BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0067.p (298 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2761 [GER] COG0697 Permeases of the drug/metabolite transport... 253 3e-67 AGpA485 [GER] COG0697 Permeases of the drug/metabolite transport... 250 3e-66 PA4287 [GER] COG0697 Permeases of the drug/metabolite transporte... 249 6e-66 RSp1638 [GER] COG0697 Permeases of the drug/metabolite transport... 243 3e-64 AGc4446 [GER] COG0697 Permeases of the drug/metabolite transport... 132 8e-31 SMc00642 [GER] COG0697 Permeases of the drug/metabolite transpor... 112 1e-24 PM1698 [GER] COG0697 Permeases of the drug/metabolite transporte... 109 8e-24 mlr3874 [GER] COG0697 Permeases of the drug/metabolite transport... 108 1e-23 mll8218 [GER] COG0697 Permeases of the drug/metabolite transport... 101 2e-21 BS_yyaM [GER] COG0697 Permeases of the drug/metabolite transport... 95 2e-19 >YPO2761 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ype Yersinia pestis Length = 305 Score = 253 bits (647), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 152/288 (52%), Positives = 208/288 (72%), Gaps = 6/288 (2%) Query: 8 FPLGAVLIWAGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLAR---QTWAARAQIRP 64 FPL AV+IW+ N V+SK+SA+ I P ISFYRW+LA L +SPFL + W A IR Sbjct: 5 FPLFAVIIWSVNAVVSKISATAIDPAAISFYRWLLALLTLSPFLLLGVVRNWQA---IRV 61 Query: 65 HLGKIVVLALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPTVGTL 124 + K+++L +LGMVL+QSLAY+AA + SA MGI++SL+PLLT+++SI LL PTVG Sbjct: 62 YWWKLMLLGMLGMVLYQSLAYYAAHSVSALFMGILSSLIPLLTVLISIVLLRVAPTVGIA 121 Query: 125 GGGILSLLGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLRTWQL 184 G +LSL GL LI G+P+ L + G+ G+L+ML A+ +Y LYGV+ +RWA+ L WQ Sbjct: 122 LGSLLSLGGLVWLISAGNPVQLLQHGIGKGELMMLGASASYALYGVLTKRWAIQLPNWQS 181 Query: 185 LYMQVLMAVVLLFPGFVLGHHSPVTRENLPILLYAGIAASIISQFLWMRGVAYLGASRCA 244 LYMQ++ VVLL PGF++ +T +N+P++L+AGI ASI++ +LW++GV LGA+ + Sbjct: 182 LYMQIVFGVVLLLPGFLMTPDVQLTAQNIPLVLFAGIPASILAPYLWIQGVMRLGANTAS 241 Query: 245 IFVNLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQVFRQRLR 292 IF+NL PVFT IIAV+ L EQLH YH +GG ITL GV++AQ R LR Sbjct: 242 IFMNLTPVFTAIIAVVFLHEQLHSYHLIGGGITLAGVVLAQRLRSPLR 289 >AGpA485 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 309 Score = 250 bits (638), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 139/292 (47%), Positives = 200/292 (68%), Gaps = 2/292 (0%) Query: 1 MHYKHLWFPLGAVLIWAGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAARA 60 M K+L F L AVLIW GNT++SK++A IAP I+F RW +A ++++P + R W R Sbjct: 7 MPVKYLLFSLLAVLIWVGNTIVSKLAAGAIAPGTIAFERWFIAFVILTPLVYRDAWRHRR 66 Query: 61 QIRPHLGKIVVLALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPT 120 I HL K+++L LLGM Q L Y+AA +AT+M I+ SL+PLLTL+LS L+E P+ Sbjct: 67 TIAAHLPKLILLGLLGMAACQGLGYYAAGLTTATNMAIMLSLVPLLTLILSAVFLAERPS 126 Query: 121 VGTLGGGILSLLGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLR 180 + GGI+SL G+ +++G+G P L QGV GD +ML A +AY YG++LRRWA+PL Sbjct: 127 SLAVIGGIISLSGIFIVLGQGDPSRLLSQGVGRGDAMMLAAVLAYAGYGILLRRWAIPLA 186 Query: 181 TWQLLYMQVLMAVVLLFPGFVLGHHSPVTRENLPILLYAGIAASIISQFLWMRGVAYLGA 240 TW +Y+Q+ AVVLL P ++L S +T N ++LYA I SI++ F+WM V +LGA Sbjct: 187 TWTSIYVQIGAAVVLLVPSYLLSAPSALTLPNTAMVLYAAIPGSILAPFVWMTAVKHLGA 246 Query: 241 SRCAIFVNLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQ--VFRQR 290 +R AIF+NL+P+FT I+A + LGE L+ YH +GG +T+ G+I+ Q FR++ Sbjct: 247 ARTAIFMNLIPIFTAIVAAIFLGEALYIYHLLGGGMTVAGIILVQRKPFREK 298 >PA4287 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 249 bits (635), Expect = 6e-66, Method: Compositional matrix adjust. Identities = 137/283 (48%), Positives = 198/283 (69%) Query: 8 FPLGAVLIWAGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAARAQIRPHLG 67 FPL AV IWAGNTV++K++ +I P +I F+RW+L L ++PF+ R I +LG Sbjct: 5 FPLLAVFIWAGNTVVNKLAVGIIQPAEIGFFRWLLVGLALTPFMLGPVLRNRRYILANLG 64 Query: 68 KIVVLALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPTVGTLGGG 127 K VVL LLGM ++QSLAY+AAA SAT+MGII SLMPL++L L+ +L+ G L G Sbjct: 65 KFVVLGLLGMAVYQSLAYYAAALTSATNMGIILSLMPLMSLGLASSILAHRLNAGALLGA 124 Query: 128 ILSLLGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLRTWQLLYM 187 ++SL G+ ++I +GH AL E GV GD +M++AT+AY +Y V+L++W+L L QLLY+ Sbjct: 125 LVSLAGVVLVISQGHLGALLEHGVNLGDAMMIVATLAYAVYSVLLKKWSLKLPAMQLLYL 184 Query: 188 QVLMAVVLLFPGFVLGHHSPVTRENLPILLYAGIAASIISQFLWMRGVAYLGASRCAIFV 247 QVL+A++ L P ++L + + NLP++LYA + ASI++ WM GVA LG SR A+F Sbjct: 185 QVLVAILALLPLYLLSPRTGLNAANLPLVLYAALFASIVAALAWMHGVARLGPSRMALFF 244 Query: 248 NLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQVFRQR 290 NL+P+ T IA L LGE+L +H VGG +TL GV++A+ +++R Sbjct: 245 NLLPIITACIATLVLGERLTVHHLVGGALTLAGVLLAEFWQRR 287 >RSp1638 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 297 Score = 243 bits (621), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 128/291 (43%), Positives = 195/291 (67%), Gaps = 6/291 (2%) Query: 8 FPLGAVLIWAGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAARAQIRPHLG 67 +PL AVL+WA NT++SK +A V+ P IS YRWV+AA +++PF AR W R + P L Sbjct: 5 YPLLAVLVWAANTIVSKAAAGVLDPAAISLYRWVIAAAVLTPFWARPLWRQRRDVLPWLP 64 Query: 68 KIVVLALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPTVGTLGGG 127 ++ VLALLG+V++Q L+Y+AA + SAT++G+I +L+P+L L+++ + +P + G Sbjct: 65 RLSVLALLGLVMYQCLSYYAAYSTSATNIGVICALIPMLGLIINGVVFRQPVGAPAVAGI 