BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0221.p (315 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGl161 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Atu ... 99 9e-21 alr2827 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Nos... 97 7e-20 MK0724 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Mka ... 87 6e-17 SMb21060 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Sm... 85 2e-16 MTH380 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Mth ... 85 2e-16 all2853 [M] COG1087 UDP-glucose 4-epimerase Nos Nostoc sp. PCC 7120 82 1e-15 CAC2334 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Cac... 82 2e-15 BMEII0832 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases B... 80 4e-15 CAC0731 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Cac... 80 5e-15 MA4464 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Mac ... 80 8e-15 >AGl161 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 378 Score = 99.4 bits (246), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 79/256 (30%), Positives = 126/256 (49%), Gaps = 12/256 (4%) Query: 4 ILITGGLGYLGGRIASQLVKAGHRVRATSRKAQPAPAWLPE---MQVLAPDWESTDELIA 60 +L+TG GY+G + L KAGH V + A++P QV + D A Sbjct: 25 VLVTGHRGYIGSVMVPILRKAGHDVHGYDTEFYHRCAYVPGGPLPQVPGVCKDIRDITPA 84 Query: 61 ACTGHDAVVHLAAM-NEIYSGRDPVGALRTNGLASLMLQNAAQSAGVRRFIFFSTAHVYG 119 G DAV+HLAA+ N+ S +P N S+ AA+ AGV+RFIF S+ YG Sbjct: 85 DMEGFDAVIHLAALSNDPLSNLNPEITYEINYRGSVRAAQAAKQAGVKRFIFASSCSNYG 144 Query: 120 APLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLSNGFG-APMTADVD 178 A G ++E +P Y + +AE + + G V +R + +G +PM Sbjct: 145 AAGEGLVNETAELKPVSAYGTSKVLAEREIASLASPG-FSPVYMRPATAYGLSPML---- 199 Query: 179 RWTLLVNDLCRQALTTGALKLQSAGTQLRDFITLDDVGRAVQHLVELDTSSLGNGLFNLG 238 R+ +++N+L A+T G + L+S G+ R + ++D+ RA +E T ++ N FN+G Sbjct: 200 RFDIVLNNLTAWAVTEGLILLKSDGSPWRPIVHIEDISRAFLAALEAPTDAIHNQAFNVG 259 Query: 239 D--RTMSILQMTEMVA 252 I ++ E+VA Sbjct: 260 QDAHNYQIREIAEIVA 275 >alr2827 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Nos Nostoc sp. PCC 7120 Length = 342 Score = 96.7 bits (239), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 98/339 (28%), Positives = 148/339 (43%), Gaps = 48/339 (14%) Query: 3 SILITGGLGYLGGRIASQLVKAGHRVRATSRKAQPAPAWLPEMQVLAPDWESTDELIAAC 62 IL+TG GYLG + S L+ GH V WL + ++ ++ I Sbjct: 2 KILVTGTEGYLGCLLPSLLIGKGHEVIGVDTGYYKV-GWLYNGTPVTA--KTLNKDIRHI 58 Query: 63 T-----GHDAVVHLAAMNEIYSGRDPVGALR------TNGLASLMLQNAAQSAGVRRFIF 111 T G +A+VH+A ++ DP G L N + S+ L N A++ GVRRF++ Sbjct: 59 