BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0012.p (548 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1047 [GEPR] COG0477 Permeases of the major facilitator superf... 737 0.0 AGl343 [GEPR] COG0477 Permeases of the major facilitator superfa... 641 0.0 NMA1574 [GEPR] COG0477 Permeases of the major facilitator superf... 490 e-138 NMB1362 [GEPR] COG0477 Permeases of the major facilitator superf... 486 e-137 BH2528 [GEPR] COG0477 Permeases of the major facilitator superfa... 273 1e-72 SPy1392 [GEPR] COG0477 Permeases of the major facilitator superf... 226 8e-59 SP1587 [GEPR] COG0477 Permeases of the major facilitator superfa... 207 4e-53 AF0367 [GEPR] COG0477 Permeases of the major facilitator superfa... 128 4e-29 lin2274 [GEPR] COG0477 Permeases of the major facilitator superf... 118 4e-26 SSO2127 [GEPR] COG0477 Permeases of the major facilitator superf... 97 1e-19 >RSp1047 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 549 Score = 737 bits (1903), Expect = 0.0, Method: Compositional matrix adjust. Identities = 380/543 (69%), Positives = 447/543 (82%), Gaps = 3/543 (0%) Query: 5 FLNKEHTVAKPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALGVTAPIACGADVGF 64 F ++E TVA GFNRWLVPPAALAIHLCIGMAYGFSVFWLPLS+ALG+T CGADV Sbjct: 9 FFSRERTVAAVGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSRALGITQSHTCGADVSL 68 Query: 65 FAQVFSSSCDWKISMLGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLLI 124 A++F++SCDW+IS LGWMYT+FFV LG SAALWGGWLE GPRKAGVV+A+CWCGGLLI Sbjct: 69 IAELFTTSCDWRISSLGWMYTLFFVFLGASAALWGGWLERVGPRKAGVVSAVCWCGGLLI 128 Query: 125 SALGVKTHQIWLMWLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGAL 184 SA GV+THQ+W++W+GSGVIGG+GLGLGYISPVSTLIKWFPD+RGMATGMAIMGFGGGA+ Sbjct: 129 SAFGVQTHQLWMLWIGSGVIGGIGLGLGYISPVSTLIKWFPDKRGMATGMAIMGFGGGAM 188 Query: 185 VGTPLADALMKKFATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPVA 244 +G PLAD LMK FA+ SVGV +TF+V+A IYFVFMMAGA GYRVPP GWKPAGW P A Sbjct: 189 IGAPLADRLMKLFASADSVGVSQTFIVLAAIYFVFMMAGALGYRVPPAGWKPAGWKPSPA 248 Query: 245 KSSATMITQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGVN 304 K++ TM+TQ HVHVS+ PQFWL+W VLCLNVSAGIGV+G+ASP+LQEVFGGKLLGV Sbjct: 249 KANDTMVTQRHVHVSQAVKTPQFWLIWAVLCLNVSAGIGVLGMASPLLQEVFGGKLLGVT 308 Query: 305 IGFNDLSVEQKTAIAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVLY 364 F +L+ QK IAA+AAGFTGL+SLFNIGGRF WAS SD GRK+TYA+FF LGFVLY Sbjct: 309 TAFTELTAAQKGQIAAIAAGFTGLLSLFNIGGRFFWASLSDRLGRKLTYAVFFALGFVLY 368 Query: 365 VSLPWSAKAGNIPLFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWATA 424 ++PW++ NI LF A C+ILSMYGGGFATVPAYLAD+FGTQMVGAIHGRLLTAW+TA Sbjct: 369 AAIPWTSHTSNIALFSLAFCVILSMYGGGFATVPAYLADMFGTQMVGAIHGRLLTAWSTA 428 Query: 425 GILGPVVVNYMREYQLAQGMPKNEVYNTTMYILAGMLILGLICNLLIRPVAAKHFMTPEE 484 GILGPV+VNY+REYQ+A G+ + VY+ TM +LAG+L+LG ICNLL+RPV KHFMT + Sbjct: 429 GILGPVLVNYLREYQIAHGVARAAVYDITMMVLAGLLVLGFICNLLVRPVDPKHFMTEAQ 488 Query: 485 LAHEKKLAHEKSAADAAVTAGSGDMSQIGSGGNPVFIGLAWAAVGIPLIWGITLVLQKSA 544 L ++ H +AA A + G+ V + LAWAAVG+PL WG+ + LQK+A Sbjct: 489 LDEQR---HAATAATPQANAPETSLEWQAHPGSAVAVVLAWAAVGLPLGWGVWITLQKAA 545 Query: 545 VLF 547 VLF Sbjct: 546 VLF 548 >AGl343 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 552 Score = 641 bits (1654), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/545 (65%), Positives = 421/545 (77%), Gaps = 13/545 (2%) Query: 5 FLNKEHTVAKPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALGVTAPIACGADVGF 64 FL++E +A+PGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSKAL T P +C + + Sbjct: 18 FLDRERIIARPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALPATDP-SC-SSLTL 75 Query: 65 FAQVFSSSCDWKISMLGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLLI 124 +F++ C+W+++ LGW+YT+FFVLLG SAA+WGGWLE GPRKAG V+A CWCGG+L+ Sbjct: 76 MGALFTTECNWRVADLGWIYTLFFVLLGCSAAIWGGWLERVGPRKAGFVSACCWCGGILV 135 Query: 125 SALGVKTHQIWLMWLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGAL 184 +A+GV THQ+WLMWLG+GVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGA+ Sbjct: 136 AAIGVATHQLWLMWLGAGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGAM 195 Query: 185 VGTPLADALMKKFATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPVA 244 +G PLA+ LM F T S+GVW+TFVVMA++YF FMMAGAFGYR+PP GW+P GWT P A Sbjct: 196 IGAPLANLLMNTFKTEASIGVWQTFVVMALVYFAFMMAGAFGYRIPPAGWRPEGWTAPAA 255 Query: 245 KSSATMITQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGV- 303 KS+ MIT HVH+ PQFWL+W VLCLNVSAGIGVIG+ASPMLQE+F G L+G+ Sbjct: 256 KSA--MITTRHVHLRDAHKTPQFWLIWAVLCLNVSAGIGVIGMASPMLQEIFAGSLIGLP 313 Query: 304 NIGFNDLSVEQKTAIAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVL 363 +GF DL QK IAA+AAGFTGL+SLFNIGGRF WAS SD GRK TY FFVLG +L Sbjct: 314 GVGFADLDAGQKAQIAAIAAGFTGLLSLFNIGGRFFWASMSDKIGRKNTYFCFFVLGIIL 373 Query: 364 YVSLPWSAKAGNIPLFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWAT 423 Y P A GN LFV A IILSMYGGGFAT+PAYLAD+FGTQ VGAIHGRLLTAWAT Sbjct: 374 YALAPTLATMGNKALFVLAFGIILSMYGGGFATIPAYLADIFGTQFVGAIHGRLLTAWAT 433 Query: 424 AGILGPVVVNYMREYQLAQGM-PKNEVYNTTMYILAGMLILGLICNLLIRPVAAKHFMTP 482 AGI GPVVVNY+RE Q+A G+ P +Y +TMYILAGML +GLI N +RP+A K FM+ Sbjct: 434 AGIAGPVVVNYIREAQIAAGVAPGPALYTSTMYILAGMLAIGLIANAFVRPLADKWFMSD 493 Query: 483 EELAHEKKLAHEKSAADAAVTAGSGDMSQIGSGGNPVFIGLAWAAVGIPLIWGITLVLQK 542 E+A + + AG IG GG LAWAAVGIPL+WG+ + ++ Sbjct: 494 AEVAALQAKTAAAN-------AGPTGSFGIGRGGLDAKAALAWAAVGIPLLWGVWVTVRS 546 Query: 543 SAVLF 547 S LF Sbjct: 547 SLALF 551 >NMA1574 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 513 Score = 490 bits (1261), Expect = e-138, Method: Compositional matrix adjust. Identities = 274/547 (50%), Positives = 371/547 (67%), Gaps = 39/547 (7%) Query: 4 DFLNKEHTVAKPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALGVTAPIACGADVG 63 FL++E ++AKPGFNRWLVPPAALA+HL IG Y +SVF PL+K +G+T Sbjct: 2 KFLDREASIAKPGFNRWLVPPAALAVHLAIGQIYAYSVFNAPLTKLIGITE--------- 52 Query: 64 FFAQVFSSSCDWKISMLGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLL 123 S++ DWK++ +GW++++ +LG SAAL+G W+E GPRKA AA C+ G Sbjct: 53 ------SAAGDWKLTTVGWIFSIALAMLGASAALFGTWMERVGPRKAIFAAACCFSLGFF 106 Query: 124 ISALGVKTHQIWLMWLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGA 183 +SA GV+TH ++L++LG+GVIGGVGLGLGYI PVSTL+KWFPD+ GMATG+AIMGFGGGA Sbjct: 107 VSAFGVRTHNLFLLYLGNGVIGGVGLGLGYIGPVSTLMKWFPDKPGMATGLAIMGFGGGA 166 Query: 184 LVGTPLADALMKKFATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPV 243 ++ +PL+ +LM F+ TSVGV ETF V+ ++Y MM GAF RVP GWKP G+T P Sbjct: 167 MLASPLSVSLMNTFSNATSVGVAETFAVLGLLYLALMMFGAFTIRVPADGWKPEGYTAP- 225 Query: 244 AKSSATMITQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGV 303 K+ +++ NHV+VS+ PQFWL++ VLCLNV+AGIGV+G AS M+QE+F +G Sbjct: 226 -KTQNKLVSSNHVNVSQAMKTPQFWLLFWVLCLNVTAGIGVLGQASVMIQELFSETSIG- 283 Query: 304 NIGFNDLSVEQKTAIAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVL 363 Q A AAGF L+SLFN+GGRF W+S SD GRK TY IFFVLG +L Sbjct: 284 ---------RQAAVGAGAAAGFVSLLSLFNMGGRFLWSSVSDKIGRKNTYTIFFVLGSLL 334 Query: 364 YVSLPWSAKAGNIPLFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWAT 423 Y ++P + G+ LF+ C+I+SMYGGGFA +PAYL DLFGT VGAIHGR+L AW+T Sbjct: 335 YFAVPSIGEGGSKALFIIGFCVIISMYGGGFAAIPAYLKDLFGTYQVGAIHGRILLAWST 394 Query: 424 AGILGPVVVNYMREYQLAQGMPKNEVYNTTMYILAGMLILGLICNLLIRPVAAKHFMTPE 483 A ++GPV+VNY+R+ Q+ G+P + Y+ TMYI+AG+LI+GL+CNL ++ V KH Sbjct: 395 AAVIGPVLVNYIRQSQIDSGIPAAQAYSVTMYIMAGLLIIGLLCNLAVKSVHEKH----- 449 Query: 484 ELAHEKKL---AHEKSAADAAVTAGSGDMSQIGSGGNPVFIGLAWAAVGIPLIWGITLVL 540 HEK + AH + D + + + + SGG + + WA IPL +G+ ++ Sbjct: 450 ---HEKDIKTAAHSGNPDDETAISDAYLVGEKVSGGG-ISVWWRWALAVIPLAYGVVMIF 505 Query: 541 QKSAVLF 547 K+ LF Sbjct: 506 VKALDLF 512 >NMB1362 