BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0110.p (398 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGc2783 [T] COG3448 CBS-domain-containing membrane protein Atu A... 330 4e-90 RSc0130 [T] COG3448 CBS-domain-containing membrane protein Rso R... 308 1e-83 mll8143 Non COG 261 3e-69 SMc02600 [T] COG3448 CBS-domain-containing membrane protein Sme ... 253 5e-67 PA1854 [T] COG3448 CBS-domain-containing membrane protein Pae Ps... 253 7e-67 slr0789 [T] COG3448 CBS-domain-containing membrane protein Syn S... 102 2e-21 alr3813 [R] COG0517 FOG Nos Nostoc sp. PCC 7120 62 3e-09 >AGc2783 [T] COG3448 CBS-domain-containing membrane protein Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 382 Score = 330 bits (845), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 188/383 (49%), Positives = 246/383 (64%), Gaps = 9/383 (2%) Query: 9 FKSFIPAKANVDRFERMRSCAGSLFGILLVGMVSYAVLPHKAGTIWLIAPMGASAVLLFA 68 + IP A V ER+R+ G+ FGILL G++ L +IAPMGASAVLLFA Sbjct: 5 LRRLIPDAAPVSNRERLRTATGAFFGILLTGLLGSFALRFDPTLPAMIAPMGASAVLLFA 64 Query: 69 VPSSPLAQPWSIIGGNLCAALIGVTCAKLVPEPALAAALAIALAIGAMFYLRCIHPPSGA 128 VPSSPLAQPWSI+ GNL +A +GVT A LV +P LA+ALAI+ AI AM LRC+HPPSGA Sbjct: 65 VPSSPLAQPWSILCGNLVSAFVGVTVALLVQDPFLASALAISFAIAAMMALRCLHPPSGA 124 Query: 129 VALTAVLGGPAVQAMGYGFVLSPVLLNSVLLLATALFFNNASGRRYPHAQQSAAPHPHHT 188 VALTAVLGGP V ++GYGF+L PV NS++LLA AL +NNA+GR YPH + H T Sbjct: 125 VALTAVLGGPVVHSLGYGFLLWPVAGNSLILLALALLYNNATGRAYPHGLKPGKA-AHGT 183 Query: 189 RDELPITRLGFSHEDLDEVLKRYNQVLDIGRDDLEEIFLQTEMRAYHRRFGQTLCASVMS 248 D PI ++GFS DLDEVLK Y++VLDI RD+LE I +TE+R+Y RR CASVMS Sbjct: 184 TDPTPIQKIGFSSTDLDEVLKEYDEVLDIDRDELETILRKTELRSYRRRALHLDCASVMS 243 Query: 249 RDVVAVEFATGLDEAWRLLQAHRLRALPVIDRGRHVIGIISRSDFLEHAGVEV---HTGL 305 RDV+ V L A L+ H +ALPV + ++GI++++DFLE A G Sbjct: 244 RDVIGVAPDDSLRHAHALMHNHHFKALPVTNDKAEIVGIVTQTDFLEKASWRNGRPSIGF 303 Query: 306 TAQLRALLHRVPLLHSDKPEVVGQIMSRPVVTAQVDTPLLELVPRMA-DGLHQIPVVQAD 364 +LR +L S + V IM+ PV T +T + E + R A +GLH +PV+ A Sbjct: 304 LQRLRLILSGA----SAPNDTVKDIMTSPVKTVLPETSIEEAIIRFAEEGLHYLPVIDAK 359 Query: 365 GKLAGMLTQSDMIAALYEKNLVA 387 GK+ G+++QSD++ A+ + A Sbjct: 360 GKMVGIVSQSDVMVAMLADKVAA 382 >RSc0130 [T] COG3448 CBS-domain-containing membrane protein Rso Ralstonia solanacearum Length = 378 Score = 308 bits (790), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 186/377 (49%), Positives = 238/377 (63%), Gaps = 16/377 (4%) Query: 8 