BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0035.0193.p (407 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Cj1687 [GEPR] COG0477 Permeases of the major facilitator superfa... 149 9e-36 AGc4286 [GEPR] COG0477 Permeases of the major facilitator superf... 132 2e-30 MA0181 [GEPR] COG0477 Permeases of the major facilitator superfa... 73 1e-12 DR0472 [GEPR] COG0477 Permeases of the major facilitator superfa... 68 4e-11 MA1516 [GEPR] COG0477 Permeases of the major facilitator superfa... 61 5e-09 VNG0501G [GEPR] COG0477 Permeases of the major facilitator super... 60 7e-09 >Cj1687 [GEPR] COG0477 Permeases of the major facilitator superfamily Cje Campylobacter jejuni Length = 423 Score = 149 bits (377), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 111/391 (28%), Positives = 194/391 (49%), Gaps = 24/391 (6%) Query: 23 SSLTIMGSVMIAPMLPKITAEFA-------AVEADALTLAPL------IVAGPALAIALF 69 +++T++GSV+I+ LP I F A A + TLA L ++ PA+ + + Sbjct: 36 AAMTMLGSVVISSALPAINRHFEELLTQSGATLASSFTLAHLDILVRLVLTIPAIFVVIL 95 Query: 70 APVAGMLADRFGRKSMLLLGCLLYALFGALPVLLHEIRLILLSRLLFGCAEALIMTCCTT 129 +P AG+L D+FG+ +L +++ L G L++I IL SR +FG A A IMT + Sbjct: 96 SPFAGILMDKFGKLKFILPAMVVWTLSGISGFFLNDIYAILTSRAIFGMATAFIMTGASA 155 Query: 130 LIADYWPP---RERMRYINRQVITIGVVGALFFVIGGVAGEGSWRTPFLLY-LTPLLMLP 185 L+ DY+ R ++ Q V GA+F I G SWR PFL+Y L L+ L Sbjct: 156 LLGDYYSRGGFNRRENALSLQGFFCAVGGAVFISIAGFVSSYSWRYPFLVYGLGILITLM 215 Query: 186 AIVAWLWEPDRRQEDSHAAPALNGGVRRTVLTACFLIFAGMVTCFVVTVMTPTVLVMRGV 245 AI+ +L+EP + + +H + F+ F MV ++ P + Sbjct: 216 AII-YLFEPRKFKFYNHTKIETKTNYWQ-FFPIYFIGFFIMVVYYISPTQLPYYIEEHLG 273 Query: 246 TSTSLIGAAAGLAILCTLIGSIAWPFVRERIGVAGVNALLLGCMAAGLCVLALAPSYAVV 305 IG + ++ LC S+++ ++ + + + + L L ++ +L L S+ V Sbjct: 274 LDPKYIGISMSVSALCYGFFSLSYRYIIKFLSIKTIYVLTLFIVSCSFLLLFLVDSFFTV 333 Query: 306 LAAMVLQGLGAGFLVSNASLPLLLGLPPHLRARGVGAFTACLYLGQFASPLIITAIAQPL 365 L A+ L G+G G ++ N + L P + R+R G +C++LGQF SP+I I + + Sbjct: 334 LIALALLGMGGGIMLVNNTAYLFSICPENARSRAYGILASCIFLGQFLSPIISQPIVRQM 393 Query: 366 GGMPAGLANAILVWALLTMVLALVWLVVGLR 396 GL +A L+W+++ ++ +V+L + + Sbjct: 394 -----GLVDAFLIWSIVIFIVCIVFLFLKQK 419 >AGc4286 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 400 Score = 132 bits (331), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 118/356 (33%), Positives = 180/356 (50%), Gaps = 12/356 (3%) Query: 13 PRQGLVIQLASSLTIMGSVMIAPMLPKITAEFAAVEADALTLAPLIVAGPALAIALFAPV 72 P L + ++LTIM +AP LP I F + D ++ +++ P++ +AL AP+ Sbjct: 6 PALKLTLLFVATLTIMAGTTVAPSLPAIEQSFLSTP-DVEIMSRMVLTLPSVFVALCAPI 64 Query: 73 AGMLADRFGRKSMLLLGCLLYALFGALPVLLHEIRLILLSRLLFGCAEALIMTCCTTLIA 132 AG+LADRFGRK +LL LLY+L G + + +L+ R G A IMT T L+ Sbjct: 65 