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 513 Score = 486 bits (1250), Expect = e-137, Method: Compositional matrix adjust. Identities = 273/547 (49%), Positives = 369/547 (67%), Gaps = 39/547 (7%) Query: 4 DFLNKEHTVAKPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALGVTAPIACGADVG 63 FL++E ++AKPGFNRWLVPPAALA+HL IG Y +SVF PL+K +G+T Sbjct: 2 KFLDREASIAKPGFNRWLVPPAALAVHLAIGQIYAYSVFNAPLTKLIGITE--------- 52 Query: 64 FFAQVFSSSCDWKISMLGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLL 123 S++ DWK++ +GW++++ +LG SAAL+G W+E GPRKA AA C+ G Sbjct: 53 ------SAAGDWKLTTVGWIFSIALAMLGASAALFGTWMERVGPRKAIFAAACCFSLGFF 106 Query: 124 ISALGVKTHQIWLMWLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGA 183 +SA GV+TH ++L++LG+GVIGGVGLGLGYI PVSTL+KWFPD+ GMATG+AIMGFGGGA Sbjct: 107 VSAFGVRTHNLFLLYLGNGVIGGVGLGLGYIGPVSTLMKWFPDKPGMATGLAIMGFGGGA 166 Query: 184 LVGTPLADALMKKFATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPV 243 ++ +PL+ +LM F+ SVGV ETF V+ ++Y MM GAF RVP GWKP G+T P Sbjct: 167 MLASPLSVSLMNTFSNAASVGVAETFAVLGLLYLALMMFGAFTIRVPADGWKPEGYTAP- 225 Query: 244 AKSSATMITQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGV 303 K+ +++ NHV+VS+ PQFWL++ VLCLNV+AGIGV+G AS M+QE+F +G Sbjct: 226 -KTQNKLVSSNHVNVSQAMKTPQFWLLFWVLCLNVTAGIGVLGQASVMIQELFSETSIG- 283 Query: 304 NIGFNDLSVEQKTAIAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVL 363 Q A AAGF L+SLFN+GGRF W+S SD GRK TY IFFVLG +L Sbjct: 284 ---------RQAAVGAGAAAGFVSLLSLFNMGGRFLWSSVSDKIGRKNTYTIFFVLGSLL 334 Query: 364 YVSLPWSAKAGNIPLFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWAT 423 Y ++P + G+ LF+ C+I+SMYGGGFA +PAYL DLFGT VGAIHGR+L AW+T Sbjct: 335 YFAVPSIGEGGSKALFIIGFCVIISMYGGGFAAIPAYLKDLFGTYQVGAIHGRILLAWST 394 Query: 424 AGILGPVVVNYMREYQLAQGMPKNEVYNTTMYILAGMLILGLICNLLIRPVAAKHFMTPE 483 A ++GPV+VNY+R+ Q+ G+P + Y+ TMYI+A +LI+GL+CNL ++ V KH Sbjct: 395 AAVIGPVLVNYIRQSQIDSGIPAAQAYSVTMYIMACLLIIGLLCNLAVKSVHEKH----- 449 Query: 484 ELAHEKKL---AHEKSAADAAVTAGSGDMSQIGSGGNPVFIGLAWAAVGIPLIWGITLVL 540 HEK + AH + D + + + + SGG + + WA IPL +G+ +V Sbjct: 450 ---HEKDIKTAAHSGNPDDETAISDAYLVGEKVSGGG-ISVWWRWALAVIPLAYGVVMVF 505 Query: 541 QKSAVLF 547 K+ LF Sbjct: 506 VKALDLF 512 >BH2528 [GEPR] COG0477 Permeases of the major facilitator superfamily Bha Bacillus halodurans Length = 419 Score = 273 bits (697), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 179/461 (38%), Positives = 254/461 (55%), Gaps = 70/461 (15%) Query: 18 NRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALGVTAPIACGADVGFFAQVFSSSCDWKI 77 NRWL+ AA+ IH+ IG Y +SVF PL + G W + Sbjct: 6 NRWLIALAAVGIHISIGSVYAWSVFTNPLIEQFG-----------------------WGL 42 Query: 78 SMLGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLLISALGVKTHQIWLM 137 + +++ LG+SAA G ++E GPRK+G+VAA + G L + L V +WL+ Sbjct: 43 GEVSLTFSIAIAFLGVSAAFMGHFVEKHGPRKSGMVAASFFGLGTLGAGLAVSLESLWLL 102 Query: 138 WLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGALVGTPLADALMKKF 197 + GV+GG GLG+GYI+PVSTL+KWFPDRRG+ATG+AIMGFG +LV +P+ +A + Sbjct: 103 YFSYGVLGGFGLGVGYITPVSTLVKWFPDRRGLATGLAIMGFGFASLVFSPIMNAFI--- 159 Query: 198 ATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPP------VAKSSATMI 251 TSVG+ TF ++ +Y + M A PP GW PAG+ + K + + Sbjct: 160 ---TSVGIAATFFILGGLYMIIMFTAALYLEPPPQGWVPAGFKEAKTENGRLQKQDLSQL 216 Query: 252 TQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGVNIGFNDLS 311 T N +K +FW +W +L +NV+ GI ++ +ASPM QE+ Sbjct: 217 TANEAVKTK-----RFWFLWTMLFINVTCGIAILAVASPMAQEI---------------- 255 Query: 312 VEQKTAIAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVLYVSLPWSA 371 AA AA GL+ LFN GR WAS SD+ GR Y FF++ V +V LP Sbjct: 256 ---TGMTAATAATMVGLMGLFNGLGRIGWASISDYIGRPNVYTAFFLIQIVAFVMLP--- 309 Query: 372 KAGNIPLFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWATAGILGPVV 431 ++ LF + I++ YGGGFA++PAY+ DLFGT+ +GAIHG +LTAWA AG++GP++ Sbjct: 310 SITHVLLFQVVLFFIMTCYGGGFASIPAYIGDLFGTKQLGAIHGYILTAWALAGLVGPMI 369 Query: 432 VNYMREYQLAQGMPKNEVYNTTMYILAGMLILGLICNLLIR 472 +Y+RE Y T+YI GM I+ L +L IR Sbjct: 370 ASYIRE--------TTNSYAGTLYIFTGMFIVALAVSLFIR 402 >SPy1392 [GEPR] COG0477 Permeases of the major facilitator superfamily Spy Streptococcus pyogenes M1 GAS Length = 398 Score = 226 bits (577), Expect = 8e-59, Method: Compositional matrix adjust. Identities = 140/456 (30%), Positives = 248/456 (54%), Gaps = 64/456 (14%) Query: 18 NRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALG-VTAPIACGADVGFFAQVFSSSCDWK 76 R+++ A + +HL +G Y +SV+ P+ + G AP+A + F Sbjct: 5 KRYIIATAGILLHLMLGSTYAWSVYRNPILQETGWDQAPVAFAFSLAIFC---------- 54 Query: 77 ISMLGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLLISALGVKTHQIWL 136 LG+SAA G +E GPR G V+AI + G +++ L + +IWL Sbjct: 55 --------------LGLSAAFMGNLVEQYGPRLTGTVSAILYASGNMLTGLAIDRKEIWL 100 Query: 137 MWLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGALVGTPLADALMKK 196 +++G GVIGG+GLG GYI+P+ST+IKWFPD+RGMATG AIMGFG +L+ +P+A L++ Sbjct: 101 LYIGYGVIGGLGLGAGYITPISTIIKWFPDKRGMATGFAIMGFGFASLLTSPIAQWLIE- 159 Query: 197 FATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPVAKSSATMITQNHV 256 + G+ TF ++ +IY + M+ + + PT + A ++++ +I + Sbjct: 