BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0142.p (401 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ZbaeS [T] COG0642 Signal transduction histidine kinase EcZ Esche... 164 3e-40 ECs2886 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 164 3e-40 baeS [T] COG0642 Signal transduction histidine kinase Eco Escher... 164 3e-40 STM2130 [T] COG0642 Signal transduction histidine kinase Sty Sal... 162 2e-39 SP0084 [T] COG0642 Signal transduction histidine kinase Spn Stre... 134 3e-31 slr0533 [T] COG0642 Signal transduction histidine kinase Syn Syn... 133 7e-31 BH1945 [T] COG0642 Signal transduction histidine kinase Bha Baci... 131 3e-30 RSp1162 [T] COG0642 Signal transduction histidine kinase Rso Ral... 126 9e-29 all4726 [T] COG0642 Signal transduction histidine kinase Nos Nos... 124 4e-28 CAC3219 [T] COG0642 Signal transduction histidine kinase Cac Clo... 121 4e-27 >ZbaeS [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 467 Score = 164 bits (415), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 99/272 (36%), Positives = 149/272 (54%), Gaps = 18/272 (6%) Query: 131 AARRLAAGDFSARALSCKQVPAALDALMRDVNEMAERLERRERELHASSAAIAHELRTPL 190 +LAAGDF+ R + L L +D N++A LE+ ++ A I+HELRTPL Sbjct: 199 GTHKLAAGDFTTRVTPTSE--DELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPL 256 Query: 191 TAAKARLQGIMDGIFDRSPQQLSMIMRQLDQLNRLISDLYLLSLVSAGQLALVRTQFLLR 250 + L+ I DG+ +P+ ++ + ++ L +L+ DL+ LS+ G LA + L Sbjct: 257 AVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLI 316 Query: 251 PLLEE-----RVAWAAPSLRL---LPMSTALYCCEHLPLNADRDRLGQAISILIDNALRY 302 PLLE R +A+ L+L LP S ++ DRDRL Q + L++N+LRY Sbjct: 317 PLLEVAGGAFRERFASRGLKLQFSLPDSITVF--------GDRDRLMQLFNNLLENSLRY 368 Query: 303 AASGKLLTISAGLHDGQIHIDVEDDGPGFAPEHLELACDRFWRAEHSRSRHAGGSGLGLA 362 SG L ISA HD + + D PG + + L+ +RF+R E SR+R +GGSGLGLA Sbjct: 369 TDSGGSLKISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLA 428 Query: 363 VAVAICEAHGGKLSVHNRPAGGARMHLELPAE 394 + + I EAH G++ + P GG + +ELP E Sbjct: 429 ICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 460 >ECs2886 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 467 Score = 164 bits (415), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 99/272 (36%), Positives = 149/272 (54%), Gaps = 18/272 (6%) Query: 131 AARRLAAGDFSARALSCKQVPAALDALMRDVNEMAERLERRERELHASSAAIAHELRTPL 190 +LAAGDF+ R + L L +D N++A LE+ ++ A I+HELRTPL Sbjct: 199 GTHKLAAGDFTTRVTPTSE--DELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPL 256 Query: 191 TAAKARLQGIMDGIFDRSPQQLSMIMRQLDQLNRLISDLYLLSLVSAGQLALVRTQFLLR 250 + L+ I DG+ +P+ ++ + ++ L +L+ DL+ LS+ G LA + L Sbjct: 257 AVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLI 316 Query: 251 PLLEE-----RVAWAAPSLRL---LPMSTALYCCEHLPLNADRDRLGQAISILIDNALRY 302 PLLE R +A+ L+L LP S ++ DRDRL Q + L++N+LRY Sbjct: 317 PLLEVAGGAFRERFASRGLKLQFSLPDSITVF--------GDRDRLMQLFNNLLENSLRY 368 Query: 303 AASGKLLTISAGLHDGQIHIDVEDDGPGFAPEHLELACDRFWRAEHSRSRHAGGSGLGLA 362 SG L ISA HD + + D PG + + L+ +RF+R E SR+R +GGSGLGLA Sbjct: 369 TDSGGSLKISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLA 428 Query: 363 VAVAICEAHGGKLSVHNRPAGGARMHLELPAE 394 + + I EAH G++ + P GG + +ELP E Sbjct: 429 ICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 460 >baeS [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 467 Score = 164 bits (415), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 99/272 (36%), Positives = 149/272 (54%), Gaps = 18/272 (6%) Query: 131 AARRLAAGDFSARALSCKQVPAALDALMRDVNEMAERLERRERELHASSAAIAHELRTPL 190 +LAAGDF+ R + L L +D N++A LE+ ++ A I+HELRTPL Sbjct: 199 GTHKLAAGDFTTRVTPTSE--DELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPL 256 Query: 191 TAAKARLQGIMDGIFDRSPQQLSMIMRQLDQLNRLISDLYLLSLVSAGQLALVRTQFLLR 250 + L+ I DG+ +P+ ++ + ++ L +L+ DL+ LS+ G LA + L Sbjct: 257 AVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLI 316 Query: 251 PLLEE-----RVAWAAPSLRL---LPMSTALYCCEHLPLNADRDRLGQAISILIDNALRY 302 PLLE R +A+ L+L LP S ++ DRDRL Q + L++N+LRY Sbjct: 317 PLLEVAGGAFRERFASRGLKLQFSLPDSITVF--------GDRDRLMQLFNNLLENSLRY 368 Query: 303 AASGKLLTISAGLHDGQIHIDVEDDGPGFAPEHLELACDRFWRAEHSRSRHAGGSGLGLA 362 SG L ISAG D + + D PG + + L+ +RF+R E SR+R +GGSGLGLA Sbjct: 369 TDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLA 428 Query: 363 VAVAICEAHGGKLSVHNRPAGGARMHLELPAE 394 + + I EAH G++ + P GG + +ELP E Sbjct: 429 ICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 460 >STM2130 [T] COG0642 Signal transduction histidine kinase Sty Salmonella typhimurium LT2 Length = 467 Score = 162 bits (409), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 100/264 (37%), Positives = 141/264 (53%), Gaps = 6/264 (2%) Query: 131 AARRLAAGDFSARALSCKQVPAALDALMRDVNEMAERLERRERELHASSAAIAHELRTPL 190 RLAAGDF+ R L L +D N++A LE+ ++ A I+HELRTPL Sbjct: 199 GTHRLAAGDFTTRVTPTS--ADELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPL 256 Query: 191 TAAKARLQGIMDGIFDRSPQQLSMIMRQLDQLNRLISDLYLLSLVSAGQLALVRTQFLLR 250 + L+ I DG+ +P+ ++ + ++ L +L+ DL+ LSL G LA +T L Sbjct: 257 AVLRGELEAIQDGVRQFTPESVTSLQAEVGTLTKLVDDLHQLSLSDEGALAYQKTTVDLV 316 Query: 251 PLLEERVAWAAPSLRLLPMSTALYCC--EHLPLNADRDRLGQAISILIDNALRYAASGKL 308 PLLE VA A R L+ + + + D