BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0063.p (219 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1168 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine... 320 2e-87 VNG1311G [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanin... 128 8e-30 MYPU_0950_1 Non COG 115 5e-26 BH1749 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine ... 114 2e-25 DR2584 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine ... 113 3e-25 RSc2569 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine... 105 7e-23 SPAPB24D3.04c [L] COG0122 3-methyladenine DNA glycosylase/8-oxog... 94 3e-19 BS_yfjP [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine... 93 5e-19 YPO1834 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine... 92 1e-18 AGl2478 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine... 92 1e-18 >RSc1168 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Rso Ralstonia solanacearum Length = 291 Score = 320 bits (819), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 148/197 (75%), Positives = 167/197 (84%) Query: 17 PAYWEEAKAELMKRDRIMRKIIPQFGDLQLTVRGDAFTTLARSVIGQQISTKAANAVWQR 76 PAYW+EA A+LMKRDRI+RKIIP FG L RGD F TLARS++GQQIS KAA +VW+R Sbjct: 90 PAYWQEACADLMKRDRILRKIIPAFGPAHLASRGDPFVTLARSIVGQQISVKAAQSVWER 149 Query: 77 FLEACPRCTPGQVIRTGPEGLAGCGLSKRKAEYILDLAAHFKAKTVHPDKWAEMEDEAVI 136 +EACP+ P Q +R G E LAGCGLSKRKAEYILDLA HF+ VH KWAEMEDE VI Sbjct: 150 LVEACPKLVPAQFLRAGHEKLAGCGLSKRKAEYILDLAEHFRNGMVHVAKWAEMEDEDVI 209 Query: 137 AEMIQIRGIGRWTAEMFLIFNLLRPNVLPLDDLGLLKGISISYFSGEPVSRSDAREVAAN 196 AE+ QIRGIGRWTAEMFL+FNLLRPNVLPLDD+GL+ IS +YFSGEPV+RS+AREVAAN Sbjct: 210 AELTQIRGIGRWTAEMFLMFNLLRPNVLPLDDIGLINAISQNYFSGEPVTRSEAREVAAN 269 Query: 197 WEPWRTVATWYLWRSLD 213 WEPWRTVATWY+WRSLD Sbjct: 270 WEPWRTVATWYMWRSLD 286 >VNG1311G [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Hbs Halobacterium sp. NRC-1 Length = 191 Score = 128 bits (322), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 66/188 (35%), Positives = 108/188 (57%), Gaps = 3/188 (1%) Query: 26 ELMKRDRIMRKIIPQFGDLQLTVRGDAFTTLARSVIGQQISTKAANAVWQRFLEACPRCT 85 + ++ D + ++ G+L +T D F L ++I QQ+ST AA + +R +A T Sbjct: 6 DALRTDPTLAPLLDAHGELAVTPHDDLFERLVVAIIRQQLSTDAAATIRERVFDAVD-VT 64 Query: 86 PGQVIRTGPEGLAGCGLSKRKAEYILDLAAHFKAKTVHPDKWAEMEDEAVIAEMIQIRGI 145 P + P L GLS++K +Y+ ++AA F+ ++AE+ D AV E+ I G+ Sbjct: 65 