BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0027.0042.p (1341 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1722_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1439 0.0 PA3763_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1191 0.0 VC0869_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1155 0.0 NMA0445_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1141 0.0 HI0752_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1139 0.0 PM1085_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1135 0.0 YPO2921_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1130 0.0 NMB1996_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1128 0.0 ECs3423_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1086 0.0 STM2565_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1084 0.0 >RSc1722_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Rso Ralstonia solanacearum Length = 1046 Score = 1439 bits (3726), Expect = 0.0, Method: Compositional matrix adjust. Identities = 714/1041 (68%), Positives = 819/1041 (78%), Gaps = 23/1041 (2%) Query: 3 ILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTYGD 62 PG+ ALSAFR QRLL+ L+ +D I VS +YLHFV A L+ +D AR+ LLTYG Sbjct: 6 CFPGALALSAFRQQRLLSTLKRIDPEIDAVSAQYLHFVAADAPLSADDAARVQALLTYGS 65 Query: 63 PFNGSDDGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLL--- 119 P + +G+ FVVIPR GTISPWASKAT+I R+C + IHR+ERG+ F V K GLL Sbjct: 66 PASAETEGDRFVVIPRFGTISPWASKATEIARHCALPQIHRIERGVEFTVTCKKGLLRGL 125 Query: 120 -GGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGG----GR 174 GG K+L+EA+ VAA LHDRMTE V+ + LF L AK L VD+ G GR Sbjct: 126 TGGRKQLDEATRAAVAAHLHDRMTEIVVATREAGYGLFDVLPAKALRFVDLGSGDAAAGR 185 Query: 175 AALERANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTI 234 ALE ANTE+GLALSDDEIDYLV+A+ K RNPTDVELMMFAQANSEHCRHKIFNADWTI Sbjct: 186 GALEAANTEMGLALSDDEIDYLVDAYRKLGRNPTDVELMMFAQANSEHCRHKIFNADWTI 245 Query: 235 DGQKQDKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNV----YEA 290 DG+ QDKSLF MI+NTHQLAP+GTVVAYSDN++++EG R++ G Y Sbjct: 246 DGETQDKSLFAMIRNTHQLAPQGTVVAYSDNAAVMEGGMAERWFPHAGTDGETGVPQYGR 305 Query: 291 SEELTHILMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMV 350 E LTH LMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRG+KPKAGLTGFTVSNL++ Sbjct: 306 REALTHTLMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGAKPKAGLTGFTVSNLLL 365 Query: 351 THAVQPWENARDVAQPVAERD-AHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRP 409 AVQ WENARD AQP A+R+ G GKP+RIASPLQIMI+GP+GGAAFNNEFGRP Sbjct: 366 PEAVQSWENARDTAQPAAQRNPGDTAPGPVGKPDRIASPLQIMIEGPIGGAAFNNEFGRP 425 Query: 410 NLGGYFRTYEQNVGGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIG 469 NLGGYFR YEQNVGG V GYHKPIMIAGG+GNI A HT K+ LP G+LL+QLGGPGMRIG Sbjct: 426 NLGGYFRVYEQNVGGTVRGYHKPIMIAGGIGNIDAGHTHKHGLPAGTLLVQLGGPGMRIG 485 Query: 470 MGGGAASSMATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGG 529 MGGGAASSMATG N ADLDFDSVQRGNPEM+RRAQEVINACWALG+DNPI SIHDVGAGG Sbjct: 486 MGGGAASSMATGTNTADLDFDSVQRGNPEMQRRAQEVINACWALGEDNPILSIHDVGAGG 545 Query: 530 LSNAFPEITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLC 589 +SNAFPE+ + A RGA FDLR+V LEESGL+P EIW NESQERY LAI P F+ +C Sbjct: 546 ISNAFPELVDGADRGARFDLRQVHLEESGLSPAEIWCNESQERYTLAIAPGDFPRFQAMC 605 Query: 590 ERERAPFAVVGTATEERQLKVIDPEH-----NNSPVDMPMDVLLGKPPKMHRDVTHVEKQ 644 ERERAPF+VVG ATEE+QL+V+D + + PV+MPMDVLLGKPP+MHRDV V + Sbjct: 606 ERERAPFSVVGFATEEQQLQVVDGDAPADAVEHFPVNMPMDVLLGKPPRMHRDVRRVAQA 665 Query: 645 LPPVDLTGMDLVEVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAV 704 LP VD+TG+DL VA+ VLR P VA KSFLITIGDR+VG + RDQMVGPWQVPVADVAV Sbjct: 666 LPEVDVTGLDLETVARDVLRHPTVASKSFLITIGDRTVGGLNTRDQMVGPWQVPVADVAV 725 Query: 705 TAMGLEGYRGEAMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMA 764 T + +GY GEAM MGERTPLAVIDAPASGRMA+GEAITNIAAAPIA + +KLSANWMA Sbjct: 726 TTLDYKGYAGEAMTMGERTPLAVIDAPASGRMAIGEAITNIAAAPIASLAQLKLSANWMA 785 Query: 765 ACGQPGQDAALFDTVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIV 824 ACG G+DA L+DTVKAVGMELCPALG+SIPVGKDSLSMR+ W D AK V +PVSLIV Sbjct: 786 ACGVDGEDARLYDTVKAVGMELCPALGISIPVGKDSLSMRTKWDDAGEAKEVVAPVSLIV 845 Query: 825 SGFAPVTDVRRVLTPQLRK-----DKGETVLILIDLGRGKNRMGASALTQVMQQIGNETP 879 S FAPVTDVR+ LTPQL+ + +T LI+IDLG GK+R+G S L QV QQIGN P Sbjct: 846 SAFAPVTDVRKTLTPQLKPVASAGEAADTTLIVIDLGHGKHRLGGSILAQVTQQIGNSVP 905 Query: 880 DVDSADDLKAFFNAIQQLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTME 939 DV A+DLK FF AIQQLN LLAYHDRSDGGL+AT+ EMAFAGH G+S+N+D+LT++ Sbjct: 906 DVGDAEDLKRFFAAIQQLNAAGMLLAYHDRSDGGLWATVCEMAFAGHCGVSINVDMLTLD 965 Query: 940 GEHAADWGDSKNWTTQVAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGAC 999 G HA+D+GD+KNW QV+ RR ++TLRALF+EELGAVIQVPA Q+ V VLR + L AC Sbjct: 966 GAHASDYGDAKNWAQQVSGRRADMTLRALFAEELGAVIQVPAAQRDAVFAVLREHGLAAC 1025 Query: 1000 SHIIGKPNDRDVIEFMRDAKN 1020 SH+IG PN IE RDAK Sbjct: 1026 SHVIGAPNASGQIEIWRDAKK 1046 >PA3763_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Pae Pseudomonas