TPEDLEGVEAIVHMAELS-----NDPTGQLSPNITYDINHIGSVRLANLAKTMGVRRFVY 113 Query: 112 FSTAHVYGAPLAGDIDEATLARPRHPYAITHRVAE-DFVLAAHDSGQIEGVVVRLSNGFG 170 S+ VYG GD+ EA+ P+ YA + E D L A D +R + FG Sbjct: 114 MSSCSVYGVATEGDVTEASPVNPQTAYAECKTLVERDVTLLADD--DFSPTFMRNATAFG 171 Query: 171 APMTADVDRWTLLVNDLCRQALTTGALKLQSAGTQLRDFITLDDVGRAVQHLVELDTSSL 230 A R+ +++N+L A TT +K+ S GT R + D+ +A+ +E + Sbjct: 172 ASPRM---RFDIVLNNLAGLAWTTKEIKMISDGTPWRPLVHALDICKAIVCALEAPRDIV 228 Query: 231 GNGLFNLGDRTMSILQMTEMVAARASKLLGRDIPIIRPADNGAPVPSLHYHTEKIRNT-- 288 N +FN+GD T + ++ E+ A G + DNGA S EKI + Sbjct: 229 HNQVFNVGDTTNN-YRVKEIAQIIADTFPGCKLSF---GDNGADNRSYRVSFEKINSILP 284 Query: 289 GFR--------------LRSDIDQEIDSTLLLCQRAFSR 313 GF+ L S ID D+ L R F+R Sbjct: 285 GFKCDWDAQKGARQLFDLFSQIDMTEDTFLF---RGFTR 320 >MK0724 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Mka Methanopyrus kandleri AV19 Length = 309 Score = 86.7 bits (213), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 85/321 (26%), Positives = 139/321 (43%), Gaps = 25/321 (7%) Query: 4 ILITGGLGYLGGRIASQLVKAGHRVRATSRKAQPAPAWLPE----MQVLAPDWESTDELI 59 IL+TGG G++G + +LV GH V + L E ++++ D TD Sbjct: 2 ILVTGGAGFIGSHVVEELVDRGHDVVVLDNFSVGCEENLREVRDDIEIVRAD--VTDPRA 59 Query: 60 AACTGHD----AVVHLAA-MNEIYSGRDPVGALRTNGLASLMLQNAAQSAGVRRFIFFST 114 T + AV+HLAA +N YS P R N L +L L + A V RF++ S+ Sbjct: 60 VERTFREYRPEAVIHLAAQVNVRYSMESPFVDARINALGTLNLVSLAAEHDVERFVYASS 119 Query: 115 A-HVYGAPLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLSNGFGAPM 173 VYG P +DE RP Y ++ E +V + E V++R +N +G Sbjct: 120 GGAVYGEPEYLPVDEEHPTRPISNYGVSKLAGEYYVRVYAERDGFEYVILRYANVYGPRQ 179 Query: 174 TADVDRWTLLVNDLCRQALTTGALKLQSAGTQLRDFITLDDVGRAVQHLVELDTSSLGNG 233 + + + +A L + G Q RDF+ ++DV R VE G+G Sbjct: 180 DPRGEAGVIPI--FLLRAARGEPLTIFGDGEQTRDFVFVEDVARVTAEAVE-----RGDG 232 Query: 234 LFNLGD-RTMSILQMTEMVAARASKLLGRDIPIIRPADNGAPVPSLHYHTEKIRNT-GFR 291 ++N+G R S+ + V A + G D+ ++ V ++ + R GF Sbjct: 233 VYNIGTGRETSVNDIVNAVKA----VTGVDVEVVYEDPRPGEVRRIYLDPSRAREELGFE 288 Query: 292 LRSDIDQEIDSTLLLCQRAFS 312 R D+++ I+ T +R + Sbjct: 289 PRVDLEEGIERTWEWIRRKIA 309 >SMb21060 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Sme Sinorhizobium meliloti Length = 349 Score = 85.1 bits (209), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/246 (29%), Positives = 114/246 (46%), Gaps = 22/246 (8%) Query: 3 SILITGGLGYLGGRIASQLVKAGHRVRATSR---KAQPAPAWLPEMQVLAPDWESTDELI 59 +L+TG GY+G + L + H V ++ L + + D D +I Sbjct: 2 KVLVTGHRGYIGAVLTPMLHQRDHDVTGLDSDIFRSCTFEGTLDDTPTMEEDVR--DIVI 59 Query: 60 