BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0063.p (1192 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1199 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1411 0.0 YPO2849 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pe... 1249 0.0 ECs2884 [V] COG0841 Cation/multidrug efflux pump Ecs Escherichia... 1224 0.0 yegO [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 1222 0.0 ZyegO [V] COG0841 Cation/multidrug efflux pump EcZ Escherichia c... 1218 0.0 STM2128 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1197 0.0 PA2526 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1116 0.0 RSp1198 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1051 0.0 PA2527 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1003 0.0 YPO2848 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pe... 977 0.0 >RSp1199 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1033 Score = 1411 bits (3652), Expect = 0.0, Method: Compositional matrix adjust. Identities = 713/1057 (67%), Positives = 859/1057 (81%), Gaps = 47/1057 (4%) Query: 1 MNISLPFIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMA 60 MN+S FI RP+AT LLTIG+ALAGI AF LLPVSPLPQVD+PTIS++AS+PGASPETMA Sbjct: 1 MNLSATFIARPVATALLTIGVALAGIAAFNLLPVSPLPQVDFPTISVNASLPGASPETMA 60 Query: 61 ATVATPLERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLP 120 ATVATPLER++G IAG+TEMTS S+ STR+TLQFDLSRDIDGAARDVQAA+NA+R+LLP Sbjct: 61 ATVATPLERSLGRIAGITEMTSQSALGSTRVTLQFDLSRDIDGAARDVQAAINASRSLLP 120 Query: 121 TGMPSNPTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGS 180 +G+PSNPTYRKVNPADAPI+IL +TSDT ++G++YDAA +I+AQKLSQ+ GVGQV++GG+ Sbjct: 121 SGLPSNPTYRKVNPADAPIMILGLTSDTKSRGELYDAASTILAQKLSQITGVGQVNIGGA 180 Query: 181 SQPAVRIELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAE 240 S PAVR+ELNPTALNKYGI T VRT + ATNAN+PKG+LE +R W +YANDQA+ A E Sbjct: 181 SLPAVRVELNPTALNKYGISTETVRTVITATNANKPKGMLEAGNRVWTLYANDQARHAEE 240 Query: 241 YAPLIVSYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNV 300 Y PLI++YRNG PVR+ DVAEV DSV D+RN GS+NGKPSVL+IINRQPGANIIDTVD + Sbjct: 241 YKPLIIAYRNGAPVRLSDVAEVTDSVQDIRNYGSANGKPSVLLIINRQPGANIIDTVDRI 300 Query: 301 RELLPQLQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATL 360 +LP L+ +IP+ I++ V++DRTPTIRASL++ E TL+LS+ LVIMVV+LFLRN RATL Sbjct: 301 NAILPYLRNTIPAQINLDVMMDRTPTIRASLRDVERTLMLSIGLVIMVVYLFLRNLRATL 360 Query: 361 IPAVAVPVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKP 420 IP+VAVPVSLIGTFGVMYL G+SLDNLSLMALT+ATGFVVDDAIVVLEN+SRHIE+GM+P Sbjct: 361 IPSVAVPVSLIGTFGVMYLCGYSLDNLSLMALTVATGFVVDDAIVVLENVSRHIENGMRP 420 Query: 421 YKAALLGAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLT 480 +AAL GAREVGFTV+SMS SLIAVFIP+LMM GIVGRLFREFA+TLSVAILVSL +SLT Sbjct: 421 MQAALKGAREVGFTVVSMSFSLIAVFIPLLMMGGIVGRLFREFAVTLSVAILVSLAISLT 480 Query: 481 TTPMMCAQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLAYQRTLAWALRAAPLM 540 TTPMMCA+LL+ PA+ + W + ++ F +L Y+ +LAWALR + L Sbjct: 481 TTPMMCARLLK--PAS-----EEEPGWFHR---KTEGFFNLLLDGYRHSLAWALRHSWLT 530 Query: 541 MLILLATIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRAD 600 +LILLAT+ LN YLY +PKGFFPQQD GRL+G I+ DQAISFQAMRTKL +FI IV+ D Sbjct: 531 LLILLATVCLNGYLYVVVPKGFFPQQDVGRLMGFIQADQAISFQAMRTKLVDFIHIVQQD 590 Query: 601 PAVSDVVAFTGGQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLVPVQD 660 PAV +VV FTGG + N G M++ LKPL+ERK SAD+V+ RLR K A+ GA +FL VQD Sbjct: 591 PAVENVVGFTGGSQINSGQMFIQLKPLAERKLSADQVINRLRGKLAREPGANLFLQAVQD 650 Query: 661 IRIGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTTLTID 720 IRIG R S++QY+Y+L++D++ LR WEPKIR AL+ +K L D++TD QD G QT L D Sbjct: 651 IRIGGRPSNAQYQYTLQADNLEELRAWEPKIRQALTQIKSLVDVNTDAQDKGQQTALVFD 710 Query: 721 RESAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRDTYVS 780 R+ AM G+TP+ ID+ L++ FGQRQ+STIY+ +NQY VVMEAAPQYWQ+PE LRD Y+ Sbjct: 711 RDKAMALGITPKDIDNALNNAFGQRQVSTIYNPLNQYRVVMEAAPQYWQNPEGLRDIYL- 769 Query: 781 LAGSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTTTSLS 840 ++ASG Q+PL+ FS + PT T L+ Sbjct: 770 -------------------ITASGA-----------------QVPLSTFSHYGPTNTPLA 793 Query: 841 VSHEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSSTSSQ 900 V+H+GQF ASTLSFNLA G SLS AT I AM ++GVPT V G+F GTA AFQ S SSQ Sbjct: 794 VNHQGQFAASTLSFNLAPGASLSAATQQIQDAMNRIGVPTTVHGSFQGTARAFQDSLSSQ 853 Query: 901 PLLILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALIGVIL 960 P+LIL AL+ +YIVLG+LYES +HPITI+STLPSAGVGALLAL+VT TDFS+IALIGVIL Sbjct: 854 PVLILFALITIYIVLGVLYESYVHPITILSTLPSAGVGALLALIVTDTDFSVIALIGVIL 913 Query: 961 LIGIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPLMLGT 1020 LIGIVKKNAIMMIDFALEAER +G SP +AI+ AC+LRFRPILMTTMAALLGALPL LG Sbjct: 914 LIGIVKKNAIMMIDFALEAERSQGMSPADAIFHACVLRFRPILMTTMAALLGALPLALGH 973 Query: 1021 GVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFD 1057 G G+ELRQPLGI++VGGLLVSQ+LTL+TTPV+YL D Sbjct: 974 GDGAELRQPLGISIVGGLLVSQILTLYTTPVVYLALD 1010 Score = 142 bits (357), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 76/92 (82%), Positives = 88/92 (95%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMM+DFA++AER++GMSP DAIF AC LRFRPI+MTTMAALLGA+PLA+GHGDGAE Sbjct: 919 KKNAIMMIDFALEAERSQGMSPADAIFHACVLRFRPILMTTMAALLGALPLALGHGDGAE 978 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYME 1171 LRQPLGISIVGGL+VSQ+LTLYTTPVVYL ++ Sbjct: 979 LRQPLGISIVGGLLVSQILTLYTTPVVYLALD 1010 >YPO2849 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pestis Length = 1024 Score = 1249 bits (3233), Expect = 0.0, Method: Compositional matrix adjust. Identities = 642/1064 (60%), Positives = 806/1064 (75%), Gaps = 56/1064 (5%) Query: 7 FIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMAATVATP 66 FIQRP+ATTLLT+ I L+GI+ F LLPVSPLPQVDYP I +SASMPGA PETMA++VATP Sbjct: 7 FIQRPVATTLLTLAITLSGIIGFSLLPVSPLPQVDYPVIMVSASMPGADPETMASSVATP 66 Query: 67 LERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLPTGMPSN 126 LERA+G IAGV EMTSTSS STRI LQFDL+RDI+GAARDVQAALNAA++LLP+GMPS Sbjct: 67 LERALGRIAGVNEMTSTSSLGSTRIILQFDLNRDINGAARDVQAALNAAQSLLPSGMPSR 126 Query: 127 PTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGSSQPAVR 186 PTYRK+NP+DAPI+I+ +TSDT +QGQ+YD A + +AQK++Q GV V+VGGSS PAVR Sbjct: 127 PTYRKMNPSDAPIMIMTLTSDTFSQGQLYDYASTKLAQKIAQTEGVSDVTVGGSSLPAVR 186 Query: 187 IELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAEYAPLIV 246 +ELNP+AL G+ VR A++A N RP+G ++ + +WQ+ AND+ KTA Y PLIV Sbjct: 187 VELNPSALFNQGVSLDAVRQAISAANVRRPQGSVDAAETHWQVQANDEIKTAEGYRPLIV 246 Query: 247 SYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNVRELLPQ 306 Y NG+PVR+QDVA V DSV DVRNAG S G+P+VL++I+R+PGANII TVD +R LP Sbjct: 247 HYNNGSPVRLQDVANVIDSVQDVRNAGMSAGQPAVLLVISREPGANIIATVDRIRAELPA 306 Query: 307 LQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATLIPAVAV 366 L+ASIP++I + + DR+PTIRASL E E +L+++VALVI+VVF+FLR+ RATLIPAVAV Sbjct: 307 LRASIPASIQLNIAQDRSPTIRASLDEVERSLVIAVALVILVVFIFLRSGRATLIPAVAV 366 Query: 367 PVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKPYKAALL 426 PVSLIGTF MYL GFSL+NLSLMALTIATGFVVDDAIVVLENISRH+E+G+KP AAL Sbjct: 367 PVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGVKPKVAALR 426 Query: 427 GAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLTTTPMMC 486 G REVGFTVLSMSISL+AVFIP+L+M G+ GRLFREFA+TLSVAI +SLV+SLT TPMMC Sbjct: 427 GVREVGFTVLSMSISLVAVFIPLLLMAGLPGRLFREFAVTLSVAIGISLVISLTLTPMMC 486 Query: 487 AQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLA----YQRTLAWALRAAPLMML 542 A LLR P R + F +LLA Y R+L WAL +M+ Sbjct: 487 AWLLRSHPKGQQQRIRG---------------FGKVLLAIQQGYGRSLNWALSHTRWVMV 531 Query: 543 ILLATIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRADPA 602 +LL+TIALNV+LY +IPK FFP+QDTGR++G I+ DQ+ISFQ+M+ KL +F+ IV ADPA Sbjct: 532 VLLSTIALNVWLYISIPKTFFPEQDTGRMMGFIQADQSISFQSMQQKLKDFMQIVGADPA 591 Query: 603 VSDVVAFTGGQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLVPVQDIR 662 V V FTGG R N G M+++LKPLSER+++A +V+ RLR K AK GA +FL VQDIR Sbjct: 592 VDSVTGFTGGSRTNSGSMFISLKPLSERQETAQQVITRLRGKLAKEPGANLFLSSVQDIR 651 Query: 663 IGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTTLTIDRE 722 +G R S++ Y+++L +DD+ LR WEPK+R AL+ L +L D+++DQQD G + LT DRE Sbjct: 652 VGGRHSNAAYQFTLLADDLAALREWEPKVRAALAKLPQLADVNSDQQDKGAEMALTYDRE 711 Query: 723 SAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRDTYVSLA 782 + R G+ ++ L++ FGQRQISTIY +NQY VVME AP+Y Q +L +V Sbjct: 712 TMARLGIDVSEANALLNNAFGQRQISTIYQPLNQYKVVMEVAPEYTQDVSSLDKMFV--- 768 Query: 783 GSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTTTSLSVS 842 +N+N + IPL+ F++++P L+V+ Sbjct: 769 -----------------------INSN-----------GQSIPLSYFAKWQPANAPLAVN 794 Query: 843 HEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSSTSSQPL 902 H+G AST+SFNL +G SLS+ATAA++RAM +LGVP+ V G FAGTA FQ + SQ Sbjct: 795 HQGLSAASTISFNLPDGGSLSEATAAVERAMTELGVPSTVRGAFAGTAQVFQETLKSQLW 854 Query: 903 LILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALIGVILLI 962 LI+ A+ VYIVLGILYES +HP+TI+STLPSAGVGALLAL + FSLIALIG++LLI Sbjct: 855 LIMAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFDAPFSLIALIGIMLLI 914 Query: 963 GIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPLMLGTGV 1022 GIVKKNAIMM+DFAL+A+R+ S REAI+QA LLRFRPI+MTT+AAL GALPL+L +G Sbjct: 915 GIVKKNAIMMVDFALDAQRNGNISAREAIFQASLLRFRPIIMTTLAALFGALPLVLSSGD 974 Query: 1023 GSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAE 1066 G+ELRQPLGIT+VGGL+VSQ+LTL+TTPVIYL FD L R + Sbjct: 975 GAELRQPLGITIVGGLVVSQLLTLYTTPVIYLYFDRLRNRFSKQ 1018 Score = 156 bits (394), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 74/105 (70%), Positives = 89/105 (84%), Gaps = 4/105 (3%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMMVDFA+DA+RN +S R+AIF+A LRFRPI+MTT+AAL GA+PL + GDGAE Sbjct: 918 KKNAIMMVDFALDAQRNGNISAREAIFQASLLRFRPIIMTTLAALFGALPLVLSSGDGAE 977 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYMERLSSWSKRRFGRK 1184 LRQPLGI+IVGGLVVSQLLTLYTTPV+YLY +RL + RF ++ Sbjct: 978 LRQPLGITIVGGLVVSQLLTLYTTPVIYLYFDRL----RNRFSKQ 1018 >ECs2884 [V] COG0841 Cation/multidrug efflux pump Ecs Escherichia coli O157:H7 Length = 1025 Score = 1224 bits (3166), Expect = 0.0, Method: Compositional matrix adjust. Identities = 640/1066 (60%), Positives = 800/1066 (75%), Gaps = 58/1066 (5%) Query: 7 FIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMAATVATP 66 FI RP+AT LL++ I L GI+ FR+LPV+PLPQVD+P I +SAS+PGASPETMA++VATP Sbjct: 7 FIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATP 66 Query: 67 LERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLPTGMPSN 126 LER++G IAGV+EMTS+SS STRI LQFD RDI+GAARDVQAA+NAA++LLP+GMPS Sbjct: 67 LERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSR 126 Query: 127 PTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGSSQPAVR 186 PTYRK NP+DAPI+IL +TSDT +QG++YD A + +A +SQ+ GVG V VGGSS PAVR Sbjct: 127 PTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVR 186 Query: 187 IELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAEYAPLIV 246 + LNP AL G+ DVRTA++ N +P+G LED WQI ND+ KTAAEY PLI+ Sbjct: 187 VGLNPQALFNQGVSLDDVRTAISNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLII 246 Query: 247 SYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNVRELLPQ 306 Y NG VR+ DVA V DSV DVRNAG +N KP++L++I + P ANII TVD++R LP+ Sbjct: 247 HYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPE 306 Query: 307 LQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATLIPAVAV 366 LQ +IP+AID+++ DR+PTIRASL+E E TLI+SVALVI+VVFLFLR+ RAT+IPAVAV Sbjct: 307 LQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVAV 366 Query: 367 PVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKPYKAALL 426 PVSLIGTF MYL GFSL+NLSLMALTIATGFVVDDAIVVLENI+RH+E+GMKP +AAL Sbjct: 367 PVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQ 426 Query: 427 GAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLTTTPMMC 486 G REVGFTVLSMS+SL+AVF+P+L+M G+ GRL REFA+TLSVAI +SL+VSLT TPMMC Sbjct: 427 GTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMC 486 Query: 487 AQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLA----YQRTLAWALRAAPLMML 542 +L+ A R Q+R F ML+A Y ++L W L L+ + Sbjct: 487 GWMLK----ASKPREQKRLRG-----------FGRMLVALQQGYGKSLKWVLNHTRLVGM 531 Query: 543 ILLATIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRADPA 602 +LL TIALN++LY +IPK FFP+QDTG L+GGI+ DQ+ISFQAMR KL +F+ I+R DPA Sbjct: 532 VLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPA 591 Query: 603 VSDVVAFTGGQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLVPVQDIR 662 V +V FTGG R N G M++TLKP ER ++A +++ RLR+K AK GA +FL+ VQDIR Sbjct: 592 VDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIR 651 Query: 663 IGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTTLTIDRE 722 +G RQS++ Y+Y+L SDD+ LR WEPKIR L+ L EL D+++DQQDNG + L DR+ Sbjct: 652 VGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRD 711 Query: 723 SAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRDTYVSLA 782 + R G+ Q +S L++ FGQRQISTIY MNQY VVME P+Y Q L +V Sbjct: 712 TMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFV--- 768 Query: 783 GSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTTTSLSVS 842 ++ GK IPL+ F++++P LSV+ Sbjct: 769 -----------------INNEGK-----------------AIPLSYFAKWQPANAPLSVN 794 Query: 843 HEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSSTSSQPL 902 H+G AST+SFNL G SLS A+AAIDRAM QLGVP+ V G+FAGTA FQ + +SQ + Sbjct: 795 HQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVI 854 Query: 903 LILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALIGVILLI 962 LI+ A+ VYIVLGILYES +HP+TI+STLPSAGVGALLAL + FSLIALIG++LLI Sbjct: 855 LIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLI 914 Query: 963 GIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPLMLGTGV 1022 GIVKKNAIMM+DFALEA+RH +P+EAI+QACLLRFRPI+MTT+AAL GALPL+L G Sbjct: 915 GIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGD 974 Query: 1023 GSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAERH 1068 GSELRQPLGIT+VGGL++SQ+LTL+TTPV+YL FD L RLR R Sbjct: 975 GSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL--RLRFSRK 1018 Score = 159 bits (403), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 74/107 (69%), Positives = 93/107 (86%), Gaps = 4/107 (3%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMMVDFA++A+R+ ++P++AIF+AC LRFRPIMMTT+AAL GA+PL + GDG+E Sbjct: 918 KKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSE 977 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYMERLSSWSKRRFGRKNK 1186 LRQPLGI+IVGGLV+SQLLTLYTTPVVYL+ +RL + RF RK+K Sbjct: 978 LRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL----RLRFSRKSK 1020 >yegO [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1025 Score = 1222 bits (3163), Expect = 0.0, Method: Compositional matrix adjust. Identities = 640/1066 (60%), Positives = 800/1066 (75%), Gaps = 58/1066 (5%) Query: 7 FIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMAATVATP 66 FI RP+AT LL++ I L GI+ FR+LPV+PLPQVD+P I +SAS+PGASPETMA++VATP Sbjct: 7 FIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATP 66 Query: 67 LERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLPTGMPSN 126 LER++G IAGV+EMTS+SS STRI LQFD RDI+GAARDVQAA+NAA++LLP+GMPS Sbjct: 67 LERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSR 126 Query: 127 PTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGSSQPAVR 186 PTYRK NP+DAPI+IL +TSDT +QG++YD A + +A +SQ+ GVG V VGGSS PAVR Sbjct: 127 PTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVR 186 Query: 187 IELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAEYAPLIV 246 + LNP AL G+ DVRTAV+ N +P+G LED WQI ND+ KTAAEY PLI+ Sbjct: 187 VGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLII 246 Query: 247 SYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNVRELLPQ 306 Y NG VR+ DVA V DSV DVRNAG +N KP++L++I + P ANII TVD++R LP+ Sbjct: 247 HYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPE 306 Query: 307 LQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATLIPAVAV 366 LQ +IP+AID+++ DR+PTIRASL+E E TLI+SVALVI+VVFLFLR+ RAT+IPAV+V Sbjct: 307 LQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSV 366 Query: 367 PVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKPYKAALL 426 PVSLIGTF MYL GFSL+NLSLMALTIATGFVVDDAIVVLENI+RH+E+GMKP +AAL Sbjct: 367 PVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQ 426 Query: 427 GAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLTTTPMMC 486 G REVGFTVLSMS+SL+AVF+P+L+M G+ GRL REFA+TLSVAI +SL+VSLT TPMMC Sbjct: 427 GTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMC 486 Query: 487 AQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLA----YQRTLAWALRAAPLMML 542 +L+ A R Q+R F ML+A Y ++L W L L+ + Sbjct: 487 GWMLK----ASKPREQKRLRG-----------FGRMLVALQQGYGKSLKWVLNHTRLVGV 531 Query: 543 ILLATIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRADPA 602 +LL TIALN++LY +IPK FFP+QDTG L+GGI+ DQ+ISFQAMR KL +F+ I+R DPA Sbjct: 532 VLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPA 591 Query: 603 VSDVVAFTGGQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLVPVQDIR 662 V +V FTGG R N G M++TLKP ER ++A +++ RLR+K AK GA +FL+ VQDIR Sbjct: 592 VDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIR 651 Query: 663 IGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTTLTIDRE 722 +G RQS++ Y+Y+L SDD+ LR WEPKIR L+ L EL D+++DQQDNG + L DR+ Sbjct: 652 VGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRD 711 Query: 723 SAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRDTYVSLA 782 + R G+ Q +S L++ FGQRQISTIY MNQY VVME P+Y Q L +V Sbjct: 712 TMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFV--- 