BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0035.0030.p (220 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0600_3 [T] COG4585 Signal transduction histidine kinase Pae Ps... 92 1e-18 SMa0204 [T] COG4585 Signal transduction histidine kinase Sme Sin... 85 1e-16 RSc0191_2 [T] COG4585 Signal transduction histidine kinase Rso R... 84 2e-16 BH2214_2 [T] COG4585 Signal transduction histidine kinase Bha Ba... 84 3e-16 narX [T] COG3850 Signal transduction histidine kinase, nitrate/n... 83 6e-16 ZnarX [T] COG3850 Signal transduction histidine kinase, nitrate/... 83 6e-16 ECs1727 [T] COG3850 Signal transduction histidine kinase, nitrat... 83 6e-16 CAC2940 [T] COG4585 Signal transduction histidine kinase Cac Clo... 81 2e-15 BMEI1583 Non COG 79 6e-15 BH0784 [T] COG4585 Signal transduction histidine kinase Bha Baci... 79 9e-15 >PA0600_3 [T] COG4585 Signal transduction histidine kinase Pae Pseudomonas aeruginosa Length = 244 Score = 92.0 bits (227), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 106/208 (50%), Gaps = 8/208 (3%) Query: 13 HIREQERERIARDLHDDLGGVLAGVGM--ALGRLQEQLAAQGLAAPLAEADEARQLLQQA 70 +RE+E+ RIAR++HD+LG VL + + ++ L A +GL L ++L+ Q Sbjct: 38 SVREEEKARIAREVHDELGQVLTVLKLETSMCELAYADAQEGLRERLGNM---KKLIAQL 94 Query: 71 MASMHDIIDELHPPIVEFGLVDALQWQCRQIQREYRLHCQLDCPPALEQEDRFLILGLLR 130 + D+ L PPI++ G+ A++WQ R+ + ++ C ++ P Q +GL R Sbjct: 95 FQLVRDVATALRPPILDAGIGSAVEWQARRFEARTQIPCLVEVPENSPQLVDAKAIGLFR 154 Query: 131 ILREAASNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGHGLRNMR 190 IL+EA +N RH A +++ L L + ++DDG G ++ GL MR Sbjct: 155 ILQEALTNVMRHAEAHTVQLRLLREGDELCLSVSDDGRGFDVATVGRGSS---FGLVGMR 211 Query: 191 ERAQALGGELFIEAGQDGGVVIRTLIPV 218 ER +GG L I++ G + IP+ Sbjct: 212 ERVLMMGGTLDIDSAPGEGTTLSVRIPL 239 >SMa0204 [T] COG4585 Signal transduction histidine kinase Sme Sinorhizobium meliloti Length = 415 Score = 85.1 bits (209), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/210 (32%), Positives = 108/210 (51%), Gaps = 16/210 (7%) Query: 16 EQERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQLLQQAMASMH 75 EQER+RI DLHD LA + L R ++L+ G AP A +R L Q M + Sbjct: 204 EQERQRIGMDLHDQ---TLADL-TRLARRIDRLSRNGEVAPEALEPVSRSL-QHCMQDLR 258 Query: 76 DIIDELHPPIVE-FGLVDALQWQCRQIQREYRLHCQL----DCPPALEQEDRFLILGLLR 130 II++ P +++ FGL A++ + R+ + + ALE+ + +I+ L R Sbjct: 259 QIIEQAKPSVLQLFGLTQAIEHHLDRSTRDTGSIIEWGLADETNGALERLEPTVIVALFR 318 Query: 131 ILREAASNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGHGLRNMR 190 I +EA +NA RH A++V L RL ++I+DDG G+A R G G+ NM+ Sbjct: 319 IAQEAINNAVRHAAPLAVKVRLDADDDRLSIEISDDGTGLAKTRG-----RIGEGIDNMK 373 Query: 191 ERAQALGGELFIEAGQDG-GVVIRTLIPVA 219 RA+ + I G + G V+R ++P+A Sbjct: 374 TRARLISARFTIGPGHNNRGTVVRVVLPLA 403 >RSc0191_2 [T] COG4585 Signal transduction histidine kinase Rso Ralstonia solanacearum Length = 235 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/208 (31%), Positives = 104/208 (50%), Gaps = 11/208 (5%) Query: 15 REQERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQ-LLQQAMAS 73 RE+ER RIAR+LHDDLG L+ + M + L L A+G L EA Q ++ + +++ Sbjct: 25 REEERHRIARELHDDLGQRLSALKMDISLLAADLQAEGGDRTLIAQTEAMQRVIDETISA 84 Query: 74 MHDIIDELHPPIV-EFGLVDALQWQCRQIQREYRLHCQLDCPPALEQEDRFLILGLLRIL 132 + I +L PP++ E LV A++W + ++ + L + QE + + RI+ Sbjct: 85 VRQISADLRPPLLDELELVPAIEWIAKNFRQRFGLIVNVHAQEMPMQER--AAISVFRIV 142 Query: 133 REAASNAARHGRASALRVGLRMRQARLEMQIADDG---CGIAPLHAKEDATRHGHGLRNM 189 +EA +N RH A+ + + LE+ I D+G G+ P + R GL + Sbjct: 143 QEALNNVVRHADATRVEIEFVRLDDMLELSIQDNGRGWSGVPPAPGE----RKPLGLLGI 198 Query: 190 RERAQALGGELFIEAGQDGGVVIRTLIP 217 RERA+ LGG+ I D G + P Sbjct: 199 RERARLLGGQATIAHTPDSGFRLSVRFP 226 >BH2214_2 [T] COG4585 Signal transduction histidine kinase Bha Bacillus halodurans Length = 275 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 100/202 (49%), Gaps = 14/202 (6%) Query: 17 QERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQLLQQAMASMHD 76 QER+R+A+DLHD + +L +G+ +++ L PLA +QL +AM M Sbjct: 82 QERQRLAQDLHDSVNQLLFSIGLTAKGAEQRAKDDTLKKPLA---MIQQLSSEAMVEMRH 138 Query: 77 IIDELHPPIVEFGLVDALQWQCRQIQREYRLHCQLDCPPALEQEDRFLILGLLRILREAA 136 +I +L P +E GL+ A++ QIQ + +ED L I++EA Sbjct: 139 LIWQLRPLGLEKGLIFAIETYAGQIQLPVSFSSCEVIRWSKAKED-----ALFPIVQEAL 193 Query: 137 SNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGHGLRNMRERAQAL 196 +N +H S + V + + + I DDGCGI +A+ G G+++M+ERA+ + Sbjct: 194 NNCKKHANPSDVVVHMYKNRGTGIISIQDDGCGIKETNAE------GFGMKHMKERAKQI 247 Query: 197 GGELFIEAGQDGGVVIRTLIPV 218 GG + + + G VI +P Sbjct: 248 GGMIHVRSQPGEGTVISIHVPF 269 >narX [T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific Eco Escherichia coli K12 Length = 598 Score = 82.8 bits (203), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 109/212 (51%), Gaps = 26/212 (12%) Query: 17 QERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQLLQQ------- 69 +ER IAR+LHD + L+ + M + LQ QG A P + +R+LL Q Sbjct: 389 EERATIARELHDSIAQSLSCMKMQVSCLQ----MQGDALP----ESSRELLSQIRNELNA 440 Query: 70 AMASMHDIIDELHPPIVEFGLVDALQWQCRQIQREYRLHCQLD--CPPALEQEDRFLILG 