BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0455.p (254 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1565 [IQR] COG1028 Dehydrogenases with different specificitie... 319 4e-87 SMb21111 [IQR] COG1028 Dehydrogenases with different specificiti... 303 2e-82 BMEI1709 [IQR] COG1028 Dehydrogenases with different specificiti... 303 3e-82 AGl807 [IQR] COG1028 Dehydrogenases with different specificities... 301 7e-82 mll4781 [IQR] COG1028 Dehydrogenases with different specificitie... 285 9e-77 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 191 2e-48 ucpA [IQR] COG1028 Dehydrogenases with different specificities (... 166 7e-41 STM2445 [IQR] COG1028 Dehydrogenases with different specificitie... 165 9e-41 ZucpA [IQR] COG1028 Dehydrogenases with different specificities ... 164 2e-40 ECs3297 [IQR] COG1028 Dehydrogenases with different specificitie... 164 2e-40 >YPO1565 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ype Yersinia pestis Length = 246 Score = 319 bits (817), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 156/247 (63%), Positives = 187/247 (75%), Gaps = 3/247 (1%) Query: 8 LAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHLDELAGIAGVETHLLDVTDDA 67 L GK L+TAA QGIG + LFAR+GA VIA+DI+ L + GI V LDVTD Sbjct: 3 LKGKKALVTAAGQGIGFNTATLFARKGAEVIASDINIAALSNIPGITAVS---LDVTDTL 59 Query: 68 AIKALVAKIGTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKAMFHSIRAVLPGMLAK 127 AI + IG IDVLFNCAG V +G+IL C ++ W F+ +LN AMFH IRA LPGM+A Sbjct: 60 AINDVAQAIGPIDVLFNCAGVVHSGDILTCSEQEWQFALDLNVTAMFHMIRAFLPGMIAC 119 Query: 128 KAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQGIRCNAICPGTIESP 187 + GSI+N++S ASS+KGV NRFAY SKAAV+GLT+SVAAD+V QGIRCNAICPGT+ESP Sbjct: 120 QQGSIINMSSVASSIKGVPNRFAYSTSKAAVIGLTRSVAADYVTQGIRCNAICPGTVESP 179 Query: 188 SLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALYLASDESNFTTGSIHM 247 SL QRI+ QA G+SE +V AF RQP+GRIGKAEE+A LALYLASD S +TTG+IH+ Sbjct: 180 SLRQRIAVQAHAEGRSEADVFQAFAARQPIGRIGKAEEIAQLALYLASDASAYTTGTIHI 239 Query: 248 IDGGWSN 254 IDGGWSN Sbjct: 240 IDGGWSN 246 >SMb21111 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 244 Score = 303 bits (776), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 151/249 (60%), Positives = 189/249 (75%), Gaps = 7/249 (2%) Query: 5 TGRLAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHLDELAGIAGVETHLLDVT 64 T LAGK VL+TAAAQGIGRA+ FA+ GA+V ATDI+ + L G AG+ TH LDV Sbjct: 2 TANLAGKVVLVTAAAQGIGRATALAFAKAGAKVHATDINADAVGSLEGEAGISTHRLDVL 61 Query: 65 DDAAIKALVAKIGTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKAMFHSIRAVLPGM 124 D AA++ALVA+IG +DVLFNCAG+V AG++L D+ DF+F+LN K+M +IRAVLPGM Sbjct: 62 DTAAVEALVAEIGAVDVLFNCAGFVHAGSVLTMKDEDLDFAFDLNVKSMIRTIRAVLPGM 121 Query: 125 LAKKAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQGIRCNAICPGTI 184 +A+K GSIVN+AS ASS+KGV NRFAYG +KAAV+GLTK+VAAD+V GIRCNAICPGT+ Sbjct: 122 IARKDGSIVNMASVASSIKGVPNRFAYGVTKAAVIGLTKAVAADYVGDGIRCNAICPGTV 181 Query: 185 ESPSLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALYLASDESNFTTGS 244 ESPSL R+ Q E RAAF+ RQPMGR+G EE+A LA+YLA + +T+G Sbjct: 182 ESPSLESRMRAQG-----DYETARAAFISRQPMGRLGTPEEIADLAVYLAG--ATYTSGQ 