BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0027.0197.p (438 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMa1447 [GEPR] COG0477 Permeases of the major facilitator superf... 470 e-132 AGc4107 [GEPR] COG0477 Permeases of the major facilitator superf... 469 e-132 BMEII0740 [GEPR] COG0477 Permeases of the major facilitator supe... 469 e-132 DRA0271 [GEPR] COG0477 Permeases of the major facilitator superf... 332 1e-90 Cgl2919 [GEPR] COG0477 Permeases of the major facilitator superf... 243 6e-64 PA3467 [GEPR] COG0477 Permeases of the major facilitator superfa... 226 7e-59 RSp0052 [GEPR] COG0477 Permeases of the major facilitator superf... 205 2e-52 BS_yceI [GEPR] COG0477 Permeases of the major facilitator superf... 199 1e-50 TM1603 [GEPR] COG0477 Permeases of the major facilitator superfa... 199 1e-50 PAE2330 [GEPR] COG0477 Permeases of the major facilitator superf... 173 7e-43 >SMa1447 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 450 Score = 470 bits (1209), Expect = e-132, Method: Compositional matrix adjust. Identities = 253/446 (56%), Positives = 319/446 (71%), Gaps = 19/446 (4%) Query: 1 MSTLPASVEQGLQAAGVGKFQYRLFVIFGLVWLADAMQVLSIGFSAPTIAKTFGLTVPQA 60 M+T+ +V+ L AG G +Q RL IFGLVW ADAMQVL++GF+A +IA TFGLTVPQA Sbjct: 14 MTTI--TVDDALDRAGTGTYQRRLMAIFGLVWAADAMQVLAVGFTAASIAATFGLTVPQA 71 Query: 61 LQTGTMFFVGMLLGAFVFGRLADRIGRRPVLMGAVVIDACFGVASAFAPDFTWLLALRLL 120 LQTGT+FF+GML GA FGRLADRIGRR VL+ V DA FG+ S FA DFT LL LR L Sbjct: 72 LQTGTLFFLGMLFGAAGFGRLADRIGRRRVLIATVACDAVFGLLSVFAQDFTVLLLLRFL 131 Query: 121 TGIGVGGTLPVDYTMMAEFLPSARRGRWLVMLESFWAIGTICLAVLALVAVSWG-NDAWR 179 TG VGGTLPVDY MMAEFLP+ RGRWLVMLE FWA+GT+ +A+ A A G DAWR Sbjct: 132 TGAAVGGTLPVDYAMMAEFLPARNRGRWLVMLEGFWAVGTLIVALAAWAASLAGVADAWR 191 Query: 180 VIFFVTGLPALVGVVLRFYVPESPMYLNRSGKSDAARLVLERVAKVNG--------SSTP 231 IF VT +PAL+GV LRF VPESP+YL R GK+ A+ +++ + VNG S P Sbjct: 192 YIFAVTAIPALIGVGLRFLVPESPLYLLRLGKTSEAKAIVDEILVVNGKMRLGAGASLVP 251 Query: 232 IPPLQPEVVERKPMSALFSAALRRRSLSLYLAWGLISIAYYGVFVYLPVKLGSEGFGFMR 291 PP + +FSA LR+RSL + W L+SI+YYGVF ++P +L EGFGF+R Sbjct: 252 PPP--------TASAGIFSADLRKRSLMILAIWFLVSISYYGVFTWMPPRLAGEGFGFVR 303 Query: 292 GQIFLIFLALVQLPGYALSAYGVERWGRKPTLVGFLVLSAVGCMLYSLGKDPMLVVGSTL 351 G FL+ LAL Q+PGYAL+AYGVE+WGR+PTL+GF +LSA+GC+L+ ML+ S L Sbjct: 304 GYGFLVVLALAQIPGYALAAYGVEKWGRRPTLIGFCLLSALGCLLFVAAGTAMLIGVSLL 363 Query: 352 LLSFSLLGTWAALYAFTPEVYPTDLRASGMGTAGAVARFGGLFAPAIVAPVMASHFTLAL 411 ++SF+LLGTW ALYA+TPE+YPT RA+GMG AGA+AR GGL AP+++ V+A F LA+ Sbjct: 364 IMSFALLGTWGALYAYTPELYPTASRATGMGAAGAMARLGGLLAPSLMGLVVAQSFGLAI 423 Query: 412 AMLSAFLVAGAVAILCVDVESRNRAL 437 + + L+ AVA +D E+R +L Sbjct: 424 GIFAGLLLVAAVAAFLIDAETRRVSL 449 >AGc4107 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 437 Score = 469 bits (1208), Expect = e-132, Method: Compositional matrix adjust. Identities = 245/436 (56%), Positives = 319/436 (73%), Gaps = 9/436 (2%) Query: 7 SVEQGLQAAGVGKFQYRLFVIFGLVWLADAMQVLSIGFSAPTIAKTFGLTVPQALQTGTM 66 ++ L+ AG G +Q RL IFGLVW ADAMQVL++GF+A +IA TFGLTVPQALQTGT Sbjct: 5 TMNDALERAGAGAYQRRLMGIFGLVWAADAMQVLAVGFTAASIAATFGLTVPQALQTGTA 64 Query: 67 FFVGMLLGAFVFGRLADRIGRRPVLMGAVVIDACFGVASAFAPDFTWLLALRLLTGIGVG 126 FF GMLLGA FGRLADR GRR VL+ V DA FGV S F+PDFT LL LR LTG VG Sbjct: 65 FFFGMLLGAAGFGRLADRYGRRRVLIVTVACDALFGVLSIFSPDFTILLVLRFLTGAAVG 124 Query: 127 GTLPVDYTMMAEFLPSARRGRWLVMLESFWAIGTICLAVLALVAVSWG-NDAWRVIFFVT 185 GTLPVDY MMAEFLP+ RGRWLV LE FWA+GT+ +A+ A A G DAWR IF VT Sbjct: 125 GTLPVDYAMMAEFLPAKNRGRWLVFLEGFWAVGTLIVALAAWGASLAGVADAWRYIFAVT 184 Query: 186 GLPALVGVVLRFYVPESPMYLNRSGKSDAARLVLERVAKVNGSSTPIPP----LQPEVVE 241 PA++G+ LRF VPESP+YL R+G+S+ A+ V+ R+ VNG + P+ QP+V + Sbjct: 185 AFPAVLGLGLRFLVPESPLYLLRTGRSEEAKAVVNRMLVVNGRA-PLDAGTGLFQPDVTK 243 Query: 242 RKPMSALFSAALRRRSLSLYLAWGLISIAYYGVFVYLPVKLGSEGFGFMRGQIFLIFLAL 301 + +FS ALR+RS+ + W L+S++YYGVF ++P KL +GFGF+RG FL+ +AL Sbjct: 244 GQ---GIFSPALRQRSMMILAIWFLVSVSYYGVFTWMPAKLAGDGFGFVRGYGFLVLVAL 300 Query: 302 VQLPGYALSAYGVERWGRKPTLVGFLVLSAVGCMLYSLGKDPMLVVGSTLLLSFSLLGTW 361 Q+PGYA++AYGVE+WGRKPTL+GF +LSA+GC+L++L ++ S L++SF+LLGTW Sbjct: 301 AQIPGYAIAAYGVEKWGRKPTLIGFCLLSALGCLLFTLASAGAMIAASLLIMSFALLGTW 360 Query: 362 AALYAFTPEVYPTDLRASGMGTAGAVARFGGLFAPAIVAPVMASHFTLALAMLSAFLVAG 421 ALYAFTPE+YPT+ RA+GMG AGA+AR GGL AP+++ +A F +A+ + + LV Sbjct: 361 GALYAFTPELYPTESRATGMGAAGAMARLGGLLAPSLLGYAIAQGFGVAIGIFAGLLVLA 420 Query: 422 AVAILCVDVESRNRAL 437 A+A ++ E+R AL Sbjct: 421 AIAATMINAETRQVAL 436 >BMEII0740 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 