BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0375.p (296 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0746 [Q] COG2175 Probable taurine catabolism dioxygenase Rso ... 377 e-104 PA2310 [Q] COG2175 Probable taurine catabolism dioxygenase Pae P... 355 5e-98 PA3935 [Q] COG2175 Probable taurine catabolism dioxygenase Pae P... 196 5e-50 tauD [Q] COG2175 Probable taurine catabolism dioxygenase Eco Esc... 192 1e-48 ZtauD [Q] COG2175 Probable taurine catabolism dioxygenase EcZ Es... 191 1e-48 ECs0422 [Q] COG2175 Probable taurine catabolism dioxygenase Ecs ... 191 1e-48 YPO0185 [Q] COG2175 Probable taurine catabolism dioxygenase Ype ... 186 7e-47 PA0194 [Q] COG2175 Probable taurine catabolism dioxygenase Pae P... 154 2e-37 Rv3406 [Q] COG2175 Probable taurine catabolism dioxygenase Mtu M... 134 2e-31 MT3514 [Q] COG2175 Probable taurine catabolism dioxygenase MtC M... 134 2e-31 >RSc0746 [Q] COG2175 Probable taurine catabolism dioxygenase Rso Ralstonia solanacearum Length = 301 Score = 377 bits (968), Expect = e-104, Method: Compositional matrix adjust. Identities = 183/284 (64%), Positives = 226/284 (79%), Gaps = 2/284 (0%) Query: 14 QEFEIHRF-DAPLGAEIVGLDLNKPVSAAELARIRKALVEH-GVVVFRDQRITPQQHIDF 71 + F++ R APLGAEI+GL+ +S A++A IR+A + H G++VFRD R+ P+ +DF Sbjct: 17 RRFQVRRLPGAPLGAEILGLNDAAGLSDADVAAIRQAWLAHDGLLVFRDVRLAPRAQVDF 76 Query: 72 SRRFGPLQVHVLNRFHLAGHPEILIVSNVVENGKPIGLVDAGADWHSDLSYMPKPSLGAL 131 SRRFGPLQVHVLN+FHL HPEIL+VSNVVENGKPIGL DAG DWHSDLSY P+PSLG+L Sbjct: 77 SRRFGPLQVHVLNQFHLPAHPEILVVSNVVENGKPIGLGDAGRDWHSDLSYRPRPSLGSL 136 Query: 132 LHSQELPAERGDTLYANTAAAWDSLPAALKTLLEGKRAVHSYVYRYERLRKLSPWRAPLT 191 L ++ELP GDTL+AN A+++LPA LK +EG+RAVHSYVYRYERLR LS WR PLT Sbjct: 137 LLARELPQAGGDTLFANMVRAYETLPAELKHSIEGRRAVHSYVYRYERLRALSAWRPPLT 196 Query: 192 QQQIDEVPPVEHPVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPEN 251 Q Q D VPPV+HPVV THPE+GR+ LFV+EGFTS I+G+P DES +L +L+ H RP+N Sbjct: 197 QAQRDAVPPVDHPVVRTHPETGRRALFVNEGFTSRILGLPEDESTTVLAQLFAHSIRPDN 256 Query: 252 VYTHRWQAHDLVFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 +YTHRWQ D++FWDNRST H+A P RRTL+RTT+EGDVP Sbjct: 257 IYTHRWQPGDMLFWDNRSTLHFAPGCPDTHRRTLHRTTIEGDVP 300 >PA2310 [Q] COG2175 Probable taurine catabolism dioxygenase Pae Pseudomonas aeruginosa Length = 295 Score = 355 bits (912), Expect = 5e-98, Method: Compositional matrix adjust. Identities = 173/280 (61%), Positives = 206/280 (73%) Query: 16 FEIHRFDAPLGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQRITPQQHIDFSRRF 75 +I DA GAE++GLDL P++A + RI +A ++H V+VFR+QRITP Q I FSRRF Sbjct: 15 LQIRALDAAFGAEVLGLDLGLPLAAEDFRRIHRAHLDHHVLVFREQRITPAQQIAFSRRF 74 Query: 76 