WFKSFIPAKANVDRFERMRSCAGSLFGILLVGMVSYAVLPHKAGTIWLIAPMGASAVLLF 67 WF SF PA V ER+RS AG+L GIL G+ V L+APMGASAVLLF Sbjct: 9 WFASFAPAPVTVRWTERLRSAAGALIGILFTGVAMRYVPVAPVPVPLLVAPMGASAVLLF 68 Query: 68 AVPSSPLAQPWSIIGGNLCAALIGVTCAKLVPEPALAAALAIALAIGAMFYLRCIHPPSG 127 AVP+SPLAQPWSIIGGNL A+++GVTCA+++ +P LA ALA++LAIG MF LRC+HPPSG Sbjct: 69 AVPASPLAQPWSIIGGNLVASVVGVTCARMIGDPVLACALAVSLAIGGMFALRCVHPPSG 128 Query: 128 AVALTAVLGGPAVQAMGYGFVLSPVLLNSVLLLATALFFNNASGRRYPHAQQSAAPHPHH 187 AVALTAVLGGPAV A+GY FVL PV L S LLL A+ ++ +G RYPHA + AA Sbjct: 129 AVALTAVLGGPAVHALGYRFVLEPVALQSALLLVAAIAYHAVTGHRYPHAHRRAA----- 183 Query: 188 TRDELPITRLGFSHEDLDEVLKRYNQVLDIGRDDLEEIFLQTEMRAYHRRFGQTLCASVM 247 T P G + D+ L+R + LDI +DL + + + +AY R F CA +M Sbjct: 184 TEHAPPPG--GLTRADVLAALRRQGEWLDIDPEDLTALLQEMQQQAYARTFHTLTCADIM 241 Query: 248 SRDVVAVEFATGLDEAWRLLQAHRLRALPVIDRGRHVIGIISRSDFLEHAGVEVHTGLTA 307 + VV AT + A RLLQ H ++ALPVID GR +IGI++R+D AG T A Sbjct: 242 TPSVVTASAATSVPHALRLLQRHGVKALPVIDDGRRLIGIVTRADL---AG----TAPRA 294 Query: 308 QLRALLHRVPLLHSDKPEVVGQIMSRPVVTAQVDTPLLELVPRMAD-GLHQIPVVQADGK 366 + L + P V G +M+ V+T + D P+ +LVP A G H IPVV A G+ Sbjct: 295 PRQRLRDWFAIGAMTPPRVRG-VMNPRVLTIRADAPMADLVPMFASAGHHHIPVVDAHGR 353 Query: 367 LAGMLTQSDMIAALYEK 383 LAG+LTQ+D+I ALY + Sbjct: 354 LAGILTQADVIHALYRQ 370 >mll8143 Non COG Length = 361 Score = 261 bits (666), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 157/379 (41%), Positives = 217/379 (57%), Gaps = 40/379 (10%) Query: 7 LWFKSFIPAKANVDRFERMRSCAGSLFGILLVGMVSYAVL---PHKAGTIWLIAPMGASA 63 + F+ F+P A ER+ +C G+ GI L G++S + PH A L+APMGASA Sbjct: 1 MAFRLFVPILAGATLRERLFACIGATIGIALTGVISGLAMGGGPHVA---LLVAPMGASA 57 Query: 64 VLLFAVPSSPLAQPWSIIGGNLCAALIGVTCAKLVPEPALAAALAIALAIGAMFYLRCIH 123 VLLFAVP+SPLAQPWSIIGGN +AL+GVT V +P +A+ LA+ALAI AM + RC+H Sbjct: 58 VLLFAVPASPLAQPWSIIGGNSISALVGVTVGHFVHDPVMASGLAVALAIAAMSFTRCLH 117 Query: 124 PPSGAVALTAVLGGPAVQAMGYGFVLSPVLLNSVLLLATALFFNNASGRRYPHAQQSAAP 183 PP GA ALTAVLGGPAV + G+ F PV LNS++L+ F+ + R YPH AAP Sbjct: 118 PPGGAAALTAVLGGPAVVSAGFLFPFVPVALNSIILVTLGFLFHRLARRNYPHV---AAP 174 Query: 184 --HPHHTRDELPITRLGFSHEDLDEVLKRYNQVLDIGRDDLEEIFLQTEMRAYHRRFGQT 241 + H T D R+GF ED+D L ++ DI R+DLE + Q E++A R Sbjct: 175 PANSHGTADPPSQQRVGFRPEDIDAALTTLDETFDIDRNDLERLLRQVELQAMVRSQRTL 234 Query: 242 LCASVMSRDVVAVEFATGLDEAWRLLQAHRLRALPVIDRGRHVIGIISRSDFLEHAGVEV 301 LC +MSRDVV+V DEA + L H +R LPV+D ++G + Sbjct: 235 LCRDIMSRDVVSVREQATADEARQQLLDHNIRTLPVVDAEARLVGAVG------------ 282 Query: 302 