BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0213.p (345 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value NMB0068 [M] COG2089 Sialic acid synthase Nme Neisseria meningiti... 491 e-138 Cj1141 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni 417 e-116 Cj1327 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni 196 1e-49 MJ1065 [M] COG2089 Sialic acid synthase Mja Methanococcus jannas... 195 2e-49 BS_spsE [M] COG2089 Sialic acid synthase Bsu Bacillus subtilis 162 1e-39 CC2868 [M] COG2089 Sialic acid synthase Ccr Caulobacter vibrioides 161 2e-39 CAC2187 [M] COG2089 Sialic acid synthase Cac Clostridium acetobu... 156 7e-38 FN1684 [M] COG2089 Sialic acid synthase Fnu Fusobacterium nucleatum 150 3e-36 Cj1317 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni 142 1e-33 HP0178 [M] COG2089 Sialic acid synthase Hpy Helicobacter pylori ... 126 7e-29 >NMB0068 [M] COG2089 Sialic acid synthase Nme Neisseria meningitidis MC58 Length = 349 Score = 491 bits (1264), Expect = e-138, Method: Compositional matrix adjust. Identities = 233/343 (67%), Positives = 278/343 (81%), Gaps = 1/343 (0%) Query: 3 EFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSD 62 EF I R VG +H PL+I EIGINHEGSL A MVDAA +AGAEV+KHQTH+VEDEMSD Sbjct: 6 EFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSD 65 Query: 63 EAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDI 122 EAK VIPGNADVSIYEIMERCAL+E DE KL +YV+S+G IFISTPFSRAAA RL R DI Sbjct: 66 EAKQVIPGNADVSIYEIMERCALNEEDEIKLKEYVESKGMIFISTPFSRAAALRLQRMDI 125 Query: 123 AAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNV 182 A+KIGSGECNNYPLIK VA +GKP+I+STGMN++ES++ +VEI+R+AGVP+ALLHCTN+ Sbjct: 126 PAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESIKKSVEIIREAGVPYALLHCTNI 185 Query: 183 YPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPG 242 YPTP E VRLG M +L +A+PDA++GLSDHT+ N+ CLGAVALG SILERHFTDRMDRPG Sbjct: 186 YPTPYEDVRLGGMNDLSEAFPDAIIGLSDHTLDNYACLGAVALGGSILERHFTDRMDRPG 245 Query: 243 PDILCSMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETL 301 PDI+CSM+P +L G+ + ARG K + A E PT FAFASVVA K I +GE L Sbjct: 246 PDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELL 305 Query: 302 TEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 + DNLW++RPG GDF +YE L G+VAA +I+ GAQI+K D+ Sbjct: 306 SGDNLWVKRPGNGDFSVNEYETLFGKVAACNIRKGAQIKKTDI 348 >Cj1141 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni Length = 343 Score = 417 bits (1072), Expect = e-116, Method: Compositional matrix adjust. Identities = 193/330 (58%), Positives = 250/330 (75%), Gaps = 2/330 (0%) Query: 16 TPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSDEAKSVIPGNADVS 75 PL+I EIGINH GSL +A MVDAA AGA++IKHQTH+VEDEMS EAK+VIPGNA++S Sbjct: 14 NPLIIPEIGINHNGSLEIAKLMVDAAKRAGAKIIKHQTHIVEDEMSQEAKNVIPGNANIS 73 Query: 76 IYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDIAAFKIGSGECNNY 135 IYEIME+CAL+ DE L +YV+ +G +++STPFSRAAA RL ++A+KIGSGECNNY Sbjct: 74 