448 Score = 469 bits (1206), Expect = e-132, Method: Compositional matrix adjust. Identities = 245/437 (56%), Positives = 314/437 (71%), Gaps = 9/437 (2%) Query: 7 SVEQGLQAAGVGKFQYRLFVIFGLVWLADAMQVLSIGFSAPTIAKTFGLTVPQALQTGTM 66 ++E+ L AG G FQ L IFGLVW ADAMQVL++GF+ IAKTFGLTVPQALQTGT+ Sbjct: 16 TIEETLDQAGTGSFQRGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTL 75 Query: 67 FFVGMLLGAFVFGRLADRIGRRPVLMGAVVIDACFGVASAFAPDFTWLLALRLLTGIGVG 126 FF+GML+GA +FGRLAD+ GRR +L+ V DA FG+ SAFAPDF LLALR LTG+ VG Sbjct: 76 FFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVG 135 Query: 127 GTLPVDYTMMAEFLPSARRGRWLVMLESFWAIGTICLAVLA-LVAVSWGNDAWRVIFFVT 185 GTLPVDY MMAEFLP+ RGRWLVMLE FWA+GT+ +A+ A +V+ DAWR IF VT Sbjct: 136 GTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVT 195 Query: 186 GLPALVGVVLRFYVPESPMYLNRSGKSDAARLVLERVAKVNGSSTPIPP----LQPEVVE 241 PAL+G+ LRF VPESPM+L +SG+ + A+ V+ V NG +PP L P +V Sbjct: 196 AAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVLSRNGKP-ELPPGAKLLAPRLVT 254 Query: 242 RKPMSALFSAALRRRSLSLYLAWGLISIAYYGVFVYLPVKLGSEGFGFMRGQIFLIFLAL 301 + L S LR+R+L+ W L+S++YYG+F ++P KL S+GFGF+RG FL+ +AL Sbjct: 255 NER---LLSPNLRQRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVAL 311 Query: 302 VQLPGYALSAYGVERWGRKPTLVGFLVLSAVGCMLYSLGKDPMLVVGSTLLLSFSLLGTW 361 QLPGYAL+AYGVE WGR+ TL+GFL +SA C L+++ +V S L++SF+LLGTW Sbjct: 312 AQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTW 371 Query: 362 AALYAFTPEVYPTDLRASGMGTAGAVARFGGLFAPAIVAPVMASHFTLALAMLSAFLVAG 421 ALYAFTPE+YPT LRASGMG AGA+AR GGL AP+ +A V+ F A+AM + L Sbjct: 372 GALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALA 431 Query: 422 AVAILCVDVESRNRALE 438 + ++VE+R +AL Sbjct: 432 GIIAFFINVETRQQALN 448 >DRA0271 [GEPR] COG0477 Permeases of the major facilitator superfamily Dra Deinococcus radiodurans Length = 454 Score = 332 bits (851), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 197/441 (44%), Positives = 275/441 (62%), Gaps = 5/441 (1%) Query: 2 STLPASVEQGLQAAGVGKFQYRLFVIFGLVWLADAMQVLSIGFSAPTIAKTFGLT--VPQ 59 ++P +V++ L G+G+FQ++L I GL W ADAM+VL +GF+ P I+ F L P Sbjct: 9 KSVPMTVDRVLDDLGLGRFQWKLLAICGLTWAADAMEVLLMGFALPGISAAFELPKGSPA 68 Query: 60 ALQTGTMFFVGMLLGAFVFGRLADRIGRRPVLMGAVVIDACFGVASAFAPDFTWLLALRL 