HTGLTAQLRALLHRVPLLHSDKPEVVGQIMSRPVVTAQVDTPLLELVPRMADGL-HQIPV 360 LR L + P+ V +MS+ TA +TP + L+P + DG H + + Sbjct: 283 -------LREL--------TKAPDTVKGVMSK-AGTASPETPAMSLLPVLTDGRSHAVVI 326 Query: 361 VQADGKLAGMLTQSDMIAA 379 V + + G++TQ+D++AA Sbjct: 327 VDGERHILGLITQTDLLAA 345 >SMc02600 [T] COG3448 CBS-domain-containing membrane protein Sme Sinorhizobium meliloti Length = 382 Score = 253 bits (646), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 149/376 (39%), Positives = 210/376 (55%), Gaps = 29/376 (7%) Query: 9 FKSFIPAKANVDRFERMRSCAGSLFGILLVGMVSYAVLPHKAGTIWLIAPMGASAVLLFA 68 FK F P A ER+ C G+L GI + G+V V ++AP+GASAVLLFA Sbjct: 18 FKLFSPILAGATLKERLIGCIGALIGICVTGLVCGFVFGDDPQLPLIVAPIGASAVLLFA 77 Query: 69 VPSSPLAQPWSIIGGNLCAALIGVTCAKLVPEPALAAALAIALAIGAMFYLRCIHPPSGA 128 VP+SPLAQPWSIIGGN +ALIGV+ +V + LA LA+ALAI AM R +HPP GA Sbjct: 78 VPASPLAQPWSIIGGNTISALIGVSVTYIVADQMLAIGLAVALAILAMSLTRSLHPPGGA 137 Query: 129 VALTAVLGGPAVQAMGYGFVLSPVLLNSVLLLATALFFNNASGRRYPHAQQSAAPHPHHT 188 ALTAV+GG AV G+ F PV +NS++L+ + F+ + R+YPH A + H T Sbjct: 138 AALTAVIGGAAVARSGFWFPFIPVAINSLILVGLGMVFHRLARRQYPHRPGVAPVNTHAT 197 Query: 189 RDELPITRLGFSHEDLDEVLKRYNQVLDIGRDDLEEIFLQTEMRAYHRRFGQTLCASVMS 248 D P R+GF+ ED+D + R N+ LD+ R+D++ + + E++A R+ G+ CA +MS Sbjct: 198 ADPPPALRVGFNSEDIDSAIARLNETLDVSREDIDALLREVELQALIRQRGELTCADIMS 257 Query: 249 RDVVAVEFATGLDEAWRLLQAHRLRALPVIDRGRHVIGIISRSDFLEHAGVEVHTGLTAQ 308 RDVV V T D A LL H +R LPV+D + G + E AG E + L Sbjct: 258 RDVVTVPGDTTPDHARYLLLKHDIRTLPVLDENEKLQGTVG---LRELAGKEPGSKLPIS 314 Query: 309 LRALLHRVPLLHSDKPEVVGQIMSRPVVTAQVDTPLLELVPRMADG-LHQIPVVQADGKL 367 A TA+ P + L+PR+ DG H + ++ DGK+ Sbjct: 315 AAA-------------------------TARPSDPAIGLLPRLTDGATHAVVILDDDGKV 349 Query: 368 AGMLTQSDMIAALYEK 383 G+++Q+D++A L + Sbjct: 350 VGIISQTDLLATLAKS 365 >PA1854 [T] COG3448 CBS-domain-containing membrane protein Pae Pseudomonas aeruginosa Length = 385 Score = 253 bits (645), Expect = 7e-67, Method: Compositional matrix adjust. Identities = 154/383 (40%), Positives = 217/383 (56%), Gaps = 16/383 (4%) Query: 4 SISLWFKSFIPAKANVDRFERMRSCAGSLFGILLVGMVSYAVLPHKAGTIWLIAPMGASA 63 ++ W K F P N + +R+ G+ G L A+ + + L AP+GASA Sbjct: 8 AVRTWLKGFRPLTLNARPRDCLRAGLGACIGALAAVFACQALFGSELA-LRLAAPLGASA 66 Query: 64 VLLFAVPSSPLAQPWSIIGGNLCAALIGVTCAKLVPEPALAAALAIALAIGAMFYLRCIH 123 VLLFA+ SSPLAQPWS++GGNL AAL G A A + +AL + MF LRC+H Sbjct: 67 VLLFALASSPLAQPWSMLGGNLVAALAGGLSAYWFGHDLAPALVGMALGMLLMFALRCLH 126 Query: 124 