aeruginosa Length = 976 Score = 1191 bits (3080), Expect = 0.0, Method: Compositional matrix adjust. Identities = 610/1011 (60%), Positives = 725/1011 (71%), Gaps = 55/1011 (5%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTY 60 MLIL G+ ALSAFR +LL QL A+TG+ + HF D ALT ++E L LL Y Sbjct: 1 MLILRGAPALSAFRHGKLLEQLTQHVPAVTGLYAEFAHFADVTGALTADEEQVLARLLKY 60 Query: 61 GDPFNGSD-DGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLL 119 G + G F+V+PR GTISPW+SKA+DI RNCG+A I R+ERGI + VQ Sbjct: 61 GPSVPVQEPSGRLFLVVPRFGTISPWSSKASDIARNCGLAKIDRLERGIAYYVQ------ 114 Query: 120 GGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAALER 179 +L+E+ VAA LHDRMT+ VL + A+ LFS Q +PL +VDVLGGGRAALE+ Sbjct: 115 ---GELSESDAQQVAARLHDRMTQLVLDRLEGAAELFSHAQPRPLTAVDVLGGGRAALEK 171 Query: 180 ANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQKQ 239 AN ELGLAL++DEIDYL+++F + RNP DVELMMFAQANSEHCRHKIFNA W IDGQ Q Sbjct: 172 ANVELGLALAEDEIDYLLKSFGELGRNPHDVELMMFAQANSEHCRHKIFNASWDIDGQAQ 231 Query: 240 DKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNVYEASEELTHILM 299 DKSLFGMIKNT+++ +G + AY DN+++I G RF+ + Y AS E ILM Sbjct: 232 DKSLFGMIKNTYEMNREGVLSAYKDNAAVIVGHVAGRFFPDPQTR--EYAASREPVQILM 289 Query: 300 KVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPWEN 359 KVETHNHPTAI+PFPGASTG+GGEIRDEGATGRG+KPKAGLTGFTVSNL + QPWE Sbjct: 290 KVETHNHPTAIAPFPGASTGSGGEIRDEGATGRGAKPKAGLTGFTVSNLQIPGFEQPWEV 349 Query: 360 ARDVAQPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYE 419 YGKPERI + L IM++GPLGGAAFNNEFGRP L GYFRT+E Sbjct: 350 P------------------YGKPERIVTALDIMVEGPLGGAAFNNEFGRPALTGYFRTFE 391 Query: 420 QNV----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAA 475 Q + G +V GYHKPIM+AGGMGNI +H +K ++ VG+ LI LGGP M IG+GGGAA Sbjct: 392 QKIATPHGEEVRGYHKPIMLAGGMGNIRDEHVQKGEISVGAKLIVLGGPAMLIGLGGGAA 451 Query: 476 SSMATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFP 535 SSMATG ++ADLDF SVQR NPEMERR QEVI+ CW LG+ NPI IHDVGAGGLSNA P Sbjct: 452 SSMATGASSADLDFASVQRDNPEMERRCQEVIDRCWQLGERNPISFIHDVGAGGLSNALP 511 Query: 536 EITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAP 595 E+ ND RG F+LR VP +E G++P EIW NESQERYVL++ E FK +CERER P Sbjct: 512 ELINDGGRGGRFELRAVPNDEPGMSPLEIWCNESQERYVLSVDAADFETFKAICERERCP 571 Query: 596 FAVVGTATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDL 655 FAVVG A E+RQL V D +N PVDMP++VLLGK P+MHR VT + D G++L Sbjct: 572 FAVVGEAIEQRQLTVADSHFDNKPVDMPLEVLLGKAPRMHRAVTREAELGDDFDAAGLEL 631 Query: 656 VEVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGE 715 E +RVLR PAVA KSFLITIGDR++ + RDQMVGPWQVPVAD AVTA + Y GE Sbjct: 632 QESVERVLRHPAVASKSFLITIGDRTITGLVARDQMVGPWQVPVADCAVTATSFDVYTGE 691 Query: 716 AMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAAL 775 AMAMGERTPLA++DAPASGRMA+GE +TN+AAA + ++ DIKLSANWMAA G PG+DA L Sbjct: 692 AMAMGERTPLALLDAPASGRMAIGETVTNLAAARVGKLSDIKLSANWMAAAGHPGEDARL 751 Query: 776 FDTVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRR 835 +DTVKAVGMELCP LG++IPVGKDS+SM++ W D KSVTSPVSLIV+GFAPV DVR+ Sbjct: 752 YDTVKAVGMELCPELGITIPVGKDSMSMKTRWQDNGEDKSVTSPVSLIVTGFAPVADVRQ 811 Query: 836 VLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQ 895 LTPQLR DKGET LILIDLGRGKNR+G S L QV ++G PDVD A+DLKAFF IQ Sbjct: 812 SLTPQLRLDKGETDLILIDLGRGKNRLGGSILAQVHGKLGRAVPDVDDAEDLKAFFAVIQ 871 Query: 896 QLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEGEHAADWGDSKNWTTQ 955 LN + +LAYHDRSDGGL ++ EMAFAGH G+ +NLD L Sbjct: 872 GLNADGHILAYHDRSDGGLITSVLEMAFAGHCGVELNLDAL------------------- 912 Query: 956 VAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKP 1006 A+ R EL LFSEELGAVIQV +V+ + L C +IG+P Sbjct: 913 -ADSREELA-AVLFSEELGAVIQVREGATPEVLAQFSAAGLDDCVAVIGQP 961 >VC0869_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Vch Vibrio cholerae Length = 972 Score = 1155 bits (2988), Expect = 0.0, Method: Compositional matrix adjust. Identities = 584/1019 (57%), Positives = 716/1019 (70%), Gaps = 58/1019 (5%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTY 60 M IL GS ALS FR +LLT + +TG+ ++HF D L ++ +L LLTY Sbjct: 1 MRILRGSPALSEFRVNKLLTACREQQLPVTGIYAEFMHFADLKAELNPQELEKLEKLLTY 60 Query: 61 GDPFNGSD-DGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLL 119 G + G +V PR GTISPW+SKATDI NCG+ I R+ERG + V+ +T L Sbjct: 61 GPTIQEHEPQGLLLLVTPRPGTISPWSSKATDIAHNCGLHGIKRLERGTAYYVEAETALT 120 Query: 120 GGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAALER 179 A + + ALLHDRM E V + A LFS + P+ VDVL GGR ALE Sbjct: 121 A-------AQIATLEALLHDRMMEVVFAELTDAQQLFSVAEPAPMSQVDVLAGGRRALEE 173 Query: 180 ANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQKQ 239 AN LGLAL++DEIDYLVE+FTK RNP D+ELMMFAQANSEHCRHKIFNADWTIDG KQ Sbjct: 174 ANVSLGLALAEDEIDYLVESFTKLGRNPNDIELMMFAQANSEHCRHKIFNADWTIDGVKQ 233 Query: 240 DKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNVYEASEELTHILM 299 DKSLF MIKNT + P + AY DN++++ G+TV RF+ + Y E HILM Sbjct: 234 DKSLFKMIKNTFEQTPDYVLSAYKDNAAVMTGSTVGRFFPDPESRQYTYH--HEDAHILM 291 Query: 300 KVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPWEN 359 KVETHNHPTAISP+PGASTG+GGEIRDEGATG G KPKAGL GFT SNL + QPWE+ Sbjct: 292 KVETHNHPTAISPWPGASTGSGGEIRDEGATGIGGKPKAGLVGFTTSNLRIPGFEQPWES 351 Query: 360 ARDVAQPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYE 419 +GKP RI + L IM++GPLGGAAFNNEFGRPNL GYFRTYE Sbjct: 352 D------------------FGKPSRIVNALDIMLEGPLGGAAFNNEFGRPNLLGYFRTYE 393 Query: 420 QNV----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAA 475 + V G +V GYHKPIMIAGGMGNI A+H +K ++PVG+ LI LGGP M IG+GGGAA Sbjct: 394 EKVTSHAGEEVRGYHKPIMIAGGMGNIRAEHIQKKEIPVGAKLIVLGGPAMNIGLGGGAA 453 Query: 476 SSMATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFP 535 SSMA+G +A DLDF SVQR NPEMERR QEVI+ CW LGD NPI IHDVGAGG+SNA P Sbjct: 454 SSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQLGDKNPIAFIHDVGAGGISNALP 513 Query: 536 EITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAP 595 E+ ND RG F LR VP +E G++P EIW NESQERYVLA+ E + LF +C+RERAP Sbjct: 514 ELVNDGDRGGKFQLRNVPNDEPGMSPLEIWCNESQERYVLAVAAEDMPLFDAICQRERAP 573 Query: 596 FAVVGTATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDL 655 +AVVG ATEER L + D N+P+DMPMD+LLGKPPKMHR+ + ++ P ++ +G++L Sbjct: 574 YAVVGEATEERHLTLEDSHFANTPIDMPMDILLGKPPKMHREASTLKVSSPALERSGIEL 633 Query: 656 VEVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGE 715 E RVLRLPAVA+K+FLITIGDRSV + RDQMVGPWQVPVA+ AVTA + Y GE Sbjct: 634 NEAVDRVLRLPAVAEKTFLITIGDRSVTGLVARDQMVGPWQVPVANCAVTAASFDSYHGE 693 Query: 716 AMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAAL 775 AM+MGERTP+A++D AS R+AVGEAITNIAA I E+ IKLSANWM+ G PG+DA L Sbjct: 694 AMSMGERTPVALLDFGASARLAVGEAITNIAATDIGELKRIKLSANWMSPAGHPGEDAGL 753 Query: 776 FDTVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRR 835 ++ VKAVG ELCPALG++IPVGKDS+SM++ W + K VTSP+SLI++ FA V D+R+ Sbjct: 754 YEAVKAVGEELCPALGITIPVGKDSMSMKTKWQENGEQKEVTSPLSLIITAFARVEDIRK 813 Query: 836 VLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQ 895 +TPQLR D GET LILIDLG G+NR+GA+AL QV +Q+G++ DVD+A LK FF+A+Q Sbjct: 814 TVTPQLRTDLGETSLILIDLGNGQNRLGATALAQVYKQLGDKPADVDNAAQLKGFFDAVQ 873 Query: 896 QLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEGEHAADWGDSKNWTTQ 955 L D+L+AYHD+ DGGL TLAEMAFAGH GI N++ L GD Sbjct: 874 TLVRNDKLVAYHDKGDGGLLVTLAEMAFAGHCGIKANIETL----------GDD------ 917 Query: 956 VAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIG--KPNDRDVI 1012 L ALF+EELGAV+QV ++ + V+ L ++ L AC+H+IG + +DR +I Sbjct: 918 --------ALAALFNEELGAVVQVKNDELNAVLATLAAHGLEACAHVIGEVEASDRLLI 968 >NMA0445_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain NmA Neisseria meningitidis Z2491 Length = 1001 Score = 1141 bits (2952), Expect = 0.0, Method: Compositional matrix adjust. Identities = 601/1025 (58%), Positives = 728/1025 (71%), Gaps = 37/1025 (3%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLL-- 58 +L L G ALS FR ++LL + A+ +S + +FV + +AL +L LL Sbjct: 4 VLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFVGSEKALDAATVEKLQALLAA 63 Query: 59 -TYGDPFNGSDDGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTG 117 + + F+V PRLGTISPWASKAT+I NCG+A I R+ERG+ Sbjct: 64 QSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAV------- 116 Query: 118 LLGGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAAL 177 L GA L + AALLHDRMTE+VL D Q AS LF L+++ +VDVLGGG+ AL Sbjct: 117 WLEGA--LTDEQQQQWAALLHDRMTESVLPDFQTASKLFHHLESETFSTVDVLGGGKEAL 174 Query: 178 ERANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQ 237 +ANTE+GLALS DEIDYLVE + QRNP+DVELMMFAQANSEHCRHKIFNAD+ ++G+ Sbjct: 175 VKANTEMGLALSADEIDYLVENYQALQRNPSDVELMMFAQANSEHCRHKIFNADFILNGE 234 Query: 238 KQDKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNVYEASEELTHI 297 KQ KSLFGMI++TH P+GTVVAY DNSS+IEGA V RFY A + Y EE THI Sbjct: 235 KQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKVERFYPNAA-ENQGYRFHEEDTHI 293 Query: 298 LMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPW 357 +MKVETHNHPTAI+PF GA+TGAGGEIRDEGATG+GS+PKAGLTGFTVSNL + QPW Sbjct: 294 IMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPGLKQPW 353 Query: 358 ENARDVAQPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRT 417 E YGKPE I+SPL IMI+GP+GGAAFNNEFGRPNL GYFRT Sbjct: 354 EQD------------------YGKPEHISSPLDIMIEGPIGGAAFNNEFGRPNLLGYFRT 395 Query: 418 YEQNVGGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAASS 477 +E+ GQV GYHKPIMIAGG+G+I A+ T K+++P G+LLIQLGGPGM IG+GGGAASS Sbjct: 396 FEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAASS 455 Query: 478 MATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFPEI 537 M TG N A LDF+SVQRGNPE+ERRAQEVI+ CW LGD NPI SIHDVGAGGLSNAFPE+ Sbjct: 456 MDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGDKNPIISIHDVGAGGLSNAFPEL 515 Query: 538 TNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAPFA 597 NDA RGA+F LR+VPLEE GL P +IW NESQERYVL+IL + L++F+ +CERER PFA Sbjct: 516 VNDAGRGAVFKLREVPLEEHGLNPLQIWCNESQERYVLSILEKDLDIFRSICERERCPFA 575 Query: 598 VVGTATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDLVE 657 VVGTAT++ LKV D +N+PVD+P++VLLGKPPK