BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0051.p (216 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mlr2803 [IQR] COG1028 Dehydrogenases with different specificitie... 252 3e-67 RSc2534 [IQR] COG1028 Dehydrogenases with different specificitie... 241 1e-63 SMa1452 [IQR] COG1028 Dehydrogenases with different specificitie... 233 2e-61 AGc2613 [IQR] COG1028 Dehydrogenases with different specificitie... 229 5e-60 Rv1144 [IQR] COG1028 Dehydrogenases with different specificities... 228 9e-60 MT1177 [IQR] COG1028 Dehydrogenases with different specificities... 228 9e-60 BMEII0816 [IQR] COG1028 Dehydrogenases with different specificit... 218 1e-56 PA2554 [IQR] COG1028 Dehydrogenases with different specificities... 214 1e-55 CC0124 [IQR] COG1028 Dehydrogenases with different specificities... 211 9e-55 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 116 5e-26 >mlr2803 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 253 Score = 252 bits (644), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 124/216 (57%), Positives = 161/216 (74%), Gaps = 1/216 (0%) Query: 1 MEAAQALADELRCHAVRCDITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDG 60 +E A +A ++ +V+CD++ +DS AAL G PRIL+NCAGI + +GKDG Sbjct: 39 IERAAKVAADIGGISVQCDVSSADSGTAALAETASKLGEPRILVNCAGIAIGVKTIGKDG 98 Query: 61 KPMPLEDFSRIVNVNLIGTFNVIRLAAARMAAAEALAEGERGVIVATASVAAFDGQVGQA 120 P PL+ + +++ VNLIGTFN+IRL A R A+ E L GERGVIV TASVAA+DGQ+GQA Sbjct: 99 -PHPLDQYRKVIEVNLIGTFNMIRLVADRAASLEPLQGGERGVIVNTASVAAYDGQIGQA 157 Query: 121 GYAASKGGITAMTLPLARDLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIPFPKR 180 Y+ASKGG+ MTLP+ARDLA+ GIRV TIAPG+F TP++ +P+EVQ SL +++PFP R Sbjct: 158 AYSASKGGVVGMTLPVARDLARSGIRVCTIAPGIFKTPMMAGMPQEVQDSLGAAVPFPSR 217 Query: 181 LGKAEEYAQLALHIATNLSLNGEVIRLDGALRLAPR 216 LG+ EYA LALHI N LNGE IRLDGA+R+AP+ Sbjct: 218 LGEPSEYAALALHIIENQMLNGETIRLDGAIRMAPK 253 >RSc2534 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Rso Ralstonia solanacearum Length = 252 Score = 241 bits (614), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 128/214 (59%), Positives = 155/214 (72%), Gaps = 2/214 (0%) Query: 3 AAQALADELRCHAVRCDITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDGKP 62 A ALA E+ VRCD++ +AA+QAA GA L+NCAGI A R VGK G P Sbjct: 41 AGAALAQEIGGRFVRCDVSSEADGQAAVQAATSL-GALAGLVNCAGIAPASRTVGKAG-P 98 Query: 63 MPLEDFSRIVNVNLIGTFNVIRLAAARMAAAEALAEGERGVIVATASVAAFDGQVGQAGY 122 PL+ F+R++N+NLIGTFN+IRLAA M A A GERGVI+ TASVAAFDGQ+GQA Y Sbjct: 99 HPLDQFARVININLIGTFNMIRLAATAMTANAPNAGGERGVIINTASVAAFDGQIGQAAY 158 Query: 123 AASKGGITAMTLPLARDLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIPFPKRLG 182 AASKGG+ AMTL +ARDL++ GIRV+TIAPG+F TP+L +P EVQ +L +PFP RLG Sbjct: 159 AASKGGVVAMTLAIARDLSRDGIRVMTIAPGIFETPMLLGMPPEVQDALGKMVPFPPRLG 218 Query: 183 KAEEYAQLALHIATNLSLNGEVIRLDGALRLAPR 216 K EYAQLA I N LNGE IRLDGA+R+ P+ Sbjct: 219 KPAEYAQLARAIIENPMLNGETIRLDGAIRMQPK 252 >SMa1452 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 255 Score = 233 bits (594), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 120/198 (60%), Positives = 152/198 (76%), Gaps = 1/198 (0%) Query: 19 DITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDGKPMPLEDFSRIVNVNLIG 78 D+T+ AAL A+Q G L+NCAG ++++G+ G P L+ F+R V VNLIG Sbjct: 59 DVTNEADATAALAFAKQEFGHVHGLVNCAGTAPGEKILGRSG-PHALDSFARTVAVNLIG 117 Query: 79 TFNVIRLAAARMAAAEALAEGERGVIVATASVAAFDGQVGQAGYAASKGGITAMTLPLAR 138 TFN+IRLAA M+ E A+GERGVIV TAS+AAFDGQ+GQA YAASKGG+ A+TLP AR Sbjct: 118 TFNMIRLAAEVMSQGEPDADGERGVIVNTASIAAFDGQIGQAAYAASKGGVAALTLPAAR 177 Query: 139 DLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIPFPKRLGKAEEYAQLALHIATNL 198 +LA++GIRVVTIAPG+F TP++ +P++VQ +LA+S+PFP RLG+AEEYA L HI N Sbjct: 178 ELARFGIRVVTIAPGIFDTPMMAGMPQDVQDALAASVPFPPRLGRAEEYAALVKHICENT 237 Query: 199 SLNGEVIRLDGALRLAPR 216 LNGEVIRLDGALR+APR Sbjct: 238 MLNGEVIRLDGALRMAPR 255 >AGc2613 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 257 Score = 229 bits (583), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 122/220 (55%), Positives = 156/220 (70%), Gaps = 7/220 (3%) Query: 2 EAAQALADELRCHAVRCDITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDGK 61 EA + LA E+ AV+ D+T +AA++ A G RIL+NCAGIG A R++G++G Sbjct: 40 EAGKKLAAEIGGKAVQGDVTSDADAQAAIKVAASAKGGLRILVNCAGIGTAGRILGREG- 98 Query: 62 PMPLEDFSRIVNVNLIGTFNVIRLAAARMAAAEALAEGE-----RGVIVATASVAAFDGQ 116 P PL DF +++ VNLIGTFN++RLAAA MA E EG+ GVIV TASVAAF+GQ Sbjct: 99 PQPLGDFEQVIRVNLIGTFNMMRLAAAHMAEREQ-DEGQDSRQDNGVIVNTASVAAFEGQ 157 Query: 117 VGQAGYAASKGGITAMTLPLARDLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIP 176 +GQA YAASKGGI ++ LP AR+LA++ IRV T+APG+FLTPLL LP+EVQ+SLA IP Sbjct: 158 IGQAAYAASKGGIVSLALPAARELARFRIRVNTVAPGIFLTPLLQGLPQEVQESLAGQIP 217 Query: 177 FPKRLGKAEEYAQLALHIATNLSLNGEVIRLDGALRLAPR 216 P RLG E+A + N +NGEVIRLDGA+R+ PR Sbjct: 218 HPSRLGDPAEFADTVRFLIENDYMNGEVIRLDGAIRMQPR 257 >Rv1144 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mtu Mycobacterium tuberculosis H37Rv Length = 250 Score = 228 bits (580), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 118/205 (57%), Positives = 145/205 (70%), Gaps = 3/205 (1%) Query: 12 RCHAVRCDITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDGKPMPLEDFSRI 71 R + D+TD +V AL+ A G R+++NCAG G A R++ +DG PL F +I Sbjct: 49 RARFAQADVTDEAAVSNALELADSL-GPVRVVVNCAGTGNAIRVLSRDGV-FPLAAFRKI 