BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0471.p (254 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH1646 [H] COG0302 GTP cyclohydrolase I Bha Bacillus halodurans 130 3e-30 HI1447 [H] COG0302 GTP cyclohydrolase I Hin Haemophilus influenzae 122 6e-28 lin2047 [H] COG0302 GTP cyclohydrolase I Lin Listeria innocua 122 8e-28 PM0693 [H] COG0302 GTP cyclohydrolase I Pmu Pasteurella multocida 120 2e-27 ML0223 [H] COG0302 GTP cyclohydrolase I Mle Mycobacterium leprae 119 9e-27 Cgl2639 [H] COG0302 GTP cyclohydrolase I Cgl Corynebacterium glu... 118 1e-26 Rv3609c [H] COG0302 GTP cyclohydrolase I Mtu Mycobacterium tuber... 117 2e-26 MT3713 [H] COG0302 GTP cyclohydrolase I MtC Mycobacterium tuberc... 117 2e-26 BS_mtrA [H] COG0302 GTP cyclohydrolase I Bsu Bacillus subtilis 116 4e-26 SPy1097 [H] COG0302 GTP cyclohydrolase I Spy Streptococcus pyoge... 116 6e-26 >BH1646 [H] COG0302 GTP cyclohydrolase I Bha Bacillus halodurans Length = 188 Score = 130 bits (327), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 78/184 (42%), Positives = 104/184 (56%), Gaps = 7/184 (3%) Query: 67 EVQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERL 124 ++Q + +LE++ D + +DT KRVAKMY EVF G Q P F I E Sbjct: 8 KIQQAVVMILEAIGED-PAREGLEDTPKRVAKMY-EEVFAGLNQ--DPKEHFATIFGEDH 63 Query: 125 NELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEE 184 EL++V I S C HHL P GK VG +P + GLSK AR +E V RPQ+QE Sbjct: 64 EELVLVKDIPFFSMCEHHLVPFFGKAHVGYIPK-GGKVTGLSKLARAVEAVARRPQLQER 122 Query: 185 AVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREF 244 S AD L++ L+P G+ +V+EA+H CM RGVK + + S +RG+F DA R E Sbjct: 123 ITSTVADALVETLEPHGVIVVVEAEHMCMTMRGVKKPGAATVTSAVRGTFANDAAARAEV 182 Query: 245 LALI 248 L+LI Sbjct: 183 LSLI 186 >HI1447 [H] COG0302 GTP cyclohydrolase I Hin Haemophilus influenzae Length = 218 Score = 122 bits (307), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 60/164 (36%), Positives = 95/164 (57%), Gaps = 3/164 (1%) Query: 86 DHNTQDTAKRVAKMYLNEVFKG-RYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLC 144 D + ++T R+AKM+++E+F G Y P +T+ N +++E++ V IT+ S C HH Sbjct: 55 DDSLEETPNRLAKMFIDEIFSGMDYANFPKMTKIKNQMKVSEMVQVNDITLTSTCEHHFV 114 Query: 145 PIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAI 204 I GKV V P + +IGLSK R++ + RPQ+QE Q L+ D +A+ Sbjct: 115 TIDGKVCVAYYPKDW--VIGLSKINRIVSFFAQRPQVQERLTEQLLTAFQTILETDDVAV 172 Query: 205 VMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 248 ++A HFC+ RG++D +S + S G FL D + R+EFLA + Sbjct: 173 YVKATHFCVKARGIRDTNSYTVTSAYGGVFLEDRDTRKEFLATV 216 >lin2047 [H] COG0302 GTP cyclohydrolase I Lin Listeria innocua Length = 189 Score = 122 bits (306), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 69/160 (43%), Positives = 94/160 (58%), Gaps = 6/160 (3%) Query: 91 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLNELMIVGPITVRSACSHHLCPIMG 148 DT RVA+MY EVF G + P F I E+ EL++V I S C HHL P G Sbjct: 31 DTPMRVARMY-EEVFAGLKK--DPSVHFDTIFEEQHEELVLVKDIRFSSMCEHHLVPFFG 87 Query: 149 KVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEA 208 V +P ++ + GLSK AR+++ V RPQ+QE + A+++M KL+P G+ ++MEA Sbjct: 88 VAHVAYLP-QNGRVAGLSKLARVVDDVSRRPQLQERITTTVAEIMMDKLKPLGVMVIMEA 146 Query: 209 DHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 248 +H CM RGV +K I S +RG+F D LR E LALI Sbjct: 147 EHMCMTIRGVNKPGTKTITSAVRGAFKNDDKLRSEVLALI 186 >PM0693 [H] COG0302 GTP cyclohydrolase I Pmu Pasteurella multocida Length = 218 Score = 120 bits (302), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 63/187 (33%), Positives = 106/187 (56%), Gaps = 4/187 (2%) Query: 65 QAEVQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKG-RYQAAPPVTEFPNIER 123 +A ++ + V++ + +D+ D + ++T R+AKM+++E+F G Y P +T N + Sbjct: 35 RAGIEQHMREVMKLIGLDLRDD-SLEETPVRLAKMFVDEIFSGLDYANFPKITNIENRMK 93 Query: 124 LNELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQE 183 ++E+++V +T+ S C HH I G V V P + +IGLSK R++ + RPQ+QE Sbjct: 94 VSEMVLVNDVTLTSTCEHHFVTIDGMVSVAYYPKKW--VIGLSKINRIVAFFAQRPQVQE 151 Query: 184 EAVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRRE 243 Q L+ D +A+ ++A HFC+ RG+KD +S + S G FL D R+E Sbjct: 152 RLTEQILLAFQTILETDDVAVYVKATHFCVKCRGIKDTNSYTVTSAFGGVFLDDRETRKE 211 Query: 244 FLALITQ 250 FL LI + Sbjct: 212 FLTLINK 218 >ML0223 [H] COG0302 GTP cyclohydrolase I Mle Mycobacterium leprae Length = 205 Score = 119 bits (297), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 67/161 (41%), Positives = 86/161 (53%), Gaps = 1/161 (0%) Query: 91 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKV 150 DT RVA+ E+F G Y V E NEL+IV I + S C HHL G Sbjct: 46 DTPARVARA-CRELFSGLYTDPQTVLNTMFDEEHNELVIVKEIPMYSTCEHHLVSFHGVA 104 Query: 151 WVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADH 210 +G +P + GLSK ARL++ RPQ+QE SQ AD L+ KL P G+ IV+EA+H Sbjct: 105 HIGYLPGADGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALVSKLDPRGVIIVVEAEH 164 Query: 211 FCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 251 CM RGV+ + S +RG F DA R E L LI ++ Sbjct: 165 LCMAMRGVRKPGAITTTSAVRGQFKTDAASRAEALGLILRK 205 >Cgl2639 [H] COG0302 GTP cyclohydrolase I Cgl Corynebacterium glutamicum Length = 201 Score = 118 bits (296), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 66/181 (36%), Positives = 96/181 (53%), Gaps = 4/181 (2%) Query: 71 KLAAVLESLVIDVESDHNTQ---DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNEL 127 + A + L+I V D + + +T RVA+ Y E F G ++ V E E EL Sbjct: 19 RATAAIRELLIAVGEDPDREGLLETPARVARAY-KETFAGLHEDPTTVLEKTFSEGHEEL 77 Query: 128 MIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVS 187 ++V I + S C HHL P G +G +P + + GLSK ARL + RPQ+QE S Sbjct: 78 VLVREIPIYSMCEHHLVPFFGVAHIGYIPGKSGKVTGLSKLARLADMFAKRPQVQERLTS 137 Query: 188 QAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLAL 247 Q AD L++KL +A+V+EA+H CM RG++ + S +RG F +A R E +L Sbjct: 138 QIADALVEKLDAQAVAVVIEAEHLCMAMRGIRKPGAVTTTSAVRGGFKNNAASRAEVFSL 197 Query: 248 I 248 I Sbjct: 198 I 198 >Rv3609c [H] COG0302 GTP cyclohydrolase I Mtu Mycobacterium tuberculosis H37Rv Length = 202 Score = 117 bits (293), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 66/160 (41%), Positives = 88/160 (55%), Gaps = 