BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0030.0056.p (326 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC2960 Non COG 234 3e-61 PA1850 [K] COG4977 Transcriptional regulator containing an amida... 228 1e-59 SMb20215 [K] COG4977 Transcriptional regulator containing an ami... 207 2e-53 mll5195 [K] COG4977 Transcriptional regulator containing an amid... 205 1e-52 mll3844 [K] COG4977 Transcriptional regulator containing an amid... 179 6e-45 PA3782 [K] COG4977 Transcriptional regulator containing an amida... 166 5e-41 CC3367 Non COG 163 6e-40 Z2164 [K] COG4977 Transcriptional regulator containing an amidas... 156 6e-38 ECs2143 [K] COG4977 Transcriptional regulator containing an amid... 156 6e-38 mlr2766 [K] COG4977 Transcriptional regulator containing an amid... 150 5e-36 >CC2960 Non COG Length = 312 Score = 234 bits (596), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 131/306 (42%), Positives = 189/306 (61%), Gaps = 11/306 (3%) Query: 1 MNLLDLSGPMQVLATTNRLQGREVYRLHVVSAQGGTILTSAGLPVGTQSLQEMDRLLQAT 60 LLD +GP+ RL Y LH +S +GG I +++G+ V T++L E Sbjct: 13 FQLLDATGPIAAFEIAGRL-APGAYSLHFLSLRGGLIPSTSGMVVQTKALAE-------A 64 Query: 61 PDLHTLISPGGSSGDQFPLDAALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRVTT 120 P L TL+ GG + +A++RQ ++A R+ SVC+G + LAEAG+LDG R TT Sbjct: 65 PPLDTLLIAGGDAVKVPASCPETLAFVRQAGRSARRVASVCSGTYVLAEAGLLDGKRATT 124 Query: 121 HWDWAQELQRRYPALQVDADPIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIATAR 180 HW ++ QRRYP ++++ D I+I+ G +W+SAG+TAGIDL+LAL+ D G A A TA+ Sbjct: 125 HWSRTKDFQRRYPHVRLEPDRIWIQDGAVWSSAGITAGIDLSLALIGADEGEAVARRTAQ 184 Query: 181 QLVMFIKRPGGQSQFSTPLATQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPRTF 240 QLV++ RPGGQSQ S + + GRF L +W +L++ L VE LA RA MSPR F Sbjct: 185 QLVVYHHRPGGQSQHSALIDLRP---GRFDGLLSWARQNLSEPLSVEQLADRAAMSPRNF 241 Query: 241 ARLYVAETGRTPARTVELMRLEAARRALEETRLPLKRIASQAGYGEEQNLRRVFLRQLGV 300 ARL+ ETG TPA+ +E +R+EAAR L+ L ++ +A + G+G+ + +RR F+R G Sbjct: 242 ARLFAQETGVTPAKAIERLRVEAARALLDSQPLQVEDVALETGFGDPERMRRAFIRAFGQ 301 Query: 301 SPGQYR 306 P R Sbjct: 302 PPQALR 307 >PA1850 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Pae Pseudomonas aeruginosa Length = 334 Score = 228 bits (581), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 136/319 (42%), Positives = 191/319 (59%), Gaps = 19/319 (5%) Query: 4 LDLSGPMQVLATTNRLQGRE----VYRLHVVSAQGGTILTSAGLPVGTQSLQEMDRLLQA 59 LD++GP+QV A+ N + R+ YR+ V+ + + +SAG+ + D + Sbjct: 18 LDVTGPLQVFASANVERQRQGLPPFYRIQVLGERSEAVPSSAGIRICA------DLAWRD 71 Query: 60 TP--DLHTLISPGGSSGDQFPLDAALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLR 117 P L TL+ PGG + +A L+AW++ R+ SVC+GA LA AGVLDG Sbjct: 72 