119 A T F GML GA+ +G LADR+GRR V + V + FG+A A AP TWLL R Sbjct: 69 ATMLLTATFAGMLFGAWFWGYLADRVGRRSVFLTTVALGVVFGLAGALAPTLTWLLVARF 128 Query: 120 LTGIGVGGTLPVDYTMMAEFLPSARRGRWLVMLESFWAIGTICLAVLA-LVAVSWG-NDA 177 LTG +GGTLPVDY+MMAEF+P+A RGR+LV LESFWA+GT+ +A LA V+ ++ + Sbjct: 129 LTGFAIGGTLPVDYSMMAEFVPTAWRGRFLVYLESFWAVGTVVVAALAWWVSTAFAPAEG 188 Query: 178 WRVIFFVTGLPALVGVVLRFYVPESPMYLNRSGKSDAARLVLERVAKVNGSSTPIPPL-Q 236 WR + + LP LVG++ R +P+SP L G+ AR L++VA+ NG + P PL Sbjct: 189 WRWLLGLAALPGLVGLIARIGIPDSPRSLLARGEEAQARAALQKVAQANGGTLPAAPLAH 248 Query: 237 PEVVERKPMSALFSAALRRRSLSLYLAWGLISIAYYGVFVYLPVKLGSEGFGFMRGQIFL 296 PE R + LF L RR+ L + W +S+ YYG+F +LP L ++G Sbjct: 249 PEQPPRVSPAQLFRGVLARRTPLLMVTWFGLSLGYYGIFSWLPSFLRAQGLDLGAVYRST 308 Query: 297 IFLALVQLPGYALSAYGVERWGRKPTLVGFLVLSAVGCMLYSLGKDPMLVVGSTLLLSFS 356 + LAL Q+PGY L+AY VE+ GR+ TLVGFL L AVG L+ L D V+ ++ LLSF+ Sbjct: 309 LLLALAQVPGYLLAAYLVEKIGRRVTLVGFLTLGAVGAYLFLLAHDANTVLLTSALLSFA 368 Query: 357 LLGTWAALYAFTPEVYPTDLRASGMGTAGAVARFGGLFAPAIVAPVMASHFTLALAMLSA 416 LLG W +LYA+TPE++PT LR +GMG VAR + +P+I A ++ + TLAL + + Sbjct: 369 LLGAWGSLYAYTPELFPTPLRTTGMGLVSGVARLASVVSPSIGAMLLTGNLTLALTVFAV 428 Query: 417 FLVAGAVAILCVDVESRNRAL 437 A+A + VE+R +AL Sbjct: 429 CFALAALAAWGIGVETRGQAL 449 >Cgl2919 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 439 Score = 243 bits (620), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 139/379 (36%), Positives = 220/379 (58%), Gaps = 3/379 (0%) Query: 29 GLVWLADAMQVLSIGFSAPTIAKTFGLTVPQALQTGTMFFVGMLLGAFVFGRLADRIGRR 88 G+ W DAM V I F +A +GL+ + G++ FVGM +GA + G LAD++GRR Sbjct: 26 GIGWALDAMDVGLISFVMAALATHWGLSPTETSLLGSIGFVGMAIGASLGGLLADKLGRR 85 Query: 89 PVLMGAVVIDACFGVASAFAPDFTWLLALRLLTGIGVGGTLPVDYTMMAEFLPSARRGRW 148 V ++++ ASA + L+ALR + G+G+G LPV T+++EF P RGR Sbjct: 86 QVFALSLLVYGVATGASALSVSLAMLMALRFVVGLGLGAELPVASTLISEFSPRKVRGRM 145 Query: 149 LVMLESFWAIGTICLAVLALVAVSWGNDAWRVIFFVTGLPALVGVVLRFYVPESPMYLNR 208 +V+LE+FWA+G I A++ V+ ++ WR + +PA+ V +R +PES +L + Sbjct: 146 VVILEAFWALGWIMAAIVGTFVVAGSDNGWRWALALGCVPAIYAVYVRLGLPESVRFLEK 205 Query: 209 SGKSDAARLVLERVAKVNGSSTPIPPLQPEVVERKPMS---ALFSAALRRRSLSLYLAWG 265 G+ D A ++ + + VV +++SAALR+R+++L++ W Sbjct: 206 KGRHDEAEAIVVSFEEAAAAEGKAADATTAVVHDNAAEGSVSIWSAALRKRTVALWIVWF 