1/160 (0%) Query: 92 TAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKVW 151 T RVA+ Y E+F G Y V E +EL++V I + S C HHL G Sbjct: 44 TPSRVARSY-REMFAGLYTDPDSVLNTMFDEDHDELVLVKEIPMYSTCEHHLVAFHGVAH 102 Query: 152 VGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADHF 211 VG +P + + GLSK ARL++ RPQ+QE SQ AD LM+KL P G+ +V+EA+H Sbjct: 103 VGYIPGDDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALMKKLDPRGVIVVIEAEHL 162 Query: 212 CMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 251 CM RGV+ S S +RG F +A R E L LI ++ Sbjct: 163 CMAMRGVRKPGSVTTTSAVRGLFKTNAASRAEALDLILRK 202 >MT3713 [H] COG0302 GTP cyclohydrolase I MtC Mycobacterium tuberculosis CDC1551 Length = 202 Score = 117 bits (293), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 66/160 (41%), Positives = 88/160 (55%), Gaps = 1/160 (0%) Query: 92 TAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKVW 151 T RVA+ Y E+F G Y V E +EL++V I + S C HHL G Sbjct: 44 TPSRVARSY-REMFAGLYTDPDSVLNTMFDEDHDELVLVKEIPMYSTCEHHLVAFHGVAH 102 Query: 152 VGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADHF 211 VG +P + + GLSK ARL++ RPQ+QE SQ AD LM+KL P G+ +V+EA+H Sbjct: 103 VGYIPGDDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALMKKLDPRGVIVVIEAEHL 162 Query: 212 CMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 251 CM RGV+ S S +RG F +A R E L LI ++ Sbjct: 163 CMAMRGVRKPGSVTTTSAVRGLFKTNAASRAEALDLILRK 202 >BS_mtrA [H] COG0302 GTP cyclohydrolase I Bsu Bacillus subtilis Length = 190 Score = 116 bits (291), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 69/163 (42%), Positives = 90/163 (55%), Gaps = 6/163 (3%) Query: 91 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLNELMIVGPITVRSACSHHLCPIMG 148 DT KRVAKMY EVF G + P F I E EL++V I S C HHL P G Sbjct: 31 DTPKRVAKMYA-EVFSGLNE--DPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYG 87 Query: 149 KVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEA 208 K V +P + GLSK AR +E V RPQ+QE S A+ +++ L P G+ +V+EA Sbjct: 88 KAHVAYIPR-GGKVTGLSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEA 146 Query: 209 DHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 251 +H CM RGV+ +K + S +RG F DA R E L I ++ Sbjct: 147 EHMCMTMRGVRKPGAKTVTSAVRGVFKDDAAARAEVLEHIKRQ 189 >SPy1097 [H] COG0302 GTP cyclohydrolase I Spy Streptococcus pyogenes M1 GAS Length = 200 Score = 116 bits (290), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 65/162 (40%), Positives = 93/162 (57%), Gaps = 6/162 (3%) Query: 91 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLNELMIVGPITVRSACSHHLCPIMG 148 DT KRVAKMY E+F G P EF + E+ +++IV I+ S C HHL P G Sbjct: 42 DTPKRVAKMY-AEMFLG--LGKDPKEEFTAVFKEQHEDVVIVKDISFYSICEHHLVPFYG 98 Query: 149 KVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEA 208 K + +P++ + GLSK AR +E RPQ+QE SQ AD L++ L P G +++EA Sbjct: 99 KAHIAYLPSD-GRVTGLSKLARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEA 157 Query: 209 DHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQ 250 +H CM RG+K SK I + RG + R+E ++L+T+ Sbjct: 158 EHMCMTMRGIKKPGSKTITTTARGLYKESRAERQEVISLMTK 199