106 Query: 72 VNVNLIGTFNVIRLAAARMAAAEALAEGERGVIVATASVAAFDGQVGQAGYAASKGGITA 131 V++NL+GTFNV+RL A R+A E + E ERGVI+ TASVAAFDGQ+GQA Y+ASKGG+ Sbjct: 107 VDINLVGTFNVLRLGAERIAKTEPIGE-ERGVIINTASVAAFDGQIGQAAYSASKGGVVG 165 Query: 132 MTLPLARDLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIPFPKRLGKAEEYAQLA 191 MTLP+ARDLA IRVVTIAPGLF TPLL LP E + SL +P P RLG +EY L Sbjct: 166 MTLPIARDLASKLIRVVTIAPGLFDTPLLASLPAEAKASLGQQVPHPSRLGNPDEYGALV 225 Query: 192 LHIATNLSLNGEVIRLDGALRLAPR 216 LHI N LNGEVIRLDGA+R+APR Sbjct: 226 LHIIENPMLNGEVIRLDGAIRMAPR 250 >MT1177 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MtC Mycobacterium tuberculosis CDC1551 Length = 250 Score = 228 bits (580), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 118/205 (57%), Positives = 145/205 (70%), Gaps = 3/205 (1%) Query: 12 RCHAVRCDITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDGKPMPLEDFSRI 71 R + D+TD +V AL+ A G R+++NCAG G A R++ +DG PL F +I Sbjct: 49 RARFAQADVTDEAAVSNALELADSL-GPVRVVVNCAGTGNAIRVLSRDGV-FPLAAFRKI 106 Query: 72 VNVNLIGTFNVIRLAAARMAAAEALAEGERGVIVATASVAAFDGQVGQAGYAASKGGITA 131 V++NL+GTFNV+RL A R+A E + E ERGVI+ TASVAAFDGQ+GQA Y+ASKGG+ Sbjct: 107 VDINLVGTFNVLRLGAERIAKTEPIGE-ERGVIINTASVAAFDGQIGQAAYSASKGGVVG 165 Query: 132 MTLPLARDLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIPFPKRLGKAEEYAQLA 191 MTLP+ARDLA IRVVTIAPGLF TPLL LP E + SL +P P RLG +EY L Sbjct: 166 MTLPIARDLASKLIRVVTIAPGLFDTPLLASLPAEAKASLGQQVPHPSRLGNPDEYGALV 225 Query: 192 LHIATNLSLNGEVIRLDGALRLAPR 216 LHI N LNGEVIRLDGA+R+APR Sbjct: 226 LHIIENPMLNGEVIRLDGAIRMAPR 250 >BMEII0816 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bme Brucella melitensis Length = 255 Score = 218 bits (554), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 104/175 (59%), Positives = 139/175 (79%), Gaps = 1/175 (0%) Query: 42 ILINCAGIGGAKRMVGKDGKPMPLEDFSRIVNVNLIGTFNVIRLAAARMAAAEALAEGER 101 +L+NCAG+ ++++G++G LE F+R +++NLIGTFN++RLAA MA E GER Sbjct: 82 VLVNCAGVAPGEKVLGREGA-HKLETFTRTISINLIGTFNMLRLAAEAMAKNEPGQGGER 140 Query: 102 GVIVATASVAAFDGQVGQAGYAASKGGITAMTLPLARDLAQYGIRVVTIAPGLFLTPLLY 161 GVI+ TASVAAFDGQ+GQA Y+ASKGG+ AMTLP+AR+LA++GIRV+TIAPG+F TP++ Sbjct: 141 GVIINTASVAAFDGQIGQAAYSASKGGVAAMTLPVARELARHGIRVMTIAPGIFKTPMMA 200 Query: 162 KLPEEVQQSLASSIPFPKRLGKAEEYAQLALHIATNLSLNGEVIRLDGALRLAPR 216 +P+EVQ +L +S+PFP RLG+ EYA L HI N LNGEVIRLDGALR+A + Sbjct: 201 GMPQEVQDALGASVPFPPRLGEPAEYAALVRHIVENQMLNGEVIRLDGALRMAAK 255 >PA2554 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pae Pseudomonas aeruginosa Length = 255 Score = 214 bits (544), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 107/201 (53%), Positives = 146/201 (72%), Gaps = 1/201 (0%) Query: 16 VRCDITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDGKPMPLEDFSRIVNVN 75 VR DI A+ AA + G L NCAG+ A++++G++G LE F R++++N Sbjct: 56 VRADIASEADGRQAVAAALEAFGGLHGLANCAGVAPAEKVLGRNGI-HALESFRRVIDIN 114 Query: 76 LIGTFNVIRLAAARMAAAEALAEGERGVIVATASVAAFDGQVGQAGYAASKGGITAMTLP 135 L+G+FN++RLAA M+ + GERGVIV TASVAAFDGQ+GQA Y+ASK G+ MTLP Sbjct: 115 LVGSFNMLRLAAEAMSQGQPDEGGERGVIVNTASVAAFDGQIGQAAYSASKSGVVGMTLP 174 Query: 136 LARDLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIPFPKRLGKAEEYAQLALHIA 195 +AR+LA++GIRV+TIAPG+F TP++ +P+EV+ SL +S+PFP RLG+ +EYA L I Sbjct: 175 IARELARFGIRVMTIAPGIFETPMMAGMPQEVRDSLGASVPFPPRLGRPDEYAALVRQII 234 Query: 196 TNLSLNGEVIRLDGALRLAPR 216 N LNGEVIRLDGA+R+A R Sbjct: 235 ENSMLNGEVIRLDGAIRMAAR 255 >CC0124 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ccr Caulobacter vibrioides Length = 260 Score = 211 bits (537), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 110/215 (51%), Positives = 141/215 (65%), Gaps = 5/215 (2%) Query: 7 LADELRCHAVRCDITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDG-----K 61 +A E+ + ++T V+A + A+ +G RIL+NCAG G A + +D K Sbjct: 46 VAKEIGGVFCKVNVTSDADVDAGFEKARAAHGQERILVNCAGTGNAAKTASRDKATGETK 105 Query: 62 PMPLEDFSRIVNVNLIGTFNVIRLAAARMAAAEALAEGERGVIVATASVAAFDGQVGQAG 121 PL+ F RI+ +NL+GTF I +A M E L +GERG IV TASVAA DGQ+GQA Sbjct: 106 HFPLDAFDRIIQINLVGTFRCIAKSAKGMLDLEPLEDGERGAIVNTASVAAEDGQMGQAA 165 Query: 122 YAASKGGITAMTLPLARDLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIPFPKRL 181 Y+ASKGG+ MTLP+ARDL GIRV TI PG+F TPL+ PE V+ LA+S+PFPKRL Sbjct: 166 YSASKGGVVGMTLPIARDLMGEGIRVNTILPGIFNTPLMNNAPEAVKAGLAASVPFPKRL 225 Query: 182 GKAEEYAQLALHIATNLSLNGEVIRLDGALRLAPR 216 G EEYAQLAL + T NGE +RLDG +R+APR Sbjct: 226 GHPEEYAQLALTMITCGYFNGEDVRLDGGIRMAPR 260 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 116 bits (290), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 73/195 (37%), Positives = 104/195 (53%), Gaps = 14/195 (7%) Query: 19 DITDSDSVEAALQAAQQTNGAPRILINCAGIGGAKRMVGKDGKPMPLEDFSRIVNVNLIG 78 ++TD D ++ ++ Q G +L+N AGI +V M ED+ ++NVNL G Sbjct: 62 NVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLV-----RMKEEDWDAVINVNLKG 116 Query: 79 TFNVIRLAAARMAAAEALAEGERGVIVATASVAAFDGQVGQAGYAASKGGITAMTLPLAR 138 FNV ++ M G IV +SV G GQ YAASK G+ MT A+ Sbjct: 117 VFNVTQMVVPYMIKQR------NGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAK 170 Query: 139 DLAQYGIRVVTIAPGLFLTPLLYKLPEEVQQSLASSIPFPKRLGKAEEYAQLALHIATNL 198 +LA IRV +APG TP+ KLPE+ +++ S IP R GK EE AQ+ L +A++ Sbjct: 171 ELAGRNIRVNAVAPGFIETPMTEKLPEKARETALSRIPL-GRFGKPEEVAQVILFLASDE 229 Query: 199 S--LNGEVIRLDGAL 211 S + G+VI +DG L Sbjct: 230 SSYVTGQVIGIDGGL 244