BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0027.0278.p (707 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC0544 [F] COG1864 DNA/RNA endonuclease G, NUC1 Ccr Caulobacter ... 162 2e-39 FN1280_2 [F] COG1864 DNA/RNA endonuclease G, NUC1 Fnu Fusobacter... 151 5e-36 DR1599 [O] COG0265 Trypsin-like serine proteases, typically peri... 146 2e-34 MA3330_2 [F] COG1864 DNA/RNA endonuclease G, NUC1 Mac Methanosar... 144 6e-34 PA1327 [F] COG1864 DNA/RNA endonuclease G, NUC1 Pae Pseudomonas ... 140 8e-33 FN1280_1 [O] COG0265 Trypsin-like serine proteases, typically pe... 140 1e-32 MA3330_1 [O] COG0265 Trypsin-like serine proteases, typically pe... 127 6e-29 >CC0544 [F] COG1864 DNA/RNA endonuclease G, NUC1 Ccr Caulobacter vibrioides Length = 695 Score = 162 bits (411), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 110/306 (35%), Positives = 154/306 (50%), Gaps = 33/306 (10%) Query: 395 THAQEALRIDPDYSKRSGYDPAFIAGVQVPLPQPDGTLAAQIVPLLAE--DAAHGD-GEL 451 A++ L D R GY P F+ P+P P TLA +I LA+ DA G EL Sbjct: 383 VEAKDGLHTADDLKDREGYVPGFLGKTTPPVPWP--TLAPEIAAGLAKPVDALPGRPHEL 440 Query: 452 KYEHFSIKLLKPRRLAAFTATNIDGARYLEVDRGSGRVNGAEGDAWFRDPRVPAGAVLEQ 511 +Y HF + + +L A TA NIDG + + + RG D WF D R+ Sbjct: 441 RYTHFGVLFSQDLKLPAATAVNIDGKQPVRIKRGD--------DKWFVDARIDPACQYTA 492 Query: 512 DFYGAWSNYFDRGHLTRRSDPSWGSPEEAERANADTFHFTNCSPQHFRFNQSAVYWQGLE 571 YG DRGH+ RR DP+WG ++A +AN DTFH+TN +PQH NQ WQGLE Sbjct: 493 KHYG--DQAIDRGHMVRREDPNWG--DDAIQANFDTFHYTNAAPQHALLNQGKSLWQGLE 548 Query: 572 RYVLENGVLASSTKG-RLCVFQGPVFNDQVDLWADE--VQIPSSFFKIVVW-----KGKQ 623 Y+L+N S T+G + CVF GP+ N + +E V++P F+K+ V G+ Sbjct: 549 NYILDN----SRTEGFKACVFTGPILNGDYEYLPEEGDVRVPLEFWKVAVMTAKTEDGQD 604 Query: 624 GLRAVALVADQSALLSESRHSLGAPQALPSVEVNHWR---VAVPEVEQMTGLDFGKLVRQ 680 L A A V Q L+ + +AL + +R VA+ ++E TG++F L R Sbjct: 605 TLHATAYVLSQGHLIRKLLEDRQRSEALEGFRLGAYRTFQVAIRDLEAATGMNFHDL-RN 663 Query: 681 ADTIAA 686 D +AA Sbjct: 664 YDPLAA 669 >FN1280_2 [F] COG1864 DNA/RNA endonuclease G, NUC1 Fnu Fusobacterium nucleatum Length = 262 Score = 151 bits (382), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 96/270 (35%), Positives = 140/270 (51%), Gaps = 32/270 (11%) Query: 412 GYDPAFIA-GVQVPLPQPDGTLAAQIVPLLAEDAAHGDGELKYEHFSIKLLKPRRLAAFT 470 GY+P F+ ++PLP+ + ED G+ L Y HFSI + K R LA FT Sbjct: 1 GYNPLFLGKDYEIPLPKLSKEMEKDTAK--TED---GNYVLDYIHFSIVMKKSRGLAYFT 55 Query: 471 ATNIDGARYLEVDRGSGRVNGAEGDAWFRDPRVPAGAVLEQDFYGAWSNYFDRGHLTRRS 530 A NIDG +++ R + D W DPR+ + Y +N DRGHL RR+ Sbjct: 56 AVNIDGTDAVKIRRTA--------DNWKFDPRISQNYQYGDEVYV--NNDLDRGHLVRRT 105 Query: 531 DPSWGSPEEAERANADTFHFTNCSPQHFRFNQSAVYWQGLERYVLENGVLASSTKGRLCV 590 DP+WG + A +AN DTF+FTN +PQH NQ W LE Y+ N VL + ++ V Sbjct: 106 DPNWG--KNALKANEDTFYFTNSTPQHKNLNQKT--WVELEDYIFRNAVL---NQFKVSV 158 Query: 591 FQGPVFNDQVDLWADEVQIPSSFFKIVVWKGKQG-LRAVALVADQSALLSESRHSLGAPQ 649 F GPVF + ++ + QIP+ F+K+VV + G + A A + Q ++ + G Sbjct: 159 FTGPVFREDDMIYRQKYQIPAEFWKVVVMLKEDGNISATAYLQTQKNMIENLEFAYG--- 215 Query: 650 ALPSVEVNHWRVAVPEVEQMTGLDFGKLVR 679 E ++V V +E++TGLDFG L + Sbjct: 216 -----EYKTYQVPVRNIEKLTGLDFGNLSK 240 >DR1599 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Dra Deinococcus radiodurans Length = 470 Score = 146 bits (368), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 92/246 (37%), Positives = 127/246 (51%), Gaps = 26/246 (10%) Query: 59 ESIIGDTEDFLRASFLAQGAAVARAVAYVEV--SSAQVNEVATGFMVSPRLFLTNQHVIA 116 E ++G D + +L Q + +RAV V + S + TG++ SP++ +TN HV+ Sbjct: 90 ERVLG-ANDLVGVGYLDQARSCSRAVCRVVIRDSRGRTQGFGTGWLCSPQVMVTNHHVLE 148 Query: 117 DLAAARGTRVSFLRELDERGVPRASTSFLLAPQRLALFSASDQLDYALIALGERQSGTAT 176 D AR + V F EL G T+F L P+RL F S+ LDY+ +A+ SG Sbjct: 149 DAQTARQSVVEFDYELRPDGTLMERTTFALDPERL--FLTSEGLDYSFVAVQGDPSG--- 203 Query: 177 ADMLGFCPLSDQPDKHVIGMNANIIQHPGGWLKMISIRNNTVTARTEHTLLYETDTEQGS 236 G+ PL DK+V+G +IIQHP G K +++R N + R L YETDT GS Sbjct: 204 ---FGWLPLYSSADKNVLGEALSIIQHPSGEPKQVALRENRLVDRLPDFLHYETDTAPGS 260 Query: 237 SGSPVFNDDWQLVALHHWGEPYRDA---------------ASAQDTPRKVNEGIRISAIY 281 SGSPVFND W++VALHH G P R+A S NEG+R+S + Sbjct: 261 SGSPVFNDAWEVVALHHSGVPRRNAQGQVLKRDGQPLRAGESGDQIDWLANEGVRVSRLM 320 Query: 282 RDLLQR 287 DL R Sbjct: 321 EDLQTR 326 >MA3330_2 [F] COG1864 DNA/RNA endonuclease G, NUC1 Mac Methanosarcina acetivorans str.C2A Length = 271 Score = 144 bits (364), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 98/265 (36%), Positives = 133/265 (50%), Gaps = 32/265 (12%) Query: 412 GYDPAFIAGV-QVPLPQPDGTLAAQIVPLLAEDAAHGDGELKYEHFSIKLLKPRRLAAFT 470 GY+P F+ + Q+PLP+ L +++ L G L Y HFSI + RRLA +T Sbjct: 1 GYNPDFLGYLHQLPLPKLADNLQSKVAKL-----KDGGEILNYLHFSIVMNADRRLAFYT 55 Query: 471 ATNIDGARYLEVDRGSGRVNGAEGDAWFRDPRVPAGAVLEQDFYGAWSNYFDRGHLTRRS 530 A NIDG + ++ R + D W+ DPR+ Y N DRGHL RR Sbjct: 56 AANIDGKKLKKIKR--------DRDKWYFDPRLDQRYQAGPKLYKG--NPLDRGHLVRRL 105 Query: 531 DPSWGSPEEAERANADTFHFTNCSPQHFRFNQSAVYWQGLERYVLENGVLASSTKGRLCV 590 DP WG A A DTFHFTNCSPQH R NQ W +E Y+L+ A + ++ V Sbjct: 106 DPCWGP--NARDAGEDTFHFTNCSPQHERLNQHD--WLEVEDYILKT---ADNANVQISV 158 Query: 591 FQGPVFNDQVDLWADEVQIPSSFFKIVVWKGKQG-LRAVALVADQSALLSESRHSLGAPQ 649 F GPVF + ++ +E +P+ F+K+V + K G L A A + Q L ES Sbjct: 159 FTGPVFREDDMIYRNEYLLPADFWKVVAFVNKNGKLSATAYLRTQKNYL-ESLEFFDD-- 215 Query: 650 ALPSVEVNHWRVAVPEVEQMTGLDF 674 E W+V V +VE +TGL F Sbjct: 216 -----EFKTWQVPVAQVEALTGLSF 235 >PA1327 [F] COG1864 DNA/RNA endonuclease G, NUC1 Pae Pseudomonas aeruginosa Length = 656 Score = 140 bits (354), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 125/384 (32%), Positives = 176/384 (45%), Gaps = 51/384 (13%) Query: 311 PATAVAWPSAAASDTREETSMSTGNDSGAHARTGVGAQAATLTIPLEITVRVAGATATAA 370 P V P A T + +++ G +SG+ + G + L + A+ Sbjct: 269 PGEVVGLPHDAWYLTHDCSTL--GGNSGSAVLSIDGGEVVGLHFGGQFRKTNYAVKASVI 326 Query: 371 SSPAAPSTPVPAQPQARRLSPPRPTHAQEALRIDPDYSKRSGYDPAFIAGVQVPLPQPDG 430 S A VP + PR QE R D ++R G+D AF+ G + LP+P Sbjct: 327 RSLLARRAWVPVAGAELKRGVPR---FQEKQRSVADLAERKGFDEAFL-GPKAALPKPGK 382 Query: 431 TLAAQIVPLLAEDAAHGDG-ELKYEHFSIKLLKPRRLAAFTATNIDGARYLEVDRGSGRV 489 + Q++P+ G G L Y HFS+ + RRL TA NIDGA + R Sbjct: 383 S--HQVLPV-------GKGTRLDYLHFSVVMSASRRLPILTAVNIDGALKRSLKRK---- 429 Query: 490 NGAEGDAWFRDPRVPAGA-VLEQDFYGAWSNYFDRGHLTRRSDPSWGSPEEAER-ANADT 547 D+W DPR+ A A V +DFYG S FD+GH+ RR DP WG + R A DT Sbjct: 430 -----DSWGFDPRIEAAAQVGHKDFYGPAS--FDKGHMVRREDPGWGDSDAVARQAEDDT 482 Query: 548 FHFTNCSPQHFRFNQSAVYWQGLERYVLENGVLASSTKGRLCVFQGPVFNDQVDLWADEV 607 F +TN PQ + NQ + W LE YVL+N A S R+ VF GPVF D L+ V Sbjct: 483 FVYTNAVPQVAQLNQRS--WLSLEDYVLQN---ARSEGFRISVFTGPVFRDDDPLYQG-V 536 Query: 608 QIPSSFFKIVVWKGKQGLRAVALVADQSALLSESRHSLGAPQALPSVEVNH-----WRVA 662 Q+P F+K+ VA++ S L S + LG +PS + ++V Sbjct: 537 QVPLEFWKV-----------VAMIDADSGELGVSAYLLGQEGMMPSEGFRYGAFKTYQVP 585 Query: 663 VPEVEQMTGLDFGKLVRQADTIAA 686 + +VE L F +R+AD +A Sbjct: 586 