BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0026.0005.p (300 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2225 [GER] COG0697 Permeases of the drug/metabolite transport... 258 1e-68 NMB1593 [GER] COG0697 Permeases of the drug/metabolite transport... 159 1e-38 NMA1785 [GER] COG0697 Permeases of the drug/metabolite transport... 158 1e-38 YPO1348 [GER] COG0697 Permeases of the drug/metabolite transport... 106 8e-23 PA2628 [GER] COG0697 Permeases of the drug/metabolite transporte... 100 4e-21 SMc02371 [GER] COG0697 Permeases of the drug/metabolite transpor... 99 2e-20 AGc1807 [GER] COG0697 Permeases of the drug/metabolite transport... 82 1e-15 mlr7703 [GER] COG0697 Permeases of the drug/metabolite transport... 82 1e-15 BMEI1323 [GER] COG0697 Permeases of the drug/metabolite transpor... 80 5e-15 PA4834 [GER] COG0697 Permeases of the drug/metabolite transporte... 78 2e-14 >RSc2225 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 324 Score = 258 bits (660), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 143/287 (49%), Positives = 194/287 (67%), Gaps = 5/287 (1%) Query: 1 MLVASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRDHLI 60 M++A+F FS MGVCVKLAS +YST EIV R LIG++++ A++ G RTP H+ Sbjct: 23 MVLAAFAFSAMGVCVKLASAHYSTGEIVFYRSLIGVALMGAVLYHTGAGVRTPHFASHIK 82 Query: 61 RGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNK-KFEWGLAATV 119 R GV SL LWF S SLLP+ATA TLNYMS +WIA+++ A A G + + + Sbjct: 83 RSVFGVTSLLLWFSSISLLPLATAMTLNYMSPVWIALIIGAGATLAGKAGGADRKMVTAI 142 Query: 120 VLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSLT 179 ++SF+GV L++PS+ Q+ GG I L SGV +AL Y++VR+LG LGE E R+VFYFSL Sbjct: 143 LMSFVGVICLLQPSVGPSQMTGGMIGLVSGVFTALAYVEVRQLGDLGENEARIVFYFSLV 202 Query: 180 GVLAGLVGSVATGRVPLWHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTANLQY 239 +AG + G H+H+WQ A L++ +GL ATL Q AMTRAY+ GNTL+TANLQY Sbjct: 203 SSIAGGAWMLIAGA----HAHTWQSAWLLVAVGLLATLGQTAMTRAYKRGNTLLTANLQY 258 Query: 240 TGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHRSSQIA 286 TGIVF+S +G+L+W+D L W+GM +I+ SG++ T R S +A Sbjct: 259 TGIVFASGWGMLLWHDHLNALSWMGMALIIGSGIVTTVMRARQSGVA 305 >NMB1593 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Nme Neisseria meningitidis MC58 Length = 287 Score = 159 bits (401), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 10/278 (3%) Query: 1 MLVASFLFSIMGVCVKLASDYYS--TSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRDH 58 MLVA+ F+IM V +K AS ++ + E+V R L + A +R TFRTP ++H Sbjct: 1 MLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKNH 60 Query: 59 LIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAAT 118 L R VG ++ L FY+ + LP+AT TL+Y SSI++AV F ++ A Sbjct: 61 LNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQAV 116 Query: 119 VVLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSL 178 ++L F GV LL+ PS + Q L G +S YL+VR+L L GEP +RVVFY S+ Sbjct: 117 LLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLSV 176 Query: 179 TGVLAGLVGSVATGRVPLWHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTANLQ 238 TGV V + TG WH+ S+ A + IG++A +AQ++MTRAY++G+ A+L Sbjct: 177 TGVAMSSVWATLTG----WHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASLS 232 Query: 239 YTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLAT 276 Y +VFS+L + W LGM +I+ SG+L++ Sbjct: 233 YMTVVFSALSAAFFLGEELFWQEILGMCIIILSGILSS 270 >NMA1785 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily NmA Neisseria meningitidis Z2491 Length = 300 Score = 158 bits (400), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 10/278 (3%) Query: 1 MLVASFLFSIMGVCVKLASDYYS--TSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRDH 58 MLVA+ F+IM V +K AS ++ + E+V R L + A +R TFRTP ++H Sbjct: 14 MLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKNH 73 Query: 59 LIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAAT 118 L R VG ++ L FY+ + LP+AT TL+Y SSI++AV F ++ A Sbjct: 74 LNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQAV 129 Query: 119 VVLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSL 178 ++L F GV LL+ PS + Q L G +S YL+VR+L L GEP +RVVFY S+ Sbjct: 130 LLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLSV 189 Query: 179 TGVLAGLVGSVATGRVPLWHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTANLQ 238 TGV V + TG WH+ S+ A + IG++A +AQ++MTRAY++G+ A+L Sbjct: 190 TGVAMSSVWATLTG----WHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASLS 245 Query: 239 YTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLAT 276 Y +VFS+L + W LGM +I+ SG+L++ Sbjct: 246 YMTVVFSALSAAFFLAEELFWQEILGMCIIILSGILSS 283 >YPO1348 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ype Yersinia pestis Length = 281 Score = 106 bits (264), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 18/274 (6%) Query: 2 LVASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRDHLIR 61 ++AS +FS+M V VK +D T EIV R IG +I L+ RG F ++R Sbjct: 9 ILASLIFSVMNVLVKTIADEIPTGEIVFFRSSIGCLLIGLLMYQRGIAFSREDRPLLVLR 68 Query: 62 GGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAATVVL 121 G +G + L +FYS + L +A A+ L Y+S + V+ ++ +A +V+ Sbjct: 69 GTMGALYLICYFYSIAHLTLADASMLAYLSPFFSIVLSLLVL----RERVNATMAFWLVM 124 Query: 122 SFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSLTGV 181 IG +L+RP + L + + S V +A+ YL V KL Y +VFYF Sbjct: 125 VIIGAIILIRPWNFSTYTLASLVGVMSAVFAAIAYLSVNKLTK-RHHNYEIVFYFLFITT 183 Query: 182 LAGLVGSVATGRVPL-WHSHSWQGA---ALVIMIGLTATLAQIAMTRAYRLGNTLVTANL 237 L +PL WH+ W ++I I L + L Q+ +T+A+ N +V + + Sbjct: 184 LIS---------IPLMWHNFVWPSGYQFGILIAIALVSLLGQVVLTQAFSSDNLIVVSVV 234 Query: 238 QYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILAS 271 +Y GIVF+ +G L W++ P L +G G+++ S Sbjct: 235 RYIGIVFNITWGWLFWDEVPLMLSLMGGGLVVVS 268 >PA2628 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 100 bits (249), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 85/289 (29%), Positives = 143/289 (49%), Gaps = 24/289 (8%) Query: 3 VASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRG-GTFRTPFPRDHLIR 61 +++ F++MG ++ AS + +V R L+G+ L RG G RT P HL+R Sbjct: 23 LSALFFALMGGLIREASSTVNNETVVFFRNLVGVLFFLPLALTRGIGPLRTRRPLSHLLR 82 Query: 62 GGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAATVVL 121 G+ ++ +FY+ + LP+ A +Y + ++ ++ A W + AT+V Sbjct: 83 TTYGLGGMYCYFYALAHLPLTDAMLFSYAAPVFTPLI---AHLWIKEPLTRRMMVATLV- 138 Query: 122 SFIGVALLMRPS---LDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSL 178 F+GV L+ RPS + L+G A SL ++A ++ +R++ EP YR+VFYF+L Sbjct: 139 GFLGVLLVARPSGAVVAPIALVGIASSL----MAACAFVSIREMSD-SEPAYRIVFYFAL 193 Query: 179 TGVLAGLVGSVATGRVPL---WHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTA 235 G L VPL W + Q L++ GL A+L Q+ M++AY L + V Sbjct: 194 FGTL--------FSAVPLAWAWQPLNGQELLLLLGAGLFASLGQLTMSQAYALASPGVIG 245 Query: 236 NLQYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHRSSQ 284 + Y IVF+ + L W++ P LG +I A+ L+ N + + Sbjct: 246 PIAYMAIVFAGVIAWLRWDELPSHTSLLGAALIFAASLIPLLGNRPAER 294 >SMc02371 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 312 Score = 98.6 bits (244), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 79/284 (27%), Positives = 126/284 (44%), Gaps = 17/284 (5%) Query: 7 LFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRGG---TFRTPFPRDHLIRGG 63 +F M C+K A D T +I R + I + RG FRT HL+RG Sbjct: 21 VFVCMSTCIKAAGDDIPTGQITFYRSAFAMVPILGFLACRGALRDAFRTTDITGHLVRGF 80 Query: 64 VGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEW-----GLAAT 118 VG++++ FY LP+ A + Y + +AV A + + + W GLA Sbjct: 81 VGILAMSCGFYGLVHLPLPEAIAIGYAMPL-LAVAFAAIFLGEIVRLYRWSAVFVGLAGV 139 Query: 119 VVLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSL 178 ++++ + L + + +G L S L A + VRKL + E + +V YFSL Sbjct: 140 FIITWPRLTLFNEGGFGSAEAMGAVAVLLSAALGATAMVLVRKL-VQKERTHTIVLYFSL 198 Query: 179 TGVLAGLVGSVATGRVPL-WHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTANL 237 + V S+AT +P W SWQ L+ + G + QI +T +YR + A Sbjct: 199 SAA----VFSLAT--LPFGWSELSWQAFVLLTIAGFCGGVGQILLTESYRHADMSTIAPF 252 Query: 238 QYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHR 281 +YT IV + G ++ D P G +++ +G+ Y HR Sbjct: 253 EYTSIVLGIVIGYFLFGDVPTATMLAGTAIVVGAGIFIIYREHR 296 >AGc1807 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 311 Score = 82.4 bits (202), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 76/289 (26%), Positives = 129/289 (44%), Gaps = 18/289 (6%) Query: 2 LVASFLFSIMGVCVKLASDYYSTSEIVLCR---GLIGISVIAALVRVRGGTFRTPFPRDH 58 L++ F +M C+K A D +I R ++ I V A + T H Sbjct: 16 LISVGFFLVMQTCIKAAGDV-PAGQITFFRSAFAILPIVVYLAWLHALASALHTNNLLGH 74 Query: 59 LIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEW----- 113 RG +G++S+ FY ++LP+ + Y S + +AV+ A + + + W Sbjct: 75 FKRGFLGILSMVCGFYGLTMLPLPEFIAIGYASPL-LAVVFAAFILREKVRIYRWSAVFV 133 Query: 114 GLAATVVLSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVV 173 G+ +V+ + + LL A + LG L L L +QVR+L + E +V Sbjct: 134 GMMGVLVILWPKMTLLREGGFAAGEGLGAIAVLCGAALGGLAMIQVRQL-VETEKTPTIV 192 Query: 174 FYFSLTGVLAGLVGSVATGRVPL-WHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTL 232 YFSLT L L+ VPL W + + A L+I G+ +AQI +T +YR Sbjct: 193 LYFSLTATLLSLIS------VPLGWSALTMTQAMLLITSGICGGVAQILLTESYRHAEVS 246 Query: 233 VTANLQYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHR 281 V A +Y+ IVF +++ D P +G +++ +G+ + H+ Sbjct: 247 VIAPFEYSSIVFGIAVSYILFGDIPTITMLIGTAIVILAGIFIIFREHQ 295 >mlr7703 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 347 Score = 82.4 bits (202), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 82/294 (27%), Positives = 139/294 (47%), Gaps = 27/294 (9%) Query: 2 LVASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRGG---TFRTPFPRDH 58 +V+ +F M C+K A D +IV R I I A + ++G F T P +H