BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0036.0032.p (324 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transport... 94 3e-19 DR0135 [GER] COG0697 Permeases of the drug/metabolite transporte... 74 3e-13 yijE [GER] COG0697 Permeases of the drug/metabolite transporter ... 67 6e-11 ZyijE [GER] COG0697 Permeases of the drug/metabolite transporter... 66 9e-11 PA2101 [GER] COG0697 Permeases of the drug/metabolite transporte... 66 1e-10 ECs4872 [GER] COG0697 Permeases of the drug/metabolite transport... 66 1e-10 PH0593 [GER] COG0697 Permeases of the drug/metabolite transporte... 64 6e-10 >BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 292 Score = 94.4 bits (233), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 73/278 (26%), Positives = 135/278 (48%), Gaps = 10/278 (3%) Query: 41 IWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAVVLCKLRLPTRQEWPVVVGVGVL 100 IWG W MK G IPPL F+ R A+ F+I + K +L ++E + L Sbjct: 14 IWGYTWVAMKVGIHDIPPLLFSGLRLFIGAVPLFLILFIQRK-KLSIQKEHLKSYIIMSL 72 Query: 101 QMGL-FTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKQKLSPQQSLATVCSYAGM 159 MGL + ++T + FV G+ S++ Y I+V + L +K++ +++ VC G+ Sbjct: 73 LMGLGYMGILTYGMQFVDSGKTSVLVYTMPIFVTVISHFSLNEKMNVYKTMGLVCGLFGL 132 Query: 160 AVIVLPALLHADLHSMIGYLMLGVASLSWAM-NI---LQIKMSPGVKLDFALLPWQTLVA 215 I +L+ D ++ G L + VA+LSW + N+ LQ K + ++ W ++ Sbjct: 133 LFIFGKEMLNIDQSALFGELCVLVAALSWGIANVFSKLQFKHIDIIHMN----AWHLMMG 188 Query: 216 ALPLSLLALAVDGAPSFLADPHAWGVIAYTGPLATALTFLIVLQMTQRLSPVTVSVCMLG 275 A+ L + + + PS A + + G L+T TF++ + ++ S+ ++ Sbjct: 189 AVMLLVFSFIFEAVPSAEWTYQAVWSLLFNGLLSTGFTFVVWFWVLNQIQASKASMALMF 248 Query: 276 VPVVGLTLSSLVFGERLSSDLVLGMGLLCLGLVLPALP 313 VPV+ L L E+++ +++LG L+C G+ + Sbjct: 249 VPVLALFFGWLQLHEQITINIILGALLICCGIFMNTFT 286 >DR0135 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Dra Deinococcus radiodurans Length = 325 Score = 74.3 bits (181), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 96/313 (30%), Positives = 143/313 (45%), Gaps = 18/313 (5%) Query: 18 AASSPAPAPMSRLFLVCVVLAICIWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIA 77 +AS+PA +P++ L +L IWG N+ V+K+ PL AA RFL AA F Sbjct: 2 SASAPA-SPLNARSLGLALLITLIWGVNFVVIKWSVAGASPLLVAALRFLLAA---FPAV 57 Query: 78 VVLCKLRLPTRQEWPVVVGVGVLQMGL-FTALVTGALHFVMPGRASLIAYATSIWVVPGA 136 + + + + R W + VGV+Q GL + A+ G + G SL+ + + A Sbjct: 58 LFVPRPTIAPRLLWGYGLAVGVMQFGLLYLAIQLG----MSAGMGSLLMQTQAFFTALLA 113 Query: 137 ALVLKQKLSPQQSLATVCSYAGMAVIVLPALLHADLHSMIGYLMLGVASLSWAMNILQIK 196 A +K+ P Q+ ++ GMA+I L A ++ + A+L WA++ L +K Sbjct: 114 ARFFGEKVMPWQAAGITLAFGGMALIGLTAGHDVPFFPLL---LTLTAALGWAISNLVVK 170 Query: 197 MSPGVKLDFALLPWQTLVAALPLSLLA-LAVDGAPSFLADPHA----WGVIAYTGPLATA 251 SP F L+ W L+ +PL+LLA L P H+ W + + G T Sbjct: 171 ASPQAN-GFGLVVWSALIPPIPLALLAGLTAGWGPVMQTLTHSDWKFWAAVLFMGLGNTV 229 Query: 252 LTFLIVLQMTQRLSPVTVSVCMLGVPVVGLTLSSLVFGERLSSDLVLGMGLLCLGLVLPA 311 L F I + QR V+ L VPV G S+L F E VLG L+ GLVL Sbjct: 230 LGFGIWSGLIQRHGASRVAPLSLLVPVFGTLASALAFHEGFPPGKVLGAALIAAGLVLHV 