LAKVEASADLRFSSALRKADVLAG 609 >FN1280_1 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Fnu Fusobacterium nucleatum Length = 317 Score = 140 bits (353), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 89/255 (34%), Positives = 134/255 (52%), Gaps = 25/255 (9%) Query: 59 ESIIGDTEDFLRASFLAQGAAVARAVAYVEV--SSAQVNEVATGFMVSPRLFLTNQHVIA 116 E I+G D S+L G ++++V + + S V TGF+V+P + LTN HVI Sbjct: 58 ERIVGKN-DLFPISYLQIGLNISKSVCRISIRDSRGVVVGYGTGFLVAPNIILTNNHVIN 116 Query: 117 DLAAARGTRVSFLRELDERGVPRASTSFLLAPQRLALFSASDQLDYALIALGERQSGTAT 176 A + F + DE +P + +F L PQ F + +LD+ L+AL E + Sbjct: 117 SYEVASNSIAEFNYQDDENFMPCPTYNFRLNPQ--TFFITNVKLDFTLVALNENVTNQKH 174 Query: 177 ADMLGFCPLSDQ-----PDKHVIGMNANIIQHPGGWLKMISIRNNTVTARTEHTLLYETD 231 + G+ ++ + P+++V +IIQHP G K +++R N V+ E+ + Y TD Sbjct: 175 LEDFGYLKMTQKEGTILPEEYV-----SIIQHPKGGPKSVTLRENKVSGLKENFIHYLTD 229 Query: 232 TEQGSSGSPVFNDDWQLVALHHWGEP---YRDAASAQDTPRKVNEGIRISAIYRDLLQRL 288 TE GSSGSPVFND W LVALHH G P +D A NEGI ISAI L ++ Sbjct: 230 TEPGSSGSPVFNDQWTLVALHHSGVPNPEIKDEWIA-------NEGILISAIVNYLAKKY 282 Query: 289 PTLPEAARPLLQEAL 303 +L E + +++E + Sbjct: 283 SSLKENEQAIIKEIV 297 >MA3330_1 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Mac Methanosarcina acetivorans str.C2A Length = 383 Score = 127 bits (320), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 93/259 (35%), Positives = 124/259 (47%), Gaps = 23/259 (8%) Query: 59 ESIIGDTEDFLRASFLAQGAAVARAVAYVEVSS--AQVNEVATGFMVSPRLFLTNQHVIA 116 E IIG + D + S+L G AR V ++V + + TGF+V P L LTN HV+ Sbjct: 88 ERIIGKS-DLVGISYLELGLLAARPVCRIQVVNPFGRPEGYGTGFLVGPNLLLTNNHVLD 146 Query: 117 DLAAARGTRVSFLRELDERGVPRASTSFLLAPQRLALFSASDQLDYALIALGERQS-GTA 175 AR + F E D G + S SF L P + F LD+ L+++ + GT Sbjct: 147 TAELARKSFAEFEFEQDINGRRKTSKSFDLRPDEV--FVTDPDLDFTLVSVAPVATEGTE 204 Query: 176 TADMLGFCPLSDQPDKHVIGMNANIIQHPGGWLKMISIRNNTVTARTEHTLLYETDTEQG 235 D G L + K G +IIQHP G LK +R N V ++ + Y TDT+ G Sbjct: 205 LTDY-GLLRLVEDTGKVRNGEYVSIIQHPEGGLKQCCLRENEVVDLFDNWIHYLTDTQPG 263 Query: 236 SSGSPVFNDDWQLVALHHWGEPYRDAA------------SAQDTPRKV----NEGIRISA 279 +SGSPVFND W +V LHH G P +DA D P + NEG+RIS Sbjct: 264 TSGSPVFNDQWLVVCLHHSGVPMKDAQGNILKTDGQPYREGIDNPGTIAWVANEGVRISR 323 Query: 280 IYRDLLQRLPTLPEAARPL 298 I++ L R P AA L Sbjct: 324 IFQALESRSENEPMAAESL 342