265 Query: 266 LISIAYYGVFVYLPVKLGSEGFGFMRGQIFLIFLALVQLPGYALSAYGVERWGRKPTLVG 325 I+++YYG F+++P L ++GF ++ F + + L QLPGYA++A+ +E+WGR+ TL Sbjct: 266 CINLSYYGAFIWIPSLLVADGFTLVKSFQFTLIITLAQLPGYAVAAWLIEKWGRRSTLAT 325 Query: 326 FLVLSAVGCMLYSLGKDPMLVVGSTLLLSFSLLGTWAALYAFTPEVYPTDLRASGMGTAG 385 FLV SA+ LY L ++ + LLSF LG W ALYA PE+YPT++R +G G A Sbjct: 326 FLVGSAISAALYGLANVEWQILVAGCLLSFFNLGAWGALYAIGPELYPTNVRGTGTGAAA 385 Query: 386 AVARFGGLFAPAIVAPVMA 404 R + AP IV PV+A Sbjct: 386 GFGRIASIIAPLIVPPVIA 404 >PA3467 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 455 Score = 226 bits (577), Expect = 7e-59, Method: Compositional matrix adjust. Identities = 152/457 (33%), Positives = 240/457 (52%), Gaps = 25/457 (5%) Query: 1 MSTLPASVEQGLQAAGVGKFQYRLFVIFGLVWLADAMQVLSIGFSAPTIAKTFGLTVPQA 60 M PAS + L+ + + +FVI L + D+M + + F +I FGL QA Sbjct: 1 MPDAPASAAERLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQA 60 Query: 61 LQTGTMFFVGMLLGAFVFGRLADRIGRRPVLMGAVVIDACFGVASAFAPDFTWLLALRLL 120 + F GM++GA + G LADR GR+PV ++V+ + A D L R+L Sbjct: 61 GLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVL 120 Query: 121 TGIGVGGTLPVDYTMMAEFLPSARRGRWLVMLESFWAIGTICLAVLALVAVSWGNDAWRV 180 GIG+G P+ ++++E +P++RRG+++ +++ FW +G + L+ + WR Sbjct: 121 LGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLP--LTGWRS 178 Query: 181 IFFVTGLPALVGVVLRFYVPESPMYLNRSGKSDAARLVLE----RVAKVNGSSTPIPPL- 235 IF V LPA+ + +RF +PESP +L ++G+ + A VL RV + G + PPL Sbjct: 179 IFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGLTELPPPLR 238 Query: 236 QPEVVERKP-----MSALFSAALRRRSLSLYLAWGLISIAYYGVFVYLPVKLGSEGFGFM 290 QP+ +P + L+S A RRR+L+++ W + +YG+ +L L GF Sbjct: 239 QPQRERSRPGFFSAFAELWSPAYRRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVT 298 Query: 291 RGQIFLIFLALVQLPGYALSAYGVERWGRKPTLVGFLVLSAVGCMLYSLGKDPM------ 344 + + + ++L +PG+ +A+ VE WGRKP+ V L+L G M Y+ G+ + Sbjct: 299 QSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCV--LMLLGGGAMAYAYGQTAVFGGSLA 356 Query: 345 LVVGSTLLLSFSLLGTWAALYAFTPEVYPTDLRASGMGTAGAVARFGGLFAP---AIVAP 401 L++G L + F L G WA LY +TPE+YPT RA+G G A AV R G L P +V P Sbjct: 357 LLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLP 416 Query: 402 VMASHFTLALAMLSAFLVAGAVAILCVDVESRNRALE 438 + L L F VA