BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0035.0108.p (670 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2356_1 [H] COG1587 Uroporphyrinogen-III synthase Rso Ralstoni... 169 2e-41 PA5259 [H] COG1587 Uroporphyrinogen-III synthase Pae Pseudomonas... 88 7e-17 STM3937 [H] COG1587 Uroporphyrinogen-III synthase Sty Salmonella... 86 2e-16 hemD [H] COG1587 Uroporphyrinogen-III synthase Eco Escherichia c... 67 1e-10 ZhemD [H] COG1587 Uroporphyrinogen-III synthase EcZ Escherichia ... 67 1e-10 ECs4734 [H] COG1587 Uroporphyrinogen-III synthase Ecs Escherichi... 67 1e-10 VC0119 [H] COG1587 Uroporphyrinogen-III synthase Vch Vibrio chol... 65 7e-10 NMB0777 [H] COG1587 Uroporphyrinogen-III synthase Nme Neisseria ... 64 1e-09 >RSc2356_1 [H] COG1587 Uroporphyrinogen-III synthase Rso Ralstonia solanacearum Length = 368 Score = 169 bits (428), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 111/256 (43%), Positives = 145/256 (56%), Gaps = 3/256 (1%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 V+VTRPR QA A+++ G + FPLL+I+ ++ L+A LA +ALVVFVSPN Sbjct: 24 VIVTRPRAQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 83 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQ-RAD--KMDSEE 117 A+ AFA +P G WP V +VG S AL AHGV A + P AD + DSE Sbjct: 84 AVQQAFAAMPEGFRWPQDVPAAVVGPASAQALAAHGVAAPTYRVIRPDSHADDARQDSEA 143 Query: 118 LLKSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLL 177 L L +A L G+ LIVRG GR++L++ L++ GV V + AYRR+ P D L Sbjct: 144 LYARLDVATLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDTAAWAALR 203 Query: 178 DLLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERV 237 ++L G W +TSSEA RNL L R + V L F H RI E A+ GF V Sbjct: 204 EVLAGRHAWTLTSSEAARNLDSLARASLSAAEVEALYAAPCFAPHARIVEQAQSLGFRDV 263 Query: 238 VLTGSGDERLLAALAA 253 LTG+GD+RLLA + A Sbjct: 264 TLTGAGDDRLLAGVLA 279 >PA5259 [H] COG1587 Uroporphyrinogen-III synthase Pae Pseudomonas aeruginosa Length = 251 Score = 87.8 bits (216), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 84/246 (34%), Positives = 125/246 (50%), Gaps = 26/246 (10%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 +++TRP ++ A AAS+ G + PLL I +E+ + ++ L+ + VV VS Sbjct: 6 LLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKP 65 Query: 61 AIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELLK 120 A +L P P + VG + L A+G+D P++ D DSE LL Sbjct: 66 AARLGLERLDRYWPQPPQQTWCSVGAATAAILEAYGLDVTY-----PEQGD--DSEALL- 117 Query: 121 SLPLAQ----LRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLL 176 +LP Q + + LI+RG+ GR+FL+E L+ QGV V+YL YRR AP D G LL Sbjct: 118 ALPAFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAP--DYPAGELL 175 Query: 177 ----LDLLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQ 232 + L+G V++S + L+NL L E + R +FV R+AE ARE Sbjct: 176 ARVRAERLNG---LVVSSGQGLQNLYQLAAADWPE-----IGRLPLFVPSPRVAEMAREL 227 Query: 233 GFERVV 238 G +RV+ Sbjct: 228 GAQRVI 233 >STM3937 [H] COG1587 Uroporphyrinogen-III synthase Sty Salmonella typhimurium LT2 Length = 246 Score = 86.3 bits (212), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 85/254 (33%), Positives = 122/254 (48%), Gaps = 