BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0007.p (312 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA5422 [G] COG0676 Uncharacterized enzymes related to aldose 1-e... 285 6e-77 XF2270 Non COG 168 2e-41 VC2001 [G] COG0676 Uncharacterized enzymes related to aldose 1-e... 152 7e-37 YPO2156 [G] COG0676 Uncharacterized enzymes related to aldose 1-... 145 1e-34 yeaD [G] COG0676 Uncharacterized enzymes related to aldose 1-epi... 131 2e-30 ZyeaD [G] COG0676 Uncharacterized enzymes related to aldose 1-ep... 127 3e-29 ECs2489 [G] COG0676 Uncharacterized enzymes related to aldose 1-... 127 3e-29 STM1289 [G] COG0676 Uncharacterized enzymes related to aldose 1-... 124 2e-28 PM0711 [G] COG0676 Uncharacterized enzymes related to aldose 1-e... 115 1e-25 HI1317 [G] COG0676 Uncharacterized enzymes related to aldose 1-e... 108 2e-23 >PA5422 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase Pae Pseudomonas aeruginosa Length = 318 Score = 285 bits (730), Expect = 6e-77, Method: Compositional matrix adjust. Identities = 147/294 (50%), Positives = 191/294 (64%), Gaps = 4/294 (1%) Query: 16 IQRIEVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQEPLIWMSEEAAFEAGNSVRGGI 75 +++++V+ L C R+ TA E LIA+QGAQ+L YQ H Q PL+W+S+EA + G SVRGG+ Sbjct: 23 VEQVQVDDLACWRIHTAHGEALIAQQGAQLLSYQPHEQPPLVWLSDEAGYRRGQSVRGGV 82 Query: 76 PVCWPWFGDLMRNPPQVQS-LHSGGRLPAHGLVRGIPWLLMENAIEGDSVRLVLAIPPTS 134 PVCWPWFG L RNP +V+ + G + PAHGLVR + W + + A E + + + Sbjct: 83 PVCWPWFGPLERNPQEVRGQVEDGLKAPAHGLVRAVDWKIDDIAEEDGDLCVSFRLDAPD 142 Query: 135 ESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSEQHLALTQALHSYFAVSSIHDVTIEG 194 P H LR+ +RL L+LT+ N + L L+QALH+YFAVS ++ IEG Sbjct: 143 GLPGWPH---PAALRMLFRFGERLTLRLTSENLGSKPLVLSQALHTYFAVSDSREIAIEG 199 Query: 195 LEGHRYIETLEGWAEREQKRALVVSSETDRIYLDLPPRLSIRDDGWNRRIQIEASGSTSA 254 LEG RYIETLE W ER Q A+ V E DRIYL L L I+D W R I + A S SA Sbjct: 200 LEGARYIETLENWEERTQHGAVRVKGELDRIYLGLERDLLIKDPRWERSIHLHALDSRSA 259 Query: 255 VVWNPWVSKARRLSQFADDAWQRMLCVETANVMEDLVELEPGAEHTLGVTLWSE 308 VVWNPWV K+RRLSQFADDAWQ+MLC+ET V +DL+ + PG + GV +WSE Sbjct: 260 VVWNPWVDKSRRLSQFADDAWQQMLCIETGRVWDDLMVVAPGRSESFGVQIWSE 313 >XF2270 Non COG Length = 288 Score = 168 bits (425), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 107/299 (35%), Positives = 157/299 (52%), Gaps = 31/299 (10%) Query: 12 DLPHIQRIEVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQEPLIWMSEEAAFEAGNSV 71 D+P + + + L +QT + I+ G Q+L + G E +IW+S ++ Sbjct: 3 DIPGLSTGDFHGFPSLLIQTPFSHAAISLFGGQLLSFVPSGGEEVIWLSPLVQ-PPPTAI 61 Query: 72 