BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0030.0209.p (460 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value all3141 [O] COG0464 ATPases of the AAA+ class Nos Nostoc sp. PCC... 397 e-110 mlr6544 Non COG 154 4e-37 Cj0377 [O] COG0464 ATPases of the AAA+ class Cje Campylobacter j... 143 1e-33 MK0878 [O] COG1222 ATP-dependent 26S proteasome regulatory subun... 109 1e-23 AF0477 [O] COG0464 ATPases of the AAA+ class Afu Archaeoglobus f... 107 9e-23 SSO0909 [O] COG0464 ATPases of the AAA+ class Sso Sulfolobus sol... 106 1e-22 APE0960 [O] COG0464 ATPases of the AAA+ class Ape Aeropyrum pernix 103 6e-22 MJ1156 [O] COG0464 ATPases of the AAA+ class Mja Methanococcus j... 103 6e-22 PAB2233 [O] COG1222 ATP-dependent 26S proteasome regulatory subu... 103 7e-22 PH0201 [O] COG1222 ATP-dependent 26S proteasome regulatory subun... 102 1e-21 >all3141 [O] COG0464 ATPases of the AAA+ class Nos Nostoc sp. PCC 7120 Length = 448 Score = 397 bits (1020), Expect = e-110, Method: Compositional matrix adjust. Identities = 197/447 (44%), Positives = 285/447 (63%), Gaps = 2/447 (0%) Query: 15 ALAANARSLEREIAWFGKVMETRFHAYFMHEGGPHDIHAHAPP-DIADDPSLFAAALREH 73 L ANA++L+ + + +V++ R + F H I PP D+ + + +H Sbjct: 3 TLDANAQTLQYALDYLARVIQWRITSSF-HNQEQQAITIPQPPHDLLTAETPLTQFICKH 61 Query: 74 ALGFDARLVLILALLPHVRPQALDLLFTQNKNIERSYTEFGGYKGKQHGGILPTCETALF 133 L +L L++AL PH++ D L T Y + GG++GK H G LPT ET LF Sbjct: 62 QLNTAEQLTLLIALAPHLQADFFDQLITSQLPQAGDYPQIGGWRGKSHRGFLPTGETILF 121 Query: 134 LLAGDDLARRFEIMQLFDPEHLFTRQAILSLATVEAGEPAASALLQVESDFLDACTSGRM 193 ++AG+ + RF + QLF EHLF R+ +L L GEP S L + D++D T G Sbjct: 122 IVAGNQFSDRFRLQQLFHNEHLFVRERVLYLEPPADGEPLMSGKLIITQDYIDLFTQGHF 181 Query: 194 HKPNYSSGFPARRITTRLQWHDLVLAPEVHEEIDAIKLWLAEGIGVMRRWGLERNVKPGY 253 P +S FPA+RI+T ++W DLVL + ++I +K W+ G ++ WG++R +K GY Sbjct: 182 SSPQFSINFPAQRISTEMEWEDLVLNTQTLDQIHDLKAWITHGSTILYDWGMKRKLKLGY 241 Query: 254 RSLFYGPPGTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFDQAQHKNWI 313 R+LF+GPPGTGKTLTA+LLGK +VY+IDLS +VSK+IGETEKN+AN+F +A+ K+WI Sbjct: 242 RALFHGPPGTGKTLTASLLGKYTNKEVYKIDLSMVVSKFIGETEKNLANLFAKAESKDWI 301 Query: 314 LFFDEADALFGKRTEGSSSNDRHANQEVAYLLQRIEDFPGVVILASNLKDNIDDAFSRRF 373 LFFDEADALF KRT ++D++ANQEV+YLLQR+E++ G+VIL+SN K NIDDAF RRF Sbjct: 302 LFFDEADALFSKRTNVRDAHDKYANQEVSYLLQRVENYDGLVILSSNFKSNIDDAFIRRF 361 Query: 374 QSAIYFPLPDGLQRRRLWENLFPGRRHLAEDVDLDRLAEDNILAGGALLNVASHAAMRAE 433 Q+ I+FPLP +R ++W+ FP + LAE V+L LA L+G ++NV + ++ Sbjct: 362 QAIIHFPLPSSKERLQIWQMAFPFQVELAEVVNLWELATTYELSGADIMNVVQYCCLQTL 421 Query: 434 REGRKTICQDDLLRGIRKEFIKEGRAI 460 + G I Q+DL I++EF K G+ + Sbjct: 422 KRGDTVIHQEDLQAAIKREFGKAGKIV 448 >mlr6544 Non COG Length = 782 Score = 154 bits (389), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 85/218 (38%), Positives = 126/218 (57%), Gaps = 2/218 (0%) Query: 204 ARRITTRLQWHDLVLAPEVHEEIDAIKLWLAEGIGVMRRW--GLERNVKPGYRSLFYGPP 261 A+RI Q ++VL + +++ I + V+ W G + G +LF+GP Sbjct: 513 AQRIEPVFQLDEVVLPADRKSQLEEIVDNVRFASRVLDAWKFGDQLPYGRGVTALFHGPS 572 Query: 262 GTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFDQAQHKNWILFFDEADA 321 GTGKT+ A + ++ + + +IDLS+IVSKYIG+TEKN+ VF +AQ + DEA+ Sbjct: 573 GTGKTMAALAVARQLNIQILKIDLSRIVSKYIGDTEKNIDRVFMEAQLSGAAVLVDEAEG 632 Query: 322 LFGKRTEGSSSNDRHANQEVAYLLQRIEDFPGVVILASNLKDNIDDAFSRRFQSAIYFPL 381 L +R+E + ++DR+AN EVAYLLQR+E G+VIL +N++ N+D AF RR + I FP Sbjct: 633 LMARRSEINDAHDRYANIEVAYLLQRMEAHEGLVILTTNMRQNLDTAFLRRLRFVIDFPR 692 Query: 382 PDGLQRRRLWENLFPGRRHLAEDVDLDRLAEDNILAGG 419 PD R +W P H+ +D LA L GG Sbjct: 693 PDATAREAIWRYCLPDGSHMLDDATFRILARKIELTGG 730 >Cj0377 [O] COG0464 ATPases of the AAA+ class Cje Campylobacter jejuni Length = 570 Score = 143 bits (360), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 75/219 (34%), Positives = 118/219 (53%), Gaps = 7/219 (3%) Query: 240 MRRWGLERNVKPGYRSLFYGPPGTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKN 299 + WG++ N + +FYGP GTGKT++A + K + V D SKI+SK++GE+E+N Sbjct: 340 LHSWGIKSNKNIEAKIIFYGPAGTGKTMSALAMAKSMKKSVLSFDCSKILSKWVGESEQN 399 Query: 300 MANVFD------QAQHKNWILFFDEADALFGKRTEGSSSNDRHANQEVAYLLQRIEDFPG 353 + +FD Q ++ IL +EAD R +GSS +D+ NQ L++IE F G Sbjct: 400 VRKIFDTYKNIVQTCKQSPILLLNEADQFLSTRVDGSSGSDKMHNQMQNIFLEQIERFSG 459 Query: 354 VVILASNLKDNIDDAFSRRFQSAIYFPLPDGLQRRRLWENLFPGRRHLAEDVDLDRLAED 413 V+I +N +++D AFSRRF I F PD R ++WE P + +D D++ L+ Sbjct: 460 VIIATTNFLESLDSAFSRRFDYKIEFKKPDFKDRLKIWEKFLPKKALFEKDFDINILSNY 519 Query: 414 NILAGGALLNVASHAAMRAEREGRKTICQDDLLRGIRKE 452 L+G +L V + A++ D + I+KE Sbjct: 520 E-LSGAQILMVVKNTALKVAVSKDGVFKIQDFIESIQKE 557 >MK0878 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit Mka Methanopyrus kandleri AV19 Length = 436 Score = 109 bits (273), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 75/209 (35%), Positives = 110/209 (52%), Gaps = 9/209 (4%) Query: 249 VKPGYRSLFYGPPGTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFDQAQ 308 V+P L YGPPGTGKTL A + A R+ ++V K+IGE + + +F+ A+ Sbjct: 210 VEPPKGVLLYGPPGTGKTLLAKAVANHADATFIRLAAPELVQKFIGEGARLVRELFELAR 269 Query: 309 HKN-WILFFDEADALFGKRTEGSSSNDRHANQEVAYLLQRIEDFPGV----VILASNLKD 363 K I+F DE DA+ +R ++S DR + + LL ++ F + VI A+N KD Sbjct: 270 EKAPSIIFIDEIDAIGARRMRDATSGDREVQRTLTQLLAEMDGFDPLDDIKVIAATNRKD 329 Query: 364 NIDDAFSR--RFQSAIYFPLPDGLQRRRLWENLFPGRRHLAEDVDLDRLAEDNILAGGAL 421 +D A R RF I PLPD R ++ + +LAEDVDL +LA+ A GA Sbjct: 330 ILDPALLRPGRFDRHIKIPLPDEEGRYEIF-KIHTRDMNLAEDVDLQKLAKITEGASGAD 388 Query: 422 LN-VASHAAMRAEREGRKTICQDDLLRGI 449 + + + A M A RE R + DD L+ + Sbjct: 389 IKAICTEAGMMAIREDRDIVTMDDFLKAV 417 >AF0477 [O] COG0464 ATPases of the AAA+ class Afu Archaeoglobus fulgidus Length = 409 Score = 107 bits (266), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 87/250 (34%), Positives = 131/250 (52%), Gaps = 22/250 (8%) Query: 211 LQWHDLVLAPEVHEEIDAIKLWLAEGIGVMRRWGLERNVKPGYRSLFYGPPGTGKTLTAT 270 + + ++ L+ E EE+ I++ L E +R+ GL K LF GPPGTGKT TA Sbjct: 162 VDFREVALSEEQLEEVRKIEIALEER-SFLRKIGLSDIGK----LLFIGPPGTGKTTTAR 216 Query: 271 LLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFDQAQHKN-WILFFDEADALFGKRTEG 329 L K+ + + + LS I S+Y+GET KN+ +FD A+ + ILF DE D + RT Sbjct: 217 ALSKKLYLPLLEVKLSMITSQYLGETSKNIEKIFDIARMMSPCILFIDEFDYVAKMRT-- 274 Query: 330 SSSNDRHA--NQEVAYLLQRIEDFPGV-----VILASNLKDNIDDAFSRRFQSAIYFPLP 382 +D HA + V LL+ I+D V +I A+N +D A RRF I FP P Sbjct: 275 ---SDEHAAIKRAVNTLLKSIDDINLVEDGVLLIAATNHPSLLDPAVWRRFDKVIEFPEP 331 Query: 383 DGLQRRRLWENLFPGRRHLAEDVDLDRLA-EDNILAGGALLNVASHAAMRAEREGRKTIC 441 R+R++E +F R + + ++D L E + G + V A + A +GR+ + Sbjct: 332 AEAIRKRIFE-IFLAR--IDGNFNIDELVRETDGFTGADIKLVVREAVLDALLQGRRELT 388 Query: 442 QDDLLRGIRK 451 Q+DLL IR+ Sbjct: 389 QEDLLNAIRE 398 >SSO0909 [O] COG0464 ATPases of the AAA+ class Sso Sulfolobus solfataricus Length = 372 Score = 106 bits (265), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 66/166 (39%), Positives = 93/166 (56%), Gaps = 10/166 (6%) Query: 256 LFYGPPGTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFDQA------QH 309 L YGPPG GKT+ A + E ++D + ++SK++GE EKN+ANVF A Q+ Sbjct: 138 LLYGPPGCGKTMIAAAVANEIDSIFMQLDAASVMSKWLGEAEKNVANVFKMAREESKKQN 197 Query: 310 KNWILFFDEADALFGKRTEGSSSNDRHANQ---EVAYLLQRIEDFPGVVILASNLKDNID 366 K I+F DE DAL G + R NQ E+ LL + E++ VI A+N +D Sbjct: 198 KPAIIFIDELDALLGVYSTEVGGEARVRNQFLKEMDGLLDKSENYKVYVIGATNKPWRLD 