124 Query: 128 ILSLLGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLRTWQLLYM 187 +SLLG+ L+GRGHP +LF+ GV GD+L+L+ + AY LY ++ RRWA P W LY+ Sbjct: 125 AVSLLGVLYLLGRGHPASLFDGGVNRGDVLVLIGSAAYALYNILYRRWAPPFGQWLNLYL 184 Query: 188 QVLMAVVLLFPGFVLGHHSPVTRENLPILLYAGIAASIISQFLWMRGVAYLGASRCAIFV 247 Q L+AVV+L P + ++ + ++L+AGI ASI++ + WM G+A LG+ R + + Sbjct: 185 QALLAVVMLLPLAFTARSLAIPQQGIGMVLFAGIGASIVAMYWWMLGLARLGSERTVVMM 244 Query: 248 NLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQ------VFRQRLR 292 NL+PVFT ++A LGE +HGYH +GG + L GV + Q + R RLR Sbjct: 245 NLLPVFTALMASAMLGETIHGYHWIGGGLILLGVSLVQGIVTLPMGRDRLR 295 >AGc4446 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 302 Score = 132 bits (333), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 91/281 (32%), Positives = 148/281 (52%), Gaps = 11/281 (3%) Query: 12 AVLIWAGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAARAQIRPHLGKIVV 71 A L W GNTV K++ I+P +F RWVLA ++ Q ++ L V Sbjct: 19 ATLCWGGNTVAGKLAVGHISPMAFTFLRWVLAVAIIFAISVPQLIKDWPVVKQRLPYFFV 78 Query: 72 LALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPTVGTLGGGILSL 131 L +G F Y A SA + +I + +P++ VL+ L G + G L++ Sbjct: 79 LGSVGYTAFNVFLYTALQHTSAINAAVIQAGIPMVIFVLNFVLFRTRVLFGQIAGFCLTI 138 Query: 132 LGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLRTWQLL-----Y 186 G+A+L G PL+L + + GD +MLLA + Y +Y V+LR W P W+ L + Sbjct: 139 SGVALLASHGDPLSLLQLEMNVGDAVMLLAVLVYAIYTVILR-WK-PAVDWRTLMAIPAF 196 Query: 187 MQVLMAVVLLFPGFVLGHHSPV--TRENLPILLYAGIAASIISQFLWMRGVAYLGASRCA 244 +L +V L+F F + S + ++ +++YAGI AS+I+Q L+++GV +GA+R Sbjct: 197 FALLTSVPLVF--FEMSRESLIWPDQKGWMLVVYAGIFASLIAQILYIKGVEQIGANRAG 254 Query: 245 IFVNLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQ 285 +F+NL+PVF +++V L E LH Y + L G+ +A+ Sbjct: 255 LFINLVPVFGTLLSVFVLSETLHTYQIAALFMALAGIAVAE 295 >SMc00642 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 296 Score = 112 bits (279), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 86/293 (29%), Positives = 150/293 (51%), Gaps = 12/293 (4%) Query: 7 WFPLG-AVLIWAGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAARAQIRPH 65 +F LG L W GN+V KM+ ++P ++ RW+LA ++ + Q +IR H Sbjct: 6 YFYLGITALFWGGNSVAGKMAVGHVSPMMLTTLRWLLALAVILVLMTPQIRRDWQKIRQH 65 Query: 66 LGKIVVLALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPTVGTLG 125 +++ +G +F + Y A SA + I+ + +P+L + + L ++ + Sbjct: 66 WLQLLAYGAVGFTMFNAFLYSAVQYTSAINAVILQAGIPMLIFIFNFALFKMKASLAQVI 125 Query: 126 GGILSLLGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLRTWQLL 185 G ++L+G+ + G +L GD LM+LA I Y Y V L RW P WQ Sbjct: 126 GFTVTLVGVLITAAHGDLASLMRLSFNFGDALMILACIVYAAYTVAL-RWK-PAMHWQSF 