RGGIPVCWPWFGDLMRNPPQVQSLHSGGR--LPAHGLVRGIPWLLMENAIEGD-SVRLVL 128 RGGIP+CWP+FG G R +PAHG VR +PW +E+ E D S+ LVL Sbjct: 62 RGGIPICWPYFG------------RQGQRDTMPAHGFVRTVPWQQVESCQENDGSLFLVL 109 Query: 129 AIPPTSESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSEQHLALTQALHSYFAVSSIH 188 A PP L+HL G+ LR+ + + L +L T N S ++ TQALH+YF VS+ Sbjct: 110 APPP------LKHL--GLHLRMTLRIGRTLEQELATENISHAPISFTQALHNYFRVSNAL 161 Query: 189 DVTIEGLEGHRYIETLEGWAEREQKRALVV------SSETDRIYLDLPPRLSIRDDGWNR 242 VT++GL+G Y++ EG+ +R +++ DRIY+D + D ++R Sbjct: 162 QVTVQGLDGVEYLDKFEGYTQRHRQQGHWTLQDPRDPGRADRIYVDTSGHYVLVDPLFSR 221 Query: 243 RIQIEASGSTSAVVWNPWVSKARRLSQFADDAWQRMLCVETANVMEDLVELEPGAEHTL 301 RI + GS S VVWNP + A + A D W+ LC+E AN D +EL PGA H L Sbjct: 222 RIVLTTEGSHSLVVWNPGHAGASNMIDVA-DGWRDYLCLEPANAGPDEIELLPGARHVL 279 >VC2001 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase Vch Vibrio cholerae Length = 296 Score = 152 bits (385), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 90/292 (30%), Positives = 145/292 (49%), Gaps = 20/292 (6%) Query: 20 EVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQEPLIWMSEEAAFEAGNSVRGGIPVCW 79 E +Q++ +RV +A I+ G VL +Q GQ L+WMS +A ++ ++RGGIPVCW Sbjct: 20 EQDQVKIVRVIHDKASAAISLHGGHVLSFQPKGQADLLWMSSQAIYDGKAALRGGIPVCW 79 Query: 80 PWFGDLMRNPPQVQSLHSGGRLPAHGLVRGIPWLLMENAIEGDSVRLVLAIPPTSESPAL 139 PWFG + PAHG R W L+E+ V + L + T ES A+ Sbjct: 80 PWFGRIAA--------------PAHGFARNQEWKLIEHREIEQGVIVTLGLQATPESLAI 125 Query: 140 RHLPPGIELRLDILLDDRLHLKLTTRNGSEQHLALTQALHSYFAVSSIHDVTIEGLEGHR 199 P ++RL + + + L + L N + + ALH+Y V I + G+ G Sbjct: 126 --WPYQFDVRLHVEIRESLTVTLDVTNTDSKAWTFSGALHTYLHVGDIRETQTSGV-GTE 182 Query: 200 YIETLEGWAEREQKRALVVSSETDRIYLDLPPRLSIRDDGWNRRIQIEASGSTSAVVWNP 259 YI++L+ Q L ++ DR+Y P ++++D R + +E G SAV+WNP Sbjct: 183 YIDSLQNSRLCTQHGLLTLTDTIDRVYTQPEPLITVQDPALARTLTVENQGHNSAVLWNP 242 Query: 260 WVSKARRLSQFADDAWQRMLCVET---ANVMEDLVELEPGAEHTLGVTLWSE 308 W A+ ++ D+ + LCVE+ A + + + L+PG H L + S+ Sbjct: 243 WQQGAQSMADMNDEGYLHFLCVESTLHAPSLAEGITLQPGQNHQLVTQITSQ 294 >YPO2156 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase Ype Yersinia pestis Length = 291 Score = 145 bits (365), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 90/296 (30%), Positives = 146/296 (49%), Gaps = 22/296 (7%) Query: 14 PHIQRIEVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQEPLIWMSEEAAFEAGNSVRG 73 P+I + ++++L + V + I+ QGA +L YQ G++P+IW+S F+ G ++RG Sbjct: 16 PYISQRQLDELPVVVVSHPKVRAAISLQGAHLLAYQPSGEQPIIWLSNNTPFKEGIAIRG 75 Query: 74 GIPVCWPWFGDLMRNPPQVQSLHSGGRLPAHGLVRGIPWLLMENAIEGDSVRLVLAIPPT 133 G+P+CWPWFG P