A+ + +E+R R LE Sbjct: 417 LTGQGGVFTLGAL-CFGVA-ALVVWAFGIETRGRTLE 451 >RSp0052 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 476 Score = 205 bits (521), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 145/424 (34%), Positives = 231/424 (54%), Gaps = 29/424 (6%) Query: 35 DAMQVLSIGFSAPTIAKTFGLTVPQALQTGTMFFVGMLLGAFVFGRLADRIGRRPVLMGA 94 D++ + ++ F +I K FGL+ A + F GM++GA V G LADR GRRPV + Sbjct: 40 DSVDLATMTFVLGSIKKEFGLSTATAGLVASSSFFGMVIGAAVAGLLADRFGRRPVFQWS 99 Query: 95 VVIDACFGVAS---AFAPDFTWLLALRLLTGIGVGGTLPVDYTMMAEFLPSARRGRWLVM 151 +V+ +GVAS + A L+A R+L GIG+G PV T+++EF+P+A RGR + + Sbjct: 100 MVL---WGVASYLCSTAQSVEALIAWRILLGIGMGMEFPVAQTLLSEFVPTANRGRLIAL 156 Query: 152 LESFWAIGTICLAVLALVAVSWGNDAWRVIFFVTGLPALVGVVLRFYVPESPMYLNRSGK 211 ++ FW +G I +++ + WR +F + +PA+ +++R VPESP +L +G+ Sbjct: 157 MDGFWPLGFITAGIVSYFVLP--QFGWRAVFALLAVPAIFVLIVRRAVPESPRWLEHAGR 214 Query: 212 SDAARLVLERV-AKVNGS--STPIPPL----QPEVVERKP-MSALFSAALRRRSLSLYLA 263 + A V+ + AKV S +T +PP+ P+ V R + ++SAA RRR+ ++L Sbjct: 215 NAQADTVMRGIEAKVMRSLNTTTLPPIVQHSAPQPVRRHSALREIWSAAYRRRTTMVWLL 274 Query: 264 WGLISIAYYGVFVYLPVKLGSEGFGFMRGQIFLIFLALVQLPGYALSAYGVERWGRKPTL 323 W + +YG+ +L L GF + + + ++L +PG+ +A+ VERWGRKPT Sbjct: 275 WFFALLGFYGLTSWLGALLQQAGFAVTQSVYYTVLISLGGVPGFLCAAWLVERWGRKPTC 334 Query: 324 VGFLVLSAVGCMLYSLGKDPM------LVVGSTLLLSFSLLGTWAALYAFTPEVYPTDLR 377 + L+ G M Y G+ + L++ + L + F L G WA LY +TPE Y T R Sbjct: 335 IASLL--GGGAMAYLYGQSALYGGSVTLLICTGLAMQFFLFGMWAVLYTYTPEQYGTGAR 392 Query: 378 ASGMGTAGAVARFGGLFAPAIVA---PVMASHFTLALAMLSAFLVAGAVAILCVDVESRN 434 A+G G A A+ R G L P +V PV L +S A+A+ + +E+R Sbjct: 393 ATGSGFASAIGRVGSLIGPYVVGVVLPVFGQGGVFTLGAIS--FAVAALAVWALGIETRG 450 Query: 435 RALE 438 ALE Sbjct: 451 LALE 454 >BS_yceI [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 400 Score = 199 bits (506), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 138/424 (32%), Positives = 225/424 (53%), Gaps = 38/424 (8%) Query: 21 QYRLFVIFGLVWLADAMQVLSIGFSAPTIAKTFGLTVPQALQTGTMFFVGMLLGAFVFGR 80 Q +L + GL WL DAM V + F + + L+ + G++ +GM GAF+FG Sbjct: 9 QRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLSPEEMKWIGSVNSIGMAAGAFLFGL 68 Query: 81 LADRIGRRPVLMGAVVIDACFGVAS---AFAPDFTWLLALRLLTGIGVGGTLPVDYTMMA 137 LADRIGR+ V ++ CF + S