234 Query: 245 IHMIDGGWS 253 + IDGGW+ Sbjct: 235 AYAIDGGWT 243 >BMEI1709 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bme Brucella melitensis Length = 244 Score = 303 bits (776), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 152/249 (61%), Positives = 188/249 (75%), Gaps = 7/249 (2%) Query: 5 TGRLAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHLDELAGIAGVETHLLDVT 64 T RL GKT L+TAA QGIG+AS F GA+V ATDI+ L +L GIAG+ T LDV Sbjct: 2 TIRLDGKTALVTAAGQGIGQASALAFVEAGAKVYATDINADALAKLEGIAGIVTRRLDVL 61 Query: 65 DDAAIKALVAKIGTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKAMFHSIRAVLPGM 124 DDAA+KALVA+IG ID+LFNCAG+V G ILE D+ DF+ NLN ++M +IRAVLPGM Sbjct: 62 DDAAVKALVAEIGQIDILFNCAGFVHNGTILEMKDEELDFAVNLNVRSMIRTIRAVLPGM 121 Query: 125 LAKKAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQGIRCNAICPGTI 184 L +K G+I+N+AS ASSVKGV+NRF YG +KAAV+GLTK+VAAD+V++GIRCNAICPGT+ Sbjct: 122 LERKDGAIINMASVASSVKGVSNRFVYGLTKAAVIGLTKAVAADYVSKGIRCNAICPGTV 181 Query: 185 ESPSLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALYLASDESNFTTGS 244 ESPSL R+ Q E RAAF+ RQP+GRIG+ EE+A LA+YLA + +TTG Sbjct: 182 ESPSLQDRLRAQG-----DYEAARAAFIARQPIGRIGQPEEIADLAVYLAG--ATYTTGQ 234 Query: 245 IHMIDGGWS 253 + IDGGWS Sbjct: 235 AYNIDGGWS 243 >AGl807 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 264 Score = 301 bits (772), Expect = 7e-82, Method: Compositional matrix adjust. Identities = 151/244 (61%), Positives = 186/244 (76%), Gaps = 8/244 (3%) Query: 10 GKTVLITAAAQGIGRASTELFAREGARVIATDISKPHLDELAGIAGVETHLLDVTDDAAI 69 G+TV+ITAA QGIGRA+ E F GARVIATDI++ L L G ET +L+V D + Sbjct: 28 GRTVVITAAGQGIGRATAERFISLGARVIATDINEQALSTLKG---AETRVLNVLDGDGV 84 Query: 70 KALVAKIGTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKAMFHSIRAVLPGMLAKKA 129 + A IG DVLFNCAG+V +G IL+C++K WDFSF+LNAKAM+ + RA LPGML K Sbjct: 85 EDFAADIGHADVLFNCAGFVHSGTILDCEEKDWDFSFDLNAKAMYRTCRAFLPGMLEKGK 144 Query: 130 GSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQGIRCNAICPGTIESPSL 189 G+IVN++S ASSVKGV NRFAY ASKAAVVGLTK++AADFV +GIRCNAICPGT++SPSL Sbjct: 145 GAIVNMSSVASSVKGVPNRFAYTASKAAVVGLTKAIAADFVTKGIRCNAICPGTVDSPSL 204 Query: 190 NQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALYLASDESNFTTGSIHMID 249 + R+ + TG E+ + A F+ RQPMGRI EE+AAL YLASDE+ FTTG IH+ID Sbjct: 205 HDRL----RATGNYEQAL-ADFIARQPMGRIATPEEIAALVTYLASDEAGFTTGQIHVID 259 Query: 250 GGWS 253 GGW+ Sbjct: 260 GGWT 263 >mll4781 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 243 Score = 285 bits (728), Expect = 9e-77, Method: Compositional matrix adjust. Identities = 144/246 (58%), Positives = 181/246 (73%), Gaps = 7/246 (2%) Query: 8 LAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHLDELAGIAGVETHLLDVTDDA 67 LAGK V+ITAAAQGIG+AS FA+ GA V ATDI++ L ELA G++T LDV +D Sbjct: 4 LAGKVVVITAAAQGIGKASALAFAKTGATVHATDINETLLAELAKTPGIKTRKLDVLNDE 63 Query: 68 AIKALVAKIGTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKAMFHSIRAVLPGMLAK 127 A+ A+IG +DVLFNCAG+V +G+ILE D DF+FNLN +AM +IRAVLPGML + Sbjct: 64 AVNTTFAEIGRVDVLFNCAGFVHSGSILEMKDGDLDFAFNLNVRAMIRTIRAVLPGMLER 123 Query: 128 KAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQGIRCNAICPGTIESP 187 GSIVN++S A + KGV NRFAYG +KAAV+GLTK++AAD+V +GIRCNAICPGT+ESP Sbjct: 124 GDGSIVNMSSVAGAGKGVPNRFAYGVTKAAVIGLTKAIAADYVGKGIRCNAICPGTVESP 183 Query: 188 SLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALYLASDESNFTTGSIHM 247 SL R+ Q E RAAF+ RQPMGR+G EE+A LA+YLA + +T+G + Sbjct: 184 SLQDRMHAQG-----DYEAARAAFIARQPMGRLGTPEEIADLAVYLAG--ATYTSGQAYN 236 Query: 248 IDGGWS 253 IDGGWS Sbjct: 237 IDGGWS 242 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 191 bits (484), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 111/254 (43%), Positives = 157/254 (61%), Gaps = 21/254 (8%) Query: 7 RLAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHLDELA----GIAG-VETHLL 61 RL GK LIT AA GIG+A+T LFA+EGA VIA DISK +LD L G+ G V+ ++L Sbjct: 2 RLEGKVCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVL 61 Query: 62 DVTDDAAIKALVAKI----GTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKAMFHSI 117 +VTD IK +V K+ G IDVL N AG ++ ++ WD N+N K +F+ Sbjct: 62 NVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKEEDWDAVINVNLKGVFNVT 121 Query: 118 RAVLPGMLAKKAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQGIRCN 177 + V+P M+ ++ GSIVN++S + G + Y ASKA V+G+TK+ A + + IR N Sbjct: 122 QMVVPYMIKQRNGSIVNVSSVV-GIYGNPGQTNYAASKAGVIGMTKTWAKELAGRNIRVN 180 Query: 178 AICPGTIESPSLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALYLASDE 237 A+ PG IE+P + +++ +A+ET S R P+GR GK EEVA + L+LASDE Sbjct: 181 AVAPGFIETP-MTEKLPEKARETALS----------RIPLGRFGKPEEVAQVILFLASDE 229 Query: 238 SNFTTGSIHMIDGG 251 S++ TG + IDGG Sbjct: 230 SSYVTGQVIGIDGG 243 >ucpA [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Eco Escherichia coli K12 Length = 285 Score = 166 bits (419), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 107/259 (41%), Positives = 145/259 (55%), Gaps = 13/259 (5%) Query: 2 SASTGRLAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHL----DELAGIAGVE 57 S G+L GKT LIT A QGIG FAR GA +I DIS P + DEL G Sbjct: 20 SIKMGKLTGKTALITGALQGIGEGIARTFARHGANLILLDIS-PEIEKLADELCGRGHRC 78 Query: 58 THLL-DVTDDA----AIKALVAKIGTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKA 112 T ++ DV D A AIK K G ID+L N AG G+ L+ D DF ++N K Sbjct: 79 TAVVADVRDPASVAAAIKRAKEKEGRIDILVNNAGVCRLGSFLDMSDDDRDFHIDINIKG 138 Query: 113 MFHSIRAVLPGMLAKKAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQ 172 +++ +AVLP M+A+K G IV ++S + AY +KAA+VGLTKS+A ++ Sbjct: 139 VWNVTKAVLPEMIARKDGRIVMMSSVTGDMVADPGETAYALTKAAIVGLTKSLAVEYAQS 198 Query: 173 GIRCNAICPGTIESPSLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALY 232 GIR NAICPG + +P + + I+ Q+ + E V PM R+ EV LA + Sbjct: 199 GIRVNAICPGYVRTP-MAESIARQSNP--EDPESVLTEMAKAIPMRRLADPLEVGELAAF 255 Query: 233 LASDESNFTTGSIHMIDGG 251 LASDES++ TG+ ++IDGG Sbjct: 256 LASDESSYLTGTQNVIDGG 274 >STM2445 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sty Salmonella typhimurium LT2 Length = 263 Score = 165 bits (418), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 102/255 (40%), Positives = 146/255 (57%), Gaps = 13/255 (5%) Query: 6 GRLAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHLDELAGIAGVETHLL---- 61 G+L GKT LIT A+QGIG +FAR GA +I