Q PAHG R +PW L + + V L + Sbjct: 76 GVPICWPWFG------PTAQ--------PAHGFARILPWTLSAHDENENGVILTFTLEDN 121 Query: 134 SESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSEQHLALTQALHSYFAVSSIHDVTIE 193 + ++ P L L D ++L + +G Q A ALH+YF + I + + Sbjct: 122 DMT--RQYWPHAFTLIARFKLGDECEVELES-HGDYQAAA---ALHTYFQIGDISQIKVS 175 Query: 194 GLEGHRYIETLEGWAEREQKRALVVSSETDRIYLDLPPRLSIRDDGWNRRIQIEASGSTS 253 GL G +Y++ + A+ Q+ LV + +TDR+Y I+D R I++ + Sbjct: 176 GL-GEKYLDKVLKVADVTQQGDLVFNGQTDRVYTQPEAYSLIKDAALKRTIEVHHHHQSD 234 Query: 254 AVVWNPWVSKARRLSQFADDAWQRMLCVETANVMEDLVELEPGAEHTLGVTLWSEK 309 V WNP + + +D ++ M+CVETA V + LV P A L +T+ S K Sbjct: 235 VVAWNPGAELSCSMVDMPNDGYKTMVCVETARVNKPLVA-APDAPARLAMTIRSRK 289 >yeaD [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase Eco Escherichia coli K12 Length = 301 Score = 131 bits (329), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 82/276 (29%), Positives = 129/276 (46%), Gaps = 19/276 (6%) Query: 14 PHIQRIEVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQEPLIWMSEEAAFEAGNSVRG 73 P + R ++++L + V + + A QGA +L ++ G+E ++W+S F+ G ++RG Sbjct: 23 PVLSRRKLDELDLIVVDHPQVKASFALQGAHLLSWKPAGEEEVLWLSNNTPFKNGVAIRG 82 Query: 74 GIPVCWPWFGDLMRNPPQVQSLHSGGRLPAHGLVRGIPWLLMENAIEGDSVRLVLAIPPT 133 G+PVCWPWFG P Q LPAHG R +PW L + + D V L + + Sbjct: 83 GVPVCWPWFG------PAAQQ-----GLPAHGFARNLPWTLKSHHEDADGVALTFELTQS 131 Query: 134 SESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSEQHLALTQALHSYFAVSSIHDVTIE 193 E+ + P L + + L + E T ALH+YF V I V++ Sbjct: 132 EETK--KFWPHDFTLLAHFRVGKTCEIDLESHGEFET----TSALHTYFNVGDIAKVSVS 185 Query: 194 GLEGHRYIETLEGWAEREQKRAL-VVSSETDRIYLDLPPRLSIRDDGWNRRIQIEASGST 252 GL G R+I+ + E + TDR+YL+ I D+ NR I + Sbjct: 186 GL-GDRFIDKVNDAKENVLTDGIQTFPDRTDRVYLNPQDCSVINDEALNRIIAVGHQHHL 244 Query: 253 SAVVWNPWVSKARRLSQFADDAWQRMLCVETANVME 288 + V WNP + + + DD ++ +CVETA E Sbjct: 245 NVVGWNPGPALSISMGDMPDDGYKTFVCVETAYASE 280 >ZyeaD [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase EcZ Escherichia coli O157:H7 EDL933 Length = 301 Score = 127 bits (320), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 81/276 (29%), Positives = 128/276 (46%), Gaps = 19/276 (6%) Query: 14 PHIQRIEVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQEPLIWMSEEAAFEAGNSVRG 73 P + R ++++L + V + + A QGA +L ++ G+E ++W+S F+ G ++RG Sbjct: 23 PVLSRRKLDELDLIVVDHPQVKASFALQGAHLLSWKPAGEEEVLWLSNNTPFKNGVAIRG 82 Query: 74 GIPVCWPWFGDLMRNPPQVQSLHSGGRLPAHGLVRGIPWLLMENAIEGDSVRLVLAIPPT 133 G+PVCWPWFG P Q LPAHG R +PW L + + + V L + + Sbjct: 83 GVPVCWPWFG------PAAQQ-----GLPAHGFARNLPWTLKSHREDANGVALTFELTQS 