DRL Q + L++N+LRY SG Sbjct: 317 PLLE--VAGGAFRERFTSRGLTLHYALPDSMTVFGDPDRLMQLFNNLLENSLRYTDSGGG 374 Query: 309 LTISAGLHDGQIHIDVEDDGPGFAPEHLELACDRFWRAEHSRSRHAGGSGLGLAVAVAIC 368 L ISA D + + D PG + E L+ DRF+R E SR+R +GGSGLGLA+ V I Sbjct: 375 LHISAEQRDKSLFLTFADSAPGVSDEQLQKLFDRFYRTEVSRNRASGGSGLGLAICVNIV 434 Query: 369 EAHGGKLSVHNRPAGGARMHLELP 392 AH G L + P GG + +ELP Sbjct: 435 HAHNGHLHAAHSPFGGVSITVELP 458 >SP0084 [T] COG0642 Signal transduction histidine kinase Spn Streptococcus pneumoniae TIGR4 Length = 350 Score = 134 bits (338), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 103/322 (31%), Positives = 164/322 (50%), Gaps = 33/322 (10%) Query: 97 LWFSLLVLIALPLIVGAGLMLSLRLS--RHLDAVAVAARRLAAGDFSARALSCKQVPAAL 154 ++F LL + + +VGAG+ L L L L + A+R+AA DF + L Q P Sbjct: 36 IYF-LLGMTIVASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDFPSN-LEV-QGPVEF 92 Query: 155 DALMRDVNEMA-------ERLERRERELHASSAAIAHELRTPLTAAKARLQGIMDGIFDR 207 L + NEM+ + LE ERE A ++H+++TP+T+ +A ++GI+DGI Sbjct: 93 QQLGQTFNEMSHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKE 152 Query: 208 SPQ--QLSMIMRQLDQLNRLISDLYLLSLVSAGQLALVRTQ---FLLRPLLEERVAWA-- 260 S Q L+ I RQ ++LN+L+ +L L+L +A ++ FL + L+E + Sbjct: 153 SEQAHYLATIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFL 212 Query: 261 ------APSLRLLPMSTALYCCEHLPLNADRDRLGQAISILIDNALRYAASGKLLTISAG 314 L+++P E + D +L + + L+DNA +Y+A G L + A Sbjct: 213 IEQERRDVHLQVIP--------ESARIEGDYAKLSRILVNLVDNAFKYSAPGTKLEVVAK 264 Query: 315 LHDGQIHIDVEDDGPGFAPEHLELACDRFWRAEHSRSRHAGGSGLGLAVAVAICEAHGGK 374 L Q+ I V D+G G APE LE R +R E SR+ GG GLGLA+A + GG+ Sbjct: 265 LEKDQLSISVTDEGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQLGGE 324 Query: 375 LSVHNRPAGGARMHLELPAEGT 396 ++V ++ G+ L L G+ Sbjct: 325 ITVSSQYGLGSTFTLVLNLSGS 346 >slr0533 [T] COG0642 Signal transduction histidine kinase Syn Synechocystis Length = 405 Score = 133 bits (335), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 100/295 (33%), Positives = 148/295 (50%), Gaps = 22/295 (7%) Query: 112 GAGLMLSLRLSRHLDAVAVAARRLAAGDFSARALSCKQVPAALDALMRDVNEMAERLERR 171 G + + R+ + LD + +A + LA GD +R + +P L+ L + N MA+ LE Sbjct: 117 GLSFLAADRIMQPLDRLKLATKNLAEGDLQSR-MPPSDIPE-LEELGQSFNRMADSLENV 174 Query: 172 ERELHASSAAIAHELRTPLTAAKARLQGIMDGIFDRSPQQLSMIMRQLDQLNRLISDLYL 231 E++ + + HELR+PLT + L+ + +G P+ ++ + +L RL DL Sbjct: 175 EQQRRELVSDLTHELRSPLTVVRGYLEQLAEGTIAGDPELYQRLVGETRRLERLTVDLQE 234 Query: 232 LSLVSAGQLALVRTQFLLRPLL---EERVAWAAPSLRLLPMSTALYCCEHLPLN---ADR 285 LS V AG L++ R L PLL ++R A +LL L PL AD Sbjct: 235 LSKVEAGYLSIQRQPLDLYPLLAKLQQRFAD-----QLLEDGPELILAVQPPLPTVLADP 