768 Query: 783 GSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTTTSLSVS 842 ++ GK IPL+ F++++P LSV+ Sbjct: 769 -----------------INNEGK-----------------AIPLSYFAKWQPANAPLSVN 794 Query: 843 HEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSSTSSQPL 902 H+G AST+SFNL G SLS A+AAIDRAM QLGVP+ V G+FAGTA FQ + +SQ + Sbjct: 795 HQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVI 854 Query: 903 LILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALIGVILLI 962 LI+ A+ VYIVLGILYES +HP+TI+STLPSAGVGALLAL + FSLIALIG++LLI Sbjct: 855 LIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLI 914 Query: 963 GIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPLMLGTGV 1022 GIVKKNAIMM+DFALEA+RH +P+EAI+QACLLRFRPI+MTT+AAL GALPL+L G Sbjct: 915 GIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGD 974 Query: 1023 GSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAERH 1068 GSELRQPLGIT+VGGL++SQ+LTL+TTPV+YL FD L RLR R Sbjct: 975 GSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL--RLRFSRK 1018 Score = 158 bits (400), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 74/107 (69%), Positives = 92/107 (85%), Gaps = 4/107 (3%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMMVDFA++A+R+ ++P++AIF+AC LRFRPIMMTT+AAL GA+PL + GDG+E Sbjct: 918 KKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSE 977 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYMERLSSWSKRRFGRKNK 1186 LRQPLGI+IVGGLV+SQLLTLYTTPVVYL+ +RL + RF RK K Sbjct: 978 LRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL----RLRFSRKPK 1020 >ZyegO [V] COG0841 Cation/multidrug efflux pump EcZ Escherichia coli O157:H7 EDL933 Length = 1025 Score = 1218 bits (3151), Expect = 0.0, Method: Compositional matrix adjust. Identities = 638/1066 (59%), Positives = 798/1066 (74%), Gaps = 58/1066 (5%) Query: 7 FIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMAATVATP 66 FI RP+AT LL++ I L GI+ FR+LPV+PLPQVD+P I +SAS+PGASPETMA++VATP Sbjct: 7 FIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATP 66 Query: 67 LERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLPTGMPSN 126 LER++G IAGV+EMTS+SS STRI LQFD RDI+ AARDV AA+NAA++LLP+GMPS Sbjct: 67 LERSLGRIAGVSEMTSSSSLGSTRIILQFDFXRDINXAARDVXAAINAAQSLLPSGMPSR 126 Query: 127 PTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGSSQPAVR 186 PTYRK NP+DAPI+IL +TSDT +QG++YD A + +A +SQ+ GVG V VGGSS PAVR Sbjct: 127 PTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVR 186 Query: 187 IELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAEYAPLIV 246 + LNP AL G+ DVRTA++ N +P+G LED WQI ND+ KTAAEY PLI+ Sbjct: 187 VGLNPQALFNQGVSLDDVRTAISNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLII 246 Query: 247 SYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNVRELLPQ 306 Y NG VR+ DVA V DSV DVRNAG +N KP++L++I + P ANII TVD++R LP+ Sbjct: 247 HYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPE 306 Query: 307 LQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATLIPAVAV 366 LQ +IP+AID+++ DR+PTIRASL+E E TLI+SVALVI+VVFLFLR+ RAT+IPAVAV Sbjct: 307 LQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVAV 366 Query: 367 PVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKPYKAALL 426 PVSLIGTF MYL GFSL+NLSLMALTIATGFVVDDAIVVLENI+RH+E+GMKP +AAL Sbjct: 367 PVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQ 426 Query: 427 GAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLTTTPMMC 486 G REVGFTVLSMS+SL+AVF+P+L+M G+ GRL REFA+TLSVAI +SL+VSLT TPMMC Sbjct: 427 GTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMC 486 Query: 487 AQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLA----YQRTLAWALRAAPLMML 542 +L+ A R Q+R F ML+A Y ++L W L L+ + Sbjct: 487 GWMLK----ASKPREQKRLRG-----------FGRMLVALQQGYGKSLKWVLNHTRLVGM 531 Query: 543 ILLATIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRADPA 602 +LL TIALN++LY +IPK FFP+QDTG L+GGI+ DQ+ISFQAMR KL +F+ I+R DPA Sbjct: 532 VLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPA 591 Query: 603 VSDVVAFTGGQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLVPVQDIR 662 V +V FTGG R N G M++TLKP ER ++A +++ RLR+K AK GA +FL+ VQDIR Sbjct: 592 VDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIR 651 Query: 663 IGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTTLTIDRE 722 +G RQS++ Y+Y+L SDD+ LR WEPKIR L+ L EL D+++DQQDNG + L DR+ Sbjct: 652 VGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRD 711 Query: 723 SAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRDTYVSLA 782 + R G+ Q +S L++ FGQRQISTIY MNQY VVME P+Y Q L +V Sbjct: 712 TMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFV--- 768 Query: 783 GSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTTTSLSVS 842 ++ GK IPL+ F++++P LSV+ Sbjct: 769 -----------------INNEGK-----------------AIPLSYFAKWQPANAPLSVN 794 Query: 843 HEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSSTSSQPL 902 H+G AST+SFNL G SLS A+AAIDRAM QLGVP+ V G+FAGTA FQ + +SQ + Sbjct: 795 HQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVI 854 Query: 903 LILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALIGVILLI 962 LI+ A+ VYIVLGILYES +HP+TI+STLPSAGVGALLAL + FSLIALIG++LLI Sbjct: 855 LIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLI 914 Query: 963 GIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPLMLGTGV 1022 GIVKKNAIMM+DFALEA+RH +P+EAI+QACLLRFRPI+MTT+AAL GALPL+L G Sbjct: 915 GIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGD 974 Query: 1023 GSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAERH 1068 GSELRQPLGIT+VGGL++SQ+LTL+TTPV+YL FD L RLR R Sbjct: 975 GSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL--RLRFSRK 1018 Score = 159 bits (403), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 74/107 (69%), Positives = 93/107 (86%), Gaps = 4/107 (3%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMMVDFA++A+R+ ++P++AIF+AC LRFRPIMMTT+AAL GA+PL + GDG+E Sbjct: 918 KKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSE 977 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYMERLSSWSKRRFGRKNK 1186 LRQPLGI+IVGGLV+SQLLTLYTTPVVYL+ +RL + RF RK+K Sbjct: 978 LRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL----RLRFSRKSK 1020 >STM2128 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1026 Score = 1197 bits (3097), Expect = 0.0, Method: Compositional matrix adjust. Identities = 625/1063 (58%), Positives = 792/1063 (74%), Gaps = 50/1063 (4%) Query: 7 FIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMAATVATP 66 FI RP+AT L+ I L GI+ FRLLPV+PLPQVD+P I +SAS+PGASPETMA++VATP Sbjct: 7 FIYRPVATILIAAAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATP 66 Query: 67 LERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLPTGMPSN 126 LER++G IAGV EMTS+SS STRI L+F+ RDI+GAARDVQAA+NAA++LLP GMPS Sbjct: 67 LERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPGGMPSR 126 Query: 127 PTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGSSQPAVR 186 PTYRK NP+DAPI+IL +TS++ +QG++YD A + +AQ ++Q+ GVG V VGGSS PAVR Sbjct: 127 PTYRKANPSDAPIMILTLTSESWSQGKLYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVR 186 Query: 187 IELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAEYAPLIV 246 + LNP AL G+ +VR A+ + N RP+G +ED WQI ND+ KTAAEY PLI+ Sbjct: 187 VGLNPQALFNQGVSLDEVREAIDSANVRRPQGAIEDSVHRWQIQTNDELKTAAEYQPLII 246 Query: 247 SYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNVRELLPQ 306 Y NG VR+ DVA V DSV DVRNAG +N KP++L++I + P ANII TVD +R LP+ Sbjct: 247 HYNNGAAVRLGDVASVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDGIRAKLPE 306 Query: 307 LQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATLIPAVAV 366 L+A IP+AID+++ DR+PTIRASL+E E TL +SVALVI+VVFLFLR+ RATLIPAVAV Sbjct: 307 LRAMIPAAIDLQIAQDRSPTIRASLQEVEETLAISVALVILVVFLFLRSGRATLIPAVAV 366 Query: 367 PVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKPYKAALL 426 PVSLIGTF MYL GFSL+NLSLMALTIATGFVVDDAIVVLENI+RH+E+GMKP +AAL Sbjct: 367 PVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQ 426 Query: 427 GAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLTTTPMMC 486 G REVGFTV+SMS+SL+AVF+P+L+M G+ GRL REFA+TLSVAI +SLVVSLT TPMMC Sbjct: 427 GTREVGFTVISMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLVVSLTLTPMMC 486 Query: 487 AQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLAYQRTLAWALRAAPLMMLILLA 546 +L+ + + R P + + A+ + Y +L W L L+ ++ L Sbjct: 487 GWMLK-------SSKPRTQPRKRGVGRLLVALQQ----GYGTSLKWVLNHTRLVGVVFLG 535 Query: 547 TIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRADPAVSDV 606 T+ALN++LY AIPK FFP+QDTG L+GGI+ DQ+ISFQAMR KL +F+ I+R DPAV++V Sbjct: 536 TVALNIWLYIAIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVNNV 595 Query: 607 VAFTGGQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLVPVQDIRIGAR 666 FTGG R N G M++TLKP ERK++A +++ RLR+K AK GAR+FL+ VQDIR+G R Sbjct: 596 TGFTGGSRVNSGMMFITLKPRGERKETAQQIIDRLRVKLAKEPGARLFLMAVQDIRVGGR 655 Query: 667 QSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTTLTIDRESAMR 726 Q+++ Y+Y+L SD + LR WEPKIR ALS L +L D+++DQQDNG + L DR++ R Sbjct: 656 QANASYQYTLLSDSLAALREWEPKIRKALSALPQLADVNSDQQDNGAEMNLIYDRDTMSR 715 Query: 727 AGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRDTYVSLAGSSN 786 G+ Q +S L++ FGQRQISTIY MNQY VVME P+Y Q L +V Sbjct: 716 LGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYSQDISALEKMFV------- 768 Query: 787 LSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTTTSLSVSHEGQ 846 ++ GK IPL+ F+++ P LSV+H+G Sbjct: 769 -------------INRDGK-----------------AIPLSYFAQWRPANAPLSVNHQGL 798 Query: 847 FVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSSTSSQPLLILT 906 AST++FNL G SLSQAT AI+R M QLGVP+ V G+F+GTA FQ + +SQ +LI+ Sbjct: 799 SAASTIAFNLPTGTSLSQATEAINRTMTQLGVPSTVRGSFSGTAQVFQQTMNSQLILIVA 858 Query: 907 ALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALIGVILLIGIVK 966 A+ VYIVLGILYES +HP+TI+STLPSAGVGALLAL + FSLIALIG++LLIGIVK Sbjct: 859 AIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVK 918 Query: 967 KNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPLMLGTGVGSEL 1026 KNAIMM+DFALEA+R G +P +AI+QACLLRFRPI+MTT+AAL GALPL+L G GSEL Sbjct: 919 KNAIMMVDFALEAQRSGGLTPEQAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSEL 978 Query: 1027 RQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAERHH 1069 RQPLGIT+VGGL++SQ+LTL+TTPV+YL FD L RLR R + Sbjct: 979 RQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL--RLRFSRKN 1019 Score = 160 bits (406), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 75/106 (70%), Positives = 91/106 (85%), Gaps = 4/106 (3%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMMVDFA++A+R+ G++P AIF+AC LRFRPIMMTT+AAL GA+PL + GDG+E Sbjct: 918 KKNAIMMVDFALEAQRSGGLTPEQAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSE 977 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYMERLSSWSKRRFGRKN 1185 LRQPLGI+IVGGLV+SQLLTLYTTPVVYL+ +RL + RF RKN Sbjct: 978 LRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL----RLRFSRKN 1019 >PA2526 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1036 Score = 1116 bits (2887), Expect = 0.0, Method: Compositional matrix adjust. Identities = 609/1081 (56%), Positives = 797/1081 (73%), Gaps = 55/1081 (5%) Query: 1 MNISLPFIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMA 60 M++S PFI+RP+ATTLLT+ + LAG ++F LLPV+PLP VD+P I +SAS+PGASPETMA Sbjct: 1 MSLSTPFIRRPVATTLLTLALLLAGTLSFGLLPVAPLPNVDFPAIVVSASLPGASPETMA 60 Query: 61 ATVATPLERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLP 120 ++VATPLER++G IAG++EMTS+SS ST + L FDL +DIDGAAR+VQAA+N A +LLP Sbjct: 61 SSVATPLERSLGRIAGISEMTSSSSLGSTTVVLVFDLEKDIDGAAREVQAAINGAMSLLP 120 Query: 121 TGMPSNPTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGS 180 +GMP+NP+YRK