Sbjct: 51 IVSVAVFVGMQTCIKAAGDV-PAGQIVFFRSFFAIFPIIAFLALKGQLPTAFVTKRPFNH 109 Query: 59 LIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWW-QGNKKFEWGLAA 117 + RG VGV ++ L F++ + LP+ A TLNY + + V F++ + + + + W + Sbjct: 110 VARGVVGVGAMGLGFFALTRLPLPEAITLNYAQPLLVVV--FSSVFLGESIRVYRW---S 164 Query: 118 TVVLSFIGVALLMRPSL---------DADQLLGGAISLFSGVLSALVYLQVRKLGLLGEP 168 V + IGV ++ P L D ++LG +L + +SA+ L VR L + E Sbjct: 165 AVAVGLIGVLIISWPELTLLNSDEGLDDQEVLGVMAALVAAAISAVAMLLVRNL-VQTEK 223 Query: 169 EYRVVFYFSLTGVLAGLVGSVATGRVPL-WHSHSWQGAALVIMIGLTATLAQIAMTRAYR 227 +V +FS T + L+ +P W S + AAL++M G L QI MT AYR Sbjct: 224 TATIVLWFSSTASVLSLL------TLPFGWQSLTPVQAALLVMAGFCGGLGQILMTSAYR 277 Query: 228 LGNTLVTANLQYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHR 281 V A +YT ++ + G ++ D +G +++A+G+ + + Sbjct: 278 HAEASVVAPFEYTSMILGVVVGYFIFGDVTSLNTLIGGAIVVAAGVFIIWRERQ 331 >BMEI1323 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bme Brucella melitensis Length = 319 Score = 80.5 bits (197), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 71/257 (27%), Positives = 126/257 (49%), Gaps = 19/257 (7%) Query: 47 GGTFRTPFPRDHLIRGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQ 106 GG F T H RG VGV S+ + F++ + LP+ A +NY S + I V+L AA + Sbjct: 73 GGVFSTRHGFSHFWRGLVGVCSMSMSFFALTKLPLPEAIAINYASPL-ITVILGAAILHE 131 Query: 107 GNKKFEWGLAATVVLSFIGVALLMRP--------SLDADQLLGGAISLFSGVLSALVYLQ 158 + + W + V++ GV +++ P S+ D+ +G +L + V+SA+ + Sbjct: 132 VVRFYRW---SAVLIGLFGVMIIIWPRLTLFSAGSVGRDEAVGALAALGAAVMSAVAMML 188 Query: 159 VRKLGLLGEPEYRVVFYFSLTGVLAGLVGSVATGRVPLWHSHSWQGAALVIMIGLTATLA 218 VR+L + E +V YFS++ + LV S+ G W +W A+++ G + Sbjct: 189 VRRL-VQTERTPTIVIYFSISASVIALV-SLPFG----WVVPNWSQLAMLVGAGFAGGIG 242 Query: 219 QIAMTRAYRLGNTLVTANLQYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYH 278 QI +T YR A +YT ++ + G +++ D P + +G G+++A+G Y Sbjct: 243 QILLTECYRHAPMSTIAPFEYTSMLLGLVIGFMLFGDIPTFEMLIGSGIVMAAGGFIIYR 302 Query: 279 NHRSSQIAAR-NLPKVD 294 H+ S + N P+ Sbjct: 303 EHQLSLAPHKVNAPQAQ 319 >PA4834 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 284 Score = 78.2 bits (191), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 77/285 (27%), Positives = 139/285 (48%), Gaps = 20/285 (7%) Query: 2 LVASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRDHLIR 61 ++ASF FS+M VK AS +EIV R IG +I L+R G L+R Sbjct: 14 VLASFTFSVMNALVKEASATLPAAEIVFFRSAIGTLLIYLLMRQAGVALSRQGVPMLLVR 73 Query: 62 GGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAATVVL 121 G +G + L +FY+ + +P+A A+ L +MS + V+LF+A + ++ + +++ Sbjct: 74 GVMGALYLVCYFYAIAHIPLADASILAHMSPFF--VILFSALFL--GERIPRAVYWLLLV 129 Query: 122 SFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSLTGV 181 +G ++++P + + + L S V +A + +R+L Y +VFYF Sbjct: 130 VVLGALMIVKPFSYSSYSVYAVVGLLSAVFAAGASVAIRQLSA-RHHTYEIVFYFLAVAT 188 Query: 182 LAGLVGSVATGRVPL-WHSH----SWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTAN 236 L +PL W+ + + L++ IG+ + L Q+ +TRA+ + + A Sbjct: 189 LVA---------IPLMWNDFVVPATLREWGLLLAIGVVSLLGQVFLTRAFSHESATIVAV 239 Query: 237 LQYTGIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHR 281 +Y GIVF++ +G L W++ P L G GV++ +A + Sbjct: 240 TRYIGIVFNAGWGWLFWSEVPDALTIAG-GVLIVVACIALSRTKK 283