289 Query: 286 DRLGQAISILIDNALRYAASGKLLTISAGL--------HDGQIHIDVEDDGPGFAPEHLE 337 DR Q + LI NA+RY SG + TI A L + + + V D G G A L Sbjct: 290 DRAEQILVNLIGNAVRYTPSGAI-TIDAYLCTNRKDMEKENLLWVTVTDTGIGIAEGDLP 348 Query: 338 LACDRFWRAEHSRSRHAGGSGLGLAVAVAICEAHGGKLSVHNRPAGGARMHLELP 392 +RFWRA+ SRSR++GG+GLGLA+A + E GG L+V + G+ LP Sbjct: 349 YVFERFWRADKSRSRYSGGTGLGLAIAKRLVELQGGSLTVTSTLGQGSEFRFSLP 403 >BH1945 [T] COG0642 Signal transduction histidine kinase Bha Bacillus halodurans Length = 462 Score = 131 bits (330), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 83/266 (31%), Positives = 135/266 (50%), Gaps = 7/266 (2%) Query: 131 AARRLAAGDFSARALSCKQVPAALDALMRDVNEMAERLERRERELHASSAAIAHELRTPL 190 AA ++A GDFS R S + + L N ++ LER E + A ++HELRTPL Sbjct: 200 AAIQMAKGDFSLRISSTRSRKDEIGQLAESFNTLSSSLERVEEKRREFLADVSHELRTPL 259 Query: 191 TAAKARLQGIMDGIFDRSPQQLSMIMRQLDQLNRLISDLYLLSLVSAGQLALVRTQFLLR 250 + K +G+ +G+ D S + LS+I ++ ++L RL++DL L+ + + Sbjct: 260 SYMKGYAEGVEEGVIDPS-KGLSIIQKEANRLERLVNDLLDLAQLEGESYVMKDEPIAFA 318 Query: 251 PLLEERVA---WAAPSLRLLPMSTALYCCEHLPLNADRDRLGQAISILIDNALRYAASGK 307 L+ E V + A RL L E + ++ D DR+ Q I L+DNA++YA Sbjct: 319 QLVYEVVEQFRYLAAQKRL---QVHLDLDEDVIISGDPDRIEQVIRNLLDNAIKYAHEET 375 Query: 308 LLTISAGLHDGQIHIDVEDDGPGFAPEHLELACDRFWRAEHSRSRHAGGSGLGLAVAVAI 367 ++++ G + + D G G + L L +RF+R SRSR GG+GLGLA+A I Sbjct: 376 TISLTIGREGSRAQFILSDQGIGIPEDKLALVFERFYRVNKSRSRKKGGTGLGLAIASQI 435 Query: 368 CEAHGGKLSVHNRPAGGARMHLELPA 393 + HGG + + ++ G + + L Sbjct: 436 IKKHGGTIDITSQELKGTTVTITLKT 461 >RSp1162 [T] COG0642 Signal transduction histidine kinase Rso Ralstonia solanacearum Length = 512 Score = 126 bits (316), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 101/320 (31%), Positives = 153/320 (47%), Gaps = 20/320 (6%) Query: 87 FTPEVLQADLLWFSLLVLIALPLIVGAGLMLSLRLSRHLDAVAVAARRLAAGDFSARALS 146 F + L+A + +L VL+A G ++L+ + + +A A RR+A GD++AR Sbjct: 196 FLAQQLRATWIIAALSVLLA----AGVAILLARGVLAPMRRLAHATRRMAEGDYAARV-- 249 Query: 147 CKQVPAALDALMRDVNEMAERLERRERELHASSAAIAHELRTPLTAAKARLQGIMDGIFD 206 + L D N +AE LE ++ +A I+HELRTPL + L+ + DG+ Sbjct: 250 DVHSGDEIGHLADDFNRLAETLEANQKMRRQLTADISHELRTPLAVLRGELEALEDGVRA 309 Query: 207 RSPQQLSMIMRQLDQLNRLISDLYLLSLVSAGQLALVRTQFLLRPL-LEERVAWAAPSLR 265 +P L+ + ++ L++LI DLY LSL G LA F + + L + V AA Sbjct: 310 LTPASLTSLQAEVGTLSKLIDDLYELSLADVGALA-----FHMESIDLADTVCSAAQGFT 364 Query: 266 LLPMSTALYCCEHLPLNADRD--------RLGQAISILIDNALRYAASGKLLTISAGLHD 317 M + LP RD RL Q + L++N LRY +G L I Sbjct: 365 PRLMDKRIALQLDLPTGPSRDAAIQGDPQRLRQLMQNLLENTLRYTDAGGTLRIHVHRAG 424 Query: 318 