NP+D PI++L +TS+T ++G+MYD A +++A KLSQV+GVGQVS+GGS Sbjct: 121 SGMPNNPSYRKANPSDMPIMVLTLTSETQSRGEMYDLASTVLAPKLSQVQGVGQVSIGGS 180 Query: 181 SQPAVRIELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAE 240 S PAVR++LNP A+++YG+ VRTA+AA N+N PKG +E D++WQ+ ANDQ + A E Sbjct: 181 SLPAVRVDLNPDAMSQYGLSLDSVRTAIAAANSNGPKGAVEKDDKHWQVDANDQLRKARE 240 Query: 241 YAPLIVSYR--NGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVD 298 Y PL++ Y NG VR+ DVA+V DSV DVRNAG S+ P+VL+I+ RQPGANII+ D Sbjct: 241 YEPLVIHYNADNGAAVRLGDVAKVSDSVEDVRNAGFSDDLPAVLLIVTRQPGANIIEATD 300 Query: 299 NVRELLPQLQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARA 358 + LP LQ + + + V+ DR+P+IRASL+E E TL++SVALVI+VVFLFLRN RA Sbjct: 301 AIHAQLPVLQELLGPQVKLNVMDDRSPSIRASLEEAELTLLISVALVILVVFLFLRNGRA 360 Query: 359 TLIPAVAVPVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGM 418 TLIP++AVPVSLIGTF VMYL FSL+NLSLMAL IATGFVVDDAIVV+ENI+R IE G Sbjct: 361 TLIPSLAVPVSLIGTFAVMYLCDFSLNNLSLMALIIATGFVVDDAIVVVENIARRIEEGD 420 Query: 419 KPYKAALLGAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVS 478 P +AA+ GAR+VGFTVLSM++SL+AVFIP+L+M G+ GRLFREFA+TLS AILVSLVVS Sbjct: 421 PPIQAAITGARQVGFTVLSMTLSLVAVFIPLLLMGGLTGRLFREFAVTLSAAILVSLVVS 480 Query: 479 LTTTPMMCAQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLAYQRTLAWALRAAP 538 LT TPM+CA+LL R + P +A +S F +L Y+ +L WAL + Sbjct: 481 LTLTPMLCARLL----------RPLKRPEGASLARRSDRFFAAFMLRYRASLGWALEHSR 530 Query: 539 LMMLILLATIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVR 598 LM++I+LA IA+N++L+ +PKGF PQQD+GRL G DQ+ISFQ++ K+ E+ I+ Sbjct: 531 LMVVIMLACIAMNLWLFVVVPKGFLPQQDSGRLRGYAVADQSISFQSLSAKMGEYRKILS 590 Query: 599 ADPAVSDVVAFTGG---QRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFL 655 +DPAV +VV F GG Q N G +VTLKP+ ER D +KV+ RLR + AKV GA ++L Sbjct: 591 SDPAVENVVGFIGGGRWQSSNTGSFFVTLKPIGER-DPVEKVLTRLRERIAKVPGAALYL 649 Query: 656 VPVQDIRIGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQT 715 QD+R+G R S++QYE++L+SDD+ LLR W PK+ A+ L +L D+++D QD G+QT Sbjct: 650 NAGQDVRLGGRDSNAQYEFTLRSDDLTLLREWAPKVEAAMRKLPQLVDVNSDSQDKGVQT 709 Query: 716 TLTIDRESAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLR 775 L IDR+ A G+ +++D+ L+D FGQRQ+STI++ +NQY VVME QY QSPE LR Sbjct: 710 RLVIDRDRAATLGINVEMVDAVLNDSFGQRQVSTIFNPLNQYRVVMEVDQQYQQSPEILR 769 Query: 776 DTYVSLAGSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPT 835 V N G +++PL+AFS +EP+ Sbjct: 770 QVQVI---------------------------GNDG----------QRVPLSAFSHYEPS 792 Query: 836 TTSLSVSHEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQS 895 L V+H+GQF A+TLSFNLA G + AI +A+ L +P +V +F G A A Q Sbjct: 793 RAPLEVNHQGQFAATTLSFNLAPGAQIGPTREAIMQALEPLHIPVDVQTSFEGNAGAVQD 852 Query: 896 STSSQPLLILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIAL 955 + + P LIL ALLAVYIVLGILYES +HP+TI+STLPSAGVGALLAL++ ++ SLIAL Sbjct: 853 TQNQMPWLILLALLAVYIVLGILYESYVHPLTILSTLPSAGVGALLALILCRSELSLIAL 912 Query: 956 IGVILLIGIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALP 1015 IG+ILLIGIVKKNAIMMIDFALEAER+ G SPREAI +AC++RFRPI+MTT+AALLGALP Sbjct: 913 IGIILLIGIVKKNAIMMIDFALEAERNHGLSPREAILEACMMRFRPIMMTTLAALLGALP 972 Query: 1016 LMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAER--HHDGGL 1073 L+ G G + LR+PLGIT+VGGL+ SQ+LTL+TTPV+YL D L + +R DG L Sbjct: 973 LIFGIGGDAALRRPLGITIVGGLIGSQLLTLYTTPVVYLYLDRLRHWVNQKRGVRTDGAL 1032 Query: 1074 R 1074 Sbjct: 1033 E 1033 Score = 140 bits (354), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 73/103 (70%), Positives = 88/103 (85%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMM+DFA++AERN G+SPR+AI EAC +RFRPIMMTT+AALLGA+PL G G A Sbjct: 923 KKNAIMMIDFALEAERNHGLSPREAILEACMMRFRPIMMTTLAALLGALPLIFGIGGDAA 982 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYMERLSSWSKRRFG 1182 LR+PLGI+IVGGL+ SQLLTLYTTPVVYLY++RL W ++ G Sbjct: 983 LRRPLGITIVGGLIGSQLLTLYTTPVVYLYLDRLRHWVNQKRG 1025 >RSp1198 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1041 Score = 1051 bits (2719), Expect = 0.0, Method: Compositional matrix adjust. Identities = 566/1078 (52%), Positives = 743/1078 (68%), Gaps = 51/1078 (4%) Query: 1 MNISLPFIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMA 60 MN S FI RP+ATTLL + I L+G+VA+R+LP+S LP+VDYPTI ++ PGASP+ M Sbjct: 1 MNPSRIFILRPVATTLLMVAILLSGLVAYRMLPLSALPEVDYPTIQVTTLYPGASPDVMT 60 Query: 61 ATVATPLERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLP 120 +++ PLER G + G+ +MTS SS ++ ITLQFDLS +D A ++VQAA+NAA NLLP Sbjct: 61 SSITAPLERQFGQMPGLKQMTSASSGGASVITLQFDLSLSLDIAEQEVQAAINAAGNLLP 120 Query: 121 TGMPSNPTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGS 180 T +P P Y KVNPADAPIL LA+TS T+ ++ D D+ VAQKLSQ+ G+G VS+ G Sbjct: 121 TDLPMPPIYSKVNPADAPILTLAITSRTLPLPKLEDIVDTRVAQKLSQLPGIGLVSISGG 180 Query: 181 SQPAVRIELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAE 240 +PAVRI+ N AL G+ D+RTA+ N N KG + R I ANDQ ++AAE Sbjct: 181 QRPAVRIQANTQALAALGLSIDDIRTAIGNANVNGAKGSFDGPMRASTIDANDQLRSAAE 240 Query: 241 YAPLIVSYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNV 300 Y +IV+Y+NG P+R+ DVA++ D + + A +N P++++ + RQPGAN+ID V+ Sbjct: 241 YGTMIVAYKNGAPIRLTDVAQIIDGAENSKLAAWANTTPAIILNVQRQPGANVIDVVNRA 300 Query: 301 RELLPQLQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATL 360 + LLPQL+ ++P+ ID+ V+ DRT TIRAS+ + +F L+L+VALV+MV+FLFLRN AT+ Sbjct: 301 KALLPQLKDTLPANIDVAVLTDRTTTIRASVADVQFELLLAVALVVMVIFLFLRNIPATI 360 Query: 361 IPAVAVPVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKP 420 IPAVAVP+SL+GTFGVMYLAGFS++NL+LMALTIATGFVVDDAIV++ENI+R+IE G P Sbjct: 361 IPAVAVPLSLVGTFGVMYLAGFSVNNLTLMALTIATGFVVDDAIVMIENIARYIEDGDPP 420 Query: 421 YKAALLGAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLT 480 +AAL GAR++GFT++S++ SLIAV IP+L M +VGRLFREFAITL+V+IL+S VVSLT Sbjct: 421 MEAALKGARQIGFTIISLTFSLIAVLIPLLFMSDVVGRLFREFAITLAVSILISAVVSLT 480 Query: 481 TTPMMCAQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLAYQRTLAWALRAAPLM 540 TPMMCA+LLRH P P + + F++++ Y R L W L Sbjct: 481 LTPMMCARLLRHIP----------EPEQTRFYHAAGQFFDNVIAQYGRMLQWVLDRQRTT 530 Query: 541 MLILLATIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRAD 600 +L+ + T+AL LY +PKGFFP QDTG + G Q+ISF AM + + +++ D Sbjct: 531 LLVAIGTLALTGLLYVYVPKGFFPVQDTGVIQGISDATQSISFPAMAERQQKLAEVILKD 590 Query: 601 PAVSDVVAFTG----GQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLV 656 PAV + +F G N G M + LKP R A +++ RL+ + AKV G +F+ Sbjct: 591 PAVESLSSFIGVDGTNTTLNSGRMLINLKPKDARDADATEIIQRLQPELAKVGGISLFMQ 650 Query: 657 PVQDIRIGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTT 716 PVQD+ I R S +QY+++++ D L W P++ L EL D+++D QDNGL+ Sbjct: 651 PVQDLTIEDRVSRTQYQFTVEDPDPNNLSKWVPRLVERLQQTGELRDVASDLQDNGLRAY 710 Query: 717 LTIDRESAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRD 776 + IDR+ A GVT +DS L +GQR ISTI++ NQY VV+EAAPQ + P++L D Sbjct: 711 VQIDRDKAAVYGVTTAAVDSALYSAYGQRLISTIFTQSNQYRVVLEAAPQLQKGPQSLYD 770 Query: 777 TYVSLAGSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTT 836 V A+TG +Q+PL AF+ Sbjct: 771 LRV----------------------------ASTG---------GQQVPLGAFATVVEQP 793 Query: 837 TSLSVSHEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSS 896 SL V+H+GQF ++T+SFNLA G SL A AI+ A +G+P ++ +F G A AFQSS Sbjct: 794 GSLVVNHQGQFPSATISFNLARGASLGAAVDAINAAEQAIGLPASMQTSFQGAALAFQSS 853 Query: 897 TSSQPLLILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALI 956 S++ LIL A++ +YIVLG+LYES IHP+TI+STLPSAGVGALL+L+V+G D +IA+I Sbjct: 854 LSNELWLILAAIITMYIVLGVLYESTIHPVTILSTLPSAGVGALLSLLVSGKDMGIIAII 913 Query: 957 GVILLIGIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPL 1016 G+ILLIGIVKKNAIMMIDFALEAER +G +PR+AIYQACLLRFRPILMTTMAALLGALPL Sbjct: 914 GIILLIGIVKKNAIMMIDFALEAEREQGMAPRDAIYQACLLRFRPILMTTMAALLGALPL 973 Query: 1017 MLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAERHHDGGLR 1074 MLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYL FDSLG RLR R R Sbjct: 974 MLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLAFDSLGHRLRDWRERRAARR 1031 Score = 162 bits (409), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 74/117 (63%), Positives = 96/117 (82%), Gaps = 4/117 (3%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMM+DFA++AER +GM+PRDAI++AC LRFRPI+MTTMAALLGA+PL +G G G+E Sbjct: 923 KKNAIMMIDFALEAEREQGMAPRDAIYQACLLRFRPILMTTMAALLGALPLMLGTGVGSE 982 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYME----RLSSWSKRRFGRKNKTETSAA 1192 LRQPLGI++VGGL+VSQ+LTL+TTPV+YL + RL W +RR R+ + S + Sbjct: 983 LRQPLGITMVGGLLVSQVLTLFTTPVIYLAFDSLGHRLRDWRERRAARRTGADQSGS 1039 >PA2527 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1043 Score = 1003 bits (2592), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/1075 (51%), Positives = 742/1075 (69%), Gaps = 51/1075 (4%) Query: 1 MNISLPFIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMA 60 MN S PFI RP+ATTLL + I L+G++A+R LP+S LP+VDYPTI + PGASPE M Sbjct: 1 MNPSRPFILRPVATTLLMVAILLSGLIAYRFLPISALPEVDYPTIQVVTLYPGASPEIMT 60 Query: 61 ATVATPLERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLP 120 +++ PLE +G I G+ EM+S+SS ++ ITLQF L ++D A ++VQAA+NAA++LLP Sbjct: 61 SSITAPLENQLGQIPGLNEMSSSSSGGASVITLQFSLQSNLDVAEQEVQAAINAAQSLLP 120 Query: 121 TGMPSNPTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGS 180 +P+ P + KVNPADAPIL LA+ SD M Q+ D D+ +AQK+SQ+ GVG VS+ G Sbjct: 121 NDLPNQPVFSKVNPADAPILTLAVMSDGMPLPQIQDLVDTRLAQKISQISGVGLVSISGG 180 Query: 181 SQPAVRIELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAE 240 +PAVR+ NPTAL G+ D+R+ V + N N PKG + R + ANDQ ++A Sbjct: 181 QRPAVRVRANPTALAAAGLSLEDLRSTVTSNNLNGPKGSFDGPTRASTLDANDQLRSADA 240 Query: 241 YAPLIVSYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNV 300 Y LI++Y+NG+P+R++DVA V D +VR A +N P+V++ I RQPGAN+I+ VD + Sbjct: 241 YRDLIIAYKNGSPLRIRDVASVEDDAENVRLAAWANNLPAVVLNIQRQPGANVIEVVDRI 300 Query: 301 RELLPQLQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATL 360 + LLPQLQ+++P +D++V+ DRT TIRAS+K+ +F L L+VALV+MV FLFLRN ATL Sbjct: 301 KALLPQLQSTLPGNLDVQVLTDRTTTIRASVKDVQFELALAVALVVMVTFLFLRNVYATL 360 Query: 361 IPAVAVPVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKP 420 IP+ AVP+SLIGTFGVMYL+GFS++NL+LMALTIATGFVVDDAIV++ENI+R++E G P Sbjct: 361 IPSFAVPLSLIGTFGVMYLSGFSINNLTLMALTIATGFVVDDAIVMVENIARYLEQGDSP 420 Query: 421 YKAALLGAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLT 480 +AAL G++++GFT++S++ SLIAV IP+L M + GRLFREFAITL+VAIL+S VSLT Sbjct: 421 LEAALKGSKQIGFTIISLTFSLIAVLIPLLFMGDVAGRLFREFAITLAVAILISGFVSLT 480 Query: 481 TTPMMCAQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLAYQRTLAWALRAAPLM 540 TPM+ A+LLRH D ++ R A + + + ++ Y + L LR PL Sbjct: 481 LTPMLSAKLLRH---IDEDQQGR-------FARAAGRVIDGLIAQYAKALRVVLRHQPLT 530 Query: 541 MLILLATIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRAD 600 +L+ +AT+AL LY A+PKGFFP QDTG + G Q+ISFQAM + ++V D Sbjct: 531 LLVAIATLALTALLYLAMPKGFFPVQDTGVIQGVAEAPQSISFQAMSERQRALAEVVLKD 590 Query: 601 PAVSDVVAFTG----GQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLV 656 PAV+ + ++ G N G + + LKP SER +A +V+ RL+ + + G ++++ Sbjct: 591 PAVASLSSYIGVDGSNPTLNTGRLLINLKPHSERDVTASEVIQRLQPELDHLPGIKLYMQ 650 Query: 657 PVQDIRIGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTT 716 PVQD+ I R + +QY+++L+ D +L W PK+ L L +L D+++D QD GLQ Sbjct: 651 PVQDLTIEDRVARTQYQFTLQDADPDVLAEWVPKLVARLQELPQLADVASDWQDKGLQAY 710 Query: 717 LTIDRESAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRD 776 L IDR++A R GV IDS L + FGQR ISTI++ QY VV+E APQ+ P+ L Sbjct: 711 LNIDRDTASRLGVKLSDIDSVLYNAFGQRLISTIFTQATQYRVVLEVAPQFQLGPQALEQ 770 Query: 777 TYVSLAGSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTT 836 YV S+ G Q+ L++ ++ E Sbjct: 771 LYVP--------------------SSDGT-----------------QVRLSSLAKVEERH 793 Query: 837 TSLSVSHEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSS 896 T L+++H QF ++TLSFNLA+G SL +A AI A L +P ++ G+F G A AF++S Sbjct: 794 TLLAINHIAQFPSATLSFNLAKGYSLGEAVEAIRGVEASLELPLSMQGSFRGAALAFEAS 853 Query: 897 TSSQPLLILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALI 956 S+ LLIL +++ +YIVLGILYES IHP+TI+STLPSAGVGALLALM+ G + ++A+I Sbjct: 854 LSNTLLLILASVVTMYIVLGILYESFIHPVTILSTLPSAGVGALLALMLAGQEIGIVAII 913 Query: 957 GVILLIGIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPL 1016 G+ILLIGIVKKNAIMMIDFAL+AER+EGK P EAIYQACLLRFRPILMTTMAALLGALPL Sbjct: 914 GIILLIGIVKKNAIMMIDFALDAERNEGKPPHEAIYQACLLRFRPILMTTMAALLGALPL 973 Query: 1017 MLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAERHHDG 1071 ML G G+ELRQPLGITMVGGLL+SQVLTLFTTPVIYL FD L RR A R G Sbjct: 974 MLAGGAGAELRQPLGITMVGGLLLSQVLTLFTTPVIYLYFDRLARRWAAWRKQRG 1028 Score = 157 bits (397), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 71/105 (67%), Positives = 90/105 (85%), Gaps = 4/105 (3%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMM+DFA+DAERN G P +AI++AC LRFRPI+MTTMAALLGA+PL + G GAE Sbjct: 923 KKNAIMMIDFALDAERNEGKPPHEAIYQACLLRFRPILMTTMAALLGALPLMLAGGAGAE 982 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYMERL----SSWSKRR 1180 LRQPLGI++VGGL++SQ+LTL+TTPV+YLY +RL ++W K+R Sbjct: 983 LRQPLGITMVGGLLLSQVLTLFTTPVIYLYFDRLARRWAAWRKQR 1027 >YPO2848 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pestis Length = 1052 Score = 977 bits (2525), Expect = 0.0, Method: Compositional matrix adjust. Identities = 522/1069 (48%), Positives = 721/1069 (67%), Gaps = 52/1069 (4%) Query: 7 FIQRPIATTLLTIGIALAGIVAFRLLPVSPLPQVDYPTISISASMPGASPETMAATVATP 66 FI RP+ATTL I I LAGI+ +R LPVS LP+VDYPTI + PGASP+ + +++ P Sbjct: 16 FILRPVATTLFMIAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVVTSSITAP 75 Query: 67 LERAMGAIAGVTEMTSTSSQNSTRITLQFDLSRDIDGAARDVQAALNAARNLLPTGMPSN 126 LER G ++G+ +M S SS ++ ITLQF L+ +D A ++VQAA+NAA NLLP+ +P Sbjct: 76 LERQFGQMSGLKQMASQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPYP 135 Query: 127 PTYRKVNPADAPILILAMTSDTMTQGQMYDAADSIVAQKLSQVRGVGQVSVGGSSQPAVR 186 P Y KVNPAD PIL LA+T+ + Q+ D ++ +AQK+SQV GVG V++ G +PAVR Sbjct: 136 PIYNKVNPADPPILTLAVTATAIPMTQVEDMVETRIAQKISQVTGVGLVTLSGGQRPAVR 195 Query: 187 IELNPTALNKYGIGTADVRTAVAATNANRPKGLLEDQDRNWQIYANDQAKTAAEYAPLIV 246 ++LN A+ G+ + +RTA++ N N KG L+ R+ + ANDQ K+A EY LI+ Sbjct: 196 VKLNAPAVAALGLDSETIRTAISNANVNSAKGSLDGPTRSVTLSANDQMKSAEEYRDLII 255 Query: 247 SYRNGTPVRVQDVAEVRDSVADVRNAGSSNGKPSVLIIINRQPGANIIDTVDNVRELLPQ 306 +Y+NG P+R+QDVA + + + A +N + ++++ I RQPG N+I T D++RE+LP+ Sbjct: 256 AYQNGAPIRLQDVATIEQGAENNKLAAWANTQSAIVLNIQRQPGVNVIATADSIREMLPE 315 Query: 307 LQASIPSAIDMKVVLDRTPTIRASLKETEFTLILSVALVIMVVFLFLRNARATLIPAVAV 366 L S+P ++D+KV+ DRT TIRAS+ + +F L+L++ALV+MV++LFLRNA AT+IP++AV Sbjct: 316 LIKSLPKSVDVKVLTDRTSTIRASVNDVQFELLLAIALVVMVIYLFLRNAAATIIPSIAV 375 Query: 367 PVSLIGTFGVMYLAGFSLDNLSLMALTIATGFVVDDAIVVLENISRHIESGMKPYKAALL 426 P+SL+GTF MY GFS++NL+LMALTIATGFVVDDAIVV+ENISR+IE G KP AAL Sbjct: 376 PLSLVGTFAAMYFLGFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLDAALK 435 Query: 427 GAREVGFTVLSMSISLIAVFIPILMMEGIVGRLFREFAITLSVAILVSLVVSLTTTPMMC 486 GA E+GFT++S++ SLIAV IP+L ME IVGRLFREFA+TL+VAIL+S VVSLT TPMMC Sbjct: 436 GAGEIGFTIISLTFSLIAVLIPLLFMEDIVGRLFREFAVTLAVAILISAVVSLTLTPMMC 495 Query: 487 AQLLRHDPAADAARRQRRHPWLQKIADQSAAIFEDMLLAYQRTLAWALRAAPLMMLILLA 546 A++L + ++ R+Q R ++ S F+ ++ Y L L L + + + Sbjct: 496 ARMLSY----ESLRKQNR------LSRASEKFFDWVIAHYAVALKKVLNHPWLTLSVAFS 545 Query: 547 TIALNVYLYKAIPKGFFPQQDTGRLVGGIRGDQAISFQAMRTKLNEFIDIVRADPAVSDV 606 T+ L V LY IPKGFFP QD G + G + Q++SF M + + I+ DPAV + Sbjct: 546 TLVLTVILYLLIPKGFFPLQDNGLIQGTLEAPQSVSFSNMAERQQQVAAIILKDPAVESL 605 Query: 607 VAFTG----GQRRNGGFMYVTLKPLSERKDSADKVVARLRIKTAKVAGARVFLVPVQDIR 662 +F G N G + + LKPLSER D +++ RL+ + V G +++L PVQD+ Sbjct: 606 TSFVGVDGTNATLNNGRLQINLKPLSERDDRIPQIITRLQESVSGVPGIKLYLQPVQDLT 665 Query: 663 IGARQSDSQYEYSLKSDDVGLLRIWEPKIRLALSNLKELEDISTDQQDNGLQTTLTIDRE 722 I + S +QY+++L++ + L W PK+ L +D+++D QD GL + +DR+ Sbjct: 666 IDTQLSRTQYQFTLQATSLEELSTWVPKLVNELQQKAPFQDVTSDWQDQGLVAFVNVDRD 725 Query: 723 SAMRAGVTPQLIDSTLSDLFGQRQISTIYSGMNQYHVVMEAAPQYWQSPETLRDTYVSLA 782 SA R G+T ID+ L + FGQR ISTIY+ NQY VV+E Sbjct: 726 SASRLGITMAAIDNALYNAFGQRLISTIYTQSNQYRVVLE-------------------- 765 Query: 783 GSSNLSPTTSSLSTPPALSASGKLNANTGLAQTISTAPSRQIPLAAFSRFEPTTTSLSVS 842 + P L+A + TG+ + +PL++ + E LS++ Sbjct: 766 ---------HDVQATPGLAAFNDIRL-TGI-------DGKGVPLSSIATIEERFGPLSIN 808 Query: 843 HEGQFVASTLSFNLAEGVSLSQATAAIDRAMAQLGVPTNVLGTFAGTANAFQSSTSSQPL 902 H QF ++T+SFNLA+G SL +A AA+ A ++ +P ++ F G+ AFQ++ S Sbjct: 809 HLNQFPSATVSFNLAQGYSLGEAVAAVTLAEKEIQLPADITTRFQGSTLAFQAALGSTLW 868 Query: 903 LILTALLAVYIVLGILYESLIHPITIISTLPSAGVGALLALMVTGTDFSLIALIGVILLI 962 LI+ A++A+YIVLG+LYES IHPITI+STLP+AGVGALLALM+TG + +IA+IG+ILLI Sbjct: 869 LIIAAIVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMLTGNELDVIAIIGIILLI 928 Query: 963 GIVKKNAIMMIDFALEAERHEGKSPREAIYQACLLRFRPILMTTMAALLGALPLMLGTGV 1022 GIVKKNAIMMIDFAL AER +G +P +AIYQACLLRFRPILMTT+AAL GALPLML TGV Sbjct: 929 GIVKKNAIMMIDFALAAERDQGMTPYDAIYQACLLRFRPILMTTLAALFGALPLMLSTGV 988 Query: 1023 GSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLRAE-RHHD 1070 G+ELRQPLG+ MVGGL+VSQVLTLFTTPVIYL FD L R R + RH D Sbjct: 989 GAELRQPLGVCMVGGLIVSQVLTLFTTPVIYLLFDKLARNTRGKNRHRD 1037 Score = 147 bits (370), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 64/107 (59%), Positives = 90/107 (84%) Query: 1080 KKNAIMMVDFAIDAERNRGMSPRDAIFEACKLRFRPIMMTTMAALLGAIPLAIGHGDGAE 1139 KKNAIMM+DFA+ AER++GM+P DAI++AC LRFRPI+MTT+AAL GA+PL + G GAE Sbjct: 932 KKNAIMMIDFALAAERDQGMTPYDAIYQACLLRFRPILMTTLAALFGALPLMLSTGVGAE 991 Query: 1140 LRQPLGISIVGGLVVSQLLTLYTTPVVYLYMERLSSWSKRRFGRKNK 1186 LRQPLG+ +VGGL+VSQ+LTL+TTPV+YL ++L+ ++ + +++ Sbjct: 992 LRQPLGVCMVGGLIVSQVLTLFTTPVIYLLFDKLARNTRGKNRHRDE 1038