183 Query: 186 -----YMQVLMAVVLLFPGFVLGHHSPVTRE--NLPILLYAGIAASIISQFLWMRGVAYL 238 + +L A+ LL + +G + + + I++YA I S++SQ L++RGV + Sbjct: 184 IAAPAFGALLSAIPLLL--WEMGKGTAIMPDATGWAIVIYAAIFPSLMSQVLYVRGVEMI 241 Query: 239 GASRCAIFVNLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQVFRQRL 291 GA+R +F+N +PVF +++VL +GE H +H + LGG+ +A+ R +L Sbjct: 242 GANRAGLFINAIPVFGTLLSVLLVGEIFHPFHLAALALVLGGIAIAERGRPKL 294 >PM1698 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pmu Pasteurella multocida Length = 301 Score = 109 bits (272), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 77/281 (27%), Positives = 137/281 (48%), Gaps = 7/281 (2%) Query: 12 AVLIWAGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAARAQIRPHLGKIVV 71 A W GN + K+ ++ I P +++ RW AAL++ ++++ IR H ++ Sbjct: 15 ATFFWGGNYLFGKILSTDIPPIVLNYARWFPAALILLLLFSKRSCQFTPVIRQHWRILIA 74 Query: 72 LALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPTVGTLGGGILSL 131 L+LLG+V+F Y T ++ + I +++P+ L L+ + +P L G + S Sbjct: 75 LSLLGIVIFPVFLYQGLQTTTSLNASIYLAVVPIFVLFLNRLVFGDPINFTGLTGALFSF 134 Query: 132 LGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLRTWQLLYMQVLM 191 +G+ L+ RG L + V GDL L + +++ +Y ++R L LL V M Sbjct: 135 VGVLWLLSRGDIQRLTQLEVNQGDLWALGSALSWSIYCCLIRLKPAQLPNTVLLTTLVCM 194 Query: 192 AVVLLFPGFVLGHH-------SPVTRENLPILLYAGIAASIISQFLWMRGVAYLGASRCA 244 A++L P F+ + S +T I+ Y I SI+S W G++ +GA + A Sbjct: 195 AMLLFTPLFIWQYQQLPPAFFSTLTPTQYSIITYLIIGPSILSYGFWNYGISLVGADKGA 254 Query: 245 IFVNLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQ 285 F N P+F ++ VL L E L YH + + + G+++ Sbjct: 255 AFTNATPLFAALLGVLVLNEALAFYHMISAGLIITGLLLCN 295 >mlr3874 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 303 Score = 108 bits (271), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 78/275 (28%), Positives = 135/275 (49%), Gaps = 7/275 (2%) Query: 16 WAGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAARAQIRPHLGKIVVLALL 75 W GN+V K++ ++P + F RWVLA ++ P R +R H + L Sbjct: 16 WGGNSVAGKLAVDHVSPMMLVFLRWVLAVAILLPIGWRSIQQDWPVVRRHWLILAALGAS 75 Query: 76 GMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPTVGTLGGGILSLLGLA 135 G LF + Y A +A ++ I + MP+L + + + G +L++ G+ Sbjct: 76 GFTLFNVIFYTALNYTTAINVSIEQAAMPILIMTANFVFFRLRVNWAQIAGVVLTIAGVI 135 Query: 136 VLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLRTWQLLYMQVLMAVVL 195 + G P L + GD +ML+A + Y Y V LR P WQ L + + +A ++ Sbjct: 136 LTACHGDPRRLLTLELNFGDAIMLVAVVLYSGYSVGLR--LKPALRWQSLMLTMSIAALI 193 Query: 196 LFPGFVLGHHSPVT-----RENLPILLYAGIAASIISQFLWMRGVAYLGASRCAIFVNLM 250 F+L + T +++Y I AS++SQ ++RG +GA+R +F+NL+ Sbjct: 194 TSLPFLLWEVAAGTVVVPDARGWTVIVYTAIGASVVSQITYIRGNELIGANRAGLFINLV 