IYEIMEQCALNYKDELALKEYVEKQGLVYLSTPFSRAAANRLEDMGVSAYKIGSGECNNY 133 Query: 136 PLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNVYPTPPELVRLGAM 195 PLIKH+A++ KPMI+STGMN++ES++PTV+I+R +PF LLH TN+YPTP LVRL AM Sbjct: 134 PLIKHIAQFKKPMIISTGMNSIESIKPTVKILRDYEIPFVLLHTTNLYPTPSHLVRLQAM 193 Query: 196 QELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPGPDILCSMDPSALS 255 EL + + + + GLSDHT +N C+GA+ALGAS+LERHFTD MDR GPDI+CSMD S L Sbjct: 194 LELYKEF-NCLYGLSDHTTNNLACIGAIALGASVLERHFTDTMDRKGPDIVCSMDESTLK 252 Query: 256 DLVHGSATIFKARG-AGKGPVEAEAPTIAFAFASVVAYKAIGEGETLTEDNLWLRRPGTG 314 DL++ + + RG K P++ E TI FAFASVV+ K I +GE L+ DN+W++RP G Sbjct: 253 DLINQTQEMVLLRGDNNKNPLKEEQVTIDFAFASVVSIKDIKKGEILSMDNIWVKRPSKG 312 Query: 315 DFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 D+E +LG+ A + IK Q+ DD Sbjct: 313 GISAKDFEAILGKRAKKDIKNNIQLTWDDF 342 >Cj1327 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni Length = 334 Score = 196 bits (497), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 120/331 (36%), Positives = 174/331 (52%), Gaps = 10/331 (3%) Query: 18 LVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSDEAK----SVIPGNAD 73 L+IAE G+NH G L +A +++ A D+GA+ +K Q+ ++ +S +AK + D Sbjct: 5 LIIAEAGVNHNGDLNLAKKLIEIAADSGADFVKFQSFKAKNCISTKAKKAPYQLKTTAND 64 Query: 74 VSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDIAAFKIGSGECN 133 S +++++ L K+L+ + + F+STPF + + L + FKI SGE Sbjct: 65 ESQLQMVQKLELDLKAHKELILHAKKCNIAFLSTPFDLESVDLLNELGLKIFKIPSGEIT 124 Query: 134 NYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVP---FALLHCTNVYPTPPELV 190 N P +K +AK K +I+STGM L + + ++ K G LLHCT YP P V Sbjct: 125 NLPYLKKIAKLNKKIILSTGMANLGEIEEALNVLCKNGAKRQNITLLHCTTEYPAPFNEV 184 Query: 191 RLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPGPDILCSMD 250 L AMQ LK A+ VG SDHT H+ L AVALGA ++E+HFT + GPD S++ Sbjct: 185 NLKAMQSLKDAFK-LDVGYSDHTRGIHISLAAVALGACVIEKHFTLDKNMSGPDHKASLE 243 Query: 251 PSALSDLVHGSATIFKARGAG-KGPVEAEAPTIAFAFASVVAYKAIGEGETLTEDNLWLR 309 P L L I KA G G K ++E I S+VA K I +GE +E NL + Sbjct: 244 PQELKMLCTQIRQIQKAMGDGIKKASKSEQKNINIVRKSLVAKKDIKKGEIFSEGNLTTK 303 Query: 310 RPGTGDFGPTDYEPLLGRVAARSIKAGAQIR 340 RP G YE LG++A ++ K IR Sbjct: 304 RPANG-ISAMRYEEFLGKIATKNYKEDELIR 333 >MJ1065 [M] COG2089 Sialic acid synthase Mja Methanococcus jannaschii Length = 337 Score = 195 bits (495), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 115/316 (36%), Positives = 175/316 (55%), Gaps = 13/316 (4%) Query: 1 MAEFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEM 60 M + I R VG +IAE G+NH G + + +V A GA+ IK Q++ ED + Sbjct: 1 MEKIKIGDRYVGKGEPTFIIAEGGLNHNGDIDIGKELVKEAKKCGADAIKFQSYHTEDFI 60 Query: 61 SDEAKSVIPGNADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARF 120 S +++ YE+ + LSE + +L +Y + G +FISTP + L + Sbjct: 61 SKKSE----------YYELFKSLELSEEEFYELKEYAEKIGIMFISTPLDLKYVDILNKM 110 Query: 121 DIAAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGV-PFALLHC 179 ++ AFKI SG+ YPL++ VAK GKP+I+STGM+ + + V+++ G LLHC Sbjct: 111 