GPLQVHVLNRFHLAGHPEILIVSNVVENGKPIGLVDAGADWHSDLSYMPKPSLGALLHSQ 135 G LQ+HVL +F L GHPEILIVSN+VENG+PIGL DAG WHSDLSY PSLG++LH+Q Sbjct: 75 GELQIHVLKQFLLPGHPEILIVSNIVENGQPIGLGDAGKFWHSDLSYKELPSLGSMLHAQ 134 Query: 136 ELPAERGDTLYANTAAAWDSLPAALKTLLEGKRAVHSYVYRYERLRKLSPWRAPLTQQQI 195 ELP E GDTL+A+ AWDSLP AL+ +EG+ A HSY RY R WR L+ Q+ Sbjct: 135 ELPEEGGDTLFADMHKAWDSLPEALRKAIEGRTAAHSYTARYSEPRFEGNWRPTLSAAQL 194 Query: 196 DEVPPVEHPVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPENVYTH 255 EV V HP+V THPESGRK LFVSEGFT+ I+G+P DES LL ELY H RPE++Y H Sbjct: 195 AEVREVVHPIVRTHPESGRKALFVSEGFTTRIVGLPADESAQLLAELYAHSVRPEHIYRH 254 Query: 256 RWQAHDLVFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 RWQAHDLVFWDNRS H A P HLRR LYRTT++GD P Sbjct: 255 RWQAHDLVFWDNRSLIHLAGGCPAHLRRKLYRTTIQGDAP 294 >PA3935 [Q] COG2175 Probable taurine catabolism dioxygenase Pae Pseudomonas aeruginosa Length = 277 Score = 196 bits (499), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 112/273 (41%), Positives = 162/273 (59%), Gaps = 10/273 (3%) Query: 25 LGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQRITPQQHIDFSRRFGPLQVHVLN 84 LGA + G+DL P+ I +AL+EH V+ FRDQ + P+ F+ RFG L +H + Sbjct: 12 LGAIVSGIDLGAPLDDTGQRAIEQALLEHQVLFFRDQSLEPRSQARFAARFGDLHIHPIY 71 Query: 85 RFHLAGHPEILIVSNVVENGKPIGLVDAGADWHSDLSYMPKPSLGALLHSQELPAERGDT 144 + PE++++ V + V A WH+D++++ P+LGA+L +++LP GDT Sbjct: 72 P-SVPEQPEVIVLDTAVTD------VRDNAIWHTDVTFLETPALGAVLAAKQLPPYGGDT 124 Query: 145 LYANTAAAWDSLPAALKTLLEGKRAVHSYVYRY--ERLRKLSPWRAPLTQQQIDEVPPVE 202 L+A++ AA+++L A L+ LL+G A H + ER A L + ++ PP Sbjct: 125 LWASSTAAYEALSAPLRRLLDGLTATHDIGKSFPRERFGVTEADLARLEEARLKN-PPRS 183 Query: 203 HPVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPENVYTHRWQAHDL 262 HPVV THP +GRK LFVS+GFT+ I + ESDALLK L+ H TRPE RWQ +D+ Sbjct: 184 HPVVRTHPVTGRKGLFVSDGFTTRINELEPAESDALLKFLFAHATRPEFTVRWRWQENDV 243 Query: 263 VFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 FWDNR TQHYA + RR ++R T+ GD P Sbjct: 244 AFWDNRVTQHYAVDDYRPQRRVMHRATILGDKP 276 >tauD [Q] COG2175 Probable taurine catabolism dioxygenase Eco Escherichia coli K12 Length = 283 Score = 192 bits (487), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 108/277 (38%), Positives = 162/277 (58%), Gaps = 18/277 (6%) Query: 25 LGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQRITPQQHIDFSRRFGPLQVHVLN 84 +GA+I G DL +P+S + ++ A++ H VV RDQ ITPQQ ++RFG L +H + Sbjct: 14 IGAQISGADLTRPLSDNQFEQLYHAVLRHQVVFLRDQAITPQQQRALAQRFGELHIHPVY 73 Query: 85 RFHLAGHPEILIVSNVVENGKPIGLVDAGADWHSDLSYMPKPSLGALLHSQELPAERGDT 144 H G EI+++ N P +WH+D++++ P GA+L ++ELP+ GDT Sbjct: 74 P-HAEGVDEIIVLD--THNDNP----PDNDNWHTDVTFIETPPAGAILAAKELPSTGGDT 126 Query: 