253 Query: 251 PVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQ 285 P+F +++VL +GE Y A+ V+ LGG+ +A+ Sbjct: 254 PIFGTLLSVLIVGETFQLYQALALVLVLGGIGLAE 288 >mll8218 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 319 Score = 101 bits (252), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 85/289 (29%), Positives = 145/289 (50%), Gaps = 13/289 (4%) Query: 12 AVLIW---AGNTVISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAARAQIRPHLGK 68 A+L W AG + +K A + P + F+R LA ++ P + R A +R + Sbjct: 27 AILCWLLSAGVYIAAKWVAPEMPPWGLCFWRLTLACAILLPIVHRHHGAMIGLLRTRAVE 86 Query: 69 IVVLALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPPTVGTLGGGI 128 +V + +G+ L Q + Y +AT+ GII +L P++T+VL+ +L EP + G + Sbjct: 87 VVAVGAIGLTLCQGMIYHGLNDTNATTAGIIMALSPVMTMVLARFVLGEPLGLWKSLGAL 146 Query: 129 LSLLGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWALPLRTWQLLYMQ 188 ++L G+ ++ G+ AL + G+L ++ + +GLY V+LRR + +LL M Sbjct: 147 VALAGMIFIVAHGNLTALLQLEFNAGELWIVGSAFCWGLYTVLLRRAKFGI---ELLPMV 203 Query: 189 VLM-----AVVLLFPGFVL--GHHSPVTRENLPILLYAGIAASIISQFLWMRGVAYLGAS 241 VL+ V L F + L S + ++ L Y + +L+ + V LGAS Sbjct: 204 VLLLGAGALVALPFHLWELFNDERSVMNVHSILALAYLAGPGGALMYYLYNKSVETLGAS 263 Query: 242 RCAIFVNLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQVFRQR 290 R ++ + L VF ++A L LGE LH Y +G + G+I+A V + R Sbjct: 264 RASMLLYLQTVFVAMLAYLLLGEDLHDYDLIGAAFIVAGIILATVIKPR 312 >BS_yyaM [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 305 Score = 94.7 bits (234), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 78/296 (26%), Positives = 148/296 (50%), Gaps = 18/296 (6%) Query: 1 MHYKHLWFPLGAVLIWAGNTV-ISKMSASVIAPEDISFYRWVLAALLMSPFLARQTWAAR 59 M + +++ L I+ G T ++K + +P + +R+ LAA +M L + Sbjct: 1 MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLAAAVMLIILIFTEGIKK 60 Query: 60 AQIRPHLGKIVVLALLGMVLFQSLAYFAAATASATSMGIIASLMPLLTLVLSIKLLSEPP 119 +Q+R + +VL ++G+ F +L + S + +I L PLLT +L+ +L + Sbjct: 61 SQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMGLNPLLTAILARIILKDNM 120 Query: 120 TVGTLGGGILSLLGLAVLIGRGHPLALFEQGVVTGDLLMLLATIAYGLYGVMLRRWA--- 176 T + G + +G+ ++I +G + + GDL++ + + LYGV+ RR+ Sbjct: 121 TKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIFTGNVCWALYGVLGRRFVKDG 180 Query: 177 --LPLRTWQLLYMQVLMAVVLLFPGFVLGHHSPVTRENLPILLYAGIA-----ASIISQF 229 L T+ ++ V + VV LF PV+ N+PI ++ IA S++ Sbjct: 181 TPLSTTTYTMVIGAVSLIVVSLFT------SKPVSLSNIPIGVWGAIAFMAFFTSVLGYL 234 Query: 230 LWMRGVAYLGASRCAIFVNLMPVFTVIIAVLALGEQLHGYHAVGGVITLGGVIMAQ 285 W +G+ +GAS+ ++F NL+PV T+II+ A+G + + +G V+ + GV+ A Sbjct: 235 WWNQGIKEIGASKTSLFFNLVPVVTMIIS-FAVGTPIKVFQVIGAVLVILGVLTAS 289