CPPESLDTLLVPGGLGVEAQTRNADLLAWLKAAEPCIRRLGSVCSGALILAAAGVLDGRP 131 Query: 118 VTTHWDWAQELQRRYPALQVDADPIYIRQGR-------IWTSAGVTAGIDLALALVEQDL 170 TTHW L++ +P + V D ++ R I+TSAGVTAGIDLALALVE DL Sbjct: 132 ATTHWADVATLRQGFPGVHVQGDRLHTYDPRCRDGDAHIFTSAGVTAGIDLALALVEADL 191 Query: 171 GHASAIATARQLVMFIKRPGGQSQFSTPLATQSAGAGRFAELHAWIAAHLADDLRVENLA 230 G + A++ AR+LVMF+KRPGGQ+QFS L + + R A L WI A+LA DL +E LA Sbjct: 192 GRSLALSVARRLVMFLKRPGGQAQFSAWLTPEPSRTPRLAALLEWIPANLAGDLSLEALA 251 Query: 231 HRAGMSPRTFARLYVAETGRTPARTVELMRLEAARRALEETRLPLKRIASQAGYGEEQNL 290 +A MSPRT +R+++ E G P R VE +RLEAAR L++ + + ++ G+G +NL Sbjct: 252 DQACMSPRTLSRVFLQELGVAPGRYVERVRLEAARALLQDAQASIATVSRLCGFGHPENL 311 Query: 291 RRVFLRQLGVSPGQYRERF 309 RR F + L VSP +Y ERF Sbjct: 312 RRTFHKHLSVSPQEYAERF 330 >SMb20215 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Sme Sinorhizobium meliloti Length = 326 Score = 207 bits (528), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 119/286 (41%), Positives = 172/286 (60%), Gaps = 11/286 (3%) Query: 21 GREVYRLHVVSAQGGTILTSAGLPVGTQSLQEMDRLLQATPDLHTLISPGGSSGDQFPLD 80 G VY + ++S GG + +SAG V T++ T++ G + P+ Sbjct: 42 GETVYEIELLSEAGGEVKSSAGFGVLTKTFDHTA--------YDTVMFGAGVQIE--PMT 91 Query: 81 AALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRVTTHWDWAQELQRRYPALQVDAD 140 LV + R+ + A R+ + CTGAF LAE+G+LDG R TTHW +A++LQ R+PA++V+ D Sbjct: 92 PGLVEFARRSFETARRVAAPCTGAFVLAESGLLDGRRATTHWAFARQLQDRFPAVKVEED 151 Query: 141 PIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIATARQLVMFIKRPGGQSQFSTPLA 200 I+I G +WTSAG+TA IDLALA+VE+D G A + AR+LV++ +R GGQSQFS L Sbjct: 152 RIFIVDGSVWTSAGMTASIDLALAMVEKDYGQGVARSVARKLVVYHRRAGGQSQFSALLE 211 Query: 201 TQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPRTFARLYVAETGRTPARTVELMR 260 + + R + A+L L VE LA AG+S R F+R + AETG++PA+ VE +R Sbjct: 212 LEPK-SDRIQRSIDYAKANLRRGLSVEELADAAGLSARQFSRAFRAETGQSPAKAVETLR 270 Query: 261 LEAARRALEETRLPLKRIASQAGYGEEQNLRRVFLRQLGVSPGQYR 306 +EAAR +E+ R + IA + G+ +RR FLR LG P R Sbjct: 271 VEAARLMMEQGRHSMDVIAEETGFAIADRMRRAFLRTLGQPPQTIR 316 >mll5195 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Mlo Mesorhizobium loti Length = 325 Score = 205 bits (521), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 131/283 (46%), Positives = 167/283 (59%), Gaps = 17/283 (6%) Query: 1 MNLLDLSGPMQVLATTNRLQGREV--YRLHVVSAQGGTILTSAGLPVGTQSLQEMDRLLQ 58 LLD +GP A +G V Y L +++ G I +S+G+ + R L Sbjct: 43 FQLLDAAGPA---AAFELAEGFCVGSYMLEILAPGGEEIESSSGMRLAA-------RPLS 92 Query: 59 ATPDLHTLISPGGSSGDQFPLDAALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRV 118 L T I GG +VAW+R+ R SVCTGA+ LAEAG+LDG R Sbjct: 93 MEEPLDTAIISGGEIIRSMAAAQEIVAWLRR--TGVRRTASVCTGAYLLAEAGLLDGRRA 150 Query: 119 TTHWDWAQELQRRYPALQVDADPIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIAT 178 TTHW + RRYPA+++DA+ I++R G +WTSAG++AGIDLALAL+E DLG A A Sbjct: 151 TTHWWSTHDFARRYPAVKLDAERIFVRDGSVWTSAGISAGIDLALALIEDDLGPAIARRV 210 Query: 179 ARQLVMFIKRPGGQSQFSTPLATQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPR 238 A+QLV+ +RPGGQSQFS L GRF EL W+ LA L VE LA RA MSPR Sbjct: 211 AQQLVVHQRRPGGQSQFSA-LVELGGRTGRFIELIEWMRTALAQPLTVECLADRAAMSPR 269 Query: 239 TFARLYVAETGRTPARTVELMRLEAARRALEETRLPLKRIASQ 281 FAR + AETG TPA+ VE +RLE+AR A+E P + IAS+ Sbjct: 270 HFARAFKAETGTTPAKAVERIRLESARIAVETA--PCRSIASR 310 >mll3844 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Mlo Mesorhizobium loti Length = 332 Score = 179 bits (455), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 115/294 (39%), Positives = 153/294 (52%), Gaps = 15/294 (5%) Query: 20 QGREVYRLHVVSAQGGTILTSAGLPVGTQSLQEMDRLLQATPDL----HTLISPGGSSGD 75 G + YR V G + G+ + + PDL T+I PG G Sbjct: 43 MGSDWYRFAVAGIDAGEMRAMGGVRI----------VADGGPDLIGEAGTVIVPG-WRGV 91 Query: 76 QFPLDAALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRVTTHWDWAQELQRRYPAL 135 P+ L+ +R ++ ARI S+C+G F LA AG+L G + TTHW ++ L+ YP + Sbjct: 92 DCPVPPLLIEALRAASERGARILSICSGVFVLAAAGLLSGKKATTHWRYSDRLREMYPDI 151 Query: 136 QVDADPIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIATARQLVMFIKRPGGQSQF 195 V D +YI +G + TSAG AGIDL L LV +D G +A AR+LV+ R GGQ+Q+ Sbjct: 152 TVVPDVLYIDEGNVLTSAGSAAGIDLCLHLVRRDFGTKAANMVARRLVVPPHRDGGQAQY 211 Query: 196 STPLATQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPRTFARLYVAETGRTPART 255 + GR L + A +A D V LA AGMS RTF R + A TG TPAR Sbjct: 212 VESSVPEPHERGRLGPLIDRMRADIAADYPVATLADLAGMSERTFLRRFAAATGVTPARW 271 Query: 256 VELMRLEAARRALEETRLPLKRIASQAGYGEEQNLRRVFLRQLGVSPGQYRERF 309 + RL AR LE+T LP++RIA AG+G LR F RQ +P YR RF Sbjct: 272 LLSERLSRARTLLEDTALPIERIAETAGFGAAATLRHHFRRQFATTPAAYRARF 325 >PA3782 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Pae Pseudomonas aeruginosa Length = 317 Score = 166 bits (421), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 114/308 (37%), Positives = 161/308 (52%), Gaps = 7/308 (2%) Query: 4 LDLSGPMQVLATTNRLQGREVYRLHVVSAQGGTILTSAGLPVGTQSLQEMDRLLQATPDL 63 LS P V + + L V +A+ G + T+ G + E + L+A + Sbjct: 17 FHLSVPCLVFGQECYDPCAQAFDLRVCTAEPGRLRTTVGFTI------EAEAGLEALAEA 70 Query: 64 HTLISPGGSSGDQFPLDAALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRVTTHWD 123 T+I P + P A L A I A+ A ++ +C GAF LAEAG+LDG R TTHW Sbjct: 71 QTVIVPSWRDPHERPPQALLDALIAARARGA-QLVGLCLGAFVLAEAGLLDGRRATTHWM 129 Query: 124 WAQELQRRYPALQVDADPIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIATARQLV 183 WA++ R+PA++V+ D +YI + TSAG AGID L LV Q LG + AR+LV Sbjct: 130 WAEDFAGRFPAVRVEPDVLYIEDDGLLTSAGTVAGIDCCLHLVRQRLGAQTTNHLARRLV 