BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0128.p (200 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ZcaiE [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleu... 244 1e-64 ECs0038 [R] COG0663 Carbonic anhydrases/acetyltransferases, isol... 244 1e-64 STM0069 [R] COG0663 Carbonic anhydrases/acetyltransferases, isol... 241 8e-64 caiE [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleuc... 240 1e-63 paaY [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleuc... 236 2e-62 TVN0980 [R] COG0663 Carbonic anhydrases/acetyltransferases, isol... 125 6e-29 PAB0393 [R] COG0663 Carbonic anhydrases/acetyltransferases, isol... 124 1e-28 Ta0881m [R] COG0663 Carbonic anhydrases/acetyltransferases, isol... 124 1e-28 Rv3525c [R] COG0663 Carbonic anhydrases/acetyltransferases, isol... 121 1e-27 MT3625 [R] COG0663 Carbonic anhydrases/acetyltransferases, isole... 121 1e-27 >ZcaiE [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 203 Score = 244 bits (622), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 111/186 (59%), Positives = 142/186 (76%) Query: 1 VPCYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQD 60 V Y+ EG+IPVV P+A+VHP+AVLIGDVIVG Y+GP A LRGD+GR+++Q GAN+QD Sbjct: 8 VSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQD 67 Query: 61 TCVIHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAF 120 C++HG+ DT+V ENGHIGHGA+LH C + RDALVGMN+V+MD AV+GE++IVAA +F Sbjct: 68 GCIMHGYTDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSF 127 Query: 121 VRAGMQIPPRTLAAGLPAKVVRELTADEMAWKQAGTRTYQDLTVRCLASLREVSPLSQIE 180 V+AG R L G PA+ VR ++ DE+ WK+ T+ YQDL RC ASL E PL Q+E Sbjct: 128 VKAGFHGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQME 187 Query: 181 ENRPAL 186 ENRP L Sbjct: 188 ENRPRL 193 >ECs0038 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Ecs Escherichia coli O157:H7 Length = 203 Score = 244 bits (622), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 111/186 (59%), Positives = 142/186 (76%) Query: 1 VPCYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQD 60 V Y+ EG+IPVV P+A+VHP+AVLIGDVIVG Y+GP A LRGD+GR+++Q GAN+QD Sbjct: 8 VSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQD 67 Query: 61 TCVIHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAF 120 C++HG+ DT+V ENGHIGHGA+LH C + RDALVGMN+V+MD AV+GE++IVAA +F Sbjct: 68 GCIMHGYTDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSF 127 Query: 121 VRAGMQIPPRTLAAGLPAKVVRELTADEMAWKQAGTRTYQDLTVRCLASLREVSPLSQIE 180 V+AG R L G PA+ VR ++ DE+ WK+ T+ YQDL RC ASL E PL Q+E Sbjct: 128 VKAGFHGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQME 187 Query: 181 ENRPAL 186 ENRP L Sbjct: 188 ENRPRL 193 >STM0069 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Sty Salmonella typhimurium LT2 Length = 198 Score = 241 bits (615), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 109/185 (58%), Positives = 140/185 (75%) Query: 4 YSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQDTCV 63 Y+ EG+IPVV P A+VHP+AVLIGDVIVG Y+GP A LRGD+GR++L+ G+N+QD C+ Sbjct: 4 YAFEGLIPVVHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLILEAGSNLQDGCI 63 Query: 64 IHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAFVRA 123 +HG+ DT+V ENGHIGHGA+LH C V RDALVGMN+V+MD AV+GE++IVAA +FV+A Sbjct: 64 MHGYCDTDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIMDGAVIGEESIVAAMSFVKA 123 Query: 124 GMQIPPRTLAAGLPAKVVRELTADEMAWKQAGTRTYQDLTVRCLASLREVSPLSQIEENR 183 G Q R L G PA+V+R++T E+ WK T+ YQDL +RC L E PL+Q EENR Sbjct: 124 GFQGEARQLLVGSPARVLRQVTDQELHWKHLNTKEYQDLAIRCRTGLSETKPLTQAEENR 183 Query: 184 PALAA 188 P L Sbjct: 184 PRLKG 188 >caiE [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Eco Escherichia coli K12 Length = 203 Score = 240 bits (613), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 110/186 (59%), Positives = 142/186 (76%) Query: 1 VPCYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQD 60 V Y+ EG+IPVV P+A+VHP+AVLIGDVIVG Y+GP A LRGD+GR+++Q GAN+QD Sbjct: 8 VSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQD 67 Query: 61 TCVIHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAF 120 C++HG+ DT+V ENGHIGHGA+LH C + RDALVGMN+V+MD AV+GE++IVAA +F Sbjct: 68 GCIMHGYCDTDTIVGENGHIGHGAILHGCLIGRDALVGMNSVIMDGAVIGEESIVAAMSF 127 Query: 121 VRAGMQIPPRTLAAGLPAKVVRELTADEMAWKQAGTRTYQDLTVRCLASLREVSPLSQIE 180 V+AG + R L G PA+ VR ++ DE+ WK+ T+ YQDL RC SL E PL Q+E Sbjct: 128 VKAGFRGEKRQLLMGTPARAVRNVSDDELHWKRLNTKEYQDLVGRCHVSLHETQPLRQME 187 Query: 181 ENRPAL 186 ENRP L Sbjct: 188 ENRPRL 193 >paaY [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Eco Escherichia coli K12 Length = 196 Score = 236 bits (603), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 111/186 (59%), Positives = 137/186 (73%) Query: 1 VPCYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQD 60 +P Y I+G+ PVV ++VHPTAVLIGDVI+G YVGP A LRGDFGRIV++ GAN+QD Sbjct: 1 MPIYQIDGLTPVVPEESFVHPTAVLIGDVILGKGVYVGPNASLRGDFGRIVVKDGANIQD 60 Query: 61 TCVIHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAF 120 CV+HGFP DTVV E+GHIGH A+LH C +RR+ALVGMNAVVMD AV+GE +IV A AF Sbjct: 61 NCVMHGFPEQDTVVGEDGHIGHSAILHGCIIRRNALVGMNAVVMDGAVIGENSIVGASAF 120 Query: 121 VRAGMQIPPRTLAAGLPAKVVRELTADEMAWKQAGTRTYQDLTVRCLASLREVSPLSQIE 180 V+A ++P L G PAK +REL+ E+AWK+ GT YQ L RC +L +V PL +IE Sbjct: 121 VKAKAEMPANYLIVGSPAKAIRELSEQELAWKKQGTHEYQVLVTRCKQTLHQVEPLREIE 180 Query: 181 ENRPAL 186 R L Sbjct: 181 PGRKRL 186 >TVN0980 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Tvo Thermoplasma volcanium Length = 173 Score = 125 bits (314), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 62/171 (36%), Positives = 99/171 (57%) Query: 4 YSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQDTCV 63 Y EG +P +DPSAYV +A +IG V +G + ++GP A LRGD+G I + + ++D CV Sbjct: 3 YEFEGRVPDIDPSAYVSESATVIGKVKIGKEVWIGPGAVLRGDYGEIEVGDYSAIEDNCV 62 Query: 64 IHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAFVRA 123 IH PG T + ++ IGH +V+H+ +R A++GM + V D AVVG A + A V+ Sbjct: 63 IHARPGEKTFIGQHVTIGHLSVIHTGRIRDWAVIGMGSTVSDFAVVGVWAAIGEGAVVKN 122 Query: 124 GMQIPPRTLAAGLPAKVVRELTADEMAWKQAGTRTYQDLTVRCLASLREVS 174 +IP ++A G+PAKV+ ++ D Y + R +L+++ Sbjct: 123 RQEIPDESIAVGVPAKVIGKIDEDYKKLWTDYKHNYNTFSSRYKTNLKKMK 173 >PAB0393 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Pab Pyrococcus abyssi Length = 173 Score = 124 bits (311), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 62/171 (36%), Positives = 98/171 (57%) Query: 3 CYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQDTC 62 Y + G P + PSA++ +AV+IGDV++ V P+A LRGD RI + + +NVQD Sbjct: 3 VYELNGKKPKIHPSAFIDESAVVIGDVVLEEKTSVWPSAVLRGDIERIYVGKYSNVQDNV 62 Query: 63 VIHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAFVR 122 IH G+ T + E IGH AV+H + ++G+ +V++D A +G+ I+ A A V Sbjct: 63 SIHTSHGYPTEIGEYVTIGHNAVVHGAKIGNYVIIGIGSVILDGAKIGDHVIIGAGAVVP 122 Query: 123 AGMQIPPRTLAAGLPAKVVRELTADEMAWKQAGTRTYQDLTVRCLASLREV 173 +IP +L G+P KVVR+LT +E+ W + Y +L + L R++ Sbjct: 123 PNKEIPDYSLVLGVPGKVVRQLTEEEIEWTKKNAEIYVELAEKHLKGRRKL 173 >Ta0881m [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Tac Thermoplasma acidophilum Length = 174 Score = 124 bits (311), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 63/172 (36%), Positives = 98/172 (56%) Query: 3 CYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQDTC 62 Y EG IP +DPSAYV +A +IG V +G + ++GP A LRGD+G I + + ++D C Sbjct: 2 IYEFEGRIPEIDPSAYVSESATVIGKVKIGKEVWIGPGAVLRGDYGEIEVGDYSAIEDNC 61 Query: 63 VIHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAFVR 122 VIH PG T + ++ IGH +V+H+ +R A++GM + V D AVVG A + A V+ Sbjct: 62 VIHARPGEKTTIGQHVTIGHLSVIHTGRIRDWAVIGMGSTVSDFAVVGVWAAIGEGAVVK 121 Query: 123 AGMQIPPRTLAAGLPAKVVRELTADEMAWKQAGTRTYQDLTVRCLASLREVS 174 +IP +A G+PAKV+ ++ D Y + R +L+ ++ Sbjct: 122 NRQEIPDEAVAVGVPAKVIGKIDDDYKKLWTDYKHNYNTFSSRYKTNLKPIN 173 >Rv3525c [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Mtu Mycobacterium tuberculosis H37Rv Length = 174 Score = 121 bits (303), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 73/173 (42%), Positives = 97/173 (56%), Gaps = 3/173 (1%) Query: 1 VPCYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQD 60 +P +S EG P +DP+A+V PTA LIGDV + V A LRGD+ +V++ GANVQD Sbjct: 1 MPLFSFEGRSPRIDPTAFVAPTATLIGDVTIEAGASVWFNAVLRGDYAPVVVREGANVQD 60 Query: 61 TCVIHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAF 120 V+H PG + + H V+H V +AL+ +A V+D AV+G + ++AA A Sbjct: 61 GAVLHAPPGIPVDIGPGATVAHLCVIHGVHVGSEALIANHATVLDGAVIGARCMIAAGAL 120 Query: 121 VRAGMQIPPRTLAAGLPAKVVR--ELTADEMAWKQAGTRTYQDLTVRCLASLR 171 V AG QIP L G PAKV E T EM W + Y+DL R LA L Sbjct: 121 VVAGTQIPAGMLVTGAPAKVKGPIEGTGAEM-WVNVNPQAYRDLAARHLAGLE 172 >MT3625 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily MtC Mycobacterium tuberculosis CDC1551 Length = 174 Score = 121 bits (303), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 73/173 (42%), Positives = 97/173 (56%), Gaps = 3/173 (1%) Query: 1 VPCYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYVGPTACLRGDFGRIVLQRGANVQD 60 +P +S EG P +DP+A+V PTA LIGDV + V A LRGD+ +V++ GANVQD Sbjct: 1 MPLFSFEGRSPRIDPTAFVAPTATLIGDVTIEAGASVWFNAVLRGDYAPVVVREGANVQD 60 Query: 61 TCVIHGFPGHDTVVEENGHIGHGAVLHSCTVRRDALVGMNAVVMDEAVVGEQAIVAACAF 120 V+H PG + + H V+H V +AL+ +A V+D AV+G + ++AA A Sbjct: 61 GAVLHAPPGIPVDIGPGATVAHLCVIHGVHVGSEALIANHATVLDGAVIGARCMIAAGAL 120 Query: 121 VRAGMQIPPRTLAAGLPAKVVR--ELTADEMAWKQAGTRTYQDLTVRCLASLR 171 V AG QIP L G PAKV E T EM W + Y+DL R LA L Sbjct: 121 VVAGTQIPAGMLVTGAPAKVKGPIEGTGAEM-WVNVNPQAYRDLAARHLAGLE 172