289 Query: 312 LPSLGLRRLATKG 324 R A++G Sbjct: 290 FGGRWWRGAASQG 302 >yijE [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Eco Escherichia coli K12 Length = 312 Score = 67.0 bits (162), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 74/257 (28%), Positives = 123/257 (47%), Gaps = 14/257 (5%) Query: 41 IWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAVVLCKLRLPTRQEWPVVVGVGVL 100 IW +W MK + +I F A R + A++ F++ ++ + PT + + + +L Sbjct: 32 IWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPT--PFKYTLAIALL 89 Query: 101 QMGLFTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKQKLSPQQSLATVCSYAGMA 160 Q L AL G+ ++++Y WVV AAL L ++L Q A + + G+ Sbjct: 90 QTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAALFLGERLRRGQYFAILIAAFGLF 149 Query: 161 VIVLPALLHADLHSMIGYLMLGVASLSWAMNILQIKM----SPGVKLDFALLPWQTLVAA 216 +++ P L D SM ++ ++ +SW + + K P V L +L WQ L AA Sbjct: 150 LVLQPWQL--DFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDL-LSLTSWQMLYAA 206 Query: 217 LPLSLLALAVDGAPSFLAD--PHAWGVIAYTGPLATALTFLIVLQMTQRLSPVTVSVCML 274 L +S++AL V P D P + +AY+ LATAL + + L + + L S+ L Sbjct: 207 LVMSVVALLV---PQREIDWQPTVFWALAYSAILATALAWSLWLFVLKNLPASIASLSTL 263 Query: 275 GVPVVGLTLSSLVFGER 291 VPV G+ S + GE Sbjct: 264 AVPVCGVLFSWWLLGEN 280 >ZyijE [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 312 Score = 66.2 bits (160), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 78/275 (28%), Positives = 131/275 (47%), Gaps = 14/275 (5%) Query: 41 IWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAVVLCKLRLPTRQEWPVVVGVGVL 100 IW +W MK + +I F A R + A++ F++ ++ + PT + + + +L Sbjct: 32 IWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPT--PFKYTLAIALL 89 Query: 101 QMGLFTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKQKLSPQQSLATVCSYAGMA 160 Q L AL G+ ++++Y WVV AA+ L ++L Q A + + G+ Sbjct: 90 QTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAAVFLGERLRRGQYFAILIAAFGLF 149 Query: 161 VIVLPALLHADLHSMIGYLMLGVASLSWAMNILQIKM----SPGVKLDFALLPWQTLVAA 216 +++ P L D SM ++ ++ +SW + + K P V L +L WQ L AA Sbjct: 150 LVLQPWQL--DFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDL-LSLTSWQMLYAA 206 Query: 217 LPLSLLALAVDGAPSFLAD--PHAWGVIAYTGPLATALTFLIVLQMTQRLSPVTVSVCML 274 L +S++AL V P D P + +AY+ LATAL + + L + + L S+ L Sbjct: 207 LVMSVVALLV---PQREIDWQPTVFWALAYSAILATALAWSLWLFVLKNLPASIASLSTL 263 Query: 275 GVPVVGLTLSSLVFGERLSSDLVLGMGLLCLGLVL 309 VPV G+ S + GE + G+ L+ L L L Sbjct: 264 AVPVCGVLFSWWLLGENPGAVEXSGIVLIVLALAL 298 >PA2101 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 65.9 bits (159), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 70/298 (23%), Positives = 137/298 (45%), Gaps = 21/298 (7%) Query: 27 MSRLFLVCVVLAICI-WGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAVVLCKLRL 85 M+ L + L +CI WG W +K + +PPL A RFL ++F + ++ +LR Sbjct: 1 MASLVTAVLFLVVCISWGTTWLGIKIAVESVPPLTAAGLRFL----IAFPLFLLFARLRH 56 Query: 86 PT----RQEWPVVVGVGVLQMGLFTA---LVTGALHFVMPGRASLIAYATSIWVVPGAAL 138 T R+ V V +G F+ L+ +V G +L+ + ++++ +A+ Sbjct: 57 ETIFFPRRLLAFFVFV---TLGYFSVPYYLLNYGEQYVASGLTALLFSSMPVFILIFSAI 113 Query: 139 VLKQKLSPQQSLATVCSYAGMAVIVLPALLHADLHSMIGYLMLGVASLSWAMNILQIKMS 198 L++++ Q L + + +I+ LH D ++G L + +A++ A++ + K Sbjct: 114 FLRERIYLSQILGIAIGFGSLFMIIRSQGLHLDYTELLGVLAILLAAIMHALSYVITKRQ 173 Query: 199 PGVKLDFALLPWQTL---VAALPLSLLALAVDGAPSFLADPHAWGVIAYTGPLATALTFL 255 D ++ + TL +A L L + L ++ +W + Y G +A+ F+ Sbjct: 174 GA---DIGVITFNTLPIGIAGLGLFMAGLVMEHPNLSAVTSRSWAALIYLGLVASVGGFI 230 Query: 256 IVLQMTQRLSPVTVSVCMLGVPVVGLTLSSLVFGERLSSDLVLGMGLLCLGLVLPALP 313 + + +RLSPV +S + PV + + + G +S +L+ LL G + LP Sbjct: 231 VYFFLLKRLSPVVLSFVFIIFPVFAVIIGAWYEGVAISRELIGFTVLLLAGFAITKLP 288 >ECs4872 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ecs Escherichia coli O157:H7 Length = 312 Score = 65.9 bits (159), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 73/257 (28%), Positives = 123/257 (47%), Gaps = 14/257 (5%) Query: 41 IWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAVVLCKLRLPTRQEWPVVVGVGVL 100 IW +W MK + +I F A R + A++ F++ ++ + PT + + + +L Sbjct: 32 IWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPT--PFKYTLAIALL 89 Query: 101 QMGLFTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKQKLSPQQSLATVCSYAGMA 160 Q L AL G+ ++++Y WVV AA+ L ++L Q A + + G+ Sbjct: 90 QTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAAVFLGERLRRGQYFAILIAAFGLF 149 Query: 161 VIVLPALLHADLHSMIGYLMLGVASLSWAMNILQIKM----SPGVKLDFALLPWQTLVAA 216 +++ P L D SM ++ ++ +SW + + K P V L +L WQ L AA Sbjct: 150 LVLQPWQL--DFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDL-LSLTSWQMLYAA 206 Query: 217 LPLSLLALAVDGAPSFLAD--PHAWGVIAYTGPLATALTFLIVLQMTQRLSPVTVSVCML 274 L +S++AL V P D P + +AY+ LATAL + + L + + L S+ L Sbjct: 207 LVMSVVALLV---PQREIDWQPTVFWALAYSAILATALAWSLWLFVLKNLPASIASLSTL 263 Query: 275 GVPVVGLTLSSLVFGER 291 VPV G+ S + GE Sbjct: 264 AVPVCGVLFSWWLLGEN 280 >PH0593 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pho Pyrococcus horikoshii Length = 284 Score = 63.5 bits (153), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 80/263 (30%), Positives = 124/263 (47%), Gaps = 34/263 (12%) Query: 40 CIWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAVVLCKLRLPTRQEWPVVVGVGV 99 IWG +PVMK G + PP+ F A RF A+I ++A+VL K ++ Q +P + +G+ Sbjct: 19 AIWGTTFPVMKIGIKDFPPVSFIAFRFFLASI---ILAIVL-KDKITKDQIFPGFL-IGL 73 Query: 100 LQMGLFTALVTGALHFVMPGRASLIAYATSIWVV--PGAAL-VLKQKLSPQQSLATVCSY 156 F V G + AS A+ TS+++V P A +LK K++ +LA + Sbjct: 74 SLFAGFGFQVVGLKY----TTASNSAFITSLYMVFTPFVAFALLKSKITRVDALALAIAV 129 Query: 157 AGMAVIVLPALLHADLHSMIGYLMLGVASLSWAMNILQIKMSPGVKLDFALLPWQ----- 211 G +I A L+ G L+ +A+LS+A I+ I+ + L A WQ Sbjct: 130 LGTYLIS-----GASLNLSYGDLLTILAALSFAFQIVLIEYYKDLGLGLAF--WQIFWNF 182 Query: 212 --TLVAALPLSLLALAVDGAPSFLADPHAWGVIAYTGPLATALTFLIVLQMTQRLSPVTV 269 +LV ++ L L +G+ F I YTG +ATAL FL ++ ++ Sbjct: 183 IFSLVYSIYFESLPLPKEGSTVF--------AILYTGIVATALAFLGQVKYQPKIESHRA 234 Query: 270 SVCMLGVPVVGLTLSSLVFGERL 292 +V PV G S L+ GE L Sbjct: 235 AVLYSAEPVFGYFFSFLILGEIL 257