BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0167.p (299 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1607 [GER] COG0697 Permeases of the drug/metabolite transport... 319 4e-87 SMb20885 [GER] COG0697 Permeases of the drug/metabolite transpor... 204 2e-52 PA3358 [GER] COG0697 Permeases of the drug/metabolite transporte... 201 2e-51 AGc4246 [GER] COG0697 Permeases of the drug/metabolite transport... 154 3e-37 mlr3480 [GER] COG0697 Permeases of the drug/metabolite transport... 153 4e-37 PA2712 [GER] COG0697 Permeases of the drug/metabolite transporte... 91 3e-18 mll4580 [GER] COG0697 Permeases of the drug/metabolite transport... 89 8e-18 SMb20716 [GER] COG0697 Permeases of the drug/metabolite transpor... 82 1e-15 ECs2140 [GER] COG0697 Permeases of the drug/metabolite transport... 64 4e-10 RSc3261 [GER] COG0697 Permeases of the drug/metabolite transport... 60 4e-09 >RSc1607 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 307 Score = 319 bits (818), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 180/299 (60%), Positives = 211/299 (70%), Gaps = 16/299 (5%) Query: 12 RQLLMSLVPLLFVLIWSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLVLLFRAPWPH 71 L ++ +P LFVLIWSTGF+VAKFG+PYA P+TFL LRF GVL+ LLPLV + R P P Sbjct: 14 DSLFVAAMPWLFVLIWSTGFVVAKFGMPYAEPITFLFLRFVGVLVCLLPLVWVARVPLPR 73 Query: 72 G-----------RIRHVAVAGVLLQAGYLAGVWCAIKIGMPAGLSALIVGLQPILTAFAA 120 I H+AVAGVL+Q GYL GVW AIK+GMPAG+SALIVG+QPILTA Sbjct: 74 RAGADADAVDWRTIGHLAVAGVLMQWGYLGGVWEAIKLGMPAGMSALIVGMQPILTALYV 133 Query: 121 PLLGESVRGRQWLGLALGLCGVGLVVANKISLIGLSTASIALCVFALLCITAGTLYQKRY 180 + GE V RQWLGL G+ GVGLVVANK+ L G++ ++ CV ALL ITAGTLYQKR+ Sbjct: 134 SMRGERVSPRQWLGLLFGIAGVGLVVANKLHLAGVNVTTLGFCVGALLSITAGTLYQKRF 193 Query: 181 CAHFDLRTGTAIQFMASIVVVLPFAVVVEGLDWRLSNVAWTPQFIGALLWSVLALSIGAI 240 C FDLR G IQF AS ++ LPF E V WT IGAL+WSVLALSIGAI Sbjct: 194 CPVFDLRMGACIQFGASALLCLPFMFAFE-----TRAVQWTGPMIGALVWSVLALSIGAI 248 Query: 241 FLLFALIRRSAATSVTSLLYLTPPTTAVMAWLMFGEAFSLIGALGMLVGVIGVAFVVRK 299 LLF LIR+ AAT VTSLLYLTPPTTA MAW +FGE F + ALGM++ GVA V+R+ Sbjct: 249 SLLFMLIRQGAATKVTSLLYLTPPTTAAMAWALFGERFPPLAALGMVIAACGVALVIRR 307 >SMb20885 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 306 Score = 204 bits (519), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 126/294 (42%), Positives = 175/294 (59%), Gaps = 13/294 (4%) Query: 14 LLMSLVPLLFVLIWSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLVLLFRAPWPHGR 73 +L L P +FVL+WSTG++VAK+ +A PL FL LR++ +L+ + LL A WP Sbjct: 1 