14/254 (5%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 +++TRP A + ++ALG+ A FPL+E A ++ TL LA L E LV +S + Sbjct: 3 ILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALSQH 62 Query: 61 AIDAAFAQLP-AGRPWPAKVAIGIVGEGSRLALR-AHGVDAACATLYGPQRADKMDSEEL 118 A+ A AQL GR WP +G + LAL G D D+ SE L Sbjct: 63 AVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFDIRYPL-------DREISEAL 115 Query: 119 LKSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLD 178 L+ L + G+RALI+RG GR+ L E L +G V + Y+R A D + Sbjct: 116 LQLPELQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWH 175 Query: 179 LLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFERVV 238 G V+TS E L+ L LT E ++ R R+ V R+A ARE G++ + Sbjct: 176 -TRGVTTLVVTSGEMLQRLWSLTPQWYREHWLL---RCRLLVVSERLAHLARELGWQDIK 231 Query: 239 LTGSGD-ERLLAAL 251 + + D + LL AL Sbjct: 232 VADNADNDALLRAL 245 >hemD [H] COG1587 Uroporphyrinogen-III synthase Eco Escherichia coli K12 Length = 246 Score = 67.4 bits (163), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 80/261 (30%), Positives = 122/261 (46%), Gaps = 28/261 (10%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 ++VTRP + ++ LG+ A FPL+E S + + L LA L E L+ +S + Sbjct: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQH 62 Query: 61 AIDAAFAQL-PAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELL 119 A+ A +QL R WP +G + LAL H V + LY PQ D+ SE LL Sbjct: 63 AVAFAQSQLHQQDRKWPRLPDYFAIGRTTALAL--HTV-SGQKILY-PQ--DREISEVLL 116 Query: 120 KSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDL 179 + L + G+RALI+RG GR+ + + L +G V + Y+R A D + Sbjct: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM---- 172 Query: 180 LDGGADW--------VITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETARE 231 W V+TS E L+ L L E ++ R+ V R+A+ ARE Sbjct: 173 -----RWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHC---RLLVVSERLAKLARE 224 Query: 232 QGFERVVLTGSGD-ERLLAAL 251 G++ + + + D + LL AL Sbjct: 225 LGWQDIKVADNADNDALLRAL 245 >ZhemD [H] COG1587 Uroporphyrinogen-III synthase EcZ Escherichia coli O157:H7 EDL933 Length = 246 Score = 67.0 bits (162), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 80/261 (30%), Positives = 121/261 (46%), Gaps = 28/261 (10%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 ++VTRP + ++ LG+ A FPL+E S + L LA L E L+ +S + Sbjct: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALSQH 62 Query: 61 AIDAAFAQL-PAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELL 119 A+ A +QL R WP +G + LAL H V + LY PQ D+ SE LL Sbjct: 63 AVAFAQSQLHQQDRKWPRLPNYFAIGRTTALAL--HTV-SGQKILY-PQ--DREISEVLL 116 Query: 120 KSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDL 179 + L + G+RALI+RG GR+ + + L +G V + Y+R A D + Sbjct: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM---- 172 Query: 180 LDGGADW--------VITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETARE 231 W V+TS E L+ L L E ++ R+ V R+A+ ARE Sbjct: 173 -----RWQSREVTTVVVTSGEMLQQLWSLIPQWYREHWLLHC---RLLVVSERLAKLARE 224 Query: 232 QGFERVVLTGSGD-ERLLAAL 251 G++ + + + D + LL AL Sbjct: 225 LGWQDIKVADNADNDALLRAL 245 >ECs4734 [H] COG1587 Uroporphyrinogen-III synthase Ecs Escherichia