BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0477.p (310 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1953 [GER] COG0697 Permeases of the drug/metabolite transport... 185 1e-46 BH0390 [GER] COG0697 Permeases of the drug/metabolite transporte... 150 4e-36 BS_yetK [GER] COG0697 Permeases of the drug/metabolite transport... 122 9e-28 RSp0685 [GER] COG0697 Permeases of the drug/metabolite transport... 87 4e-17 SMc00428 [GER] COG0697 Permeases of the drug/metabolite transpor... 80 5e-15 AGc4446 [GER] COG0697 Permeases of the drug/metabolite transport... 66 9e-11 mlr8275 [GER] COG0697 Permeases of the drug/metabolite transport... 65 1e-10 lin0496 [GER] COG0697 Permeases of the drug/metabolite transport... 61 3e-09 PA1060 [GER] COG0697 Permeases of the drug/metabolite transporte... 61 3e-09 >RSc1953 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 336 Score = 185 bits (469), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 121/290 (41%), Positives = 177/290 (61%), Gaps = 4/290 (1%) Query: 14 LILSMSLVGAYVALTKPLAAMLPVFLLAWLRFGIGAVAMLRWLKKPASEQPLSTQSRWL- 72 LI +M+LVG+ V K + A++PV L A LRF I M W + S T+ W Sbjct: 25 LIAAMALVGSNVGFGKSIVAVMPVMLFALLRFVIAVACMAPWYRP--SRMRRVTRGEWTN 82 Query: 73 VFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSAIPAVVAVMSWIFLKEKISLRVWGAVA 132 +FL++ G F FTL M+ GV +T+A++AG+I S IPA VA++SW+ L+EK S R +V Sbjct: 83 LFLQALFGTFGFTLLMLNGVRLTSALAAGIITSTIPATVALLSWLVLREKPSGRTLVSVT 142 Query: 133 CGAVGIGLLSLAKDGH-GASAASGGQYAWLGNGLVFCAVLCEAAYAAIGKKLTAVLTPKR 191 G+ LL+ + G +A + A LGN LV AVLCE+ Y + ++LT L Sbjct: 143 LAVAGVALLNADRGGEFAGAAPADAARALLGNALVMGAVLCESVYVVLSRRLTQTLPAIE 202 Query: 192 ISAVINLWGLLLMTPMGVYTALHFDFGAVPANMWLLLLFYGLAASVWTVWLWMTGLKVVP 251 I A +L G LLM P+G+ L FD +VP ++W L+++Y L+AS+++ WLWM G++ VP Sbjct: 203 ICAYTHLIGALLMLPLGLAPLLTFDLSSVPPHIWGLVVWYALSASLFSFWLWMKGIRHVP 262 Query: 252 AARAGVFTVMLPVSAALVGVLALGESLSALQAGAFAIALAGMLLATLPGR 301 A AGVFT +LP++AA G++ALGE+ A A +AG+L+A+ P R Sbjct: 263 AHLAGVFTSVLPIAAAAYGIIALGEAPGWAHGAALACVVAGILVASWPAR 312 >BH0390 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bha Bacillus halodurans Length = 311 Score = 150 bits (379), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 100/295 (33%), Positives = 163/295 (55%), Gaps = 5/295 (1%) Query: 14 LILSMSLVGAYVALTKPLAAMLPVFLLAWLRFGIGAVAMLRWLKKPASEQPLSTQSRWLV 