC=2.7.-.- Length = 193 Score = 184 bits (468), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 102/194 (52%), Positives = 131/194 (67%), Gaps = 14/194 (7%) Query: 7 RRSLIFGGARSGKSAHAERLALAALASQAQAGGEILYLATASRSASGDDAEMQQRIDQHQ 66 R +L+ GGARSGKS HAE+LAL Q G + Y+ATA S D EMQ RI H+ Sbjct: 4 RLTLVLGGARSGKSHHAEQLAL-------QCAGPVTYIATARES----DEEMQLRIALHR 52 Query: 67 QRRSELGGRWRTVEEPLALGAALRTHAQPGQVVLVDCLTVWLANLLFADGIEFPDAGPIV 126 RR E +W VEEP+ L L HA+ G VLVDCLT+WL NLLFA G +P+ GPI Sbjct: 53 ARRPE---QWSVVEEPVRLAETLYAHARHGGCVLVDCLTLWLNNLLFAGGHAYPETGPIT 109 Query: 127 PPPAFTRQREDFLLALQEVRGEVILVSNEVGMGIVPQGAISRWFVDEAGRLNQAVAAQCE 186 PP A++ + E L AL + GEVILVSNE+G+G+VP GA++R++VDE GRLNQ +AAQ + Sbjct: 110 PPEAWSAEIEALLTALPLLPGEVILVSNEIGLGVVPMGAVTRFYVDELGRLNQRLAAQAD 169 Query: 187 RVQWVAAGLPLSLK 200 RV + AG+P+ +K Sbjct: 170 RVHLLVAGIPMPVK 183