MLARLAPAIFVLLWSTGWVVAKYAAIFADPLIFLALRYSFAILLFIGFCLLSGARWPRSA 60 Query: 74 --IRHVAVAGVLLQAGYLAGVWCAIKIGMPAGLSALIVGLQPILTAFAAP-LLGESVRGR 130 I H V+G+ L YL VW AI G+PA +S +I GLQP++TA AP L+GE + G+ Sbjct: 61 TAIGHAVVSGIFLHGLYLGAVWWAIGQGVPAAISGIIAGLQPLMTAAVAPWLIGEKLAGQ 120 Query: 131 QWLGLALGLCGVGLVVANKISLIGLSTASI-----ALCVFALLCITAGTLYQKRYCAHFD 185 Q LGL LG CG+ L VA K+ I + I A+ V + +T GTLYQKRY D Sbjct: 121 QKLGLILGFCGIALAVAPKMLTIDATATPIHLLPLAVNVLGMAAVTYGTLYQKRYLQTGD 180 Query: 186 LRTGTAIQFMASIVVVLPFAVVVEGLDWRLSNVAWTPQFIGALLWSVLALSIGAIFLLFA 245 +R+ A+Q++ +++V +P A+++E L V W + + AL WSVL LS+GAI LL Sbjct: 181 IRSIAALQYVGALLVTIPLALMLEDL-----RVTWNIELVAALAWSVLGLSMGAIALLLY 235 Query: 246 LIRRSAATSVTSLLYLTPPTTAVMAWLMFGEAFSLIGALGMLVGVIGVAFVVRK 299 LIRR + SL+YL PP A A L FGEA + +G ++ V GV RK Sbjct: 236 LIRRGQVSRAASLIYLVPPLAAGEAALFFGEALTWPMIIGTVIAVTGVYLTNRK 289 >PA3358 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 292 Score = 201 bits (511), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 145/291 (49%), Positives = 182/291 (62%), Gaps = 11/291 (3%) Query: 10 RPRQLLMSLVPLLFVLIWSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLVLLFRAPW 69 R L S +PLLFVL+WSTGF+ AKFGLPYA P TFL +R +L LL APW Sbjct: 2 RTPAWLGSGMPLLFVLLWSTGFLGAKFGLPYAEPFTFLAIRLLLAAALLAAFALLSGAPW 61 Query: 70 PHGRIR---HVAVAGVLLQAGYLAGVWCAIKIGMPAGLSALIVGLQPILTA-FAAPLLGE 125 P G R HVAVAG+L+ YL GV+ AI+ GM AGL++L+VGLQP+ TA A LGE Sbjct: 62 P-GSARLAGHVAVAGLLVHGLYLGGVFLAIEHGMSAGLTSLLVGLQPLATAALAGIWLGE 120 Query: 126 SVRGRQWLGLALGLCGVGLVVANKISLIGLSTASIALCVFALLCITAGTLYQKRYCAHFD 185 V RQWLGLALGL GV LVV +I G + A + AL IT GTLYQKR+C D Sbjct: 121 QVSRRQWLGLALGLAGVALVVLGRIH-GGADGLAWAAVLVALAAITCGTLYQKRFCGGMD 179 Query: 186 LRTGTAIQFMASIVVVLPFAVVVEGLDWRLSNVAWTPQFIGALLWSVLALSIGAIFLLFA 245 LRTG +Q++AS ++ A++ E + V W+ F+ L W VL LS GA+ LL+ Sbjct: 180 LRTGGVVQYLASGALLGLAALLFESRE-----VQWSTPFVLTLGWLVLGLSFGAVGLLYT 234 Query: 246 LIRRSAATSVTSLLYLTPPTTAVMAWLMFGEAFSLIGALGMLVGVIGVAFV 296 LIR AA+ V SL YL PP TA+ +WL+F E + GML+ ++GVA V Sbjct: 235 LIRHGAASKVASLFYLVPPVTALASWLLFDERLAPAAIGGMLLVMLGVALV 285 >AGc4246 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 354 Score = 154 bits (389), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 110/301 (36%), Positives = 167/301 (55%), Gaps = 16/301 (5%) Query: 10 RPRQLLMSL---VPLLFVLIWSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLVLLFR 66 R R+ MSL P +FV +WSTG++ AK+ + Y PLTFL LR+ L+L + Sbjct: 51 RHRRCSMSLDRLAPAIFVFLWSTGWVTAKYAVYYTGPLTFLCLRYLLAGLLLWAICRFSG 110 Query: 67 