160 -----TEGLVATFYLLGLIYLIVMLFAS-QLIIKPTAAEIAILDKKRLQNNSYLI--EGM 211 Query: 257 HVSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGVNIGFNDLSVEQKT 316 + F+ +W++L +N++ G+G+I + +PM Q++ G +S E Sbjct: 212 TAKEALKTKSFYCLWVILFINITCGLGLISVVAPMAQDLTG------------MSPE--- 256 Query: 317 AIAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVLYVSLPWSAKAGNI 376 ++A G + +FN GR WAS SD+ GR++T + F++ ++ +SL ++ + Sbjct: 257 ----MSAIVVGAMGIFNGFGRLVWASLSDYIGRRVTVILLFLVSIIMTISLIFAHSS--- 309 Query: 377 PLFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWATAGILGPVVVNYMR 436 +F+ ++ +++ YG GF+ +P YL+DLFG + + +HG +LTAWA A + GP++++ Sbjct: 310 LIFMISIATLMTCYGAGFSLIPPYLSDLFGAKELATLHGYILTAWAIAALTGPMLLSITV 369 Query: 437 EYQLAQGMPKNEVYNTTMYILAGMLILGLICNLLIR 472 E+ Y T+ + + ILGL+ L ++ Sbjct: 370 EW--------THNYLLTLCVFIVLYILGLMVALRLK 397 >SP1587 [GEPR] COG0477 Permeases of the major facilitator superfamily Spn Streptococcus pneumoniae TIGR4 Length = 408 Score = 207 bits (528), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 141/439 (32%), Positives = 240/439 (54%), Gaps = 62/439 (14%) Query: 18 NRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALGVTAPIACGADVGFFAQVFSSSCDWKI 77 NR+++ A + +HL +G Y +SV+ P+ + G W Sbjct: 4 NRYIIAFAGVILHLMLGSTYAWSVYRNPIIEKTG-----------------------WDQ 40 Query: 78 SMLGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLLISALGVKTHQIWLM 137 + + + +++ LG+SAA G +E GP+ G ++A + GG +++ + ++WL+ Sbjct: 41 ASVAFAFSLAIFCLGLSAAFMGRLVEKFGPKVMGSLSAFLYAGGNILTGFAIDRQELWLL 100 Query: 138 WLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGALVGTPLADALMKKF 197 +L G++GG+GLG GYI+PVST+IKWFPD+RG+ATG+AIMGFG +L+ +P+A L+ Sbjct: 101 YLAYGILGGLGLGAGYITPVSTIIKWFPDKRGLATGLAIMGFGFASLLTSPIAQHLI--- 157 Query: 198 ATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPVAKSSATMITQNHVH 257 VG+ ETF ++ YF+ M+ + + P + K +TQ + Sbjct: 158 ---AGVGLVETFYILGASYFIIMLLASQFIKRPNE--QELAILSSSGKEKTASLTQG-MA 211 Query: 258 VSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGVNIGFNDLSVEQKTA 317 ++ +F+++W++ +N++ G+G+I ASPM QE+ G LS Sbjct: 212 ANQALKSNRFYMLWIIFFINIACGLGLISAASPMAQEMAG------------LSTSH--- 256 Query: 318 IAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVLYVSLPWSAKAGNIP 377 AA G++ +FN GR WAS SD+ GR +T++I ++ +SL W + Sbjct: 257 ----AAVMVGVLGIFNGFGRLLWASLSDYIGRPLTFSILLLVNLFFSLSL-WLFT--DSV 309 Query: 378 LFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWATAGILGPVVVNYMRE 437 LFV A+ I+++ YG GF+ +PAYL+D+FGT+ + A+HG +LTAWA AG+ GP+++ Sbjct: 310 LFVVAMSILMTCYGAGFSLIPAYLSDIFGTKELAALHGYILTAWAMAGLAGPILLA--ET 