PAGIAAADPAVLRDAGLSRQKTDYVTNVAAAFREHDYTRARFAELSDAAVREELTAITGV 124 Query: 146 GRWTAEMFLIFNLLRPNVLPLDDLGLLKGISISYFSGEPVSRSDAREVAANWEPWRTVAT 205 G WTA MFL+F L R +V P+ DLG+ G+ Y G +R++ RE+A +W P+R+ A+ Sbjct: 125 GDWTASMFLLFALGRADVFPVGDLGIRTGMQALY--GADTTRAEMREIADSWRPYRSYAS 182 Query: 206 WYLWRSLD 213 Y+WR+ D Sbjct: 183 LYVWRAQD 190 >MYPU_0950_1 Non COG Length = 217 Score = 115 bits (289), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 60/194 (30%), Positives = 101/194 (52%), Gaps = 4/194 (2%) Query: 19 YWEEAKAE---LMKRDRIMRKIIPQFGDLQLTVRGDAFTTLARSVIGQQISTKAANAVWQ 75 Y+E ++ E L ++D+ + K I + G ++ ++ + F + S+IGQQISTKA +W+ Sbjct: 2 YFEYSENEVNYLKRKDKKLAKAIEKIGFIKREIKPNLFVAIVHSIIGQQISTKAHKTLWK 61 Query: 76 RFLEACPRCTPGQVIRTGPEGLAGCGLSKRKAEYILDLAAHFKAKTVHPDKWAEMEDEAV 135 RF E + G G++ RK YILD A K D M D Sbjct: 62 RFEEKVKNIDAKTLASFDLFDFDGIGIANRKLTYILDFAKKVYNKEFDIDALYSMSDNEA 121 Query: 136 IAEMIQIRGIGRWTAEMFLIFNLLRPNVLPLDDLGLLKGISISYFSGEPVSRSDAREVAA 195 I + ++GIG+WTAEM +IF++ R N+L DL +++ I + Y + V + ++ Sbjct: 122 IKSLSSLKGIGQWTAEMAMIFSMQRKNILSYKDLAIIRAIKMLY-GYKDVDKITFEKLEK 180 Query: 196 NWEPWRTVATWYLW 209 + P+ ++A+ YLW Sbjct: 181 RYSPFASIASLYLW 194 >BH1749 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Bha Bacillus halodurans Length = 221 Score = 114 bits (284), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 65/195 (33%), Positives = 105/195 (53%), Gaps = 2/195 (1%) Query: 27 LMKRDRIMRKIIPQFGDLQLTVRGDAFTTLARSVIGQQISTKAANAVWQRF--LEACPRC 84 ++ +D + + I G++QL + + F +L S++ QQ+S KAA+A++ R L Sbjct: 14 IVAQDSRLFQFIEIAGEVQLPTKPNPFQSLVSSIVEQQLSIKAASAIYGRVEQLVGGALE 73 Query: 85 TPGQVIRTGPEGLAGCGLSKRKAEYILDLAAHFKAKTVHPDKWAEMEDEAVIAEMIQIRG 144 P Q+ R E L G+SKRK EYI + H ++ + + E VI ++ I+G Sbjct: 74 KPEQLYRVSDEALRQAGVSKRKIEYIRHVCEHVESGRLDFTELEGAEATTVIEKLTAIKG 133 Query: 145 IGRWTAEMFLIFNLLRPNVLPLDDLGLLKGISISYFSGEPVSRSDAREVAANWEPWRTVA 204 IG+WTAEMF++F+L R +VL + D+GL +G Y +GE + W P+ TVA Sbjct: 134 IGQWTAEMFMMFSLGRLDVLSVGDVGLQRGAKWLYGNGEGDGKKLLIYHGKAWAPYETVA 193 Query: 205 TWYLWRSLDPLPSDY 219 YLW++ +Y Sbjct: 194 CLYLWKAAGTFAEEY 208 >DR2584 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Dra Deinococcus radiodurans Length = 225 Score = 113 bits (283), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 79/214 (36%), Positives = 115/214 (53%), Gaps = 12/214 (5%) Query: 1 LNTNRKAS--DVDPSLIVPAYWEEAKA-ELMKRDRIMRKIIPQFGDLQ-LTVRGDAFTTL 56 L+ NR+ + V ++P + A A + RD ++ ++ G+L L D F L Sbjct: 6 LHQNRRVTLPSVPLPAVLPPLTDHAGAVAHLSRDPVLAQVTSLCGELPVLAPTPDPFGRL 65 Query: 57 ARSVIGQQISTKAANAVWQRFLEACPR-CTPGQVIRTGPEGLAGCGLSKRKAEYILDLAA 115 RSV GQQ+S KAA A++ R LE P P +++ + L G GLS K + AA Sbjct: 66 VRSVAGQQLSVKAAQAIYGR-LEGLPGGVVPAALLKVSGDDLRGVGLSWAKVRTVQAAAA 124 Query: 116 HFKAKTVHPDKWAEMEDEAVIAEMIQIRGIGRWTAEMFLIFNLLRPNVLPLDDLGLLKGI 175 + + + DE VIAE++Q+ GIGRWTAEMFL+F L RP+V DL L +G+ Sbjct: 125 AAVSGQIDFAHLSGQPDELVIAELVQLPGIGRWTAEMFLLFALARPDVFSSGDLALRQGV 184 Query: 176 SISYFSGEPVSRSDAREVAANWEPWRTVATWYLW 209 + GE D R+V A W P+R++A+ YLW Sbjct: 185 E-RLYPGE-----DWRDVTARWAPYRSLASRYLW 212 >RSc2569 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Rso Ralstonia solanacearum Length = 212 Score = 105 bits (262), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 60/165 (36%), Positives = 87/165 (52%), Gaps = 6/165 (3%) Query: 51 DAFTTLARSVIGQQISTKAANAVWQRFLEACPRC---TPGQVIRTGPEGLAGCGLSKRKA 107 D + L R++ QQ+ +A +A+ R L P +P Q++ T L GCG S K Sbjct: 45 DPYEALVRAIAYQQLHARAGDAILGRLLARYPGVDFPSPRQLLETDEATLRGCGFSATKL 104 Query: 108 EYILDLA-AHFKAKTVHPDKWAEMEDEAVIAEMIQIRGIGRWTAEMFLIFNLLRPNVLPL 166 I +A A + D+ + DEA+I ++ +RG+GRWT EM LI+ L R ++LP Sbjct: 105 ATIRGIAQATLDSIVPTRDEALALPDEALIERLVTLRGVGRWTVEMLLIYTLERADILPA 164 Query: 167 DDLGLLKGI-SISYFSGEPVSRSDAREVAANWEPWRTVATWYLWR 210 DD G+ +G + P R A E+ W P+RTVA WYLWR Sbjct: 165 DDFGVREGYRRLKRLETAPTRRQMA-EIGRAWSPYRTVAAWYLWR 208 >SPAPB24D3.04c [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Spo Schizosaccharomyces pombe Length = 228 Score = 93.6 bits (231), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 54/167 (32%), Positives = 89/167 (53%), Gaps = 4/167 (2%) Query: 49 RGDAFTTLARSVIGQQISTKAANAVWQRFLEACPRC---TPGQVIRTGPEGLAGCGLSKR 105 + + + L R+V QQ+ +KAANA++ RF TP ++ E + CG S R Sbjct: 47 KKEPYEELIRAVASQQLHSKAANAIFNRFKSISNNGQFPTPEEIRDMDFEIMRACGFSAR 106 Query: 106 KAEYILDLAAHFKAKTVHPDKWAE-MEDEAVIAEMIQIRGIGRWTAEMFLIFNLLRPNVL 164 K + + +A + + + AE + +E +I + QI+GIGRWT EM LIF+L R +V+ Sbjct: 107 KIDSLKSIAEATISGLIPTKEEAERLSNEELIERLTQIKGIGRWTVEMLLIFSLNRDDVM 166 Query: 165 PLDDLGLLKGISISYFSGEPVSRSDAREVAANWEPWRTVATWYLWRS 211 P DDL + G + + ++ + + P+RT A WYLW++ Sbjct: 167 PADDLSIRNGYRYLHRLPKIPTKMYVLKHSEICAPFRTAAAWYLWKT 213 >BS_yfjP [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Bsu Bacillus subtilis Length = 287 Score = 92.8 bits (229), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 