PPSGAVALTAVLGGPAVQAMGYGFVLSPVLLNSVLLLATALFFNNASGRRYPHAQQSAAP 183 PPS A+AL+ L P++ +G V+ P+LL++++L+ AL +NN YP QS Sbjct: 127 PPSCALALSVALN-PSLSELGID-VVWPILLSTLVLIGCALLYNNLMRSPYPRPYQSPRA 184 Query: 184 HPHHTRDELPITRLGFSHEDLDEVLKRYNQVLDIGRDDLEEIFLQTEMRAYHRRFGQTLC 243 + H TRD P R FS DLD+ L+ + + +DI RDDLE + TE A RR G+ Sbjct: 185 NLHGTRDLAPSARTDFSARDLDQALQDFGEYVDITRDDLERLIHHTERYALRRRMGELTA 244 Query: 244 ASVMSRDVVAVEFATGLDEAWRLLQAHRLRALPVIDRGRHVIGIISRSDFLEHAGVEVHT 303 A +MSRDV T +D+AW+ LQ HRL+ALPV+D R + GI+++SD L+H + Sbjct: 245 ARIMSRDVQTASTETFIDDAWKQLQEHRLKALPVLDEHRRLAGIVTQSDLLKHFRPDGSP 304 Query: 304 GLTAQLRALLHRVPLLHSDKPEVVGQIMSRPVVTAQVDTPLLELVPRMAD-GLHQIPVVQ 362 R+ L K + IM+ PVV Q DT +ELV ++D GLH +PV+ Sbjct: 305 ---------FKRLRFLRGTK---LKTIMTTPVVCVQADTHAVELVSLLSDEGLHCLPVLN 352 Query: 363 ADGKLAGMLTQSDMIAALYEKNL 385 G L G+++Q+D+IAALY L Sbjct: 353 EAGYLVGIVSQTDLIAALYRNWL 375 >slr0789 [T] COG3448 CBS-domain-containing membrane protein Syn Synechocystis Length = 185 Score = 102 bits (254), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 71/183 (38%), Positives = 96/183 (52%), Gaps = 31/183 (16%) Query: 8 WFKSFIPAKANVDRFERMRSCA--------------GSLFGILLVGMVSYAVLPHKAGTI 53 WFK+ R RSC S FG L + A L K + Sbjct: 15 WFKTL----------HRWRSCPLTCPVEKPHHGHIFWSWFGSFLAISIC-AYLTVKTNSP 63 Query: 54 WLIAPMGASAVLLFAVPSSPLAQPWSIIGGNLCAALIGVTCAKLVPEPALAAALAIALAI 113 L+AP GA++VL+F VP SPLAQP ++IGGNL AAL+ +T + +A A++LAI Sbjct: 64 LLMAPFGATSVLIFGVPDSPLAQPRNVIGGNLLAALVSLTVLHFLGSSPMAMGAAVSLAI 123 Query: 114 GAMFYLRCIHPPSGAVALTAVLGGPAVQAMGYGFVLSPVLLNSVLLLATALFFNN-ASGR 172 G M + +HPPSGAVAL ++ P + F+L+P L S+LL+ A+ FNN A R Sbjct: 124 GIMQFTGTLHPPSGAVALVVMMTRP-----DWNFILTPTLEGSILLVLCAVVFNNLAEER 178 Query: 173 RYP 175 YP Sbjct: 179 TYP 181 >alr3813 [R] COG0517 FOG Nos Nostoc sp. PCC 7120 Length = 152 Score = 61.6 bits (148), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 46/147 (31%), Positives = 78/147 (53%), Gaps = 11/147 (7%) Query: 243 CASVMSRDVVAVEFATGLDEAWRLLQAHRLRALPVIDRGRHVIGIISRSDFL-EHAGVE- 300 A VMS + V V+ T L EA ++L R+ LPV+D ++GIIS +D + + GV Sbjct: 5 VADVMSHNPVVVKPETPLQEAIKILAERRISGLPVVDNDGKLLGIISETDLMWQETGVTP 64 Query: 301 ------VHTGLTAQLRALLHRVPLLHSDKPEVVGQIMSRPVVTAQVDTPLLELVPRMAD- 353 + + + Q A+ R LH + VG++MS+ VT + + + M D Sbjct: 65 PAYIMFLDSVIYLQNPAVYERD--LHKALGQTVGEVMSKNPVTVSPEKSVKQAAQLMHDR 122 Query: 354 GLHQIPVVQADGKLAGMLTQSDMIAAL 380 +H++PV+ G++ G+LT+ D+I A+ Sbjct: 123 NVHRLPVLDDAGQVIGILTRGDIIRAM 149