BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0468.p (187 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH1646 [H] COG0302 GTP cyclohydrolase I Bha Bacillus halodurans 130 1e-30 HI1447 [H] COG0302 GTP cyclohydrolase I Hin Haemophilus influenzae 122 5e-28 lin2047 [H] COG0302 GTP cyclohydrolase I Lin Listeria innocua 122 5e-28 PM0693 [H] COG0302 GTP cyclohydrolase I Pmu Pasteurella multocida 119 3e-27 ML0223 [H] COG0302 GTP cyclohydrolase I Mle Mycobacterium leprae 119 4e-27 Cgl2639 [H] COG0302 GTP cyclohydrolase I Cgl Corynebacterium glu... 119 5e-27 BS_mtrA [H] COG0302 GTP cyclohydrolase I Bsu Bacillus subtilis 117 2e-26 Rv3609c [H] COG0302 GTP cyclohydrolase I Mtu Mycobacterium tuber... 117 2e-26 MT3713 [H] COG0302 GTP cyclohydrolase I MtC Mycobacterium tuberc... 117 2e-26 SPy1097 [H] COG0302 GTP cyclohydrolase I Spy Streptococcus pyoge... 116 3e-26 >BH1646 [H] COG0302 GTP cyclohydrolase I Bha Bacillus halodurans Length = 188 Score = 130 bits (328), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 78/183 (42%), Positives = 103/183 (56%), Gaps = 7/183 (3%) Query: 1 VQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLN 58 +Q + +LE++ D + +DT KRVAKMY EVF G Q P F I E Sbjct: 9 IQQAVVMILEAIGED-PAREGLEDTPKRVAKMY-EEVFAGLNQ--DPKEHFATIFGEDHE 64 Query: 59 ELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEA 118 EL++V I S C HHL P GK VG +P + GLSK AR +E V RPQ+QE Sbjct: 65 ELVLVKDIPFFSMCEHHLVPFFGKAHVGYIPK-GGKVTGLSKLARAVEAVARRPQLQERI 123 Query: 119 VSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFL 178 S AD L++ L+P G+ +V+EA+H CM RGVK + + S +RG+F DA R E L Sbjct: 124 TSTVADALVETLEPHGVIVVVEAEHMCMTMRGVKKPGAATVTSAVRGTFANDAAARAEVL 183 Query: 179 ALI 181 +LI Sbjct: 184 SLI 186 >HI1447 [H] COG0302 GTP cyclohydrolase I Hin Haemophilus influenzae Length = 218 Score = 122 bits (306), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 60/164 (36%), Positives = 95/164 (57%), Gaps = 3/164 (1%) Query: 19 DHNTQDTAKRVAKMYLNEVFKG-RYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLC 77 D + ++T R+AKM+++E+F G Y P +T+ N +++E++ V IT+ S C HH Sbjct: 55 DDSLEETPNRLAKMFIDEIFSGMDYANFPKMTKIKNQMKVSEMVQVNDITLTSTCEHHFV 114 Query: 78 PIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAI 137 I GKV V P + +IGLSK R++ + RPQ+QE Q L+ D +A+ Sbjct: 115 TIDGKVCVAYYPKDW--VIGLSKINRIVSFFAQRPQVQERLTEQLLTAFQTILETDDVAV 172 Query: 138 VMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 181 ++A HFC+ RG++D +S + S G FL D + R+EFLA + Sbjct: 173 YVKATHFCVKARGIRDTNSYTVTSAYGGVFLEDRDTRKEFLATV 216 >lin2047 [H] COG0302 GTP cyclohydrolase I Lin Listeria innocua Length = 189 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 69/160 (43%), Positives = 94/160 (58%), Gaps = 6/160 (3%) Query: 24 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLNELMIVGPITVRSACSHHLCPIMG 81 DT RVA+MY EVF G + P F I E+ EL++V I S C HHL P G Sbjct: 31 DTPMRVARMY-EEVFAGLKK--DPSVHFDTIFEEQHEELVLVKDIRFSSMCEHHLVPFFG 87 Query: 82 KVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEA 141 V +P ++ + GLSK AR+++ V RPQ+QE + A+++M KL+P G+ ++MEA Sbjct: 88 VAHVAYLP-QNGRVAGLSKLARVVDDVSRRPQLQERITTTVAEIMMDKLKPLGVMVIMEA 146 Query: 142 DHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 181 +H CM RGV +K I S +RG+F D LR E LALI Sbjct: 147 EHMCMTIRGVNKPGTKTITSAVRGAFKNDDKLRSEVLALI 186 >PM0693 [H] COG0302 GTP cyclohydrolase I Pmu Pasteurella multocida Length = 218 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 60/166 (36%), Positives = 94/166 (56%), Gaps = 3/166 (1%) Query: 19 DHNTQDTAKRVAKMYLNEVFKG-RYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLC 77 D + ++T R+AKM+++E+F G Y P +T N +++E+++V +T+ S C HH Sbjct: 55 DDSLEETPVRLAKMFVDEIFSGLDYANFPKITNIENRMKVSEMVLVNDVTLTSTCEHHFV 114 Query: 78 PIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAI 137 I G V V P + +IGLSK R++ + RPQ+QE Q L+ D +A+ Sbjct: 115 TIDGMVSVAYYPKKW--VIGLSKINRIVAFFAQRPQVQERLTEQILLAFQTILETDDVAV 172 Query: 138 VMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQ 183 ++A HFC+ RG+KD +S + S G FL D R+EFL LI + Sbjct: 173 YVKATHFCVKCRGIKDTNSYTVTSAFGGVFLDDRETRKEFLTLINK 218 >ML0223 [H] COG0302 GTP cyclohydrolase I Mle Mycobacterium leprae Length = 205 Score = 119 bits (298), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 71/186 (38%), Positives = 96/186 (51%), Gaps = 4/186 (2%) Query: 2 QGKLAAVLESLVIDVESDHNTQ---DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLN 58 Q + A + L+ + D + + DT RVA+ E+F G Y V E N Sbjct: 21 QQRAEAAIRELLYAIGEDPDREGLADTPARVARA-CRELFSGLYTDPQTVLNTMFDEEHN 79 Query: 59 ELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEA 118 EL+IV I + S C HHL G +G +P + GLSK ARL++ RPQ+QE Sbjct: 80 ELVIVKEIPMYSTCEHHLVSFHGVAHIGYLPGADGRVTGLSKIARLVDLYAKRPQVQERL 139 Query: 119 VSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFL 178 SQ AD L+ KL P G+ IV+EA+H CM RGV+ + S +RG F DA R E L Sbjct: 140 TSQIADALVSKLDPRGVIIVVEAEHLCMAMRGVRKPGAITTTSAVRGQFKTDAASRAEAL 199 Query: 179 ALITQR 184 LI ++ Sbjct: 200 GLILRK 205 >Cgl2639 [H] COG0302 GTP cyclohydrolase I Cgl Corynebacterium glutamicum Length = 201 Score = 119 bits (297), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 66/181 (36%), Positives = 96/181 (53%), Gaps = 4/181 (2%) Query: 4 KLAAVLESLVIDVESDHNTQ---DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNEL 60 + A + L+I V D + + +T RVA+ Y E F G ++ V E E EL Sbjct: 19 RATAAIRELLIAVGEDPDREGLLETPARVARAY-KETFAGLHEDPTTVLEKTFSEGHEEL 77 Query: 61 MIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVS 120 ++V I + S C HHL P G +G +P + + GLSK ARL + RPQ+QE S Sbjct: 78 VLVREIPIYSMCEHHLVPFFGVAHIGYIPGKSGKVTGLSKLARLADMFAKRPQVQERLTS 137 Query: 121 QAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLAL 180 Q AD L++KL +A+V+EA+H CM RG++ + S +RG F +A R E +L Sbjct: 138 QIADALVEKLDAQAVAVVIEAEHLCMAMRGIRKPGAVTTTSAVRGGFKNNAASRAEVFSL 197 Query: 181 I 181 I Sbjct: 198 I 198 >BS_mtrA [H] COG0302 GTP cyclohydrolase I Bsu Bacillus subtilis Length = 190 Score = 117 bits (293), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 69/163 (42%), Positives = 90/163 (55%), Gaps = 