189 Query: 184 MFIKRPGGQSQFSTPLATQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPRTFARL 243 + R GGQ+QF SA GR EL W+ +L +++LA R MS RTF R Sbjct: 190 VAPHRQGGQAQFIEQPLPDSAQDGRLGELLVWLRQNLDQAHSLDSLAQRVLMSRRTFTRH 249 Query: 244 YVAETGRTPARTVELMRLEAARRALEETRLPLKRIASQAGYGEEQNLRRVFLRQLGVSPG 303 + TG T ++ ++ RL A+R LE T ++ IA AG+G +LR+ F G+ P Sbjct: 250 FRQLTGTTVSQWLQAERLALAQRLLETTEHSVQAIAGLAGFGSAVSLRQQFSAAFGLPPL 309 Query: 304 QYRERFAA 311 YR FA+ Sbjct: 310 GYRRAFAS 317 >CC3367 Non COG Length = 324 Score = 163 bits (412), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 101/247 (40%), Positives = 138/247 (55%), Gaps = 2/247 (0%) Query: 66 LISPGGSSGDQFPLDAALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRVTTHWDWA 125 +++PG D P+ L+ +R AR+ S+C+G F LA G+LDG R TTHW +A Sbjct: 80 IVAPGWRGLDA-PVPRPLIEALRAAHAGGARLMSICSGVFVLAATGLLDGRRATTHWRYA 138 Query: 126 QELQRRYPALQVDADPIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIATARQLVMF 185 L+ +PA+QV D +Y+ +G + TSAG AGIDL L L+ +D G +A AR+LV+ Sbjct: 139 DALRAHHPAIQVQPDVLYVDEGDVLTSAGSAAGIDLGLHLIRRDFGPEAANTVARRLVVP 198 Query: 186 IKRPGGQSQFSTPLATQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPRTFARLYV 245 R GGQ+QF + A R + + A+LAD+ ++ LA AGMS RTF R + Sbjct: 199 PHRDGGQAQFVQRPVPVAHEASRLGPILDQMRANLADEHTIKTLAALAGMSERTFLRRFE 258 Query: 246 AETGRTPARTVELMRLEAARRALEETRLPLKRIASQAGYGEEQNLRRVFLRQLGVSPGQY 305 A TG TPAR + RL AR LE + ++A G G LR F RQ +PG Y Sbjct: 259 AVTGATPARWLLAERLNHARDLLETASTSIDQVARAVGLGAPA-LRHHFRRQFSTTPGAY 317 Query: 306 RERFAAT 312 R RFA T Sbjct: 318 RARFART 324 >Z2164 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain EcZ Escherichia coli O157:H7 EDL933 Length = 327 Score = 156 bits (395), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 102/292 (34%), Positives = 153/292 (52%), Gaps = 17/292 (5%) Query: 21 GREVYRLHVVSAQGGTILTSAGLPVGTQSLQEMDRLLQATPDLHTLISPGGSSGDQFPLD 80 G YR V + + G + + G+ V D L+ P+ +I PG D + Sbjct: 41 GDNWYRFAVAAVEPGALQATGGIHVVA------DGGLELLPNADMIIIPGWRGIDA-KVP 93 Query: 81 AALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRVTTHWDWAQELQRRYPALQVDAD 140 L +R+ Q R+ S+C+G F LA AG+L + TTHW + ++LQ RYP++ V + Sbjct: 94 EMLCQSLREAHQRGTRLVSICSGVFVLAAAGLLHQRKATTHWRYTEQLQHRYPSISVSDN 153 Query: 141 PIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIATARQLVMFIKRPGGQSQ-----F 195 +Y +G++ TSAG AGIDL L +V +D GH A AR+LV+ R G Q Q Sbjct: 154 VLYQDEGQVMTSAGSAAGIDLCLHIVRKDFGHEIANNVARRLVIQPHRQGDQPQNLTRPM 213 Query: 196 STPLATQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPRTFARLYVAETGRTPART 255 ++P +Q+ GA L ++ +LA V +LA R MSPRTF R + A TG TPAR Sbjct: 214 ASPRESQTLGA-----LFDFLQQNLAQTHTVSSLAERVNMSPRTFLRRFEALTGMTPARW 268 Query: 256 