coli O157:H7 Length = 246 Score = 67.0 bits (162), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 80/261 (30%), Positives = 121/261 (46%), Gaps = 28/261 (10%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 ++VTRP + ++ LG+ A FPL+E S + L LA L E L+ +S + Sbjct: 3 ILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALSQH 62 Query: 61 AIDAAFAQL-PAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSEELL 119 A+ A +QL R WP +G + LAL H V + LY PQ D+ SE LL Sbjct: 63 AVAFAQSQLHQQDRKWPRLPNYFAIGRTTALAL--HTV-SGQKILY-PQ--DREISEVLL 116 Query: 120 KSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDL 179 + L + G+RALI+RG GR+ + + L +G V + Y+R A D + Sbjct: 117 QLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM---- 172 Query: 180 LDGGADW--------VITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETARE 231 W V+TS E L+ L L E ++ R+ V R+A+ ARE Sbjct: 173 -----RWQSREVTTVVVTSGEMLQQLWSLIPQWYREHWLLHC---RLLVVSERLAKLARE 224 Query: 232 QGFERVVLTGSGD-ERLLAAL 251 G++ + + + D + LL AL Sbjct: 225 LGWQDIKVADNADNDALLRAL 245 >VC0119 [H] COG1587 Uroporphyrinogen-III synthase Vch Vibrio cholerae Length = 260 Score = 64.7 bits (156), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 84/269 (31%), Positives = 114/269 (42%), Gaps = 44/269 (16%) Query: 1 VVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVFVSPN 60 V+VTRP +Q + G PA+ PLL ISA +A A+ L F +++ VS + Sbjct: 8 VLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLA---ALAEDLSSFDIIIAVSQH 64 Query: 61 AIDAAFAQLPAGRP-WPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADK---MDSE 116 A+ + L R WP VG+ + AH AC Q D DSE Sbjct: 65 AVIFSDQFLQHRRICWPNNAIYLAVGQKT-----AHVFSKAC-----QQSVDYPEISDSE 114 Query: 117 ELLKSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAY-RRTAPRLDA---QN 172 LL L + G++ LI+RG GR+ + L ++G TV Y AY R P A Q Sbjct: 115 HLLALSMLRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQK 174 Query: 173 GPLLLDLLDGGAD-WVITSSEALRNLVDLTRLAGGEERVVK------LQRQRIFVSHHRI 225 L D VITSSE L + R + +Q+ + V RI Sbjct: 175 WQL------AKVDSLVITSSEQLAFFI----------RQFETSHLPWVQQLTLLVPSQRI 218 Query: 226 AETAREQGFERVVLTGSGDERLLAALAAP 254 A A + GF R+V+T S R L A P Sbjct: 219 ATLAHQLGFHRIVVTLSAANRDLVAALMP 247 >NMB0777 [H] COG1587 Uroporphyrinogen-III synthase Nme Neisseria meningitidis MC58 Length = 246 Score = 64.3 bits (155), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 69/212 (32%), Positives = 96/212 (45%), Gaps = 35/212 (16%) Query: 30 LEISAVEDVATLQAMLARLEEFALVVFVSPNAIDAAFAQLPAGRPWPAKVAIGIVGEGSR 89 +EI A D A L+ + + V +VSP A++ A L A++A VG+GSR Sbjct: 30 VEIEA--DAAGLELLSEQYARADAVFWVSPTAVETAVPYLNLSDGIKAQIA---VGQGSR 84 Query: 90 LALRAHGVDAACATLYGPQRADKMDSEELLK-----SLPLAQLRGQRALIVRGQSGRDFL 144 AL T+ P D DSE +L+ SLP G R L VRG GRDFL Sbjct: 85 RALER----CLVRTVIAPD--DGNDSEAVLRLPVWNSLP----EGARVLFVRGHGGRDFL 134 Query: 145 SEALQQQGVTVEYLTAYRRTAPRLDAQNGPLLLDLLDGGADWVITSSEALRNLVDLTRLA 204 ALQ++G E Y R L+ QN + A ITS+E L RL Sbjct: 135 MNALQEKGFRTEVAEVYFRRHKPLNFQNFQ-----TENIAAAYITSTE-------LVRLL 182 Query: 205 GGEE--RVVKLQRQRIFVSHH-RIAETAREQG 233 G+ + + + ++ +HH RIAE + +G Sbjct: 183 FGQLPPQFSRFFKSLLYFTHHPRIAEALKREG 214