131 Query: 134 SESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSEQHLALTQALHSYFAVSSIHDVTIE 193 E+ + L +D + L E T ALH+YF V I V++ Sbjct: 132 EETK--KFWLHDFTLLAHFRVDKNCEIDLEAHGEFET----TSALHTYFNVGDIAKVSVS 185 Query: 194 GLEGHRYIETLEGWAEREQKRAL-VVSSETDRIYLDLPPRLSIRDDGWNRRIQIEASGST 252 GL G R+I+ + E + TDR+YL+ I D+ NR I + Sbjct: 186 GL-GDRFIDKVNDAKEDVLTDGIQTFPDRTDRVYLNPQDCSVINDEALNRIIAVGHQHHL 244 Query: 253 SAVVWNPWVSKARRLSQFADDAWQRMLCVETANVME 288 + V WNP + + + DD ++ +CVETA E Sbjct: 245 NVVGWNPGPALSVSMGDMPDDGYKTFVCVETAYASE 280 >ECs2489 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase Ecs Escherichia coli O157:H7 Length = 301 Score = 127 bits (320), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 81/276 (29%), Positives = 128/276 (46%), Gaps = 19/276 (6%) Query: 14 PHIQRIEVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQEPLIWMSEEAAFEAGNSVRG 73 P + R ++++L + V + + A QGA +L ++ G+E ++W+S F+ G ++RG Sbjct: 23 PVLSRRKLDELDLIVVDHPQVKASFALQGAHLLSWKPAGEEEVLWLSNNTPFKNGVAIRG 82 Query: 74 GIPVCWPWFGDLMRNPPQVQSLHSGGRLPAHGLVRGIPWLLMENAIEGDSVRLVLAIPPT 133 G+PVCWPWFG P Q LPAHG R +PW L + + + V L + + Sbjct: 83 GVPVCWPWFG------PAAQQ-----GLPAHGFARNLPWTLKSHREDANGVALTFELTQS 131 Query: 134 SESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSEQHLALTQALHSYFAVSSIHDVTIE 193 E+ + L +D + L E T ALH+YF V I V++ Sbjct: 132 EETK--KFWLHDFTLLAHFRVDKNCEIDLEAHGEFET----TSALHTYFNVGDIAKVSVS 185 Query: 194 GLEGHRYIETLEGWAEREQKRAL-VVSSETDRIYLDLPPRLSIRDDGWNRRIQIEASGST 252 GL G R+I+ + E + TDR+YL+ I D+ NR I + Sbjct: 186 GL-GDRFIDKVNDAKEDVLTDGIQTFPDRTDRVYLNPQDCSVINDEALNRIIAVGHQHHL 244 Query: 253 SAVVWNPWVSKARRLSQFADDAWQRMLCVETANVME 288 + V WNP + + + DD ++ +CVETA E Sbjct: 245 NVVGWNPGPALSVSMGDMPDDGYKTFVCVETAYASE 280 >STM1289 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase Sty Salmonella typhimurium LT2 Length = 294 Score = 124 bits (311), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 84/273 (30%), Positives = 126/273 (46%), Gaps = 23/273 (8%) Query: 14 PHIQRIEVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQEPLIWMSEEAAFEAGNSVRG 73 P + R +++ L + V + + A QGA +L ++ G+E ++W+S F+ G ++RG Sbjct: 16 PVLSRRQLDDLDLIVVDHPQVKASFALQGAHLLSWKPVGEEEVLWLSNNTPFKTGVALRG 75 Query: 74 GIPVCWPWFGDLMRNPPQVQSLHSGGRLPAHGLVRGIPWLLMENAIEGDSVRLVLAIPPT 133 G+P+CWPWFG P Q LP+HG R +PW L + + + V L + Sbjct: 76 GVPICWPWFG------PAAQQ-----GLPSHGFARNLPWALKAHNEDDNGVMLTFEL--- 121 Query: 134 SESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSEQH--LALTQALHSYFAVSSIHDVT 191 S A R P D L R + T E H A T ALHSYF V I +V Sbjct: 122 