VELMRLEAARRALEETRLPLKRIASQAGYGEEQNLRRVFLRQLGVSPGQYRE 307 + RL + L+ + +++IA G+G LR F ++ +SP QYR+ Sbjct: 269 LLNERLIRVQDYLQNSVFNIEKIAELTGFGNSALLRHHFHQRFLLSPSQYRK 320 >ECs2143 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Ecs Escherichia coli O157:H7 Length = 324 Score = 156 bits (394), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 102/292 (34%), Positives = 153/292 (52%), Gaps = 17/292 (5%) Query: 21 GREVYRLHVVSAQGGTILTSAGLPVGTQSLQEMDRLLQATPDLHTLISPGGSSGDQFPLD 80 G YR V + + G + + G+ V D L+ P+ +I PG D + Sbjct: 38 GDNWYRFAVAAVEPGALQATGGIHVVA------DGGLELLPNADMIIIPGWRGIDA-KVP 90 Query: 81 AALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRVTTHWDWAQELQRRYPALQVDAD 140 L +R+ Q R+ S+C+G F LA AG+L + TTHW + ++LQ RYP++ V + Sbjct: 91 EMLCQSLREAHQRGTRLVSICSGVFVLAAAGLLHQRKATTHWRYTEQLQHRYPSISVSDN 150 Query: 141 PIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIATARQLVMFIKRPGGQSQ-----F 195 +Y +G++ TSAG AGIDL L +V +D GH A AR+LV+ R G Q Q Sbjct: 151 VLYQDEGQVMTSAGSAAGIDLCLHIVRKDFGHEIANNVARRLVIQPHRQGDQPQNLTRPM 210 Query: 196 STPLATQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPRTFARLYVAETGRTPART 255 ++P +Q+ GA L ++ +LA V +LA R MSPRTF R + A TG TPAR Sbjct: 211 ASPRESQTLGA-----LFDFLQQNLAQTHTVSSLAERVNMSPRTFLRRFEALTGMTPARW 265 Query: 256 VELMRLEAARRALEETRLPLKRIASQAGYGEEQNLRRVFLRQLGVSPGQYRE 307 + RL + L+ + +++IA G+G LR F ++ +SP QYR+ Sbjct: 266 LLNERLIRVQDYLQNSVFNIEKIAELTGFGNSALLRHHFHQRFLLSPSQYRK 317 >mlr2766 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Mlo Mesorhizobium loti Length = 328 Score = 150 bits (378), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 103/310 (33%), Positives = 154/310 (49%), Gaps = 15/310 (4%) Query: 4 LDLSGPMQVLATTNRLQGREVYRLHVVSAQGGTILTSAGL----PVGTQSLQEMDRLLQA 59 LS P V G + + + + G + T AGL P G + D ++ Sbjct: 17 FHLSVPCLVFGEDRTALGLPRFEFRICAVKAGPVHTEAGLTVAAPHGLEGFDGADIVI-- 74 Query: 60 TPDLHTLISPGGSSGDQFPLDAALVAWIRQHAQAAARICSVCTGAFHLAEAGVLDGLRVT 119 P H L P PL LV +RQ + A I +C G F +A AG+L G Sbjct: 75 IPSWHHLGEPPS------PL---LVEALRQAHRRGALIVGLCLGTFAIAAAGLLSGRGAA 125 Query: 120 THWDWAQELQRRYPALQVDADPIYIRQGRIWTSAGVTAGIDLALALVEQDLGHASAIATA 179 THW +++ LQ+ +P + VDA +Y+ G + TSAGV AG+D L +V G +A+ A Sbjct: 126 THWAYSERLQKLHPDIAVDATVLYVDNGDVVTSAGVAAGLDCCLHIVRVRYGAEAALRLA 185 Query: 180 RQLVMFIKRPGGQSQFSTPLATQSAGAGRFAELHAWIAAHLADDLRVENLAHRAGMSPRT 239 RQ+V+ R GGQ+QF T+SA A RF + + A L + ++++A AG++ RT Sbjct: 186 RQIVLSPHRQGGQAQFIEYSVTRSADADRFTQALDAVRATLGEAHSLDSVAEAAGLTRRT 245 Query: 240 FARLYVAETGRTPARTVELMRLEAARRALEETRLPLKRIASQAGYGEEQNLRRVFLRQLG 299 F R + G + + R+E A+R LE T + +A +AG+G +LR+ F +L Sbjct: 246 FTRRFQKSIGTSFGDWLTNQRIELAQRLLEATEKSMDIVAFEAGFGSATSLRQHFAARLR 305 Query: 300 VSPGQYRERF 309 SP QYR F Sbjct: 306 TSPAQYRREF 315