DIS +++LA G H Sbjct: 2 GKLTGKTALITGASQGIGEGIARVFARHGANLILLDISD-EIEKLADELGGRGHRCTAVK 60 Query: 62 -DVTDDAAIKALVAKI----GTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKAMFHS 116 DV D A+++A VA+ G ID+L N AG GN L+ ++ DF ++N K +++ Sbjct: 61 ADVRDFASVQAAVARAKETEGRIDILVNNAGVCRLGNFLDMSEEDRDFHIDINIKGVWNV 120 Query: 117 IRAVLPGMLAKKAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQGIRC 176 +AVLP M+ +K G IV ++S + AY SKAA+VGLTKS+A ++ GIR Sbjct: 121 TKAVLPEMIKRKDGRIVMMSSVTGDMVADPGETAYALSKAAIVGLTKSLAVEYAQSGIRV 180 Query: 177 NAICPGTIESPSLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALYLASD 236 NAICPG + +P + + I+ Q+ E V P+ R+ EV LA +LASD Sbjct: 181 NAICPGYVRTP-MAESIARQSNP--DDPESVLTEMAKAIPLRRLADPLEVGELAAFLASD 237 Query: 237 ESNFTTGSIHMIDGG 251 ES++ TG+ ++IDGG Sbjct: 238 ESSYLTGTQNVIDGG 252 >ZucpA [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) EcZ Escherichia coli O157:H7 EDL933 Length = 285 Score = 164 bits (415), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 106/259 (40%), Positives = 145/259 (55%), Gaps = 13/259 (5%) Query: 2 SASTGRLAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHL----DELAGIAGVE 57 S G+L GKT LIT A QGIG FAR GA +I DIS P + DEL G Sbjct: 20 SIKMGKLTGKTALITGALQGIGEGIARTFARHGANLILLDIS-PEIEKLADELCGRGHRC 78 Query: 58 THLL-DVTDDA----AIKALVAKIGTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKA 112 T ++ DV D A AIK K G ID+L N AG G+ L+ D DF ++N K Sbjct: 79 TAVVADVRDPASVAAAIKRAKEKEGRIDILVNNAGVCRLGSFLDMSDDDRDFHIDINIKG 138 Query: 113 MFHSIRAVLPGMLAKKAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQ 172 +++ +AVLP M+A+K G IV ++S + AY +KAA+VGLTKS+A ++ Sbjct: 139 VWNVTKAVLPEMIARKDGRIVMMSSVTGDMVADPGETAYALTKAAIVGLTKSLAVEYAQS 198 Query: 173 GIRCNAICPGTIESPSLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALY 232 GIR NAICPG + +P + + I+ Q+ + E V P+ R+ EV LA + Sbjct: 199 GIRVNAICPGYVRTP-MAESIARQSNP--EDPESVLTEMAKAIPLRRLADPLEVGELAAF 255 Query: 233 LASDESNFTTGSIHMIDGG 251 LASDES++ TG+ ++IDGG Sbjct: 256 LASDESSYLTGTQNVIDGG 274 >ECs3297 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ecs Escherichia coli O157:H7 Length = 285 Score = 164 bits (415), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 106/259 (40%), Positives = 145/259 (55%), Gaps = 13/259 (5%) Query: 2 SASTGRLAGKTVLITAAAQGIGRASTELFAREGARVIATDISKPHL----DELAGIAGVE 57 S G+L GKT LIT A QGIG FAR GA +I DIS P + DEL G Sbjct: 20 SIKMGKLTGKTALITGALQGIGEGIARTFARHGANLILLDIS-PEIEKLADELCGRGHRC 78 Query: 58 THLL-DVTDDA----AIKALVAKIGTIDVLFNCAGYVAAGNILECDDKAWDFSFNLNAKA 112 T ++ DV D A AIK K G ID+L N AG G+ L+ D DF ++N K Sbjct: 79 TAVVADVRDPASVAAAIKRAKEKEGRIDILVNNAGVCRLGSFLDMSDDDRDFHIDINIKG 138 Query: 113 MFHSIRAVLPGMLAKKAGSIVNIASAASSVKGVANRFAYGASKAAVVGLTKSVAADFVAQ 172 +++ +AVLP M+A+K G IV ++S + AY +KAA+VGLTKS+A ++ Sbjct: 139 VWNVTKAVLPEMIARKDGRIVMMSSVTGDMVADPGETAYALTKAAIVGLTKSLAVEYAQS 198 Query: 173 GIRCNAICPGTIESPSLNQRISTQAKETGKSEEEVRAAFVGRQPMGRIGKAEEVAALALY 232 GIR NAICPG + +P + + I+ Q+ + E V P+ R+ EV LA + Sbjct: 199 GIRVNAICPGYVRTP-MAESIARQSNP--EDPESVLTEMAKAIPLRRLADPLEVGELAAF 255 Query: 233 LASDESNFTTGSIHMIDGG 251 LASDES++ TG+ ++IDGG Sbjct: 256 LASDESSYLTGTQNVIDGG 274