367 Query: 438 YQLAQGMPKNEVYNTTMYI 456 Y++A Y T+++ Sbjct: 368 YKMAHS------YTQTLFV 380 >AF0367 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu Archaeoglobus fulgidus Length = 397 Score = 128 bits (321), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 112/433 (25%), Positives = 190/433 (43%), Gaps = 68/433 (15%) Query: 18 NRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALGVTAPIACGADVGFFAQVFSSSCDWKI 77 ++WLV A ++L +G+ Y +SVF PL G W Sbjct: 3 SKWLVIFAGFLLNLMLGIVYAWSVFVNPLMNTFG-----------------------WSK 39 Query: 78 SMLGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLLISALGVKTHQIWLM 137 ++ +++F ++ + G + GPRK ++ + G L+S L + + Sbjct: 40 TIASLPFSIFLLIFALMMVPAGRTQDRIGPRKVAMLGGVLLGVGFLLSGLIESIQSPYWL 99 Query: 138 WLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGALVGTPLADALMKKF 197 GVI G G GLGY P+ KWFP+R G+ATG+ +MGFG AL+ PL L+ + Sbjct: 100 IFSYGVIAGAGCGLGYACPIPVARKWFPERVGLATGLVVMGFGMSALIFAPLERILIDTY 159 Query: 198 ATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPVAKSSATMIT----Q 253 G+ TF ++ VI + + A PP P V S+ + + Sbjct: 160 ------GISTTFYILGVILLIVAVFAASLLSNPPE-------LPAVQASNPAKVEVVTGK 206 Query: 254 NHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGVNIGFNDLSVE 313 + S++ +F+++WL AG+ VIG +P QE Sbjct: 207 PELGPSEMLRDYRFYVLWLSFFFMALAGLMVIGHIAPYAQE------------------- 247 Query: 314 QKTAIAALAAGF-TGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVLYVSLPWSAK 372 + LAA F ++S+ N GR + SD GR MT + F++ + ++ P A Sbjct: 248 --RGLEPLAAAFAVSILSVANAVGRPGAGALSDKIGRAMTMFVLFLIQGITLIAFPHVAL 305 Query: 373 AGNIPLFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWATAGILGPVVV 432 I +++ A I + YG F+ P+ D FGT+ +G +G + T++ G++GP++ Sbjct: 306 T-LITIYICAAIIGFN-YGANFSLFPSATGDFFGTKNLGVNYGLVFTSYGVGGLVGPIMA 363 Query: 433 NYMRE----YQLA 441 Y+ + Y++A Sbjct: 364 GYVFDVTGSYEIA 376 >lin2274 [GEPR] COG0477 Permeases of the major facilitator superfamily Lin Listeria innocua Length = 407 Score = 118 bits (296), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 109/413 (26%), Positives = 181/413 (43%), Gaps = 60/413 (14%) Query: 18 NRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALGVTAPIACGADVGFFAQVFSSSCDWKI 77 NRW V ++ + LC G Y FSVF PLS A G W I Sbjct: 6 NRWGVLIGSVGVLLCTGAVYAFSVFAGPLSAAHG-----------------------WTI 42 Query: 78 SMLGWMYTMFFVLLGISAALWGGWLEHAGPRK-AGVVAAICWCGGLLISALGVKTHQIWL 136 + +T+ +G + GG L G K A ++ I + G ++ T ++L Sbjct: 43 PQVMMAFTIN-AAIGPIPTILGGILTDKGKAKWAILIGGILFGLGFALTGFATSTTMLYL 101 Query: 137 MWLGSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGALVGTPLADALMKK 196 + GV+ G+G G Y +S I+ FPD+RG+A+G+ G GG ++ P+A+ L++ Sbjct: 102 SY---GVLAGLGQGFAYSGCLSNTIRLFPDKRGLASGLITAGMGGATIIAAPIANHLIET 158 Query: 197 FATPTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPVAKSSATMITQNHV 256 + V F +M +Y ++ +F RV P G+ P GWTPP ++ + +V Sbjct: 159 Y------NVMTAFKIMGAVYIAVVIGCSFLIRVAPAGYAPKGWTPPTGNAAGMV----NV 208 Query: 257 HVSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGVNIGFNDLSVEQKT 316 + + F+L+ L+L + +G+ + AS + Q +FG Sbjct: 209 PWTGMVRTVTFYLILLMLGIGAFSGLMIASNASLIGQNMFG------------------- 249 Query: 317 AIAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVLYVSLPWSAKAGNI 376 AA AA + + SL N GR W + SD GR T I + V+ +SL A ++ Sbjct: 250 LTAASAAAYVSIYSLSNCLGRVVWGAVSDRLGRSNTLMIIYT---VIALSLLALATLQSV 306 Query: 377 PLFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWATAGILGP 429 FV + + +GG P+ + + +G + G +G + ++TA P Sbjct: 307 VGFVIGIIGLGLCFGGTMGVFPSIVMENYGPKNQGVNYGIVFIGYSTAAFFAP 359 >SSO2127 [GEPR] COG0477 Permeases of the major facilitator superfamily Sso Sulfolobus solfataricus Length = 430 Score = 97.1 bits (240), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 106/397 (26%), Positives = 184/397 (46%), Gaps = 46/397 (11%) Query: 80 LGWMYTMFFVLLGISAALWGGWLEHAGPRKAGVVAAICWCGGLLISALGVKTHQIWLMWL 139 LG YT++ ++ +S + G + GPR ++ I G + SA + +++L Sbjct: 54 LGLTYTIYIIVQALSMFVAGRIADRYGPRLISMLGGIITGIGYISSAFA---KSLPILYL 110 Query: 140 GSGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGALVGTPLADALMKKFAT 199 G G +G+G+ Y + +ST +KWFPD+RG+ATG+ +GFGGG+ +PL ++ Sbjct: 111 TYG-FGSIGVGIIYGTAISTAVKWFPDKRGLATGIIEIGFGGGSFALSPLIQYII----- 164 Query: 200 PTSVGVWETFVVMAVIYFVFMMAGAFGYRVPPTGWKPAGWTPPVAKSSATMI--TQNHVH 257 TS+ F M ++ + + AF + PP W P G+ + MI ++N Sbjct: 165 -TSISYTAAFTYMGIVQLIVITLLAFFFAYPPPQWLPKGFNAEEYEKKRKMIKRSKNDYT 223 Query: 258 VSKVWGIPQFWLVWLVLCLNVSAGIGVIGIASPMLQEVFGGKLLGVNIGFNDLSVEQKTA 317 VS++ Q+W++++ L +G+ +IG P G ++GF+ Sbjct: 224 VSQMVKTWQWWVIYIAFFLIAGSGLSIIGHLIPY----------GRSLGFS--------- 264 Query: 318 IAALAAGFTGLISLFNIGGRFAWASCSDFFGRKMTYAIFFVLGFVLYVSLPWSAKAGNIP 377 IAA+ A F L N GRF + SD+ GR T + F + + +S+ + K + Sbjct: 265 IAAVIAVF--LFPFANGLGRFVMGTVSDYLGRPYTMTLSFGISGISMLSIAFIPKIAS-- 320 Query: 378 LFVGAVCIILSMYGGGFATVPAYLADLFGTQMVGAIHGRLLTAWATAGILGPVVVNYM-R 436 L++ + + +G F+ P + D +G + GA +G TA A AGI + + Sbjct: 321 LYLALIFLTAFTWGPLFSLFPPLVGDYYGPKHSGANYGLTYTAKALAGIFAGYGASILFT 380 Query: 437 EYQLAQGMPKNEVYNTTMYILAGMLILGLICNLLIRP 473 Y + + T+ I M I+ I L +RP Sbjct: 381 SYGIKE----------TLIITGSMAIMSAILALTLRP 407