AF + L LR + G+G+GG LPV T+++ Sbjct: 69 LADRIGRKKVF---IITLLCFSIGSGISAFVTSLSAFLILRFVIGMGLGGELPVASTLVS 125 Query: 138 EFLPSARRGRWLVMLESFWAIGTICLAVLALVAVSWGNDAWRVIFFVTGLPALVGVVLRF 197 E + +RGR +V+LESFWA+G + A+++ + + W+ +T L A + LR Sbjct: 126 EAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP--SFGWQAALLLTALTAFYALYLRT 183 Query: 198 YVPESPMYLNRSGKSDAARLVLERVAKVNGSSTPIPPLQPEVVERKPMSALFSAALRRRS 257 +P+SP Y + S K R + E V V ++ R + Sbjct: 184 SLPDSPKYESLSAKK---RSMWENVKSV-----------------------WARQYIRPT 217 Query: 258 LSLYLAWGLISIAYYGVFVYLPVKLGSEGFGFMRGQIFLIFLALVQLPGYALSAYGVERW 317 + L + W + +YYG+F++LP + +GF ++ +++ + L QLPGY +A+ +E+ Sbjct: 218 VMLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEKA 277 Query: 318 GRKPTLVGFLVLSAVGCMLYSLGKDPMLVVGSTLLLSFSLLGTWAALYAFTPEVYPTDLR 377 GRK LV +L+ +A + L++ + +LLSF LG W LYA+TPE YPT +R Sbjct: 278 GRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPTAIR 337 Query: 378 ASGMGTAGAVARFGGLFAPAIVAPVMASHFTLALAMLSAFLVAGAVAILCVDV---ESRN 434 A+G GT A R GG+F P +V + A H + ++ + S F +A +A+ C+ + E++ Sbjct: 338 ATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSV-IFSIFCIAILLAVACILIMGKETKQ 396 Query: 435 RALE 438 LE Sbjct: 397 TELE 400 >TM1603 [GEPR] COG0477 Permeases of the major facilitator superfamily Tma Thermotoga maritima Length = 422 Score = 199 bits (506), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 135/424 (31%), Positives = 223/424 (52%), Gaps = 19/424 (4%) Query: 19 KFQYRLFVIFGLVWLADAMQVLSIGFSAPTIAKTFGLTVPQALQTGTMFFVGMLLGAFVF 78 K Q R ++ + W+ DA V+ + F P + K + LT Q + F+GML GA Sbjct: 14 KTQRRFLILTSIAWMFDAAGVMLLSFVLPYVIKEWNLTSTQGATIASATFLGMLFGALSV 73 Query: 79 GRLADRIGRRPVLMGAVVIDACFGVASAFAPDFTWLLALRLLTGIGVGGTLPVDYTMMAE 138 G +AD +GR+ + ++ F S F+ F LL LR L+G G GG +P +AE Sbjct: 74 GFVADLLGRKVSNLFFFIVTITFTFLSGFSSSFETLLVLRGLSGFGYGGLMPSFNAYLAE 133 Query: 139 FLPSARRGRWLVMLESFWAIGTICLAVLALVAVSWGNDAWRVIFFVTGLPAL-VGVVLRF 197 F RGR+LV+LES WA+G+I + + A+ + WR +F++ + L V V LR Sbjct: 134 FTSIRLRGRYLVLLESSWAVGSILIGLFAVNVL----PNWRWVFWIFSIGYLFVPVFLR- 188 Query: 198 YVPESPMY-LNRSGKSDAARLVLERVAKVNGSSTPIPPLQPEVVERKPMSALFSAALRRR 256 +PE+P Y + GK R + +RV + +P E+ P+ AL + Sbjct: 189 -MPETPKYAFLKGGKEALERSLGKRVEE----EVELPK-----KEKVPILALLKREHLKD 238 Query: 257 