NVPAFKIASGDLTFYPLLEKVAKTGKPVILSTGMSDIGEIWEAVKVLENNGCRDIILLHC 170 Query: 180 TNVYPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMD 239 + YPTP E V L A++ LK + + VG SDHT+ + +VALGA ++E+HFT + Sbjct: 171 ISSYPTPYEDVNLNAIKTLKSIF-NIPVGYSDHTLGILAPVVSVALGADVIEKHFTLDKN 229 Query: 240 RPGPDILCSMDPSALSDLVHGSATIFKARGAG-KGPVEAEAPTIAFAFASVVAYKAIGEG 298 GPD S DP ++V+ + K G+G K P+ +E I A S+VA + I +G Sbjct: 230 MEGPDHALSADPEEFKEMVNNIRLVEKMLGSGEKIPMPSERDVIVEARRSIVAKRNIKKG 289 Query: 299 ETLTEDNLWLRRPGTG 314 E L+ DN+ +RPG G Sbjct: 290 EYLSVDNISFKRPGRG 305 >BS_spsE [M] COG2089 Sialic acid synthase Bsu Bacillus subtilis Length = 373 Score = 162 bits (410), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 123/367 (33%), Positives = 179/367 (48%), Gaps = 26/367 (7%) Query: 1 MAEFSIAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEM 60 MA F IA + VG D +IAE GINH+G L A A++DAA +AGA+ +K Q D M Sbjct: 1 MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEAGADAVKFQMFQA-DRM 59 Query: 61 SDEAKSVIPGNA--DVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLA 118 + + A DVSI+ +++ + L+DY + + IF+ST +A+ L Sbjct: 60 YQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQVIFLSTVCDEGSADLLQ 119 Query: 119 RFDIAAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAG-VPFALL 177 +AFKI S E N+ PL+K+VA+ +PMI ST + V +R G A++ Sbjct: 120 STSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISDVHEAWRTIRAEGNNQIAIM 179 Query: 178 HCTNVYPTPPELVRLGAMQELKQAYPDAVVGLSDHTVS-NHVCLGAVALGASILERHFTD 236 HC YP PPE L + L A+P+AV+G SDH+ AV LGA ++E+HFT Sbjct: 180 HCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHPTEAPCAAVRLGAKLIEKHFTI 239 Query: 237 RMDRPGPDILCSMDPSALSDLVHG----------------SATIFKARGAGKGPVEAEAP 280 + PG D +++P L ++V G S + + +E E Sbjct: 240 DKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGITKPVSEKLLGSSYKTTTAIEGEIR 299 Query: 281 TIAFAFASVVAYKAIGEGETLTEDNLWLRRPGTGDFG--PTDYEPLLGRV-AARSIKAGA 337 FA+ + I +GE +EDN+ + RPG G P +E L V A R I A Sbjct: 300 N--FAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQGLHPRFFELLTSGVRAVRDIPADT 357 Query: 338 QIRKDDL 344 I DD+ Sbjct: 358 GIVWDDI 364 >CC2868 [M] COG2089 Sialic acid synthase Ccr Caulobacter vibrioides Length = 356 Score = 161 bits (408), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 110/336 (32%), Positives = 158/336 (47%), Gaps = 7/336 (2%) Query: 6 IAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSDEAK 65 IAGR +G DH+P VI E+ NH GSL +AMVDAA D G + IK QT+ + D + Sbjct: 14 IAGRKIGADHSPYVICELSGNHNGSLERCLAMVDAAADTGCDAIKIQTYTADTITLDVDR 73 Query: 66 SVIPGNADV----SIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFD 121 + + ++YE+ E + + + RG S+PF A + L Sbjct: 74 PEFKIHGGLWDGRTLYELYEEAHTPFEWHAAIFERARQRGVTIFSSPFDETAVDLLDSLG 133 Query: 122 IAAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVP-FALLHCT 180 AFKI S E + PLIK+ A GKP+I+STGM L ++ ++ AG P LLHC Sbjct: 134 APAFKIASFEAVDLPLIKYAAAKGKPLIISTGMANLTEMQTALDTALSAGAPGVLLLHCV 193 Query: 181 NVYPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDR 240 + YP + + ++ + +GLSDHT + AV+LGA +E+HFT Sbjct: 194 SSYPATFADANVRTVPDMAARF-GCPIGLSDHTPGTAASVAAVSLGACAVEKHFTLARAD 252 Query: 241 PGPDILCSMDPSALSDLVHGSATIFKARGAGKGPVEAEAPTIAFAFASVVAYKAIGEGET 300 GPD S++P+ LV + + A G V T S+ + GE Sbjct: 253 GGPDAAFSLEPAEFKALVDDTKNAWAALGRAHYDVLGSEATSLLFRRSLYVTADVKAGEP 312 Query: 301 LTEDNLWLRRPGTGDFGPTDYEPLLGRVAARSIKAG 336 LT N+ RPG G P D + +L A R + G Sbjct: 313 LTRANVRSVRPGNG-LPPADLDKVLAGKATRDLARG 347 >CAC2187 [M] COG2089 Sialic acid synthase Cac Clostridium acetobutylicum Length = 350 Score = 156 bits (394), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 101/339 (29%), Positives = 172/339 (50%), Gaps = 10/339 (2%) Query: 6 IAGRMVGDDHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHV---VEDEMSD 62 I G+ +G+ +IAE+ NH A+ ++ AA +GA+ IK QT+ + + + Sbjct: 7 IGGKKIGEGQRTFIIAEMSANHNQDFDRAVEIIKAAKRSGADAIKLQTYTPDTITFDSDN 66 Query: 63 EAKSVIPGNA--DVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARF 120 E + G +++++ E + KL + + G I S+PF + + L + Sbjct: 67 EYFQIKQGTIWDGTTLHKLYEEAYTPWQWQPKLKEIAEEEGLICFSSPFDNTSVDFLEKM 126 Query: 121 DIAAFKIGSGECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVP-FALLHC 179 ++ A+K+ S E + P I+++A GKP+I+STG+ + + V R+ G LL C Sbjct: 127 EVPAYKVASFELTDIPFIEYIASKGKPVIMSTGIAEMGEIYEAVAACRRQGNENVILLKC 186 Query: 180 TNVYPTPPELVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMD 239 ++ YP+P E + L + +++A+ + VGLSDHT+ V AVALGA+++E+HFT + Sbjct: 187 SSSYPSPLEDINLKTIPNMREAF-NCSVGLSDHTMGYSVATAAVALGATVIEKHFTLKRS 245 Query: 240 RPGPDILCSMDPSALSDLVHGSATIFKARGAGKGPVEAEAPTIAFAFASVVAYKAIGEGE 299 GPD SM+P S +V + KA G + + S+ K I +GE Sbjct: 246 DGGPDSAFSMEPEEFSAMVKSIREVEKALGKVTYELTEKQKNSRQHSRSLFVVKDIKKGE 305 Query: 300 TLTEDNLWLRRPGTGDFGPTDY-EPLLGRVAARSIKAGA 337 T T++N+ RP G T Y E ++G+ A +K G Sbjct: 306 TFTKENVKSIRPAFG--LKTKYIEEVIGKKARVDVKKGT 342 >FN1684 [M] COG2089 Sialic acid synthase Fnu Fusobacterium nucleatum Length = 351 Score = 150 bits (380), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 93/339 (27%), Positives = 175/339 (51%), Gaps = 13/339 (3%) Query: 17 PLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEMSDEAKSVI------PG 70 P IA+I NH+G L A +++ A +AGA+V K Q + +S + + Sbjct: 14 PFFIADIAANHDGDLERAYKLIELAKEAGADVAKFQNFNAKTIVSKKGFETLGKQLSHQA 73 Query: 71 NADVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDIAAFKIGSG 130 N S+YE+ + +++ + L G ++++P+ A+ + + + + A+KIGSG Sbjct: 74 NWKKSVYEVYKDASINPDWTELLKRKCDEVGIEYMTSPYDYASVDLVDPY-VNAYKIGSG 132 Query: 131 ECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVPFALLHCTNVYPTPPE-- 188 + ++K++ KP++++TG +++E V ++I+ K L+ C Y E Sbjct: 133 DITWTEILKYILSKNKPILLATGASSMEDVDRAMDIL-KENQNIVLMQCNTNYTASTENF 191 Query: 189 -LVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPGPDILC 247 + L +++ ++ YP+A++GLSDHT LGA+ALGA ++E+HFTD DR GPD Sbjct: 192 KYINLNVLKKYEEKYPNAILGLSDHTKGFATVLGAIALGAVVIEKHFTDDNDREGPDHKF 251 Query: 248 SMDPSALSDLVHGSATIFKARGAGKGPVEA-EAPTIAFAFASVVAYKAIGEGETLTEDNL 