BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0047.p (281 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mlr7896 [GER] COG0697 Permeases of the drug/metabolite transport... 205 9e-53 mll3062 [GER] COG0697 Permeases of the drug/metabolite transport... 184 1e-46 BMEI1244 [GER] COG0697 Permeases of the drug/metabolite transpor... 181 2e-45 SMc01807 [GER] COG0697 Permeases of the drug/metabolite transpor... 167 2e-41 STM3796A [GER] COG0697 Permeases of the drug/metabolite transpor... 156 4e-38 AGc2304 [GER] COG0697 Permeases of the drug/metabolite transport... 135 1e-31 PA0539 [GER] COG0697 Permeases of the drug/metabolite transporte... 129 7e-30 VCA0599 [GER] COG0697 Permeases of the drug/metabolite transport... 88 2e-17 >mlr7896 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 278 Score = 205 bits (522), Expect = 9e-53, Method: Compositional matrix adjust. Identities = 125/281 (44%), Positives = 163/281 (58%), Gaps = 3/281 (1%) Query: 1 MNIAVIALVLAAALLHASWNALLKSSHDRLASLALMTLGAGIGAIPLILWRPWPEPASWF 60 M+ VI L L AA+LHASWNA L++ DRL ++ +M+ AIPL ++ +P ++W Sbjct: 1 MSPLVIGLALFAAILHASWNAFLRTGADRLWTVTVMSFSDTALAIPLAIFNGFPATSAWP 60 Query: 61 YIILSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGLYTVIGI 120 Y+ LS L GY++FL+ AYR G+ GQ YPI RGS PLLV LG + AG+QL TV Sbjct: 61 YVGLSACLQVGYSVFLVAAYRYGELGQVYPIVRGSVPLLVTLGGFLLAGQQL---TVPET 117 Query: 121 LLVSLGIVSLADLRAMRSREHLAGPLAAFATGAFIAAYTITDGIGARLAGDAMSYAGWLF 180 + V L + L R R L A ATGA IA Y D IG R AG+ +Y W+ Sbjct: 118 VGVVLVGGGIMGLSLGRGRAATTSILYALATGAIIAVYATVDAIGVRAAGNVGAYTAWVL 177 Query: 181 VLDSIALAVIYQRRHGRWPIALGRRETWIGLGGGVMSLLAYGIVIWAVTLAPMGMVSALR 240 + L + GR P+ ETW LGGG+ +LLAYG+V+ A L P G ++A+R Sbjct: 178 LAYGALLPATFVACRGRLPVDPRAPETWKALGGGLFALLAYGVVVAAFALGPAGPITAIR 237 Query: 241 ETSVLFALLIGALFLGERLTLRRVLSGVVIVAGTIVLGTHH 281 ETSV+FA IG LFLGE LT RRV + V+ G I LG Sbjct: 238 ETSVVFAAFIGRLFLGETLTPRRVGACAVVALGAICLGYQS 278 >mll3062 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 281 Score = 184 bits (468), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 117/261 (44%), Positives = 158/261 (60%), Gaps = 3/261 (1%) Query: 19 WNALLKSSHDRLASLALMTLGAGIGAIPLILWRPWPEPASWFYIILSGLLHTGYNLFLIR 78 WNAL+K DR S+ LMTLG G A+ ++ + +P+ W +I+ S + H GY FLI Sbjct: 19 WNALVKVHLDRFLSITLMTLGMGFAALFVLPFVEFPKAEVWPFILASVVFHMGYRTFLIG 78 Query: 79 AYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGLYTVIGILLVSLGIVSLADLRAMRS 138 AYR GDF Q+YP+ARG++PLL ALG V E + ++GILL+S G + + R Sbjct: 79 