SLSLYLAWGLISIAYYGVFVYLPVKLGSEGFGFMRGQIFLIFLALVQLPGYALSAYGVER 316 ++ +++AW ++S YY +F + P S G ++ F ++ + QLPGY +AY +E+ Sbjct: 239 TVVIWIAWFVVSFVYYALFTWAPRIFSSLGVSVVKSSWFTFYMMVAQLPGYLSAAYFIEK 298 Query: 317 WGRKPTLVGFLVLSAVGCMLYSLGKDPMLVVGSTLLLSFSLLGTWAALYAFTPEVYPTDL 376 WGRK +L + + + + +L++ + ++ + L+LSF LG W +YA+TPE+YPT L Sbjct: 299 WGRKASLGVYFIGTGLAALLWANVRGDASLLAAALVLSFFCLGVWGLVYAYTPELYPTSL 358 Query: 377 RASGMGTAGAVARFGGLFAPAIVAPVMASHFTLA--LAMLSAFLVAGAVAILCVDVESRN 434 R +G G AG AR G+ AP +M ++A LA +SA + V +L E++ Sbjct: 359 RGTGNGAAGVWARIAGIIAPYYTGFMMEKGKSIAETLAWISAMAMFAGVIVLIFGRETKG 418 Query: 435 RALE 438 + ++ Sbjct: 419 KYVD 422 >PAE2330 [GEPR] COG0477 Permeases of the major facilitator superfamily Pya Pyrobaculum aerophilum Length = 384 Score = 173 bits (438), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 136/416 (32%), Positives = 204/416 (49%), Gaps = 43/416 (10%) Query: 23 RLFVIFGLVWLADAMQVLSIGFSAPTIAKTFGLTVPQALQTGTMFFVGMLLGAFVFGRLA 82 RL + GL W+ DA+ VL + + ++ L +GML+GA +FGRLA Sbjct: 5 RLVLYTGLGWMFDALDVLILSYLLVAMSNELKLDSQAKNWIVLANNLGMLIGAMLFGRLA 64 Query: 83 DRIGRRPVLMGAVVIDACFGVASAFAPDFTWLLALRLLTGIGVGGTLPVDYTMMAEFLPS 142 DR+GR+ V M ++ + SAFA ++ +R G+G+GG LPV T ++E P Sbjct: 65 DRVGRKKVFMSTLLTYSIATAISAFARNWQEFAVIRFFVGLGLGGELPVVATYVSENSPP 124 Query: 143 ARRGRWLVMLESFWAIGTICLAVLALVAVSWGNDAWRVIFFVTGLPALVGVVLRFYVPES 202 RRGR +V+LESFW++G I A ++L + WR + G A V+RF +PES Sbjct: 125 ERRGRNVVLLESFWSLGAILAAAISLFLFT--TIGWRSSLLLMGATAFYVFVIRFTLPES 182 Query: 203 PMYL---NRSGKSDAARLVLERVAKVNGSSTPIPPLQPEVVERKPMSALFSAALRRRSLS 259 +L + G R++ E V R L+ Sbjct: 183 QRWLELREQRGGLFETRIIGEFV---------------------------------RRLT 209 Query: 260 LYLA-WGLISIAYYGVFVYLPVKLGSE-GFGFMRGQIFLIFLALVQLPGYALSAYGVERW 317 L A W L++ YYG F++LP L E GF + F+ L QLPGY +AY VE+ Sbjct: 210 LVGAVWFLLAFGYYGAFLWLPTMLVRERGFTQVGTYEFMFLTTLAQLPGYFSAAYLVEKA 269 Query: 318 GRKPTLVGFLVLSAVGCMLYSLGKDPMLVVGSTLLLSFSLLGTWAALYAFTPEVYPTDLR 377 GR+P + LSA+ + ++ L L+F LG W +YA+TPE++PT +R Sbjct: 270 GRRPVGSLYFALSALSAAFFISSNSYAELLLWALALNFFNLGVWGVVYAYTPELFPTSVR 329 Query: 378 ASGMGTAGAVARFGGLFAPAIVAPVMASHFTLALAMLSAFLVAGAVAILCVDVESR 433 G AG+ AR G + P ++ P+ AS L +A+ A+LVA A+ +L + R Sbjct: 330 GIATGLAGSAARIGMILGP-LLYPLYASTALLIIAI--AWLVASALILLLPETRGR 382