R V P +D+ E Sbjct: 576 VVGTATDDGHLKVRDDLFSNNPVDLPLNVLLGKPPKTTRTDKTVAPSKKPFHAGDIDITE 635 Query: 658 VAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGEAM 717 A RVLRLPAVA K+FLITIGDRSVG MT RDQMVG +Q PVAD AVT MG YRGEAM Sbjct: 636 AAYRVLRLPAVAAKNFLITIGDRSVGGMTHRDQMVGKYQTPVADCAVTMMGFNTYRGEAM 695 Query: 718 AMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAALFD 777 +MGE+ +A+ DAPASGRM VGEAITNIAAA I +IG+IKLSANWMAACG G+D L+ Sbjct: 696 SMGEKPTVALFDAPASGRMCVGEAITNIAAANIGDIGNIKLSANWMAACGNEGEDEKLYR 755 Query: 778 TVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRRVL 837 TV+AV + C AL +SIPVGKDSLSM++ W D E KSV SP+SLI+S FAPV DVR+ + Sbjct: 756 TVEAVS-KACQALDLSIPVGKDSLSMKTVWQDGEEKKSVVSPLSLIISAFAPVQDVRKTV 814 Query: 838 TPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQQL 897 TP+L K+ ++VL+ +DLG GK RMG SA QV + + PD+D LKAF+N IQQL Sbjct: 815 TPEL-KNVEDSVLLFVDLGFGKARMGGSAFGQVYNNMSGDAPDLDDTSRLKAFYNVIQQL 873 Query: 898 NTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDIL---TMEGEHAADWGDSKNWTT 954 ED+LLAYHDRSDGGL+A L EMAFAG G+ ++L++L T H A + Sbjct: 874 VAEDKLLAYHDRSDGGLFAVLVEMAFAGRCGLDIDLNLLLAQTFITNHTALSQSLRTEEV 933 Query: 955 QVAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIEF 1014 + E R LF+EELGAVIQV + +D++N+ L IG D + + Sbjct: 934 KALAEWQETIARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTL-I 992 Query: 1015 MRDAK 1019 +RD + Sbjct: 993 IRDGQ 997 >HI0752_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Hin Haemophilus influenzae Length = 1011 Score = 1139 bits (2946), Expect = 0.0, Method: Compositional matrix adjust. Identities = 576/1033 (55%), Positives = 720/1033 (69%), Gaps = 57/1033 (5%) Query: 6 GSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTYGDPFN 65 GS ALS FR +L + Q IT V YLHFV+ +L +++ +L LL YG F+ Sbjct: 31 GSPALSEFRLTQLQQKCQQYQLPITSVYAEYLHFVEQKTSLVEDEIVKLQALLHYGSMFS 90 Query: 66 G-SDDGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLLGGAKK 124 G +V PR+GTIS W+SKATDI NCG++ ++R+ERGI + ++ + Sbjct: 91 ELKPAGYCLIVTPRVGTISSWSSKATDIAHNCGLSKVNRIERGIAYYFNIE-------RD 143 Query: 125 LNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAALERANTEL 184 L EA L + LLHDRM ETVL +A+ LF++ + K L ++D+L GGR ALE+AN L Sbjct: 144 LTEAELATLKDLLHDRMLETVLNHETEAALLFTQQEPKALTTIDILNGGRQALEQANIAL 203 Query: 185 GLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQKQDKSLF 244 GLAL+DDE+DYLVE+FT +RNP DVEL MFAQANSEHCRHKIFNADW IDG+KQDKSLF Sbjct: 204 GLALADDEMDYLVESFTALKRNPQDVELYMFAQANSEHCRHKIFNADWIIDGKKQDKSLF 263 Query: 245 GMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNVYEASEELTHILMKVETH 304 MIKNT + P + AY DN++++EG+ V R++ Y +E HILMKVETH Sbjct: 264 KMIKNTFEQTPDFVLSAYKDNAAVMEGSKVGRWFPD---PDGQYRVHQEDVHILMKVETH 320 Query: 305 NHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPWENARDVA 364 NHPTAISPFPGA+TG+GGEIRDEGATGRG+KPKAGLTGF+VSNL++ + QPWEN Sbjct: 321 NHPTAISPFPGAATGSGGEIRDEGATGRGAKPKAGLTGFSVSNLVIPNFEQPWEN----- 375 Query: 365 QPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYEQNV-- 422 P++ KP RIAS L IMID PLG AAFNNEFGRP L GYFRTYE+ V Sbjct: 376 -PLS------------KPNRIASALDIMIDAPLGSAAFNNEFGRPALLGYFRTYEEKVNS 422 Query: 423 --GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAASSMAT 480 G +V GYHKPIM+AGG+GNI + +K ++P+G+ LI LGG M IG+GGGAASSM + Sbjct: 423 FAGKEVRGYHKPIMLAGGIGNIRGEQVQKGEIPIGAKLIVLGGAAMNIGLGGGAASSMDS 482 Query: 481 GVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFPEITND 540 G + DLDF SVQR NPEMERR QEVI+ CW LG++NPI IHDVGAGGLSNA PE+ +D Sbjct: 483 GKSKEDLDFASVQRENPEMERRCQEVIDRCWQLGEENPILFIHDVGAGGLSNAMPELVHD 542 Query: 541 AKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAPFAVVG 600 KRG FDLR + +E G++P EIW NESQERYVLA+ PE+LELF LCERERAPFAV+G Sbjct: 543 GKRGGKFDLRSILCDEKGMSPLEIWCNESQERYVLAVAPENLELFTALCERERAPFAVIG 602 Query: 601 TATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDLVEVAQ 660 AT+ L + D +N+P+D+PM+VLLGK PKM R+V + + + + L E Sbjct: 603 EATQAEHLILHDSHFDNNPIDLPMNVLLGKTPKMTREVLSKTVENQSLKIESIQLKEAFH 662 Query: 661 RVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGEAMAMG 720 RVLRLP VA+K+FLITIGDRSV M RDQMVGPWQ+PV+DVAVT L+ Y GEAMA+G Sbjct: 663 RVLRLPVVAEKTFLITIGDRSVTGMVARDQMVGPWQIPVSDVAVTTASLDSYHGEAMAIG 722 Query: 721 ERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAALFDTVK 780 ER+P+A++D AS R+AV EAITNIA I E+ IKLSANWM+A G G+DA L++ VK Sbjct: 723 ERSPVALLDFSASARLAVAEAITNIAGTLIGEMKRIKLSANWMSAAGHTGEDAGLYEAVK 782 Query: 781 AVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRRVLTPQ 840 AVG ELCPALG++IPVGKDS+SM++TW D KSVT+P+SL++S FA V DVR+ LTPQ Sbjct: 783 AVGEELCPALGLTIPVGKDSMSMKTTWIDNGEQKSVTAPLSLVISAFARVEDVRKTLTPQ 842 Query: 841 LRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQQLNTE 900 LR DKG + L+LIDLG G NR+GA+AL QV +Q+G++ DV LK F+NA+Q L E Sbjct: 843 LRTDKGFSSLLLIDLGEGHNRLGATALAQVYKQLGDKPADVVKVQRLKDFYNAMQTLVAE 902 Query: 901 DRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEGEHAADWGDSKNWTTQVAERR 960 D+LLAYHDRSDGGL TLAEMAFAGH G+ V++ L GD+ Sbjct: 903 