APWPHGR--IRHVAVAGVLLQAGYLAGVWCAIKIGMPAGLSALIVGLQPILTAFAAP-LL 123 WP R + ++GV L YL +W AI G+PA + +I GLQP++TA AA ++ Sbjct: 111 ISWPKQRADVLRAILSGVFLHGIYLGMIWWAIGQGVPAAIGGIIAGLQPLMTAVAARFMI 170 Query: 124 GESVRGRQWLGLALGLCGVGLVVANKI---SLIGLSTA--SIALCVFALLCITAGTLYQK 178 GE + Q GL LG G+ + V K+ +G+S ++A+ V ++ +T GTLYQK Sbjct: 171 GERISPLQRAGLLLGFAGIAIAVLPKVMATGALGMSVPLYAVAVNVLGMVSVTYGTLYQK 230 Query: 179 RYCAHFDLRTGTAIQFMASIVVVLPFAVVVEGLDWRLSNVAWTPQFIGALLWSVLALSIG 238 +Y ++ +Q++ +++V +PFA+++E +V W+ L WSV A+SIG Sbjct: 231 KYVHGGNIMAVATLQYVGALLVTVPFALLLED-----GHVDWSLGLAATLGWSVGAISIG 285 Query: 239 AIFLLFALIRRSAATSVTSLLYLTPPTTAVMAWLMFGEAFSLIGALGMLVGVIGVAFVVR 298 A+ LL LIRR + SL+YL PP AV A ++FGE + G ++ V GV R Sbjct: 286 AVALLLYLIRRGQVSRAASLIYLVPPLAAVEAAVLFGETLTPAMIAGTVLAVTGVYLANR 345 Query: 299 K 299 K Sbjct: 346 K 346 >mlr3480 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 303 Score = 153 bits (387), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 111/293 (37%), Positives = 169/293 (57%), Gaps = 13/293 (4%) Query: 13 QLLMSLVPLLFVLIWSTGFIVAKFGLPYAPPLTFLLLRF--TGVLL-VLLPLVLLFRAPW 69 Q + +P FV++W+TGFI A++ +P+A P TFL RF +LL VL+P++ RA Sbjct: 2 QSIKRFIPATFVVLWATGFIGARYAMPWAEPFTFLAARFVIAAILLAVLMPVLGSKRAT- 60 Query: 70 PHGRIRHVAVAGVLLQAGYLAGVWCAIKIGMPAGLSALIVGLQPILTA-FAAPLLGESVR 128 H AGVL+ YL V+ AI GMPAG SALIVGLQP++TA A LGE++ Sbjct: 61 -RKEALHATGAGVLMHGVYLGAVFWAIHRGMPAGFSALIVGLQPLITAVLAGKFLGEAIL 119 Query: 129 GRQWLGLALGLCGVGLVVANKISLIG--LSTASIALCVFALLCITAGTLYQKRYCAHFDL 186 R WLGL +GL G+ +V+ K+ +G ++ A++ + ++L ++AGT++QKR+ + DL Sbjct: 120 PRHWLGLGIGLIGIVIVLWPKLGALGGGVTAATLTASLVSVLGMSAGTIWQKRFASGGDL 179 Query: 187 RTGTAIQFMASIVVVLPFAVVVEGLDWRLSNVAWTPQFIGALLWSVLALSIGAIFLLFAL 246 T Q++ ++ ++ L + V + I A+ W VL LS+GAIFLL + Sbjct: 180 VAATMWQYVGGASLM-----ILAALAFETHTVIINGELIFAMAWLVLVLSLGAIFLLMVM 234 Query: 247 IRRSAATSVTSLLYLTPPTTAVMAWLMFGEAFSLIGALGMLVGVIGVAFVVRK 299 IR + V SL YL P TA++AW +F E + + +GM + GV + Sbjct: 235 IRDGEMSKVASLFYLVPAVTAIIAWALFDEQLNALQIVGMAITTFGVGLATAR 287 >PA2712 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 287 Score = 90.9 bits (224), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 101/281 (35%), Positives = 151/281 (53%), Gaps = 15/281 (5%) Query: 22 LFVLIWSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLVLLFRAPWPHG-RIRHVAV- 79 LFVL+WS+G I +K+GL ++ P FL+ RF L LLPL L R P R R A+ Sbjct: 17 LFVLLWSSGAIASKWGLAHSSPFAFLVFRFGIALACLLPLAPLLRLRTPRSARERGKALL 76 Query: 80 AGVLLQAGYLAGVWCAIKIGMPAGLSALIVGLQPILTAFAAPLLGESVRGRQWLGLALGL 139 G+++ Y ++K+ + G+ A I+G+QPILTA +L + GL LGL Sbjct: 77 TGLVMLGIYPIFYIFSLKLQVTPGMMATILGVQPILTAV---ILERRQSPARLFGLLLGL 133 Query: 140 CGVGLVVANKISLIGLSTASIALCVFALLCITAGTLYQKRYCAHFDLRTGT-AIQFMASI 198 G+ LVV I L G+STA I + AL +T G++ QK + GT +Q++A + Sbjct: 134 AGLVLVVYQGIGLAGMSTAGILCALLALAGVTGGSIMQKGIREN---PLGTLPLQYLAGL 190 Query: 199 VVVLPFAVVVEGLDWRLSNVAWTPQFIGALLWSVLALSIGAIFLLFALIRRSAATSVTSL 258 + L F + ++ W F+ LW + +S+GA LL+ LI + +VTSL Sbjct: 191 GLCLAF------VPFQPFEFEWNAGFLVPALWMGVVVSVGATLLLYRLIAQGNLVNVTSL 244 Query: 259 LYLTPPTTAVMAWLMFGEAFSLIGALGMLVGVIGVAFVVRK 299 YL P TA+M +++FG + LGM + V+G+ FV RK Sbjct: 245 FYLVPAVTAIMDFMVFGNRLGWLSLLGMGLIVVGLMFVFRK 285 >mll4580 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 308 Score = 89.4 bits (220), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 89/294 (30%), Positives = 138/294 (46%), Gaps = 15/294 (5%) Query: 9 SRPRQLLMSLVPLLFVLIWSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLVLLFRAP 68 ++ +L+ ++ V+ WS+GF+ ++ A + L R L+LLP LL Sbjct: 6 AKAHRLVWPMMATALVVSWSSGFVGIRYASENADVMQVLFWRTLMSGLILLPFALLIGPR 65 Query: 69 WPHGRIRHVAVAGVLLQAGYLAGVWCAIKIGMPAGLSALIVGLQPI-LTAFAAPLLGESV 127 + V GV + YL G AI +P GL ALI L P+ + A + P+LG + Sbjct: 66 ISARALVQQMVFGVAMMFLYLGGFALAIGQRVPTGLVALISDLVPLAIAALSQPVLGHRL 125 Query: 128 RGRQWLGLALGLCGVGLVVANKISLIGLSTASIALCVFALLCITAGTLYQKRY-CAHFDL 186 GRQW+G ALG+ GV +V + +SL + L V +++ + TL QKR + + Sbjct: 126 TGRQWIGTALGVTGVLIVSLDSLSLGTAPAWAYLLTVASMMVLALATLVQKRMGTINMPI 185 Query: 187 RTGTAIQFMASIVVVLPFAVVVEGLDWRLSNVAWTP----QFIGALLWSVLALSIGAIFL 242 IQ + + V+ FA E W N P +F + W VL + Sbjct: 186 YQSLCIQCLTAAVL---FAACAE---W---NGGLMPPLDARFGFGIAWLVLFSTFFCYST 236 Query: 243 LFALIRRSAATSVTSLLYLTPPTTAVMAWLMFGEAFSLIGALGMLVGVIGVAFV 296 +A +R A+ V+S++YL+PP T + W MFGE S G+ V + GV F Sbjct: 237 YYASLRLYTASQVSSVIYLSPPVTMLWGWSMFGEPLSKAMLAGLAVTLFGVWFT 290 >SMb20716 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 298 Score = 82.4 bits (202), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 87/308 (28%), Positives = 141/308 (45%), Gaps = 25/308 (8%) Query: 3 PSPAGASRPRQLLMSLVPLLFVLIWSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLV 62 P A R +LL ++ L V+ WS+GF+ ++ A + L R ++LLP Sbjct: 5 PISLSAPRHHRLLWPMMATLLVVGWSSGFVGIRYASEEAGVMLVLFWRTLLSGVILLPFA 64 Query: 63 LLFRAPWPHGRIRHVAVA---GVLLQAGYLAGVWCAIKIGMPAGLSALIVGLQPI-LTAF 118 L P R+R +A GV+ YL G AI+ +P GL ALI L P+ + A Sbjct: 65 LTIG---PLLRMRGIAEQMLFGVMSVFLYLGGFALAIEQRVPTGLVALISDLLPLAIAAL 121 Query: 119 AAPLLGESVRGRQWLGLALGLCGVGLVVANKISL-------IGLSTASIALCVFALLCIT 171 + P+LGE + RQW G A+ + GV +V + +S GL+ S + VFAL Sbjct: 122 SQPVLGERLSARQWFGTAIAVFGVLIVSFDSLSFGAAPLWAYGLTVGS--MLVFAL---- 175 Query: 172 AGTLYQKRYCAHFDLRTGTAIQFMASIVVVLPFAVVVEGLDWRLSNVAWTPQFIGALLWS 231 A L+++R H + I + V+ A++ L L+ F ++W Sbjct: 176 ASVLHKRRRTQHMPVHQSLCIHTLTGSVLFGLCAMMQGDLAPPLTRA-----FAVGMVWL 230 Query: 232 VLALSIGAIFLLFALIRRSAATSVTSLLYLTPPTTAVMAWLMFGEAFSLIGALGMLVGVI 291 VL + A + + +R V++ +YL+PP T + AW +F E + +G+ ++ Sbjct: 231 VLIATFAAYSIYYTSLRLFPVAQVSAAIYLSPPVTMLWAWALFSEPLTAATFIGLTATLV 290 Query: 292 GVAFVVRK 299 GV R Sbjct: 291 GVWMTSRS 298 >ECs2140 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ecs Escherichia coli O157:H7 Length = 299 Score = 63.9 bits (154), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 51/187 (27%), Positives = 89/187 (47%), Gaps = 6/187 (3%) Query: 27 WSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLVLLFRAPWPHGRIRHVAVAGVLLQA 86 W F+V K GL PPL LRF +LV P + F P + + G+ + Sbjct: 16 WGLNFVVIKVGLHNMPPLMLAGLRF---MLVAFPAI--FFVARPKVPLNLLLGYGLTISF 70 Query: 87 GYLAGVWCAIKIGMPAGLSALIVGLQPILT-AFAAPLLGESVRGRQWLGLALGLCGVGLV 145 A ++CAI GMPAGL++L++ Q T A GE + G+Q G+AL + GV ++ Sbjct: 71 AQFAFLFCAINFGMPAGLASLVLQAQAFFTIVLGAFTFGERLHGKQLAGIALAISGVLVL 130 Query: 146 VANKISLIGLSTASIALCVFALLCITAGTLYQKRYCAHFDLRTGTAIQFMASIVVVLPFA 205 + + + ++ L + A +G ++ K+ +H ++ ++++ ++PF Sbjct: 131 IEDSFNGQHVAMLGFMLTLAAAFSWASGNIFNKKIMSHSSRPAVMSLVVWSALIPIIPFF 190 Query: 206 VVVEGLD 212 V LD Sbjct: 191 VASLILD 197 >RSc3261 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 308 Score = 60.5 bits (145), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 72/261 (27%), Positives = 122/261 (46%), Gaps = 22/261 (8%) Query: 27 WSTGFIVAKFGLPYAPPLTFLLLRFTGVLLVLLPLVLLFRAPWPHGRIRHVAVAGVLLQA 86 W F++ K GL PP+ LRF LV P +L P P ++ + G + Sbjct: 26 WGVNFVIIKVGLHGVPPMLLGALRFA---LVAFPAILF--VPRPKIALKWLLAYGATISF 80 Query: 87 GYLAGVWCAIKIGMPAGLSALIVGLQPILT-AFAAPLLGESVRGRQWLGLALGLCGVGLV 145 G A ++ A+ +GMPAGL++L++ Q T AA +L E +R G+A+ CG+ ++ Sbjct: 81 GQFAFLFSAMYVGMPAGLASLVLQSQAFFTLTIAAVVLREPIRWYHLAGMAVAACGLAMI 140 Query: 146 ----VANKISLIGLSTASIALCVFALLCITAGTLYQKRYCAHFDLRTGTAIQFMASIVVV 201 + + G++TA L + A L ++G + KR ++ +++ Sbjct: 141 GVAGTSGAGAATGMTTAGFLLTLCAALSWSSGNIVTKR----IGPVNVVSLVVWGALIPP 196 Query: 202 LPFAVV---VEG---LDWRLSNVAWTPQFIGALLWSVLALSIGAIFLLFALIRRSAATSV 255 +PF ++ +EG + L+N+ T IGA+++ +I L L+ R AA+ V Sbjct: 197 VPFFLLSYWMEGPQQIAHSLANLGGTS--IGAIVYLAFGATIFGYSLWSRLLARYAASQV 254 Query: 256 TSLLYLTPPTTAVMAWLMFGE 276 L L P V A L+ GE Sbjct: 255 APLTLLVPVVGLVSAALLLGE 275