306 +M+P ++V S ++ + G G +E E T + K++ G L+ ++L Sbjct: 252 AMNPKTWREMVDASLELYYSLGDGIKRIEKNEEDTAMVQRRGIYITKSLKAGHILSREDL 311 Query: 307 WLRRPGTGD-FGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 RP D P + + LLG+ ++I++ + + D+ Sbjct: 312 IALRPIKIDGIQPYEIDLLLGKKLTKNIESDSYLTWKDV 350 >Cj1317 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni Length = 343 Score = 142 bits (358), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 7/337 (2%) Query: 14 DHTPLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHVVEDEM--SDEAKSVIPGN 71 D +IAE+ NH GSL +A+ + AA AGA+ IK QT+ + SD+ +I G Sbjct: 9 DKKVFIIAELSANHAGSLEMALKSIKAAKKAGADAIKIQTYTPDSLTLNSDKEDFIIKGG 68 Query: 72 A--DVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDIAAFKIGS 129 +YE+ E ++ + Q+ G + S+PF++ E L RFD A+KI S Sbjct: 69 LWDKRKLYELYESAKTPYEWHSQIFETAQNEGILCFSSPFAKEDVEFLKRFDPIAYKIAS 128 Query: 130 GECNNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKAGVP-FALLHCTNVYPTPPE 188 E N+ ++ +AK KP IVSTG+ T E + EI ++ P L CT+ YPT E Sbjct: 129 FEANDENFVRLIAKEKKPTIVSTGIATEEELFKICEIFKEEKNPDLVFLKCTSTYPTAIE 188 Query: 189 LVRLGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPGPDILCS 248 + L + LK+ + + VGLSDH+ + AVALGA ++E+HF D S Sbjct: 189 DMNLKGIVSLKEKF-NVEVGLSDHSFGFLAPVMAVALGARVIEKHFMLDKSIESEDSKFS 247 Query: 249 MDPSALSDLVHGSATIFKARGAGKGPVEAEAPTIAFAFASVVAYKAIGEGETLTEDNLWL 308 +D +V A G GK ++ + S+ A K I +GE +E+N+ Sbjct: 248 LDFDEFKAMVDAVRQAESALGDGKLDLDEKVLKNRVFARSLYASKDIKKGEMFSEENVKS 307 Query: 309 RRPGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDLR 345 RP G P Y+ LLG+ A++ IK G +++ D + Sbjct: 308 VRPSFG-LHPKFYQELLGKKASKDIKFGDALKQGDFQ 343 >HP0178 [M] COG2089 Sialic acid synthase Hpy Helicobacter pylori 26695 Length = 340 Score = 126 bits (317), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 95/334 (28%), Positives = 159/334 (47%), Gaps = 8/334 (2%) Query: 17 PLVIAEIGINHEGSLPVAIAMVDAAIDAGAEVIKHQTHV--VEDEMSDEAKSVIPGNA-- 72 P ++AE+ NH L +A + A ++GA+ +K QT+ S E +I G Sbjct: 5 PKIVAELSANHNQDLNLAKESLHAIKESGADFVKLQTYTPSCMTLNSKEDPFIIQGTLWD 64 Query: 73 DVSIYEIMERCALSESDEKKLMDYVQSRGAIFISTPFSRAAAERLARFDIAAFKIGSGEC 132 ++YE+ ++ + +L + + S+PFS A E L + +KI S E Sbjct: 65 KENLYELYQKASTPLEWHAELFELARKLDLGIFSSPFSSQALELLESLNCPMYKIASFEI 124 Query: 133 NNYPLIKHVAKYGKPMIVSTGMNTLESVRPTVEIMRKA-GVPFALLHCTNVYPTPPELVR 191 + LI+ A+ KP+I+S+G+ T ++ + + R+ LL C + YP+ E Sbjct: 125 VDLDLIEKAARTQKPIILSSGIATHTELQDAISLCRRVNNFDITLLKCVSAYPSKIEDAN 184 Query: 192 LGAMQELKQAYPDAVVGLSDHTVSNHVCLGAVALGASILERHFTDRMDRPGPDILCSMDP 251 L +M +L + + GLSDHT+ + + A LGAS++E+HF PD SMD Sbjct: 185 LLSMVKLGEIF-GVKFGLSDHTIGSLCPILATTLGASMIEKHFILNKSLQTPDSAFSMDF 243 Query: 252 SALSDLVHGSATIFKARGAGKGPVEAEAPTIAFAFA-SVVAYKAIGEGETLTEDNLWLRR 310 + +V A G + + + FA S+ K I +GE LTE+N+ R Sbjct: 244 NGFKSMVEAIKQSVLALGEEEPRINPKTLEKRRFFARSLFVIKDIQKGEALTENNIKALR 303 Query: 311 PGTGDFGPTDYEPLLGRVAARSIKAGAQIRKDDL 344 P G P Y+ +LG+ A++ +KA + DD+ Sbjct: 304 PNLG-LHPKFYKEILGQKASKFLKANTPLSADDI 336