257 Query: 367 DAFSRRFQSAIYFPLPDGLQRRRLWENLFPGRRHLAEDVDLDRLAE 412 +AF RRFQ IY PLPD QR L++ + + L +V L+ LA+ Sbjct: 258 EAFLRRFQKRIYVPLPDYEQRLSLFK-YYTSKIKLDTEVSLEELAK 302 >APE0960 [O] COG0464 ATPases of the AAA+ class Ape Aeropyrum pernix Length = 384 Score = 103 bits (258), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 69/189 (36%), Positives = 99/189 (52%), Gaps = 10/189 (5%) Query: 256 LFYGPPGTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFDQAQHKN---- 311 L YGPPGTGKT+ A+ + E + +D + I+SK++GE EKN+ +F+ A++K Sbjct: 149 LLYGPPGTGKTMLASAVANEIDGEFLYVDAANIMSKWLGEGEKNVKKLFNYARNKAKEGK 208 Query: 312 -WILFFDEADALFGKRTEGSSSNDRHANQ---EVAYLLQRIEDFPGVVILASNLKDNIDD 367 ++F DE DAL G R NQ E+ + + VI A+N +D+ Sbjct: 209 PVVIFIDEVDALLGVHGSEVGGEVRVRNQFLKEMDGIQDKGSRLHVYVIAATNKPWKLDE 268 Query: 368 AFSRRFQSAIYFPLPDGLQRRRLWENLFPGRRHLAEDVDLDRLAED-NILAGGALLNVAS 426 F RRFQ IY PLP R+R+ E ++ + LA DVDLDRLAE G + ++ Sbjct: 269 PFIRRFQKRIYVPLPSRETRKRMLE-MYTRKLRLAGDVDLDRLAEMLEGYTGSDIADIVR 327 Query: 427 HAAMRAERE 435 A M RE Sbjct: 328 EAYMATVRE 336 >MJ1156 [O] COG0464 ATPases of the AAA+ class Mja Methanococcus jannaschii Length = 903 Score = 103 bits (258), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 74/194 (38%), Positives = 105/194 (54%), Gaps = 12/194 (6%) Query: 249 VKPGYRSLFYGPPGTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFDQAQ 308 ++P L GPPGTGKTL A + EA + Y I+ +I+SKY+GETE+N+ +F++A+ Sbjct: 210 IEPPKGVLLVGPPGTGKTLLAKAVANEAGANFYVINGPEIMSKYVGETEENLRKIFEEAE 269 Query: 309 HKN-WILFFDEADALFGKRTEGSSSNDRHANQEVAYLLQRIEDFPG----VVILASNLKD 363 I+F DE DA+ KR E + +R VA LL ++ G VVI A+N + Sbjct: 270 ENAPSIIFIDEIDAIAPKRDEATGEVERRL---VAQLLTLMDGLKGRGQVVVIGATNRPN 326 Query: 364 NIDDAFSR--RFQSAIYFPLPDGLQRRRLWENLFPGRRHLAEDVDLDRLAE-DNILAGGA 420 +D A R RF I +PD R+ + + + LAEDVDLD LA+ + G Sbjct: 327 ALDPALRRPGRFDREIVIGVPDREGRKEILQ-IHTRNMPLAEDVDLDYLADVTHGFVGAD 385 Query: 421 LLNVASHAAMRAER 434 L + AAMRA R Sbjct: 386 LAALCKEAAMRALR 399 Score = 99.8 bits (247), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 80/231 (34%), Positives = 115/231 (49%), Gaps = 11/231 (4%) Query: 211 LQWHDLVLAPEVHEEIDAIKLWLAEGIGVMRRWGLERNVKPGYRSLFYGPPGTGKTLTAT 270 ++W D+ EV +E+ W + V + G V+P L +GPPGTGKTL A Sbjct: 449 VKWEDIGGLEEVKQELREAVEWPLKAKEVFEKIG----VRPPKGVLLFGPPGTGKTLLAK 504 Query: 271 LLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFDQA-QHKNWILFFDEADALFGKRTEG 329 + E+ + + +I SK++GE+EK + +F +A Q I+FFDE DA+ KR Sbjct: 505 AVANESGANFISVKGPEIFSKWVGESEKAIREIFRKARQSAPCIIFFDEIDAIAPKRGRD 564 Query: 330 SSS--NDRHANQEVAYLLQRIEDFPGVVILASNLKDNIDDAFSR--RFQSAIYFPLPDGL 385 SS D+ NQ + L E VVI A+N D ID A R R I P+PD Sbjct: 565 LSSAVTDKVVNQLLTELDGMEEPKDVVVIAATNRPDIIDPALLRPGRLDRVILVPVPDEK 624 Query: 386 QRRRLWENLFPGRRHLAEDVDLDRLAEDNILAGGALLN-VASHAAMRAERE 435 R ++ + +LAEDV+L+ LA+ GA + + AAM A RE Sbjct: 625 ARLDIF-KIHTRSMNLAEDVNLEELAKKTEGYTGADIEALCREAAMLAVRE 674 >PAB2233 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit Pab Pyrococcus abyssi Length = 399 Score = 103 bits (258), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 77/214 (35%), Positives = 109/214 (50%), Gaps = 10/214 (4%) Query: 246 ERNVKPGYRSLFYGPPGTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFD 305 E + P L YGPPG GKTL A L E R+ S++V KYIGE + + +F+ Sbjct: 168 EVGIDPPKGVLLYGPPGCGKTLMAKALAHEVNATFIRVVGSELVRKYIGEGARLVHELFE 227 Query: 306 QAQHKN-WILFFDEADALFGKRTEGSSSNDRHANQEVAYLLQRIEDFPG----VVILASN 360 A+ K I+F DE DA+ KR + ++ +R N+ + LL ++ F VI A+N Sbjct: 228 LAKEKAPTIIFIDEIDAIGAKRMDETTGGEREVNRTLMQLLAEMDGFDPRGNVKVIAATN 287 Query: 361 LKDNIDDAFSR--RFQSAIYFPLPDGLQRRRLWENLFPGRRHLAEDVDLDRLAEDNILAG 418 D +D A R RF I PLPD R + + RR ++VDL +AE A Sbjct: 288 RPDILDPALLRPGRFDRLIEVPLPDFEGRLEILK--VHTRRMKLKNVDLRVIAEITEGAS 345 Query: 419 GALLN-VASHAAMRAEREGRKTICQDDLLRGIRK 451 GA L +A+ A M A RE R + Q+D L+ + K Sbjct: 346 GADLKAIATEAGMFAIRERRTYVTQEDFLKAVDK 379 >PH0201 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit Pho Pyrococcus horikoshii Length = 399 Score = 102 bits (255), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 77/214 (35%), Positives = 108/214 (50%), Gaps = 10/214 (4%) Query: 246 ERNVKPGYRSLFYGPPGTGKTLTATLLGKEAQVDVYRIDLSKIVSKYIGETEKNMANVFD 305 E + P L YGPPG GKTL A L E R+ S++V KYIGE + + +F+ Sbjct: 168 EVGIDPPKGVLLYGPPGCGKTLMAKALAHEVNATFIRVVGSELVRKYIGEGARLVHELFE 227 Query: 306 QAQHKN-WILFFDEADALFGKRTEGSSSNDRHANQEVAYLLQRIEDFPG----VVILASN 360 A+ K I+F DE DA+ KR + ++ +R N+ + LL ++ F VI A+N Sbjct: 228 LAKEKAPTIIFIDEIDAIGAKRMDETTGGEREVNRTLMQLLAEMDGFDPRGNVKVIAATN 287 Query: 361 LKDNIDDAFSR--RFQSAIYFPLPDGLQRRRLWENLFPGRRHLAEDVDLDRLAEDNILAG 418 D +D A R RF I PLPD R + + RR + VDL +AE A Sbjct: 288 RPDILDPALLRPGRFDRLIEVPLPDFEGRLEILK--VHTRRMKLKGVDLRAIAEMTEGAS 345 Query: 419 GALLN-VASHAAMRAEREGRKTICQDDLLRGIRK 451 GA L +A+ A M A RE R + Q+D L+ + K Sbjct: 346 GADLKAIATEAGMFAIRERRTYVTQEDFLKAVDK 379