73 ++ +M +VG+ V K L PVFL + LRF I A+ ++ L K S + ++ Sbjct: 11 IMFAMVIVGSSVVAGKMLVESFPVFLASELRFLIAALILVPMLLKKEGIPTFSKKEVGIL 70 Query: 74 FLESFLGNFLFTLCMITGVSMTNAVSAGVIMSAIPAVVAVMSWIFLKEKIS-LRVWGAVA 132 FL++ G FLF++ M+ G+ T A+ G+IMS +PAVVA+M++I LKEK++ L + G + Sbjct: 71 FLQALSGVFLFSIFMLYGLMYTTAMEGGIIMSTLPAVVALMAFITLKEKLTRLTIIGILL 130 Query: 133 CGAVGIGLLSLAKDGHGASAASGGQYAWLGNGLVFCAVLCEAAYAAIGKKLTAVLTPKRI 192 AVG G L++ G S G LGN L+ AV+ EA + GK ++ ++P I Sbjct: 131 --AVG-GTLAINTSGT-LSDVERGVAPLLGNLLIIGAVISEALFIIFGKSISQRVSPLAI 186 Query: 193 SAVINLWGLLLMTPMGVYTALHFDFGAVPANMWLLLLFYGLAASVWTVWLWMTGLKVVPA 252 S +++++G++L P +Y A F V N WL++ ++G+ +V L G++ VPA Sbjct: 187 STMVSVFGVVLFLPFAIYEATRFPLTDVSLNDWLIIFYFGVVVTVIAFVLMYQGIEKVPA 246 Query: 253 ARAGVFTVMLPVSAALVGVLALGESLSALQAGAFAIALAGMLLATLPGRAAADKL 307 + GV T +LP+SA L+ L L ES S + LA +LL ++ ++ Sbjct: 247 STVGVLTGVLPISAVLLSALILKESFSTFHVAGMGLVLAAILLISIDSNVEKKEV 301 >BS_yetK [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 330 Score = 122 bits (307), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 92/308 (29%), Positives = 159/308 (51%), Gaps = 13/308 (4%) Query: 6 SRPMG-YGCLILSMSLVGAYVALTKPLAAMLPVFLLAWLRFGIGAVAMLRWLKKPASEQP 64 + MG Y L +M++VG+ V + K + +PVFL + LRF I +V +L L P Sbjct: 24 KKQMGAYVSLAAAMAIVGSSVVVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFP 83 Query: 65 -LSTQSRWLVFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSAIPAVVAVMSWIFLKEKI 123 L+ + +++ ++SF G FLF++C++ GV T +G++ S P ++ ++S+ L+EKI Sbjct: 84 ALTKKDVFVLLVQSFTGVFLFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKI 143 Query: 124 SLRVWGAV---ACGAVGIGLLSLAKDGHGASAASGGQYAWLGNGLVFCAVLCEAAYAAIG 180 + + CG + I L GA + G +A GN L+ AV+ EA + + Sbjct: 144 EKKTLIGILLAVCGVMAINLF-------GAGSQDGTPHALFGNMLIIAAVIGEALFTLMA 196 Query: 181 KKLTAVLTPKRISAVINLWGLLLMTPMGVYTALHFDFGAVPANMWLLLLFYGLAASVWTV 240 K L+ ++ IS ++L+G L P ++ A FD+ W +L+Y L +V Sbjct: 197 KLLSPHISALAISTFVSLFGFLFFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAF 256 Query: 241 WLWMTGLKVVPAARAGVFTVMLPVSAALVGVLALGESLSALQAGAFAIALAGMLLATLPG 300 +LW +G+ VPA +G+FT +LPVSA ++ + L E + A + G+ + T+ Sbjct: 257 YLWYSGVTKVPAGVSGIFTSVLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFV-TVIK 315 Query: 301 RAAADKLP 308 + D P Sbjct: 316 KKQPDAYP 323 >RSp0685 