AYRAGDFAQTYPLARGTAPLLAALGGIVVVQEVPAPFAILGILLLSAGTLVM-SFRGGAH 137 Query: 139 REHLAGPLAAFATGA--FIAAYTITDGIGARLAGDAMSYAGWLFVLDSIALAVIYQRRHG 196 E L FA G FIA+YT++DG GARLA A SYA WLFV D+ V+ G Sbjct: 138 LERLNLRAVGFALGTSIFIASYTLSDGSGARLAATAQSYAAWLFVCDATWALVLCVVFRG 197 Query: 197 RWPIALGRRETWIGLGGGVMSLLAYGIVIWAVTLAPMGMVSALRETSVLFALLIGALFLG 256 + + R+ GL GV+S AY IV+WA+T AP+ V++LRETS+LFA+LI LG Sbjct: 198 PQSLPVLARDWKAGLFTGVLSGAAYWIVMWAMTKAPIASVASLRETSILFAMLISVYALG 257 Query: 257 ERLTLRRVLSGVVIVAGTIVL 277 E++T R + + IVAG I L Sbjct: 258 EKMTGWRGAAALSIVAGVIAL 278 >BMEI1244 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bme Brucella melitensis Length = 281 Score = 181 bits (458), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 113/278 (40%), Positives = 169/278 (60%), Gaps = 1/278 (0%) Query: 1 MNIAVIALVLAAALLHASWNALLKSSHDRLASLALMTLGAGIGAIPLILWRPWPEPASWF 60 M+ V+ +VL A LH SWNA++K S D+ A +T AG+ A+ L+ + P P ASW Sbjct: 1 MSGGVLLIVLFGAFLHTSWNAIVKGSGDKFFGAASVTGAAGLIALFLVPFLPLPTAASWI 60 Query: 61 YIILSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGLYTVIGI 120 Y++LS + T Y + AY+ GD ++YPI RG+ PLLVAL + GE +G + +GI Sbjct: 61 YMLLSTITQTFYMSLVAAAYKSGDMSEAYPIMRGTPPLLVALVSGPLVGEIMGWQSWLGI 120 Query: 121 LLVSLGIVSLA-DLRAMRSREHLAGPLAAFATGAFIAAYTITDGIGARLAGDAMSYAGWL 179 +L+ G++++A D R L A A FIA+YT+ DG+G R++G+ +SY WL Sbjct: 121 VLICSGVLAMALDARRRNRGASSRTVLLALANAGFIASYTLIDGLGVRVSGEPLSYTLWL 180 Query: 180 FVLDSIALAVIYQRRHGRWPIALGRRETWIGLGGGVMSLLAYGIVIWAVTLAPMGMVSAL 239 F+L+++ LA R I R L GGV +L +YG+ +WA+T+AP+ +V+AL Sbjct: 181 FLLNAVPLAGWALYREPSRFINYIRNRWRPALIGGVGTLGSYGLALWAMTMAPIAVVAAL 240 Query: 240 RETSVLFALLIGALFLGERLTLRRVLSGVVIVAGTIVL 277 RET++LF +LI AL L E++ L R ++ IVAG I L Sbjct: 241 RETAILFGMLISALILKEKVGLPRFVAAGFIVAGAIAL 278 >SMc01807 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 278 Score = 167 bits (423), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 105/271 (38%), Positives = 163/271 (60%), Gaps = 4/271 (1%) Query: 1 MNIAVIALVLAAALLHASWNALLKSSHDRLASLALMTLGAGIGAIPLILWRPWPEPASWF 60 M VIALVL ALLHA+WNAL+K+ ++ A+++LG + A+P + + P P + Sbjct: 1 MPPDVIALVLLGALLHATWNALVKAGTEKSLDAAMVSLGGAVVALPFLPFLPMPGSEAVP 60 Query: 61 YIILSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGLYTVIGI 120 YI++S L Y + AYR GD G YP+ RG +PL+VA +++ GE+L + GI Sbjct: 61 YILVSALFQFAYFQLVAAAYRAGDIGLVYPLMRGVAPLIVAATSSLVIGEKLTGGAMAGI 120 Query: 121 LLVSLGIVSLADLRAMRSREHLAGPLAAFATGAFIAAYTITDGIGARLAGDAMSYAGWLF 180 + +S G+++LA R + + A IA+YT DGIGAR++G+A+SY W+ Sbjct: 121 MTISAGVLTLAFESRKGGRHAI---VLALLNACVIASYTYVDGIGARISGNAISYTLWMA 