AACTGHDAVVHLAAMNEIYSGRDPVGALR------TNGLASLMLQNAAQSAGVRRFIFFS 113 G DAV+HLA ++ DP+G R N AS+ L A+ AGV RF+F S Sbjct: 60 DDLAGFDAVIHLAGLSN-----DPLGDYRPNLTQQINCEASVTLARLAKRAGVPRFLFAS 114 Query: 114 TAHVYGAPLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLSNGFG-AP 172 + YGA +G + E+ P PY I+ +V + +A +R S +G +P Sbjct: 115 SCSNYGAAGSGFLTESAAFNPVTPYGIS-KVEVEHAVAPMADECFSPTFLRASTAYGLSP 173 Query: 173 MTADVDRWTLLVNDLCRQALTTGALKLQSAGTQLRDFITLDDVGRAVQHLVELDTSSLGN 232 R+ L++N+L A TTG + L+S G+ R + ++D+ RA +E D + N Sbjct: 174 RI----RFDLVLNNLTAWAFTTGQIYLKSDGSPWRPIVHVEDIARAYIAALEADRELVHN 229 Query: 233 GLFNLG 238 FN+G Sbjct: 230 QAFNVG 235 >MTH380 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Mth Methanothermobacter thermautotrophicus Length = 316 Score = 84.7 bits (208), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 69/257 (26%), Positives = 124/257 (48%), Gaps = 14/257 (5%) Query: 4 ILITGGLGYLGGRIASQLVKAGHRVRATSRKAQPAPAWL-----PEMQVLAPDWESTDEL 58 + +TGGLG++G + +L++ G+RV + +P L +++++ D L Sbjct: 6 VAVTGGLGFIGSHLTDELLERGNRVTVIDDLSTGSPDNLRDPHHEDLEIIEGSINDLD-L 64 Query: 59 IAACTGHDAVVHLAAMNEI-YSGRDPVGALRTNGLASLMLQNAAQSAGVRRFIFFSTAHV 117 G D V H AA+ + S RDP+ R N +L + A+ AGVR+ + ST+ V Sbjct: 65 EKVFQGKDYVFHQAALASVPESVRDPLRCHRVNATGTLRVLMASSRAGVRKVVNASTSAV 124 Query: 118 YGAPLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLSNGFGAPMTADV 177 YG + E P PYA++ E + D G +E V +R N +G D Sbjct: 125 YGNNPEIPLREDARPMPLSPYAVSKVTGEYYCQVFEDQG-LETVSLRYFNVYGPRQRPD- 182 Query: 178 DRWTLLVNDLCRQALTTGALKLQSAGTQLRDFITLDDVGRAVQHLVELDTSSLGNGLFNL 237 ++ ++ L+ + ++ G Q RDFI + DV RA L E S G+G++N+ Sbjct: 183 SQYAAVIPRFIDALLSGRSPEIYGDGEQSRDFIYVGDVVRANIFLAE----SRGSGVYNV 238 Query: 238 -GDRTMSILQMTEMVAA 253 G ++++ ++ ++++ Sbjct: 239 AGGSSVTVNRLFDIISG 255 >all2853 [M] COG1087 UDP-glucose 4-epimerase Nos Nostoc sp. PCC 7120 Length = 336 Score = 82.4 bits (202), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 93/324 (28%), Positives = 143/324 (44%), Gaps = 33/324 (10%) Query: 4 ILITGGLGYLGGRIASQLVKAGHRVRATSRKAQPAPAWLPEMQVLAPDWESTDELIAACT 63 +L+TGG GY+G + QL +AG+ V + +P + +++ D ++++ L Sbjct: 5 VLVTGGAGYIGSHVVRQLGEAGYDVVVYDNCSTGSPQAVLHGELIIGDLKNSECLSQVFH 64 Query: 64 GHD--AVVHLAAMNEI-YSGRDPVGALRTNGLASLMLQNAAQSAGVRRFIFFSTAHVYGA 120 H AV+H AA + S P+ N +L L GV + IF STA VYG Sbjct: 65 QHKFTAVLHFAASLSVPESVARPLDYYANNTRNTLNLLRCCHDTGVNQIIFSSTAAVYGQ 124 Query: 121 PLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLSNGFGAP-------M 173 P + E+T P +PY + E + + + V++R N GA M Sbjct: 125 