DKLLAYHDRSDGGLITTLAEMAFAGHCGVEVDISAL----------GDND---------- 942 Query: 961 NELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIEFMRDAKN 1020 L LF+EELGAVIQV Q V VL+++NL H +G D E R + Sbjct: 943 ----LAVLFNEELGAVIQVADSQLESVREVLKAHNLLGIIHQLGTVTADDRFEISRGSHK 998 Query: 1021 IYSQPRAELHRVW 1033 ++S+ R+EL +W Sbjct: 999 LFSEKRSELRSIW 1011 >PM1085_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Pmu Pasteurella multocida Length = 972 Score = 1135 bits (2936), Expect = 0.0, Method: Compositional matrix adjust. Identities = 576/1023 (56%), Positives = 715/1023 (69%), Gaps = 61/1023 (5%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTY 60 + I GS ALS FR +L + Q + ++ Y+HF D + LT+E+ A+L+ LL Y Sbjct: 2 LQIFRGSPALSEFRLNQLAVRFQKANLPVSACYAEYIHFADLSDRLTEEETAKLDQLLHY 61 Query: 61 GDPFNGSDD-GETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLL 119 G G D G F+VIPR+GTIS W+SKATDI NCG+ ++R+ERG+ F + Sbjct: 62 GPTLAGHDPVGHCFIVIPRIGTISSWSSKATDIAHNCGLNKVNRLERGLAFYFEFD---- 117 Query: 120 GGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAALER 179 + L+ + + +HDRM E ++ P++A LF + KP +VD+L GGR ALE Sbjct: 118 ---RTLSSEEQQRLVSHIHDRMLEGIIHTPEEAKVLFDQQAPKPFTTVDILSGGRQALEN 174 Query: 180 ANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQKQ 239 AN ELGLAL++DEIDYLVE FT RNP D+EL MFAQANSEHCRHKIFNADW IDG+KQ Sbjct: 175 ANVELGLALAEDEIDYLVENFTALGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGEKQ 234 Query: 240 DKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFY--QRGAIKGNVYEASEELTHI 297 +KSLF MIKNT + P + AY DN++++EG+ V RF+ Q G Y E HI Sbjct: 235 EKSLFKMIKNTFEKTPDHVLSAYKDNAAVMEGSKVGRFFPDQDGQ-----YRYHNEDAHI 289 Query: 298 LMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPW 357 LMKVETHNHPTAISPFPGA+TG+GGEIRDEGATGRG+KPKAGL GF+VSNL++ QPW Sbjct: 290 LMKVETHNHPTAISPFPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLVIPGFEQPW 349 Query: 358 ENARDVAQPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRT 417 EN PV+ KP RIAS L IMI+GPLGGAAFNNEFGRP L GYFRT Sbjct: 350 EN------PVS------------KPNRIASALDIMIEGPLGGAAFNNEFGRPALLGYFRT 391 Query: 418 YEQNV----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGG 473 YE+ V G +V GYHKPIM+AGG+GNI A+H +K ++PVG+ LI LGGP M IG+GGG Sbjct: 392 YEEKVNSFAGEEVRGYHKPIMLAGGIGNIRAEHVQKGEIPVGAKLIVLGGPAMNIGLGGG 451 Query: 474 AASSMATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNA 533 AASSMA+G + DLDF SVQR NPEMERR QEVI+ CW LG+DNPI IHDVGAGGLSNA Sbjct: 452 AASSMASGKSKEDLDFASVQRDNPEMERRCQEVIDRCWQLGEDNPILFIHDVGAGGLSNA 511 Query: 534 FPEITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERER 593 PE+ +D RG F+LRK+ +E G++P EIW NESQERYVLA+ PE LELF LCERER Sbjct: 512 MPELVHDGGRGGKFELRKILSDERGMSPLEIWCNESQERYVLAVAPEKLELFTALCERER 571 Query: 594 APFAVVGTATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGM 653 APFAV+G ATE+ L + D +N+P+D+PM+VLLGK PKM RDV + +D + + Sbjct: 572 APFAVIGEATEQEHLTLHDDHFDNNPIDLPMNVLLGKTPKMTRDVKSKTVEGSALDHSQI 631 Query: 654 DLVEVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYR 713 DL E RVLRLP VA+K+FLITIGDRSV M RDQMVGPWQ+PVAD AVT L+ Y Sbjct: 632 DLKEAFHRVLRLPVVAEKTFLITIGDRSVTGMVARDQMVGPWQIPVADCAVTTASLDSYH 691 Query: 714 GEAMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDA 773 GEAM+MGER P+A++D AS R+AV E+ITNIAA I +I IKLSANWM+A G G+DA Sbjct: 692 GEAMSMGERAPVALLDFAASARLAVAESITNIAATNIGDIKRIKLSANWMSAAGHEGEDA 751 Query: 774 ALFDTVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDV 833 L+ VKAVG ELCP LG++IPVGKDS+SM++TW + K+VT+P+SL++S FA V DV Sbjct: 752 GLYQAVKAVGEELCPQLGLTIPVGKDSMSMKTTWHENGEQKTVTAPLSLVISAFARVEDV 811 Query: 834 RRVLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNA 893 R+ +TPQLR DKG + L+LIDLG GKNR+GA+AL QV +Q+G++ DV + + LK FFNA Sbjct: 812 RKTVTPQLRTDKGHSRLLLIDLGEGKNRLGATALAQVYKQLGDKPADVVNVESLKNFFNA 871 Query: 894 IQQLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEGEHAADWGDSKNWT 953 +Q L E +LLAYHDRSDGGL ATLAEMAFAG+ G+S+++ L GD+ Sbjct: 872 MQALVAEQKLLAYHDRSDGGLIATLAEMAFAGNCGLSIHISAL----------GDND--- 918 Query: 954 TQVAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIE 1013 L LF+EELGAVIQV S V +VL + L + +G+ D IE Sbjct: 919 -----------LAVLFNEELGAVIQVRESDLSYVRDVLSQHGLIHLTKELGEVTTEDRIE 967 Query: 1014 FMR 1016 R Sbjct: 968 ISR 970 >YPO2921_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Ype Yersinia pestis Length = 986 Score = 1130 bits (2922), Expect = 0.0, Method: Compositional matrix adjust. Identities = 570/1038 (54%), Positives = 720/1038 (69%), Gaps = 58/1038 (5%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTY 60 M IL GS ALSAFR +LL++ Q ++ + Y+HF D + L+ ++ ARL LL Y Sbjct: 1 MEILRGSPALSAFRITKLLSRCQDAHLLVSDIYAEYVHFADVSAPLSADEHARLQRLLQY 60 Query: 61 GDPF-NGSDDGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLL 119 G G +V PR GTISPW+SKATDI NCG++ I R+ERG+ F +Q Sbjct: 61 GPSLPEHPPAGRLLLVTPRPGTISPWSSKATDIAHNCGLSQILRLERGLAFSIQ------ 114 Query: 120 GGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAALER 179 LNE+ +AALLHDRM E V D QQA LFS Q P++ VD+LG GR+ALE+ Sbjct: 115 --GPDLNESQWKQLAALLHDRMMEAVFTDLQQAEQLFSHHQPAPVQRVDILGQGRSALEQ 172 Query: 180 ANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQKQ 239 AN +LGLAL+ DEIDYL+ AFT RNPTD+EL MFAQANSEHCRHKIFNADW IDG Q Sbjct: 173 ANIKLGLALAQDEIDYLLTAFTGLGRNPTDIELYMFAQANSEHCRHKIFNADWVIDGVVQ 232 Query: 240 DKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNVYEASEELTHILM 299 K+LF MIKNT + P + AY DN++++EG+ V RFY A KG +Y+ +E HILM Sbjct: 233 PKTLFKMIKNTFEHTPDYVLSAYKDNAAVMEGSQVGRFYAT-AEKG-IYDYHQEEAHILM 290 Query: 300 KVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPWEN 359 KVETHNHPTAISP+PGA+TG+GGEIRDEGATGRG+KPKAGL GF+VSNL + QPWE Sbjct: 291 KVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEE 350 Query: 360 ARDVAQPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYE 419 +GKP+RI + L IM +GPLGGAAFNNEFGRP L GYFRTYE Sbjct: 351 N------------------FGKPDRIVTALDIMTEGPLGGAAFNNEFGRPALLGYFRTYE 392 Query: 420 QNV----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAA 475 + V G ++ GYHKPIM+AGG+GNI A H +K ++ VG+ L+ LGGP M IG+GGGAA Sbjct: 393 ERVNSHNGIELRGYHKPIMLAGGLGNIRADHVQKGEITVGAKLVVLGGPSMNIGLGGGAA 452 Query: 476 SSMATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFP 535 SSMA+G + ADLDF SVQR NPEMERR QEVI+ CW LG+ NPI IHDVGAGGLSNA P Sbjct: 453 SSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGEYNPILFIHDVGAGGLSNAMP 512 Query: 536 EITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAP 595 E+ ND RG F+LR + +E G++P E+W NESQERYVLA+ P + LF +C RERAP Sbjct: 513 ELVNDGGRGGRFELRDILNDEPGMSPLEVWCNESQERYVLAVAPAQMALFDEICRRERAP 572 Query: 596 FAVVGTATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDL 655 +AV+G ATEE+ L + D N P+DMP+DVLLGK PKM RDVT ++ + + + L Sbjct: 573 YAVIGEATEEKHLLLNDRHFGNQPIDMPLDVLLGKTPKMLRDVTRLQAKGDALQRADISL 632 Query: 656 VEVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGE 715 E +R++ LPAVA+K+FLITIGDR+V M RDQMVGPWQ+PVAD AVT+ L+ Y GE Sbjct: 633 AEAVKRIMHLPAVAEKTFLITIGDRTVTGMVTRDQMVGPWQIPVADCAVTSASLDSYYGE 692 Query: 716 AMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAAL 775 AM++GER P+A++D AS R+AVGEA+TNIAA I E+ IKLSANWM+A G PG+DA L Sbjct: 693 AMSLGERAPVALLDFAASARLAVGEALTNIAATQIGELKRIKLSANWMSAAGHPGEDAGL 752 Query: 776 FDTVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRR 835 +D V+AVG ELCPAL ++IPVGKDS+SM++ W + + +TSP+SL+++ FA + DVRR Sbjct: 753 YDAVRAVGEELCPALEITIPVGKDSMSMKTRWQEGHEQREMTSPLSLVITAFARIEDVRR 812 Query: 836 VLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQ 895 +TPQLR DKG+ L+LIDLG G N +GA+ALTQV +Q+G++ DV + L FFNA+Q Sbjct: 813 TVTPQLRTDKGDNALLLIDLGAGHNALGATALTQVYRQLGDKPADVRNVQQLAGFFNAMQ 872 Query: 896 QLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEGEHAADWGDSKNWTTQ 955 +L + LLAYHDRSDGGL TLAEMAFAGH G++V++ L + Sbjct: 873 RLVADQHLLAYHDRSDGGLLVTLAEMAFAGHCGVTVDIQSLGND---------------- 916 Query: 956 VAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIEFM 1015 L ALF+EELGAVIQV AEQ++DV +L + L C H +G+ D + Sbjct: 917 --------ALAALFNEELGAVIQVRAEQRADVEKLLADHGLANCVHYLGRAVAGDTFDIR 968 Query: 1016 RDAKNIYSQPRAELHRVW 1033 +YS+ R+ L R+W Sbjct: 969 SGTDVVYSEKRSTL-RLW 985 >NMB1996_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nme Neisseria meningitidis MC58 Length = 1001 Score = 1128 bits (2917), Expect = 0.0, Method: Compositional matrix adjust. Identities = 592/1025 (57%), Positives = 724/1025 (70%), Gaps = 37/1025 (3%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLL-- 58 +L L G ALS FR ++LL + A+ +S + +FV + +AL +L LL Sbjct: 4 VLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFVGSEKALDAATVEKLQALLAA 63 Query: 59 -TYGDPFNGSDDGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTG 117 + + F+V PRLGTISPWASKAT+I NCG+A I R+ERG+ ++ Sbjct: 64 QSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAVWLE---- 119 Query: 118 LLGGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAAL 177 +LN+ AALLHDRMTE+VL D Q AS LF L+++ VDVLGGG+ AL Sbjct: 120 -----GRLNDEQKQQWAALLHDRMTESVLPDFQTASKLFHHLESETFSGVDVLGGGKEAL 174 Query: 178 ERANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQ 237 +ANTE+GLALS DEIDYLVE + QRNP+DVELMMFAQANSEHCRHKIFNAD+ ++G+ Sbjct: 175 VKANTEMGLALSADEIDYLVENYQALQRNPSDVELMMFAQANSEHCRHKIFNADFILNGE 234 Query: 238 KQDKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNVYEASEELTHI 297 KQ KSLFGMI++TH P+GTVVAY DNSS+IEGA + RFY A + Y EE THI Sbjct: 235 KQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKIERFYPNAA-ENQGYRFHEEDTHI 293 Query: 298 LMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPW 357 +MKVETHNHPTAI+PF GA+TGAGGEIRDEGATG+GS+PKAGLTGFTVSNL + QPW Sbjct: 294 IMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPDLKQPW 353 Query: 358 ENARDVAQPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRT 417 E YGKPE I+SPL IMI+GP+GGAAFNNEFGRPNL GYFRT Sbjct: 354 EQD------------------YGKPEHISSPLDIMIEGPIGGAAFNNEFGRPNLLGYFRT 395 Query: 418 YEQNVGGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAASS 477 +E+ GQV GYHKPIMIAGG+G+I A+ T K+++P G+LLIQLGGPGM IG+GGGAASS Sbjct: 396 FEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAASS 455 Query: 478 MATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFPEI 537 M TG N A LDF+SVQRGNPE+ERRAQEVI+ CW LG NPI SIHDVGAGGLSNAFPE+ Sbjct: 456 MDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGGKNPIISIHDVGAGGLSNAFPEL 515 Query: 538 TNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAPFA 597 NDA+RGA+F LR+VPLEE GL P +IW NESQERYVL+IL + L+ F+ +CERER PFA Sbjct: 516 VNDARRGAVFKLREVPLEEHGLNPLQIWCNESQERYVLSILEKDLDAFRAICERERCPFA 575 Query: 598 VVGTATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDLVE 657 VVGTAT++ LKV D N+PVD+P++VLLGK PK R V P +D+ E Sbjct: 576 VVGTATDDGHLKVRDDLFANNPVDLPLNVLLGKLPKTTRTDKTVAPSKKPFHAGDIDITE 635 Query: 658 VAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGEAM 717 A RVLRLPAVA K+FLITIGDRSVG +T RDQMVG +Q PVAD AVT MG YRGEAM Sbjct: 636 AAYRVLRLPAVAAKNFLITIGDRSVGGLTHRDQMVGKYQTPVADCAVTMMGFNTYRGEAM 695 Query: 718 AMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAALFD 777 +MGE+ +A+ DAPASGRM VGEAITNIAA I +IG+IKLSANWMAACG G+D L+ Sbjct: 696 SMGEKPTVALFDAPASGRMCVGEAITNIAAVNIGDIGNIKLSANWMAACGNEGEDEKLYR 755 Query: 778 TVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRRVL 837 TV+AV + C AL +SIPVGKDSLSM++ W D E KSV SP+SLI+S FAPV DVR+ + Sbjct: 756 TVEAVS-KACQALDLSIPVGKDSLSMKTVWQDGEEKKSVVSPLSLIISAFAPVKDVRKTV 814 Query: 838 TPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQQL 897 TP+L K+ ++VL+ +DLG GK RMG SA QV + + PD+D LKAF++ IQQL Sbjct: 815 TPEL-KNVEDSVLLFVDLGFGKARMGGSAFGQVYNNMSGDAPDLDDTGRLKAFYSVIQQL 873 Query: 898 NTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDIL---TMEGEHAADWGDSKNWTT 954 E++LLAYHDRSDGGL+A L EMAFAG G+ ++L++L T H A + Sbjct: 874 VAENKLLAYHDRSDGGLFAVLVEMAFAGRCGLDIDLNLLLAQTFITNHTALSQSLRTEEV 933 Query: 955 QVAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIEF 1014 + E R LF+EELGAVIQV + +D++N+ L IG D + + Sbjct: 934 KALAEWQETIARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTL-I 992 Query: 1015 MRDAK 1019 +RD + Sbjct: 993 IRDGQ 997 >ECs3423_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Ecs Escherichia coli O157:H7 Length = 985 Score = 1086 bits (2808), Expect = 0.0, Method: Compositional matrix adjust. Identities = 560/1038 (53%), Positives = 705/1038 (67%), Gaps = 60/1038 (5%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTY 60 M IL GS ALSAFR +LL + QA + + Y+HF D L ++ A+L LL Y Sbjct: 2 MEILRGSPALSAFRINKLLARFQAARLPVHNIYAEYVHFADLNAPLNDDEHAQLERLLKY 61 Query: 61 GDPF-NGSDDGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLL 119 G + + G+ +V PR GTISPW+SKATDI NCG+ ++R+ERG+ + ++ T Sbjct: 62 GPALASHAPQGKLLLVTPRPGTISPWSSKATDIAHNCGLQQVNRLERGVAYYIEAGT--- 118 Query: 120 GGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAALER 179 L V A LHDRM ETV A LF+ Q P+ SVD+LG GR AL Sbjct: 119 -----LTNEQWQQVTAELHDRMMETVFFALDDAEQLFAHHQPTPVTSVDLLGQGRQALID 173 Query: 180 ANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQKQ 239 AN LGLAL++DEIDYL +AFTK RNP D+EL MFAQANSEHCRHKIFNADW IDG++Q Sbjct: 174 ANLRLGLALAEDEIDYLQDAFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGEQQ 233 Query: 240 DKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNVYEASEELTHILM 299 KSLF MIKNT + P + AY DN++++EG+ V R++ + Y+ +E HILM Sbjct: 234 PKSLFKMIKNTFETTPDHVLSAYKDNAAVMEGSEVGRYFADH--ETGRYDFHQEPAHILM 291 Query: 300 KVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPWEN 359 KVETHNHPTAISP+PGA+TG+GGEIRDEGATGRG+KPKAGL GF+VSNL + QPWE Sbjct: 292 KVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEE 351 Query: 360 ARDVAQPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYE 419 +GKPERI + L IM +GPLGGAAFNNEFGRP L GYFRTYE Sbjct: 352 D------------------FGKPERIVTALDIMTEGPLGGAAFNNEFGRPALNGYFRTYE 393 Query: 420 QNV----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAA 475 + V G ++ GYHKPIM+AGG+GNI A H +K ++ VG+ L+ LGGP M IG+GGGAA Sbjct: 394 EKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEINVGAKLVVLGGPAMNIGLGGGAA 453 Query: 476 SSMATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFP 535 SSMA+G + ADLDF SVQR NPEMERR QEVI+ CW LGD NPI IHDVGAGGLSNA P Sbjct: 454 SSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLSNAMP 513 Query: 536 EITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAP 595 E+ +D RG F+LR + +E G++P EIW NESQERYVLA+ + L LF LC+RERAP Sbjct: 514 ELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELCKRERAP 573 Query: 596 FAVVGTATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDL 655 +AV+G ATEE L + D +N P+D+P+DVLLGK PKM RDV ++ + + G+ + Sbjct: 574 YAVIGEATEELHLSLHDRHFDNQPIDLPLDVLLGKTPKMTRDVQTLKAKGDALVREGITI 633 Query: 656 VEVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGE 715 + +RVL LP VA+K+FL+TIGDRSV M RDQMVGPWQVPVA+ AVT L+ Y GE Sbjct: 634 ADAVKRVLHLPTVAEKTFLVTIGDRSVTGMVARDQMVGPWQVPVANCAVTTASLDSYYGE 693 Query: 716 AMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAAL 775 AMA+GER P+A++D AS R+AVGEA+TNIAA I +I IKLSANWMAA G PG+DA L Sbjct: 694 AMAIGERAPVALLDFAASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGL 753 Query: 776 FDTVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRR 835 ++ VKAVG ELCPALG++IPVGKDS+SM++ W + + +TSP+SL++S FA V DVR Sbjct: 754 YEAVKAVGEELCPALGLTIPVGKDSMSMKTRWQEGNEEREMTSPLSLVISAFARVEDVRH 813 Query: 836 VLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQ 895 +TPQL + + L+LIDLG+G N +GA+AL QV +Q+G++ DV LK F++AIQ Sbjct: 814 TITPQLSTE--DNALLLIDLGKGNNALGATALAQVYRQLGDKPADVRDVAQLKGFYDAIQ 871 Query: 896 QLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEGEHAADWGDSKNWTTQ 955 L + +LLAYHDRSDGGL TLAEMAFAGH GI + DI T+ GD + Sbjct: 872 ALVAQRKLLAYHDRSDGGLLVTLAEMAFAGHCGI--DADIATL--------GDDR----- 916 Query: 956 VAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIEFM 1015 L ALF+EELGAVIQV A + V +VL + L C H +G+ D Sbjct: 917 ---------LAALFNEELGAVIQVRAADREAVESVLAQHGLADCVHYVGQAVSGDRFVIT 967 Query: 1016 RDAKNIYSQPRAELHRVW 1033 + + ++S+ R L RVW Sbjct: 968 ANGQTVFSESRTTL-RVW 984 >STM2565_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Sty Salmonella typhimurium LT2 Length = 985 Score = 1084 bits (2804), Expect = 0.0, Method: Compositional matrix adjust. Identities = 558/1038 (53%), Positives = 699/1038 (67%), Gaps = 60/1038 (5%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTY 60 M IL GS ALSAFR +LL + QA + + + Y+HF D L ++A+L LL Y Sbjct: 2 MEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFADLNAPLNDSEQAQLTRLLQY 61 Query: 61 GDPFNG-SDDGETFVVIPRLGTISPWASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLL 119 G + + G+ +V PR GTISPW+SKATDI NCG+ + R+ERG+ + ++ T Sbjct: 62 GPALSSHTPAGKLLLVTPRPGTISPWSSKATDIAHNCGLQQVDRLERGVAYYIEAST--- 118 Query: 120 GGAKKLNEASLPGVAALLHDRMTETVLRDPQQASALFSELQAKPLESVDVLGGGRAALER 179 L VAA LHDRM ETV A LF Q P+ SVD+LG GR AL Sbjct: 119 -----LTAEQWRQVAAELHDRMMETVFSSLTDAEKLFIHHQPAPVSSVDLLGEGRQALID 173 Query: 180 ANTELGLALSDDEIDYLVEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQKQ 239 AN LGLAL++DEIDYL EAFTK RNP D+EL MFAQANSEHCRHKIFNADW IDG+ Q Sbjct: 174 ANLRLGLALAEDEIDYLQEAFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQ 233 Query: 240 DKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGAIKGNVYEASEELTHILM 299 KSLF MIKNT + P + AY DN++++EG+ V R++ Y+ +E HILM Sbjct: 234 PKSLFKMIKNTFETTPDYVLSAYKDNAAVMEGSAVGRYFADH--NTGRYDFHQEPAHILM 291 Query: 300 KVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPWEN 359 KVETHNHPTAISP+PGA+TG+GGEIRDEGATGRG+KPKAGL GF+VSNL + QPWE Sbjct: 292 KVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEE 351 Query: 360 ARDVAQPVAERDAHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYE 419 +GKPERI + L IM +GPLGGAAFNNEFGRP L GYFRTYE Sbjct: 352 D------------------FGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTYE 393 Query: 420 QNV----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAA 475 + V G ++ GYHKPIM+AGG+GNI A H +K ++ VG+ LI LGGP M IG+GGGAA Sbjct: 394 EKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGPAMNIGLGGGAA 453 Query: 476 SSMATGVNAADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFP 535 SSMA+G + ADLDF SVQR NPEMERR QEVI+ CW LGD NPI IHDVGAGGLSNA P Sbjct: 454 SSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLSNAMP 513 Query: 536 EITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAP 595 E+ +D RG F+LR + +E G++P EIW NESQERYVLA+ + L LF LC+RERAP Sbjct: 514 ELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELCKRERAP 573 Query: 596 FAVVGTATEERQLKVIDPEHNNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDL 655 +AV+G ATEE+ L + D +N P+D+P+DVLLGK PKM RDV ++ + ++ + + Sbjct: 574 YAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPKMTRDVQTLKAKGDALNRADITI 633 Query: 656 VEVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGE 715 + +RVL LP VA+K+FL+TIGDR+V M RDQMVGPWQVPVAD AVT L+ Y GE Sbjct: 634 ADAVKRVLHLPTVAEKTFLVTIGDRTVTGMVARDQMVGPWQVPVADCAVTTASLDSYYGE 693 Query: 716 AMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAAL 775 AM++GER P+A++D AS R+AVGEA+TNIAA I +I IKLSANWMAA G PG+DA L Sbjct: 694 AMSIGERAPVALLDFAASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGL 753 Query: 776 FDTVKAVGMELCPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRR 835 +D VKAVG ELCP LG++IPVGKDS+SM++ W + + +TSP+SL++S FA V DVR Sbjct: 754 YDAVKAVGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVEDVRH 813 Query: 836 VLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQ 895 LTPQL + + L+LIDLG+G N +GA+AL QV +Q+G++ DV LK F++A+Q Sbjct: 814 TLTPQLSTE--DNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRDVAQLKGFYDAMQ 871 Query: 896 QLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEGEHAADWGDSKNWTTQ 955 L +LLA+HDRSDGGL TLAEMAFAGH G+ V DI + +H Sbjct: 872 ALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQV--DIAALGDDH------------- 916 Query: 956 VAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIEFM 1015 L ALF+EELG VIQV AE + V +L Y L C H +G+ D Sbjct: 917 ---------LAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQALAGDRFVIT 967 Query: 1016 RDAKNIYSQPRAELHRVW 1033 + + ++S+ R L RVW Sbjct: 968 ANDQTVFSESRTTL-RVW 984