8/176 (4%) Query: 46 LTVRGDAFTTLARSVIGQQISTKAANAVWQRFLEACPRCTPGQVIRTGPEGLA------- 98 L + + + + +I QQ++ A + +RF+ A G PE +A Sbjct: 112 LVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKPETIAELDYQDL 171 Query: 99 -GCGLSKRKAEYILDLAAHFKAKTVHPDKWAEMEDEAVIAEMIQIRGIGRWTAEMFLIFN 157 S RKAEY +D + T+ + M DE ++ ++I+IRGIG WT + L+F Sbjct: 172 RDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRGIGPWTVQNVLMFG 231 Query: 158 LLRPNVLPLDDLGLLKGISISYFSGEPVSRSDAREVAANWEPWRTVATWYLWRSLD 213 L RPN+ PL D+GL I + + ++ ++ WEP+ + A+ YLWRS++ Sbjct: 232 LGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLSYASLYLWRSIE 287 >YPO1834 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Ype Yersinia pestis Length = 203 Score = 91.7 bits (226), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 60/191 (31%), Positives = 95/191 (49%), Gaps = 1/191 (0%) Query: 19 YWEEAKAELMKRDRIMRKIIPQFGDLQLTVRGDAFTTLARSVIGQQISTKAANAVWQRFL 78 Y E L +RD+ M I + G L+ + D F L R+++ QQIS KAA V R Sbjct: 5 YGETEINHLKRRDKKMAAAIERLGMLERPLSPDLFAALIRNIVDQQISVKAAQTVNTRLT 64 Query: 79 EACPRCTPGQVIRTGPEGLAGCGLSKRKAEYILDLAAHFKAKTVHPDKWAEMEDEAVIAE 138 TP V E + CG++ RKA YI A ++ A++ D VI + Sbjct: 65 LLLGSITPATVAAASAEAIQRCGMTMRKAGYIKGAADAAINGSLDLSVIAQLPDNEVITQ 124 Query: 139 MIQIRGIGRWTAEMFLIFNLLRPNVLPLDDLGLLKGISISYFSGEPVSRSDAREVAANWE 198 + ++ G+G WTAEM LI +L RP+++ DL + +G+ ++ + + + R + Sbjct: 125 LSRLDGVGVWTAEMLLISSLSRPDIVSWGDLAIRRGM-MNLYRHKTLPRERFERYRRRYT 183 Query: 199 PWRTVATWYLW 209 P+ T A+ YLW Sbjct: 184 PYGTTASLYLW 194 >AGl2478 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 215 Score = 91.7 bits (226), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 97/207 (46%), Gaps = 15/207 (7%) Query: 22 EAKAELMKRDRIMRKIIPQFGDLQLTVRGDAFTTLARSVIGQQISTKAANAVWQRFLEAC 81 E L + D + +I + G L+L + F LA V+ Q +S +ANA+W R L Sbjct: 12 EGLDHLARLDPALSPVIEKAGPLELRIHEPGFAGLAHIVVSQMVSRASANAIWARILAGT 71 Query: 82 P-RCTPGQVIRTGPEGLAGCGLSKRKAEYILDLAAHFKAKTVHPDKWAEMEDEAVIAEMI 140 + T + E A GLS+ KA + LA V D E A +E++ Sbjct: 72 GGKVTAENYLAVSEELRATFGLSRAKATTLEGLARAVTEGQVDLDGVVRKEAGAAFSELV 131 Query: 141 QIRGIGRWTAEMFLIFNLLRPNVLPLDDLGLLKGISISYFSGEPVSRSDAR---EVAANW 197 +RGIG WTAE++L+F P++ P+ D+ L ++ + + R DA+ E A W Sbjct: 132 ALRGIGPWTAEVYLMFCGGHPDIFPVGDVALRSAVAHAL---DLEVRPDAKWLAERATLW 188 Query: 198 EPWRTVATWYLW--------RSLDPLP 216 PWR+VA W R++ PLP Sbjct: 189 SPWRSVAARLFWGYYANIMRRAMVPLP 215