127 + A + +++ + E GL AL+ C + ++ +LD PP L + + Sbjct: 441 SWAQLRELLTTFRLQLTEPGLRPALEASCEEYSAKFGFPVKLDYQLPPRLVPSHQ--AIH 498 Query: 128 LLRILREAASNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGH-GL 186 LL+I REA SNA +H +AS + V + ++++ + D+GCG+ E+A R H G+ Sbjct: 499 LLQIAREALSNALKHSQASEVVVTVAQNDNQVKLTVQDNGCGV-----PENAIRSNHYGM 553 Query: 187 RNMRERAQALGGELFIEAGQDGGV-VIRTLIP 217 MR+RAQ+L G+ + + GG V+ T IP Sbjct: 554 IIMRDRAQSLRGDCRVRRRESGGTEVVVTFIP 585 >ZnarX [T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific EcZ Escherichia coli O157:H7 EDL933 Length = 598 Score = 82.8 bits (203), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 109/212 (51%), Gaps = 26/212 (12%) Query: 17 QERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQLLQQ------- 69 +ER IAR+LHD + L+ + M + LQ QG A P + +R+LL Q Sbjct: 389 EERATIARELHDSIAQSLSCMKMQVSCLQ----MQGDALP----ESSRELLSQIRNELNA 440 Query: 70 AMASMHDIIDELHPPIVEFGLVDALQWQCRQIQREYRLHCQLD--CPPALEQEDRFLILG 127 + A + +++ + E GL AL+ C + ++ +LD PP L + + Sbjct: 441 SWAQLRELLTTFRLQLTEPGLRPALEASCEEYSAKFGFPVKLDYQLPPRLVPSHQ--AIH 498 Query: 128 LLRILREAASNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGH-GL 186 LL+I REA SNA +H +AS + V + ++++ + D+GCG+ E+A R H G+ Sbjct: 499 LLQIAREALSNALKHSQASEVVVTVAQNDNQVKLTVQDNGCGV-----PENAIRSNHYGM 553 Query: 187 RNMRERAQALGGELFIEAGQDGGV-VIRTLIP 217 MR+RAQ+L G+ + + GG V+ T IP Sbjct: 554 IIMRDRAQSLRGDCRVRRRESGGTEVVVTFIP 585 >ECs1727 [T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific Ecs Escherichia coli O157:H7 Length = 598 Score = 82.8 bits (203), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 109/212 (51%), Gaps = 26/212 (12%) Query: 17 QERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQLLQQ------- 69 +ER IAR+LHD + L+ + M + LQ QG A P + +R+LL Q Sbjct: 389 EERATIARELHDSIAQSLSCMKMQVSCLQ----MQGDALP----ESSRELLSQIRNELNA 440 Query: 70 AMASMHDIIDELHPPIVEFGLVDALQWQCRQIQREYRLHCQLD--CPPALEQEDRFLILG 127 + A + +++ + E GL AL+ C + ++ +LD PP L + + Sbjct: 441 SWAQLRELLTTFRLQLTEPGLRPALEASCEEYSAKFGFPVKLDYQLPPRLVPSHQ--AIH 498 Query: 128 LLRILREAASNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGH-GL 186 LL+I REA SNA +H +AS + V + ++++ + D+GCG+ E+A R H G+ Sbjct: 499 LLQIAREALSNALKHSQASEVVVTVAQNDNQVKLTVQDNGCGV-----PENAIRSNHYGM 553 Query: 187 RNMRERAQALGGELFIEAGQDGGV-VIRTLIP 217 MR+RAQ+L G+ + + GG V+ T IP Sbjct: 554 IIMRDRAQSLRGDCRVRRRESGGTEVVVTFIP 585 >CAC2940 [T] COG4585 Signal transduction histidine kinase Cac Clostridium acetobutylicum Length = 402 