145 LYANTAAAWDSLPAALKTLLEGKRAVHSY-----VYRYERLRKL-SPWRAPLTQQQIDEV 198 L+ + AA+++L + LL G RA H + Y+Y + + WR + + + Sbjct: 127 LWTSGIAAYEALSVPFRQLLSGLRAEHDFRKSFPEYKYRKTEEEHQRWR-----EAVAKN 181 Query: 199 PPVEHPVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPENVYTHRWQ 258 PP+ HPVV THP SG++ LFV+EGFT+ I+ + ES+ALL L+ HIT+PE RWQ Sbjct: 182 PPLLHPVVRTHPVSGKQALFVNEGFTTRIVDVSEKESEALLSFLFAHITKPEFQVRWRWQ 241 Query: 259 AHDLVFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 +D+ WDNR TQHYA RR ++R T+ GD P Sbjct: 242 PNDIAIWDNRVTQHYANADYLPQRRIMHRATILGDKP 278 >ZtauD [Q] COG2175 Probable taurine catabolism dioxygenase EcZ Escherichia coli O157:H7 EDL933 Length = 283 Score = 191 bits (486), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 108/277 (38%), Positives = 162/277 (58%), Gaps = 18/277 (6%) Query: 25 LGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQRITPQQHIDFSRRFGPLQVHVLN 84 +GA+I G DL +P+S + ++ A++ H VV RDQ ITPQQ ++RFG L +H + Sbjct: 14 IGAQISGADLTRPLSDNQFEQLYHAVLRHQVVFLRDQAITPQQQRALAQRFGELHIHPVY 73 Query: 85 RFHLAGHPEILIVSNVVENGKPIGLVDAGADWHSDLSYMPKPSLGALLHSQELPAERGDT 144 H G EI+++ N P +WH+D++++ P GA+L ++ELP+ GDT Sbjct: 74 P-HAEGVDEIIVLD--THNDNP----PDNDNWHTDVTFIETPPAGAILAAKELPSTGGDT 126 Query: 145 LYANTAAAWDSLPAALKTLLEGKRAVHSY-----VYRYERLRKL-SPWRAPLTQQQIDEV 198 L+ + AA+++L + LL G RA H + Y+Y + + WR + + + Sbjct: 127 LWTSGIAAYEALSVPFRQLLSGLRAEHDFRKSFPEYKYRKTEEEHQRWR-----EAVAKN 181 Query: 199 PPVEHPVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPENVYTHRWQ 258 PP+ HPVV THP SG++ LFV+EGFT+ I+ + ES+ALL L+ HIT+PE RWQ Sbjct: 182 PPLLHPVVRTHPVSGKQALFVNEGFTTRIVDVSEKESEALLGFLFAHITKPEFQVRWRWQ 241 Query: 259 AHDLVFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 +D+ WDNR TQHYA RR ++R T+ GD P Sbjct: 242 PNDIAIWDNRVTQHYANADYLPQRRIMHRATILGDKP 278 >ECs0422 [Q] COG2175 Probable taurine catabolism dioxygenase Ecs Escherichia coli O157:H7 Length = 283 Score = 191 bits (486), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 108/277 (38%), Positives = 162/277 (58%), Gaps = 18/277 (6%) Query: 25 LGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQRITPQQHIDFSRRFGPLQVHVLN 84 +GA+I G DL +P+S + ++ A++ H VV RDQ ITPQQ ++RFG L +H + Sbjct: 14 IGAQISGADLTRPLSDNQFEQLYHAVLRHQVVFLRDQAITPQQQRALAQRFGELHIHPVY 73 Query: 85 RFHLAGHPEILIVSNVVENGKPIGLVDAGADWHSDLSYMPKPSLGALLHSQELPAERGDT 144 H G EI+++ N P +WH+D++++ P GA+L ++ELP+ GDT Sbjct: 74 P-HAEGVDEIIVLD--THNDNP----PDNDNWHTDVTFIETPPAGAILAAKELPSTGGDT 126 Query: 145 LYANTAAAWDSLPAALKTLLEGKRAVHSY-----VYRYERLRKL-SPWRAPLTQQQIDEV 198 L+ + AA+++L + LL G RA H + Y+Y + + WR + + + Sbjct: 127 LWTSGIAAYEALSVPFRQLLSGLRAEHDFRKSFPEYKYRKTEEEHQRWR-----EAVAKN 181 Query: 