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 300 Score = 87.4 bits (215), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 93/313 (29%), Positives = 154/313 (49%), Gaps = 27/313 (8%) Query: 6 SRPMGYGCLILSMSLVGAYVALTKPLAAMLPVFLLAWLRFGIG-----AVAMLRWLKKPA 60 +R +GY L L+M VG+ V +K +A LP F LRF + A+ +LR + P Sbjct: 3 NRTIGYLLLSLAMMTVGSTVIASKLIAGNLPPFPATALRFAVALPFLFALVLLRGQRWPR 62 Query: 61 SEQPLSTQSRWLVFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSAIPAVVAVMSWIFLK 120 LS ++ L+ L++ G+ +T +I+G++ A AGV++ +PAV A+ S I L Sbjct: 63 ----LSGRAWGLLVLQAGAGSVGYTTLLISGLAHLPAADAGVVIGTLPAVSALFSVIVLG 118 Query: 121 EKISLRVWGAVACGAVGIGLLSLAKDGHGASAASGGQYAWLGNGLVFCAVLCEAAYAAIG 180 E+ LR+ +V +G+ +++A G G++ +G + + AV+CE+A+ + Sbjct: 119 ERPKLRLMVSVLLATIGV--MAVAWTGSGSAPLTGVLF-------ILGAVVCESAFILLN 169 Query: 181 KKLTAVLTPKRISAVINLWGLLLMTPMGV--YTALHFDFGAVPANMWLLLLFYGLAASVW 238 K++ L P + + GLL+ P V + A A+ A +W Y L +V Sbjct: 170 KRMPVPLPPLLQATAMTALGLLVSLPFAVLEFPATVPSTAAIAAVVW-----YALVPTVG 224 Query: 239 TVWLWMTGLKVVPAARAGVFTVMLPVSAALVGVLALGESLSALQA-GAFAIALAGMLLAT 297 LW G V + A FT + P++A + L L E + A QA G A+ LA +L T Sbjct: 225 GFLLWYAGAARVSGSEAATFTAVAPLTAVALAALFLNERIGATQAFGVVAVILA-ILTLT 283 Query: 298 LPGRAAADKLPLN 310 L R P++ Sbjct: 284 LSVRPRPLSRPVD 296 >SMc00428 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 298 Score = 80.5 bits (197), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 88/281 (31%), Positives = 137/281 (48%), Gaps = 22/281 (7%) Query: 9 MGYGCLILSMSLVGAYVALTKPLAAMLPVFLLAWLRFGIGAVAMLRWLKKPASEQPLSTQ 68 GY L L+M LVG+ V +K +AA LP F LRF I L ++ + P + Sbjct: 6 QGYVFLSLAMVLVGSTVIASKIIAAGLPPFTATALRFAIAFPLFLGLMRATGASWPKLPK 65 Query: 69 SRWLVFL-ESFLGNFLFTLCMITGVSMTNAVSAGVIMSAIPAVVAVMSWIFLKEKISLRV 127 S WLV L ++ G+ +T +I+G+ +T+A AGVI+ +P V A ++ + L E+ V Sbjct: 66 SDWLVLLFQAGAGSVGYTTLLISGLKLTSAADAGVIIGTLPVVSAAIAIMVLGERPHRSV 125 Query: 128 WGAVACGAVGIGLLSLAKDGHGASAASGGQYAWLGNGLVFCAVLCEAAYAAIGKKLTAVL 187 A A G+ + D + A ++ G+ L+F AV+CE + + K+++ + Sbjct: 126 LAAACLAAAGVLAIVFRPDANAA-------HSLAGSALIFGAVICEGLFILLNKRVSVAI 178 Query: 188 TPKRISAVINLWGLLLMTPMGVYTALHFDFGAVPA------NMWLLLLFYGLAASVWTVW 241 P +SA LMT G AL F +P+ + +Y L +V Sbjct: 179 PPLGLSA--------LMTGFGGAIALPFALAELPSMGATGVPALAAVAYYALVPTVGGFV 230 Query: 242 LWMTGLKVVPAARAGVFTVMLPVSAALVGVLALGESLSALQ 282 LW GL+ V A VFT + PVSA L+ LGE+++A Q Sbjct: 231 LWYAGLQKVSGTEASVFTALAPVSALLLAAAVLGETITANQ 271 >AGc4446 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 302 Score = 66.2 bits (160), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 125/254 (49%), Gaps = 13/254 (5%) Query: 49 AVAMLRWLKKPA--SEQPLSTQSRWLVFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSA 106 AVA++ + P + P+ Q F+ +G F + + T + T+A++A VI + Sbjct: 50 AVAIIFAISVPQLIKDWPVVKQRLPYFFVLGSVGYTAFNVFLYTALQHTSAINAAVIQAG 109 Query: 107 IPAVVAVMSWIFLKEKISLRVWGAVA--CGAV-GIGLLSLAKDGHGASAASGGQYAWLGN 163 IP V+ V++++ + ++ ++G +A C + G+ LL+ HG + +G+ Sbjct: 110 IPMVIFVLNFVLFRTRV---LFGQIAGFCLTISGVALLA----SHGDPLSLLQLEMNVGD 162 Query: 164 GLVFCAVLCEAAYAAIGKKLTAVLTPKRISAVINLWGLLLMTPMGVYTALHFDFGAVPAN 223 ++ AVL A Y I + AV + + A+ + LL P+ + Sbjct: 163 AVMLLAVLVYAIYTVILRWKPAV-DWRTLMAIPAFFALLTSVPLVFFEMSRESLIWPDQK 221 Query: 224 MWLLLLFYGLAASVWTVWLWMTGLKVVPAARAGVFTVMLPVSAALVGVLALGESLSALQA 283 W+L+++ G+ AS+ L++ G++ + A RAG+F ++PV L+ V L E+L Q Sbjct: 222 GWMLVVYAGIFASLIAQILYIKGVEQIGANRAGLFINLVPVFGTLLSVFVLSETLHTYQI 281 Query: 284 GAFAIALAGMLLAT 297 A +ALAG+ +A Sbjct: 282 AALFMALAGIAVAE 295 >mlr8275 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 297 Score = 65.5 bits (158), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 85/279 (30%), Positives = 128/279 (45%), Gaps = 18/279 (6%) Query: 23 AYVALTKPLAAMLPVFLLAWLRFGIGAV--AMLRWLKKPASEQPLSTQSRWLVFLESFLG 80 A+ A+ LAA P+ L A LRF I AV A+ +K+PA + W + + Sbjct: 32 AFPAIRAGLAAFGPLELGA-LRFAIAAVPAAIFLAVKRPALPR---LDEVWRLVFGGAIF 87 Query: 81 NFLFTLCMITGVSMTNAVSAGVIMSAIPAVVAVMSWIFLKEKISLRVWGAVACGAVGIGL 140 L+T + G +A +AG I++ P A+M+ L E+ S W A GIG+ Sbjct: 88 VALYTAMLNFGELTVSAGAAGFIINVSPIFTAIMAMALLGERFSRWAWAGTAISFAGIGV 147 Query: 141 LSLAKDGHGASAASGGQYAWLGNGLVFCAVLCEAAYAAIGKKLTAVLTPKRISAVINLWG 200 +++A DG G +G LV + LC A + K L A P ISA + G Sbjct: 148 IAMA-DGQGLHFNAGAL-------LVLGSALCSAVNTIVQKPLFARHHPLTISASNMVLG 199 Query: 201 LLLMTPMGVYTALHFDFGAVPANMWL-LLLFYGLAASVWTVWLWMTGLKVVPAARAGVFT 259 L ++P + F AV L ++F G+ S+ W T L +PAARA F Sbjct: 200 ALCLSP---FLPSGFAQAAVANTAGLGAVIFLGIVPSLIAYAAWATALSRLPAARASNFL 256 Query: 260 VMLPVSAALVGVLALGESLSALQAGAFAIALAGMLLATL 298 ++ +AL+G LGE + L A+AL G+++ L Sbjct: 257 YLVSPMSALIGFFWLGEVPTLLGILGGALALGGVIVVNL 295 >lin0496 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Lin Listeria