PETAVVTESTATEPINPYGRSKLSCEWLIRDHAKASDLRYVILRYFNVAGAEPGGRLGQM 184 Query: 174 TADVDRWTLLVNDLCRQALTT-------GALKLQSAGTQLRDFITLDDVGRAVQHLVELD 226 T D L+ C AL G GT +RD+I ++D+ A HL L Sbjct: 185 TKDASH---LIRVTCDAALKRRLGVKIFGTDFPTPDGTAIRDYIHVEDLATA--HLDALV 239 Query: 227 TSSLGNG--LFNLG-DRTMSILQMTEMVAARASKLLGRDIPIIRPA-DNGAPVPSLHYHT 282 GN + N G + S+ Q+ + V A + G D P+I +G PV + T Sbjct: 240 YLEQGNSSQILNCGYGQGYSVRQVIDRVKA----ISGVDFPVIEAERRSGDPV-CVTACT 294 Query: 283 EKIRNT-GFRLR-SDIDQEIDSTL 304 +KIR G++ + DIDQ + STL Sbjct: 295 DKIRQVLGWQPKYDDIDQIVHSTL 318 >CAC2334 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Cac Clostridium acetobutylicum Length = 301 Score = 82.0 bits (201), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 72/307 (23%), Positives = 137/307 (44%), Gaps = 15/307 (4%) Query: 3 SILITGGLGYLGGRIASQLVKAGHRVRATSRKAQPAPAWLP-EMQVLAPDW-ESTDELIA 60 +IL+TGG G++G + L++ GH+V + LP E+ + D E+ E Sbjct: 2 NILVTGGAGFIGSHVVKSLLEHGHKVSVIDNMVHGNSSNLPDEVNIYKYDISEAEIENAF 61 Query: 61 ACTGHDAVVHLAAMNEIY-SGRDPVGALRTNGLASLMLQNAAQSAGVRRFIFFSTAHVYG 119 + V+H AA + S +DP+ + N L S+ + + VR+ I+ ++A ++G Sbjct: 62 KIERPEVVIHNAAQISVADSVKDPLYDAKVNVLGSINILEMCRKYAVRKVIYPASAAIFG 121 Query: 120 APLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLSNGFGAPMTADVDR 179 P IDE Y ++ E ++ I V+R SN +G + + Sbjct: 122 EPKYLPIDEKHPLNMISSYGVSKHTVEHYLNVYKKLYNINYTVLRYSNVYGPGQDSSGEG 181 Query: 180 WTLLVNDLCRQALTTGA-LKLQSAGTQLRDFITLDDVGRAVQHLVELDTSSLGNGLFNLG 238 + + + LT G L + G Q+RDF+ + DV A +++ L+ SL N ++N+ Sbjct: 182 GVV---SIFAEKLTKGEPLCIYGNGNQIRDFVYVKDVTEA--NILALN--SLDNDIYNVS 234 Query: 239 DRTMSILQMTEMVAARASKLLGRDIPIIRPADNGAPVPSLHYHTEKIRN-TGFRLRSDID 297 T + + + A G+++ I+ + + + +KI N G++ + D+ Sbjct: 235 TNTKTTINDLAKLMCEA---YGKEVEIMHKGERAGDIFESYMSYDKIYNACGWKPKYDLK 291 Query: 298 QEIDSTL 304 I T+ Sbjct: 292 LGIKETI 298 >BMEII0832 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Bme Brucella melitensis Length = 355 Score = 80.5 bits (197), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 72/250 (28%), Positives = 111/250 (44%), Gaps = 28/250 (11%) Query: 3 SILITGGLGYLGGRIASQLVKAGHRVRATS--------RKAQPAPAWLPEMQVLAPDWES 54 +L+TG GY+G + L+ AGH V K +P ++ D Sbjct: 4 KVLVTGSQGYIGSVMVPMLIDAGHEVSGYDIGLYEHCLFKEGGTVMNVPTIRKDVRDVSP 63 Query: 55 TDELIAACTGHDAVVHLAAMNEIYSGRDPVGALR------TNGLASLMLQNAAQSAGVRR 108 D G DAV+HLAA++ DP+G L N AS+ + AA+ AGV R Sbjct: 64 RD-----LEGFDAVIHLAALSN-----DPLGNLNEDLTYAINHHASVAMAKAAKLAGVGR 113 Query: 109 FIFFSTAHVYGAPLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLSNG 168 F+F S+ YG A IDE +P Y + AE + D+ V +R + Sbjct: 114 FLFASSCSNYGISDAELIDETGELKPVTAYGRSKVRAEQEIRKLADASFCP-VYLRPATA 172 Query: 169 FGAPMTADVDRWTLLVNDLCRQALTTGALKLQSAGTQLRDFITLDDVGRAVQHLVELDTS 228 +G + R+ +++N+L A+T G + L+S GT R + + D+ RA +E Sbjct: 173 YG---VSPFLRFDIVLNNLVAWAVTKGLIYLKSDGTPWRPIVHIHDISRAFMAAMEAPRE 229 Query: 229 SLGNGLFNLG 238 + N FN+G Sbjct: 230 KVWNEAFNVG 239 >CAC0731 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Cac Clostridium acetobutylicum Length = 725 Score = 80.1 bits (196), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 72/257 (28%), Positives = 113/257 (43%), Gaps = 43/257 (16%) Query: 4 ILITGGLGYLGGRIASQLVKAGHRVRATSR------KAQPAPAWLPEMQVLAPDWESTDE 57 ILI GG G++G + +L K GH+ K P + + + ES +E Sbjct: 3 ILIVGGCGFIGSHVVERLYKEGHKTYIIDNLSTGNLKNVTVPHKFYNLSI---ESESCEE 59 Query: 58 LIAACTGHDAVVHLAAMNEIYSGRDPVGALRTNGLASLM-----------LQNAAQSAGV 106 + A DAV+ L++ PV + TN AS L N + GV Sbjct: 60 VFKA-NKFDAVIDLSS---------PV--VNTNAEASSFELTPSVKGITNLLNFSSKYGV 107 Query: 107 RRFIFFSTAHVYGAPLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLS 166 +RFIF S+A VYG +EA + P PYA+ V E + + ++ + +R+S Sbjct: 108 KRFIFASSASVYGNNNLTIKEEAEI-NPLSPYAVNKYVGEFYTQKWFEIYGLKTISLRIS 166 Query: 167 NGFG--APMTADVDRWTLLVNDLCRQALTTGALKLQSAGTQLRDFITLDDVGRAVQHLVE 224 N FG + + + L +N +AL + + GTQ RDFI ++DV A+ +E Sbjct: 167 NVFGPRQSIKGEGNVVALFIN----KALKSSEIDRFGDGTQTRDFIYVEDVVDAIYKALE 222 Query: 225 LDTSSLGNGLFNLGDRT 241 D + G+ N+ T Sbjct: 223 SDYT----GVLNISTNT 235 >MA4464 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Mac Methanosarcina acetivorans str.C2A Length = 298 Score = 79.7 bits (195), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 113/256 (44%), Gaps = 16/256 (6%) Query: 4 ILITGGLGYLGGRIASQLVKAGHRVRATSRKAQPAPAWLPE---MQVLAPDWESTDELIA 60 +LITGG G++G IA +AGH VR +P+ ++ + D + Sbjct: 3 VLITGGAGFIGSHIAEYFAEAGHSVRILDNLTTGFSRNIPQHRNVEFIQGDICDPSSVEK 62 Query: 61 ACTGHDAVVHLAAMNEI-YSGRDPVGALRTNGLASLMLQNAAQSAGVRRFIFFSTAHVYG 119 A +G D V H AA+ + S PV A R N L +L + A AGV +F+ S+A VYG Sbjct: 63 AVSGMDCVFHEAALVSVPLSCEKPVEAFRINTLGTLNVLQACVRAGVEKFVTASSAAVYG 122 Query: 120 APLAGDIDEATLARPRHPYAITHRVAEDFVLAAHDSGQIEGVVVRLSNGFGAPMTADVDR 179 E P PYAI+ E ++ + +R N +G P Sbjct: 123 NNPELPKRENMYPEPASPYAISKLDGEYLARMFYEEHGLRTTCLRYFNVYG-PRQDPKSP 181 Query: 180 WTLLVNDLCRQALTTGALKLQSAGTQLRDFITLDDVGRAVQHLVELDTSSLGNG---LFN 236 + ++ +A L + G Q RDF+ + DV V + ++L +G +FN Sbjct: 182 YAAVIPIFLERAKAGKDLVIYGDGLQSRDFVHVKDV-------VMANVAALEHGDGQVFN 234 Query: 237 LG-DRTMSILQMTEMV 251 + +++++L++ E + Sbjct: 235 VAMGKSVTVLELAENI 250