199 PPVEHPVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPENVYTHRWQ 258 PP+ HPVV THP SG++ LFV+EGFT+ I+ + ES+ALL L+ HIT+PE RWQ Sbjct: 182 PPLLHPVVRTHPVSGKQALFVNEGFTTRIVDVSEKESEALLGFLFAHITKPEFQVRWRWQ 241 Query: 259 AHDLVFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 +D+ WDNR TQHYA RR ++R T+ GD P Sbjct: 242 PNDIAIWDNRVTQHYANADYLPQRRIMHRATILGDKP 278 >YPO0185 [Q] COG2175 Probable taurine catabolism dioxygenase Ype Yersinia pestis Length = 282 Score = 186 bits (471), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 102/272 (37%), Positives = 159/272 (58%), Gaps = 8/272 (2%) Query: 25 LGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQRITPQQHIDFSRRFGPLQVHVLN 84 +GA + +++ P+ ++ ++ L++H V+ FR+Q ITP Q D + RFG L +H + Sbjct: 14 IGALVENINIAHPLGDSQFEQLYHVLLKHQVLFFRNQPITPLQQRDLAGRFGDLHIHPV- 72 Query: 85 RFHLAGHPEILIVSNVVENGKPIGLVDAGADWHSDLSYMPKPSLGALLHSQELPAERGDT 144 + E +IV + ++ P +WH+D++++ P LGA+L +++LP GDT Sbjct: 73 -YPHTQECEEIIVLDTADDNPP-----DNDNWHTDVTFIETPPLGAILAAKQLPTTGGDT 126 Query: 145 LYANTAAAWDSLPAALKTLLEGKRAVHSYVYRY-ERLRKLSPWRAPLTQQQIDEVPPVEH 203 L+++ AA+D+L A K LL G +A H + + E + +P Q ++ PP+ H Sbjct: 127 LWSSGIAAYDALSAPFKQLLAGLQAEHDFTKSFPEHKHRTTPEEHQRWLQGKEKNPPLLH 186 Query: 204 PVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPENVYTHRWQAHDLV 263 PV+ THP SGR+ LFV+EGFT+ IIG+ ES+ALL L+ H T+PE RWQ D+ Sbjct: 187 PVIRTHPVSGRQALFVNEGFTTRIIGLSDKESEALLGFLFAHTTKPEFQVRWRWQQDDVA 246 Query: 264 FWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 WDNR TQHYA RR ++R T+ GD P Sbjct: 247 IWDNRVTQHYANADYLPQRRVMHRATILGDRP 278 >PA0194 [Q] COG2175 Probable taurine catabolism dioxygenase Pae Pseudomonas aeruginosa Length = 299 Score = 154 bits (389), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/299 (32%), Positives = 157/299 (52%), Gaps = 10/299 (3%) Query: 3 AATLERPQ-DIHQEFEIHRFDAPLGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQ 61 +AT +P+ ++ + F I +APLGAE+ GLD +P++ ++ +++AL EH ++VFR Q Sbjct: 4 SATARQPEPEVAEAFRITPLEAPLGAEVRGLDARRPLAPEQVLALKQALREHHILVFRQQ 63 Query: 62 RITPQQHIDFSRRFG-----PLQVHVLNRFHLAGHPEILIVSNVVENGKPIGLVDAGADW 116 + +Q++ F+ FG P + VL+ P+I+ V+N + L + Sbjct: 64 HLDDEQYLRFATLFGSVFQPPADIPVLSSGGDGKVPDIVKVANTGDGE----LGNFALPA 119 Query: 117 HSDLSYMPKPSLGALLHSQELPAERGDTLYANTAAAWDSLPAALKTLLEGKRAVHSYVYR 176 H D + P PS G+ L++ E+P+ G+T + N A A++SL A + ++G R ++ + Sbjct: 120 HIDHQWTPVPSSGSFLYALEVPSSGGETRFTNLARAYESLDEATRREIDGLRLINYNPFI 179 Query: 177 YERLRKLSPWRAPLTQQQIDEVPPVEHPVVITHPESGRKILFVSEGFTSHIIGIPRDESD 236 R A I+ + EHP+V THPESGR++LF+S I G Sbjct: 180 RLREGGYGGGFATYRTPDIEPIQGSEHPLVRTHPESGRRVLFLSAHTEVEIPGYDPARGQ 239 Query: 237 