innocua Length = 319 Score = 61.2 bits (147), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 76/301 (25%), Positives = 138/301 (45%), Gaps = 25/301 (8%) Query: 8 PMG-YGCLILSMSLVGAYVALTKPLAAMLPVFLLAWLRFGIGAVAMLRWLKKPASEQPLS 66 P+G Y LI M+ G V +TK L + P + R A+ ++ L + + Sbjct: 7 PIGLYFLLIAVMASWGFNVTMTKVLVSYFPTVTMTSFRIFTAAITVIIILFITKKLRLPT 66 Query: 67 TQSRWLVFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSAIPAVVAVMSWIFLKEKISL- 125 + L+FL S + + G+ +T +AG+I+ + P VVA+ S +FL+E+I Sbjct: 67 KREFGLIFLASIFNIVIHHFFLSNGLKLTTGTNAGLILGSAPIVVAIFSVVFLRERIGAW 126 Query: 126 RVWGAVACGAVGIGLLSLAKDGHGASAASGGQYAWLGNGLVFCAVLCEAAYAAIGKKLTA 185 R G +A G G+ L+ L+ +G G S S LG+ +F A+ +A I KKL Sbjct: 127 RALGFLA-GIFGVSLVVLS-NGTGISGIS------LGDIDIFIAMASQAFSFIIIKKLAG 178 Query: 186 VLTPKRISAVINLWGLLL-------MTPMGV--YTALHFDFGAVPANMWLLLLFYGLAAS 236 + ++ + G ++ M P GV A+H +WLL + + A+ Sbjct: 179 SMDTGLMTGYMLFLGSVMLFALSRFMEPGGVSELVAVH------SWKLWLLFVVSAVVAT 232 Query: 237 VWTVWLWMTGLKVVPAARAGVFTVMLPVSAALVGVLALGESLSALQAGAFAIALAGMLLA 296 + +++ + + +R+ +F P+ + + +L LGE++ Q F + G+LL Sbjct: 233 AFGNFVYNYAVGKIGPSRSAIFMNFNPLFSLIGALLFLGEAIKIPQLVGFVFIIIGVLLG 292 Query: 297 T 297 + Sbjct: 293 S 293 >PA1060 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 301 Score = 61.2 bits (147), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 76/286 (26%), Positives = 126/286 (44%), Gaps = 22/286 (7%) Query: 4 TPSRPMGYGCLILSMSLVGAYVALTKPLAAMLPVFLLAWLRFGIGAVAML---RWLKKPA 60 T +R CLIL+M+L G+ + K LP + + R +G++ L RW + Sbjct: 2 TRTRWFALACLILAMALWGSSYVVLKVAFRELPPLWVIFGRMALGSLVFLVAWRWRGR-I 60 Query: 61 SEQPLSTQSRWLVFLE-SFLGNFLFTLCMITGVSMTNAVSAGVIMSAIPAVVAVMSWIFL 119 +P W L + L+ LC + T+A AG+I + +P +VAV +W+ L Sbjct: 61 DYRP----GDWKYLLGLAVCEPCLYFLCESFALQYTSAAQAGMITALLPLLVAVGAWLLL 116 Query: 120 KEKISLRVWGAVACGAVGIGLLSLA--KDGHGASAASGGQYAWLGNGLVFCAVLCEAAYA 177 E+I W +G LSLA D H LGN A+LC Y Sbjct: 117 HERIGRMTWIGFGLAVLGSIWLSLAGEPDLHAPQPL-------LGNFFELLAMLCATGYT 169 Query: 178 AIGKKLTAVLTPKRISAVINLWGLLLMTPMGVYTALHFDFGAVPANMWLLLLFYGLAASV 237 + K L+A + ++A+ G L P+ + +A D + P+ + + + Y Sbjct: 170 LLLKHLSARYSAFALTAMQAFVGTLFFLPLALASA---DLPSQPSALGIQAVVYLGVVVT 226 Query: 238 WTVW-LWMTGLKVVPAARAGVFTVMLPVSAALVGVLALGESLSALQ 282 + L+ G+ +PA++A F ++PV + L LGE+L+ Q Sbjct: 227 VGAYGLYNFGVGRLPASQASGFINLIPVFTLVFAALFLGETLNGPQ 272