AGVLADRFGRKRLLLGAILLYSLSGISGLFADSLAGLLVGRAFLGLAIGGIMTIGTALVG 124 Query: 133 DYWPPRERMRYINRQVITIGVVGALFFVIGGVAGEGSWRTPFLLYLTPLLMLPAIVAWLW 192 DY+ R RY+ Q + G +F V GG + WR PF +Y LL+LPA + +L Sbjct: 125 DYFEGPARERYLGLQQAFTQLGGVVFVVAGGWLADIHWRAPFAVYAVALLILPAALFFLR 184 Query: 193 EPDRRQ----EDSHAAPALNGGVRRTVLTACFLIFAGMVTCFVVTVMTPTVLVMRGVTST 248 EP R ++ A+N + A FL+ A + + P L GV S Sbjct: 185 EPARNSSRATQNGEQGLAVNWLPVAVLAMAVFLVNA---LFYTIPSQLPFFLREFGVLSG 241 Query: 249 SLIGAAAGLAILCTLIGSIAWPFVRERIGVAGVNALLLGCMAAGLCVLALAPSYAVVLAA 308 S+ G A G+ L + ++++ +R RIGV + A L MA G +LA A + +L+A Sbjct: 242 SVAGYAIGIFNLAGALMALSFGRLRARIGVTVILAAGLVLMATGFALLATAGGLSSMLSA 301 Query: 309 MVLQGLGAGFLVSNASLPLLLGLPPHLRARGVGAFTACLYLGQFASPLIITAIAQP 364 + + G G G ++ + ++ P LR R G TA ++LG F SPL ++QP Sbjct: 302 LAVVGAGLGAVMPSIMSTTIMLAPLRLRGRIAGIVTASMFLGHFISPL----VSQP 353 >MA0181 [GEPR] COG0477 Permeases of the major facilitator superfamily Mac Methanosarcina acetivorans str.C2A Length = 410 Score = 73.2 bits (178), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 89/349 (25%), Positives = 164/349 (46%), Gaps = 39/349 (11%) Query: 29 GSVMIAPMLPKITAEFAAVEADALTLAPLIVAGPALAIALFAPVAGMLADRFGRKSMLLL 88 G ++AP+LP + + L+++ A++ A+FA V G DR RK +L+ Sbjct: 30 GGSLLAPVLPDMVEPLNTTSHEV----GLLISTYAISTAIFALVIGHFIDRVNRKKILVP 85 Query: 89 GCLLYALFGALPVLLHEIRLILLSRLLFGCAEALIMTCCTTLIADYWPPRERMRYINR-- 146 ++Y L G + ++ +L+ R + G A +M+ +IAD + + + +N+ Sbjct: 86 CLVIYGLTGLVSYFTSDLHSLLILRFIQGIGVAGMMSLPMLVIADVYKDHKSLYAMNKVS 145 Query: 147 QVITIGVVGALFFVIGGVAGEGSWRTPFLLYLTPLLMLP-AIVAWLWEPDRR-QEDSHAA 204 + IG V A +IGG W PFL Y +L LP A V + P+ R Q D+ + Sbjct: 146 MALAIGSVSAP--LIGGGLANLGWNYPFLFY---VLSLPLAFVVMFFLPETRVQRDNVSH 200 Query: 205 PALNGGV----RRTVLTACFLIFAGMVTCFVVTVMTPTVLVMRGVTS-----TSLIGAAA 255 + G +L FL FA V + +V+T +++ V S + LI A Sbjct: 201 KGILDGFTALKEMRILYTVFLSFA--VFFILYSVLTYVPFMLKNVLSYTAKESGLILAFQ 258 Query: 256 GLAILCTLIGSIAWPFVRERIGVAGVNALLL----GCMAAGLCVLALAPSYAVVLAAMVL 311 G+AI+ + P V+ +A ++ +L G GL + +++ +Y++V +++ Sbjct: 259 GIAIILMV------PRVKT---LASKHSTILIIAIGFALDGLAIFSISFAYSIVTVLLLI 309 Query: 312 QGLGAGFLVSNASLP-LLLGLPPHLRARGVGAFTACL-YLGQFASPLII 358 GAGF +S ++ ++ + P GV + + Y+GQ SP+++ Sbjct: 310 LLFGAGFGLSQTAIDAQIVQIAPSESKGGVLSIHNTMKYIGQSLSPILL 358 >DR0472 [GEPR] COG0477 Permeases of the major facilitator superfamily Dra Deinococcus radiodurans Length = 407 Score = 67.8 bits (164), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 61/189 (32%), Positives = 88/189 (46%), Gaps = 13/189 (6%) Query: 17 LVIQLASSLTIMGSVMIAPMLPKITAEFAAVEADALTLAPLIVAGPALAIALFAPVAGML 76 L I L + + +MG +I P+LP + E A EA ++ A A +FAP+ G L Sbjct: 12 LFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFAPILGTL 71 Query: 77 ADRFGRKSMLLLGCLLYALFGALPVLLHEIRLILLSRLLFGCAEALIMTCCTTLIADYWP 136 +DRFGR+ +LLL L L + +L+ RL+ G A +T IAD Sbjct: 72 SDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGA-SLTVANAYIADVTA 130 Query: 137 PRERMRYINRQVITIGVVGALFFVIGGVAGEGSWRTPFLL--------YLTPLLMLPAIV 188 P +R + R T GV L ++GG GE R PFL +L LL+LP + Sbjct: 131 PEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGLRAPFLFAAGLTALNFLYGLLVLPESL 190 Query: 189 AWLWEPDRR 197 P++R Sbjct: 191 ----PPEKR 195 >MA1516 [GEPR] COG0477 Permeases of the major facilitator superfamily Mac Methanosarcina acetivorans str.C2A Length = 470 Score = 60.8 bits (146), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 50/148 (33%), Positives = 73/148 (49%), Gaps = 6/148 (4%) Query: 31 VMIAPMLPKITAEFAAVEADALTLAPLIVAGPALAIALFAPVAGMLADRFGRKSMLLLGC 90 ++ P+LP++ A E D ++VA LA ALF PV GM ADR RK+ LL+ C Sbjct: 24 TLLGPVLPEMLAPLKTAEQDI----GMVVAVFTLATALFTPVFGMFADRLSRKT-LLIPC 78 Query: 91 LLYALFGALPVLL-HEIRLILLSRLLFGCAEALIMTCCTTLIADYWPPRERMRYINRQVI 149 L+ F L + +L+ R + G A ++ LI D +P ER+ +R + Sbjct: 79 LVLNGFSGLACYFAQDFETLLIFRFVQGIGAAGMLLLALLLIGDLYPGHERVHATSRVGM 138 Query: 150 TIGVVGALFFVIGGVAGEGSWRTPFLLY 177 T + F V+GG+ SW PFL Y Sbjct: 139 TSAIGLVSFPVLGGLMALKSWNFPFLFY 166 >VNG0501G [GEPR] COG0477 Permeases of the major facilitator superfamily Hbs Halobacterium sp. NRC-1 Length = 412 Score = 60.5 bits (145), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 104/359 (28%), Positives = 157/359 (43%), Gaps = 26/359 (7%) Query: 17 LVIQLASSLTIMGSVMIAPMLPKITAEFAAVEADALTL--APLIVAGPALAIALFAPVAG 74 L LA+ + +G ++ P+LP I E A + L + L+V G L VAG Sbjct: 34 LATALATFIAFLGIGVVDPILPSIAKELGADHFMVMFLFTSYLLVTG------LANLVAG 87 Query: 75 MLADRFGRKSMLLLGCLLYALFGALPVLLHEIRLILLSRLLFGCAEALIMTCCTTLIADY 134 LA R G K+ +L+G + A+F L+ + + + R +G AL T +I Sbjct: 88 TLATRIGSKNTMLVGIGIVAVFAGGCALVSSVESMAVLRGFWGLGNALFTTTALAIIVGV 147 Query: 135 WPPRERMRYINRQVITIGVVGALFFVIGGVAGEGSWRTPFLLYLTPLLMLPAIV---AWL 191 R I +G A ++GG G SWR PF T +LML V + Sbjct: 148 -SAGNSGRAITLYEAALGFGIACGPLLGGFLGAQSWRLPFAG--TSVLMLLGFVFVATTV 204 Query: 192 WEPDRRQEDSHAAPALNGGVRRTVLTACFLIFAGMVTCF-VVTVMTPTVLVMRGVTSTS- 249 EPD E AL G R T + ++ GM+ + TV+ T LV+ G T+ Sbjct: 205 TEPD--TEGREGVRALIGTFRHTGVRTNAIV--GMLYTYGFFTVLAYTPLVLEGFTTMQI 260 Query: 250 -LIGAAAGLAILCTLIGS-IAWPFVRERIGVAGVNALLLGCMAAGLCVLALAPSYAVVLA 307 L+ A GL + ++GS + P + R G V + L AA LC++ L S V+ Sbjct: 261 GLVFFAWGLLV---IVGSAVLAPRLNARFGTPEVASAALTAFAALLCLMWLVSSPMVLAG 317 Query: 308 AMVLQGLGAGFLVSNASLPLLLGLPPHLRARGVGAFTACLYLGQFASPLIITAIAQPLG 366 +V GL G L +N S L +G+ H R GA+ + + G +P++ I G Sbjct: 318 LVVTAGLACGLLNANLS-TLAMGISTHSRPSASGAYNSLRFTGGAFAPIVAGYIGGNYG 375