6/163 (3%) Query: 24 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLNELMIVGPITVRSACSHHLCPIMG 81 DT KRVAKMY EVF G + P F I E EL++V I S C HHL P G Sbjct: 31 DTPKRVAKMYA-EVFSGLNE--DPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYG 87 Query: 82 KVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEA 141 K V +P + GLSK AR +E V RPQ+QE S A+ +++ L P G+ +V+EA Sbjct: 88 KAHVAYIPR-GGKVTGLSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEA 146 Query: 142 DHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 184 +H CM RGV+ +K + S +RG F DA R E L I ++ Sbjct: 147 EHMCMTMRGVRKPGAKTVTSAVRGVFKDDAAARAEVLEHIKRQ 189 >Rv3609c [H] COG0302 GTP cyclohydrolase I Mtu Mycobacterium tuberculosis H37Rv Length = 202 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 66/160 (41%), Positives = 88/160 (55%), Gaps = 1/160 (0%) Query: 25 TAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKVW 84 T RVA+ Y E+F G Y V E +EL++V I + S C HHL G Sbjct: 44 TPSRVARSY-REMFAGLYTDPDSVLNTMFDEDHDELVLVKEIPMYSTCEHHLVAFHGVAH 102 Query: 85 VGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADHF 144 VG +P + + GLSK ARL++ RPQ+QE SQ AD LM+KL P G+ +V+EA+H Sbjct: 103 VGYIPGDDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALMKKLDPRGVIVVIEAEHL 162 Query: 145 CMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 184 CM RGV+ S S +RG F +A R E L LI ++ Sbjct: 163 CMAMRGVRKPGSVTTTSAVRGLFKTNAASRAEALDLILRK 202 >MT3713 [H] COG0302 GTP cyclohydrolase I MtC Mycobacterium tuberculosis CDC1551 Length = 202 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 66/160 (41%), Positives = 88/160 (55%), Gaps = 1/160 (0%) Query: 25 TAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKVW 84 T RVA+ Y E+F G Y V E +EL++V I + S C HHL G Sbjct: 44 TPSRVARSY-REMFAGLYTDPDSVLNTMFDEDHDELVLVKEIPMYSTCEHHLVAFHGVAH 102 Query: 85 VGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADHF 144 VG +P + + GLSK ARL++ RPQ+QE SQ AD LM+KL P G+ +V+EA+H Sbjct: 103 VGYIPGDDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALMKKLDPRGVIVVIEAEHL 162 Query: 145 CMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 184 CM RGV+ S S +RG F +A R E L LI ++ Sbjct: 163 CMAMRGVRKPGSVTTTSAVRGLFKTNAASRAEALDLILRK 202 >SPy1097 [H] COG0302 GTP cyclohydrolase I Spy Streptococcus pyogenes M1 GAS Length = 200 Score = 116 bits (291), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 65/162 (40%), Positives = 93/162 (57%), Gaps = 6/162 (3%) Query: 24 DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLNELMIVGPITVRSACSHHLCPIMG 81 DT KRVAKMY E+F G P EF + E+ +++IV I+ S C HHL P G Sbjct: 42 DTPKRVAKMY-AEMFLG--LGKDPKEEFTAVFKEQHEDVVIVKDISFYSICEHHLVPFYG 98 Query: 82 KVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEA 141 K + +P++ + GLSK AR +E RPQ+QE SQ AD L++ L P G +++EA Sbjct: 99 KAHIAYLPSD-GRVTGLSKLARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEA 157 Query: 142 DHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQ 183 +H CM RG+K SK I + RG + R+E ++L+T+ Sbjct: 158 EHMCMTMRGIKKPGSKTITTTARGLYKESRAERQEVISLMTK 199