177 Query: 181 VLDSIALAVIYQRRHGRWPIALG-RRETWIGLGGGVMSLLAYGIVIWAVTLAPMGMVSAL 239 +L + L R G P+A R W GL GG S+ +YG+ +WA+T AP+ V+AL Sbjct: 178 LLPPVLLFGWAFARRGVKPVARHVSRHWWRGLIGGAGSIGSYGLALWAMTKAPVATVAAL 237 Query: 240 RETSVLFALLIGALFLGERLTLRRVLSGVVI 270 RET++LFA++I +FL ER++ R+++ +I Sbjct: 238 RETAILFAVVISVVFLKERVSAWRIIAAFII 268 >STM3796A [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sty Salmonella typhimurium LT2 Length = 286 Score = 156 bits (395), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 101/281 (35%), Positives = 166/281 (59%), Gaps = 11/281 (3%) Query: 1 MNIAVIALVLAAALLHASWNALLKSSHDRLASLALMTLGAGIGAIPLILWRPWPEPASWF 60 M ++V ++L AALLHASWNA++K+ +D+L + ++ A + A+ L+ + P P AS Sbjct: 10 MTLSVFCILLFAALLHASWNAIVKAGNDKLYAAIGVSGSAAVMALILLPFSPQPAHASIP 69 Query: 61 YIILSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGLYTVIGI 120 ++ S L Y + + + Y++ D Q+YP+ RG++PLLVAL + +F G+ L +GI Sbjct: 70 FLAASTALQVVYTVLVAKTYQVSDMSQTYPLMRGTAPLLVALISVLFLGDSLSSLAWVGI 129 Query: 121 LLVSLGIVSLA-DLRAMRSREHLAGPLAAFATGAFIAAYTITDGIGARLAGDAMSYAGWL 179 ++ + I+ +A + RA R G + A FIA YT+ DG G RL+ A+ Y W Sbjct: 130 AVICMAILGMACNGRASSQR----GVVLALTNACFIAGYTLVDGTGVRLSETALGYTLWS 185 Query: 180 FVLDSIAL---AVIYQRRHGRWPIALGRRETWIGLGGGVMSLLAYGIVIWAVTLAPMGMV 236 F L+ L A+I +RR +A ++ G+ GG+ ++ +YG+ +WA+T AP+ +V Sbjct: 186 FFLNGACLLTWAMIARRREASRYLAQQWKK---GIFGGIGTMGSYGLALWAMTQAPLAVV 242 Query: 237 SALRETSVLFALLIGALFLGERLTLRRVLSGVVIVAGTIVL 277 +ALRETS+LF LI L L E++ R+++ I G I+L Sbjct: 243 AALRETSILFGALIAWLLLKEKVAGLRLVAAGGIALGAILL 283 >AGc2304 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 305 Score = 135 bits (339), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 108/266 (40%), Positives = 163/266 (61%), Gaps = 10/266 (3%) Query: 16 HASWNALLKSSHDRLASLALMTLGAGIGAIPLILWRPWPEPASWFYIILSGLLHTGYNLF 75 HA WNAL+KS D+ +L+ GA ++P + + P+P P + ++I S +L Y Sbjct: 43 HAGWNALVKSGSDKSLDASLIAAGAAACSLPFLPFLPFPAPVAIPFLIASAVLQFAYFRL 102 Query: 76 LIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGLYTVIGILLVSLGIVSLA-DLR 134 + AY IGD G YP+ RG +PL+VA +++F E L + GI ++S GI++LA + R Sbjct: 103 VAAAYTIGDIGLVYPVMRGVAPLIVAATSSLFLSEVLSPLALAGIAVISGGILTLAFEAR 162 Query: 135 AMRSREHLAGPLAAFATGAFIAAYTITDGIGARLAGDAMSYAGWLFVLDSIAL--AVIYQ 192 + L L AF IA+YT DG+GARL+G+A+SY W+ +L + L YQ Sbjct: 163 RGGGKAILVALLNAFV----IASYTFVDGVGARLSGNAISYTLWMSLLPPVLLFGFAFYQ 218 Query: 193 RRHGRWPIALG-RRETWIGLGGGVMSLLAYGIVIWAVTLAPMGMVSALRETSVLFALLIG 251 R G P+A +R W GL GG S+L+YG+ ++A+T AP+ +V+ALRETS+LFAL+I