ALLKELYTHITRPENVYTHRWQAHDLVFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 AL+ L H+ RPE Y+H W D+V+WDN++ H P RR L R ++ G P Sbjct: 240 ALIGRLREHLARPELSYSHAWSVGDIVWWDNQAVLHARNAFPASERRRLKRISLAGSRP 298 >Rv3406 [Q] COG2175 Probable taurine catabolism dioxygenase Mtu Mycobacterium tuberculosis H37Rv Length = 295 Score = 134 bits (338), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 93/283 (32%), Positives = 140/283 (49%), Gaps = 19/283 (6%) Query: 18 IHRFDAPLGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQ-RITPQQHIDFSRRFG 76 + + + +GA+I G+ L + A + IR AL+ H VV FR Q ++ + + F+ G Sbjct: 7 VKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLAFAGLLG 66 Query: 77 -PLQVHVLNRFHLAGHPEILIVSNVVENGKPIGLVDAGAD-WHSDLSYMPKPSLGALLHS 134 P+ GHP + +++ PI A+ WH+D+++ ++L + Sbjct: 67 TPI-----------GHPAAIALADDAPIITPINSEFGKANRWHTDVTFAANYPAASVLRA 115 Query: 135 QELPAERGDTLYANTAAAWDSLPAALKTLLEGKRAVHSYVYRYERLRKLSPWRAPLTQQQ 194 LP+ G TL+ANTAAA+ LP LK L E A+H+ Y Y + L+ A +Q Sbjct: 116 VSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKPLTA--AQRAFRQ 173 Query: 195 IDEVPP--VEHPVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPENV 252 + E P EHPVV HPE+G + L + F +G+ ES L + L IT PEN Sbjct: 174 VFEKPDFRTEHPVVRVHPETGERTLLAGD-FVRSFVGLDSHESRVLFEVLQRRITMPENT 232 Query: 253 YTHRWQAHDLVFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 W D+ WDNR+TQH A R ++R T+ GDVP Sbjct: 233 IRWNWAPGDVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVP 275 >MT3514 [Q] COG2175 Probable taurine catabolism dioxygenase MtC Mycobacterium tuberculosis CDC1551 Length = 295 Score = 134 bits (338), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 93/283 (32%), Positives = 140/283 (49%), Gaps = 19/283 (6%) Query: 18 IHRFDAPLGAEIVGLDLNKPVSAAELARIRKALVEHGVVVFRDQ-RITPQQHIDFSRRFG 76 + + + +GA+I G+ L + A + IR AL+ H VV FR Q ++ + + F+ G Sbjct: 7 VKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLAFAGLLG 66 Query: 77 -PLQVHVLNRFHLAGHPEILIVSNVVENGKPIGLVDAGAD-WHSDLSYMPKPSLGALLHS 134 P+ GHP + +++ PI A+ WH+D+++ ++L + Sbjct: 67 TPI-----------GHPAAIALADDAPIITPINSEFGKANRWHTDVTFAANYPAASVLRA 115 Query: 135 QELPAERGDTLYANTAAAWDSLPAALKTLLEGKRAVHSYVYRYERLRKLSPWRAPLTQQQ 194 LP+ G TL+ANTAAA+ LP LK L E A+H+ Y Y + L+ A +Q Sbjct: 116 VSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKPLTA--AQRAFRQ 173 Query: 195 IDEVPP--VEHPVVITHPESGRKILFVSEGFTSHIIGIPRDESDALLKELYTHITRPENV 252 + E P EHPVV HPE+G + L + F +G+ ES L + L IT PEN Sbjct: 174 VFEKPDFRTEHPVVRVHPETGERTLLAGD-FVRSFVGLDSHESRVLFEVLQRRITMPENT 232 Query: 253 YTHRWQAHDLVFWDNRSTQHYAAITPQHLRRTLYRTTVEGDVP 295 W D+ WDNR+TQH A R ++R T+ GDVP Sbjct: 233 IRWNWAPGDVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVP 275