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 98/205 (47%), Gaps = 15/205 (7%) Query: 17 QERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQLLQQAMASMHD 76 +ER RI+R++HD +G L+ V M L L L L +E ++ + ++ Sbjct: 197 RERNRISREIHDSVGHTLSAVLMQLQALL-YLIKSDKEESLKTVEEMTGFVRGGIENVRR 255 Query: 77 IIDELHPPIVEFGLVDALQWQCRQIQREYRLHCQLDCPPALEQEDRFLI----LGLLRIL 132 + EL P +F + + + ++ R+Y+ D L +E R L R++ Sbjct: 256 TVRELKPT--DFDRFEGV-FAIEEMIRKYKKLTSADIRFILSKEKRSLSSDESFISYRVV 312 Query: 133 REAASNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGHGLRNMRER 192 +EA +NA RHG+AS + V ++ Q RL ++I D+G G D + G G+ M ER Sbjct: 313 QEALNNAIRHGKASLVEVSMQFNQDRLYIRIKDNGVG-------TDGIKKGFGMTGMEER 365 Query: 193 AQALGGELFIEAGQDGGVVIRTLIP 217 + LGG + + +D G + +P Sbjct: 366 VKKLGGNIEFYSERDKGFEVTVNLP 390 >BMEI1583 Non COG Length = 439 Score = 79.3 bits (194), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 63/198 (31%), Positives = 97/198 (48%), Gaps = 8/198 (4%) Query: 12 IHIREQERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQLLQQAM 71 I +E+ER R+AR+LHD + L GV A+ Q+ AP A ++A L A+ Sbjct: 228 IDTQEEERARLARELHDGISQNLVGVRYAIDLASRQVRTGSGGAPQA-IEKASDALNGAI 286 Query: 72 ASMHDIIDELHPPIVE-FGLVDALQWQCRQIQREYRLHCQLDCPPALEQEDRFLILGLLR 130 + + +L P I++ GL AL+ C + E R ++ E L R Sbjct: 287 KEVRRLSHDLRPRILDDLGLTVALKALCERTGIETRFKAD-SLQETIKPEPS---TALYR 342 Query: 131 ILREAASNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGHGLRNMR 190 +++EA +N RH A+ + + L+ ++ M IAD+G G A K+ + G GLRNM+ Sbjct: 343 VVQEALTNVERHSGATRVDIRLKGAHGKVTMTIADNGNGFAVRGLKDPLS--GLGLRNMQ 400 Query: 191 ERAQALGGELFIEAGQDG 208 ER GG L +E DG Sbjct: 401 ERMAHFGGVLLVETSADG 418 >BH0784 [T] COG4585 Signal transduction histidine kinase Bha Bacillus halodurans Length = 393 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 99/208 (47%), Gaps = 16/208 (7%) Query: 17 QERERIARDLHDDLGGVLAGVGMALGRLQEQLAAQGLAAPLAEADEARQLLQQAMASMHD 76 +ER R++R++HD +G L + L ++ L Q + +A++ +++ +A + Sbjct: 182 EERVRLSREIHDTIGHTLTTAIVGLESVKRLLQHQRTEEAFEKLTKAQEHIKKGLAEVRR 241 Query: 77 IIDELH--PPIVEFGLVDALQWQCRQIQRE--YRLHCQLDCPPALEQEDRFLILGLLRIL 132 + LH P ++F V +L+ ++ +HC + P L E L L R Sbjct: 242 SVKTLHEKPSFLQF--VPSLEALAKETSESTGVSIHCHIGDLPKLTPEQE---LTLFRAF 296 Query: 133 REAASNAARHGRASALRVGLRMRQARLEMQIADDGCGIAPLHAKEDATRHGHGLRNMRER 192 +E +N RHG+++ L ++ R+ ++ D+G P+ + G GL M +R Sbjct: 297 QEGLTNGIRHGQSTEFFFTLEAKEERIWFELIDNGQTTTPI-------KPGFGLTMMNDR 349 Query: 193 AQALGGELFIEAGQDGGVVIRTLIPVAR 220 Q+LGGE+ I GGV + +P+ + Sbjct: 350 VQSLGGEIHISRHGSGGVHLGITLPMTK 377