Sbjct: 219 RGVG--PVARHVQRNWWRGLIGGGGSILSYGLALYAMTKAPVAVVAALRETSILFALVIS 276 Query: 252 ALFLGERLTLRRVLSGVVIVAGTIVL 277 + L ER ++ R L+G +I AG +V+ Sbjct: 277 VVILKERASIWRYLAGGIIAAGVLVM 302 >PA0539 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 276 Score = 129 bits (324), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 97/271 (35%), Positives = 143/271 (52%), Gaps = 1/271 (0%) Query: 7 ALVLAAALLHASWNALLKSSHDRLASLALMTLGAGIGAIPLILWRPWPEPASWFYIILSG 66 +LVL AA+LHA+WN L+K S DRL +A M + + AI L+ + P W +++ + Sbjct: 5 SLVLCAAVLHATWNTLVKFSSDRLLVVACMDVVGVLCAILLLPFVSLPPAEVWPWLLGAT 64 Query: 67 LLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGLYTVIGILLVSLG 126 +L Y + LI AY++GD G YP+ RG SPL+V F GEQL ++GILL+ G Sbjct: 65 VLQLLYRVLLIEAYKVGDLGLVYPLMRGLSPLVVLGLTLAFGGEQLSGRQILGILLIPFG 124 Query: 127 IVSLADLRAMRSREHLAGPLAAFATGAFIAAYTITDGIGARLAGDAMSYAGWLFVLDSIA 186 ++ L SR G I YT +DG + A+ Y WL +L + Sbjct: 125 MLCLL-WGGGGSRLPWRTLPVVLLIGLCIGGYTWSDGNALKRWPLALDYLVWLTLLSGLP 183 Query: 187 LAVIYQRRHGRWPIALGRRETWIGLGGGVMSLLAYGIVIWAVTLAPMGMVSALRETSVLF 246 +I R E +GL GV L +YG+V+WA+ L + +ALRETSVL Sbjct: 184 FPLIAVGARTRAFARFWALEWKLGLAVGVCVLASYGLVLWAMQLGSIAEAAALRETSVLL 243 Query: 247 ALLIGALFLGERLTLRRVLSGVVIVAGTIVL 277 A+L G FL E L R+L+ +++AG +++ Sbjct: 244 AVLFGMRFLNEPFGLPRLLACGLVLAGMLLM 274 >VCA0599 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Vch Vibrio cholerae Length = 301 Score = 88.2 bits (217), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 97/298 (32%), Positives = 137/298 (45%), Gaps = 23/298 (7%) Query: 1 MNIAVIALVLAAALLHASWNALLKSSHDRLASLAL-MTLGAGIGAIPLILWR----PWPE 55 M+ I LVL +ALLHA WN + K S L T + P I+W W Sbjct: 1 MSFMPIILVLFSALLHAGWNIIGKRYQSSGPSFFLGATSATSLLLTPYIVWYFTKIGWST 60 Query: 56 -PAS-WFYIILSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLG 113 P W +++SGL Y L L AY D G +YP+ARG LLV G V G L Sbjct: 61 LPTQFWLLLVVSGLSQMVYMLGLAFAYSKVDIGIAYPLARGLPVLLVGAGT-VMLGYDLQ 119 Query: 114 LYTVIGILLVSLG--IVSLADLRAMRSREHLA-GPLAAFATGAFIAAYTITDG------- 163 L +G L++LG ++ L R R ++ G + A A Y+I D Sbjct: 120 LNQWLGFALITLGCLMIPLQKFRQFRFADYANLGIVWALVAALGTAGYSIIDKEALAIIE 179 Query: 164 --IGARLAGD--AMSYAGWLFVLDSIALAVIYQRRHGRWPIALGRRETWIGLGGGVMSLL 219 +G+++ A+ Y G F I LA+ Y R P R + G+M Sbjct: 180 QTVGSQMPASYSAVLYLGIQFWAMCIPLAIWYLLTGQRAPFVEAWRIRYTATLAGLMMGG 239 Query: 220 AYGIVIWAVTLAP-MGMVSALRETSVLFALLIGALFLGERLTLRRVLSGVVIVAGTIV 276 Y +V++A+TL + + ALR+TS++F L +G FLGER + R+L IVAG +V Sbjct: 240 TYSLVLYAMTLTENVSFIVALRQTSIVFGLFMGIAFLGERWYVTRLLGVSAIVAGLVV 297