QSSEATRKYWPH-----DFTLLARFKVGKTCEIELEAHGEFATTSALHSYFNVGDIANVK 176 Query: 192 IEGLEGHRYIETLEGWAEREQKRAL-VVSSETDRIYLDLPPRLSIRDDGWNRRIQIEASG 250 + GL G R+I+ + E + TDR+YL+ I D NR I + Sbjct: 177 VSGL-GDRFIDKVNDAKEGVLTDGIQTFPDRTDRVYLNPEACSVIHDATLNRTIDVVHHH 235 Query: 251 STSAVVWNPWVSKARRLSQFADDAWQRMLCVET 283 + V WNP + + + DD ++ +CVET Sbjct: 236 HLNVVGWNPGPALSVSMGDMPDDGYKTFVCVET 268 >PM0711 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase Pmu Pasteurella multocida Length = 273 Score = 115 bits (289), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 135/293 (46%), Gaps = 36/293 (12%) Query: 14 PHIQRIEVNQLQCLRVQTARAELLIAEQGAQVLRYQEHGQ-EPLIWMSEEAAFEAGNSVR 72 P ++ ++ N + + +Q +IA QGAQ+L +Q G ++W+SE F+ ++R Sbjct: 15 PELRLVKYNAIPAISLQHDIGSAVIALQGAQLLSWQPKGSAHDVLWLSEIEPFQLRKAIR 74 Query: 73 GGIPVCWPWFGDLMRNPPQVQSLHSGGRLPAHGLVRGIPWLLMENAIEGDSVRLVLAIPP 132 GGIP+C+PWFG + + P+HG R W L++ I D VRLV + Sbjct: 75 GGIPLCYPWFGPV--------------KTPSHGTARIRLWHLIDYVISTDKVRLVFGLFT 120 Query: 133 TSESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSEQHLALTQALHSYFAVSSIHDVTI 192 HL IE ++ + ++LT + + ALHSYF V I + I Sbjct: 121 ED------HL---IEAKVSMDFAQDCQVRLTHYGQEDAQV----ALHSYFHVGDIEQIEI 167 Query: 193 EGLEGHRYIETLEGWAEREQKRALVVSSETDRIYLDLPPRLSIRDDGWNRRIQIEASGST 252 +GL H + R + D Y + SI D R I +E ++ Sbjct: 168 QGLPTHCVSNLTKQHENVPSPRQ--IQQNVDCTYHITNAKTSIVDPVLQREISLEHQQAS 225 Query: 253 SAVVWNPWVSKARRLSQFADDAWQRMLCVETANVMEDLVELEPGAEHTLGVTL 305 V+WNPW + +S+F +Q M+CVETA + + +L+ G E + +TL Sbjct: 226 EVVLWNPWHKETSGMSEF---GYQTMVCVETARITQ---QLKQGEEIAVRITL 272 >HI1317 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase Hin Haemophilus influenzae Length = 271 Score = 108 bits (270), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 70/240 (29%), Positives = 113/240 (47%), Gaps = 38/240 (15%) Query: 50 EHGQEPLIWMSEEAAFEAGNSVRGGIPVCWPWFGDLMRNPPQVQSLHSGGRLPAHGLVRG 109 ++ ++ ++W+SE F+ GN++RGG+P+C+PWFG G + PAHG R Sbjct: 49 QNAKQDVLWLSEVEPFKNGNAIRGGVPICYPWFG--------------GVKQPAHGTARI 94 Query: 110 IPWLLMENAIEGDSVRLVLAIPPTSESPALRHLPPGIELRLDILLDDRLHLKLTTRNGSE 169 W L I VRL + IE ++ ++ D+ HL T G E Sbjct: 95 RLWQLSHYYISVHKVRLEFELFSDLNI---------IEAKVSMVFTDKCHLTF-THYGEE 144 Query: 170 QHLALTQALHSYFAVSSIHDVTIEGLEGHRYIETLEGWAEREQKRALV---VSSETDRIY 226 A ALH+YF + I+ V ++GL ET ++Q+ +S D IY Sbjct: 145 SAQA---ALHTYFNIGDINQVEVQGLP-----ETCFNSLNQQQENVPSPRHISENVDCIY 196 Query: 227 LDLPPRLSIRDDGWNRRIQIEASGSTSAVVWNPWVSKARRLSQFADDAWQRMLCVETANV 286 + I D +NR I + ++ V+WNPW ++ S ++ +Q+MLC+ETA + Sbjct: 197 SAENMQNQILDKSFNRTIALHHHNASQFVLWNPW---HKKTSGMSETGYQKMLCLETARI 253