GQIHIDVEDDGPGFAPEHLELACDRFWRAEHSRSRHAGGSGLGLAVAVAICEAHGGKLSV 377 +DV+D PG L DR +RA+ SR R GG+GLGL++ I + HGG + Sbjct: 425 AWWCLDVQDSAPGVPEAMLPRVFDRLFRADPSRGRAQGGAGLGLSLCQTIVQTHGGTIDA 484 Query: 378 HNRPAGGARMHLELPAEGTA 397 P GG + + LPA ++ Sbjct: 485 RPSPLGGLWIAIRLPAANSS 504 >all4726 [T] COG0642 Signal transduction histidine kinase Nos Nostoc sp. PCC 7120 Length = 371 Score = 124 bits (311), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 94/285 (32%), Positives = 141/285 (49%), Gaps = 10/285 (3%) Query: 112 GAGLMLSLRLSRHLDAVAVAARRLAAGDFSARALSCKQVPAALDALMRDVNEMA---ERL 168 G +S R+ + L + ++ AAG AR L +P L+ L N MA E + Sbjct: 91 GLSYWVSKRIMQRLTEMEQITQQFAAGHLQAR-LPLSDIPE-LNRLGTSFNRMAASLEGV 148 Query: 169 ERRERELHASSAAIAHELRTPLTAAKARLQGIMDGIFDRSPQQLSMIMRQLDQLNRLISD 228 E R REL + HELRTPLT + L+ + DG + SP+ + ++ +L RL++D Sbjct: 149 EARRRELIGD---MTHELRTPLTVVRGYLEELADGEIEPSPEVYRRLAKETRRLERLVND 205 Query: 229 LYLLSLVSAGQLALVRTQFLLRPLLEERVA-WAAPSLRLLPMSTALYCCEHLPLNADRDR 287 L LS AG L + L PLLE V ++ L P+ A + + AD DR Sbjct: 206 LQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQLLEDGPVLLAELTPQMPLVLADIDR 265 Query: 288 LGQAISILIDNALRYAASGKLLTISAGLHDGQIHIDVEDDGPGFAPEHLELACDRFWRAE 347 Q + L+ NA+RY +G +TI + Q+ I V D G G A E + +RFWRA+ Sbjct: 266 TEQILVNLLGNAIRYTTTGS-ITIRTWTENRQLWIAVIDTGIGIASEDIPHVFERFWRAD 324 Query: 348 HSRSRHAGGSGLGLAVAVAICEAHGGKLSVHNRPAGGARMHLELP 392 SR RH+GG+G+GL + + E G++ + + G+ LP Sbjct: 325 QSRDRHSGGTGIGLTITKHLVELQSGEIHLDSELGIGSTFRFCLP 369 >CAC3219 [T] COG0642 Signal transduction histidine kinase Cac Clostridium acetobutylicum Length = 475 Score = 121 bits (303), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 138/270 (51%), Gaps = 6/270 (2%) Query: 125 LDAVAVAARRLAAGDFSARALSCKQVPAALDALMRDVNEMAERLERRERELHASSAAIAH 184 L + AR++A G+ R + + L N MA +E+ E+ + ++H Sbjct: 205 LKNINDVARKIAKGEVEKRV--NIESNDEIGELGESFNFMANAIEKSEKNRREFISNVSH 262 Query: 185 ELRTPLTAAKARLQGIMDGIFDRSPQQ--LSMIMRQLDQLNRLISDLYLLSLVSAGQLAL 242 E+R+P+T+ K + G++DG+ + ++ LS+ ++++L RL++DL LS + AG L L Sbjct: 263 EIRSPITSIKGFIGGMLDGVIPKEKERYYLSLTYDEINRLTRLVNDLLDLSSIEAGHLKL 322 Query: 243 VRTQFLLRPLLEERVAWAAPSLRLLPMSTAL-YCCEHLPLNADRDRLGQAISILIDNALR 301 T+ + ++ V ++ ++ + + + + + AD+DR+ Q ++ LIDNA++ Sbjct: 323 NLTKIDINEIIRFTVLKFETKIKEKKLNVDVCFNNDKVYVIADKDRISQVVTNLIDNAVK 382 Query: 302 YAASGKLLTISAGLHDGQIHIDVEDDGPGFAPEHLELACDRFWRAEHSRSRHAGGSGLGL 361 Y + + IS + +I + ++GP E DRF++++ +R+ +GLGL Sbjct: 383 YVYAEGEIKISTKERYNKAYITIYNNGPQIPEEDFNHIWDRFYKSDKARTTKM-STGLGL 441 Query: 362 AVAVAICEAHGGKLSVHNRPAGGARMHLEL 391 + +I HG ++V N+ GG L Sbjct: 442 PIVRSILTEHGQDINVINKKEGGVEFTFTL 471