BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0343.p (429 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA5484 [T] COG0642 Signal transduction histidine kinase Pae Pseu... 109 1e-23 ECs4926 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 108 2e-23 ZhydH [T] COG0642 Signal transduction histidine kinase EcZ Esche... 108 2e-23 STM4173 [T] COG0642 Signal transduction histidine kinase Sty Sal... 108 3e-23 AGl3043 [T] COG4191 Signal transduction histidine kinase regulat... 107 7e-23 BH1802 [T] COG0642 Signal transduction histidine kinase Bha Baci... 106 1e-22 atoS_3 [T] COG0642 Signal transduction histidine kinase Eco Esch... 105 2e-22 hydH [T] COG0642 Signal transduction histidine kinase Eco Escher... 105 3e-22 BS_yycG [T] COG5002 Signal transduction histidine kinase Bsu Bac... 103 8e-22 BH1920 [T] COG0642 Signal transduction histidine kinase Bha Baci... 102 3e-21 >PA5484 [T] COG0642 Signal transduction histidine kinase Pae Pseudomonas aeruginosa Length = 595 Score = 109 bits (272), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 82/218 (37%), Positives = 114/218 (52%), Gaps = 18/218 (8%) Query: 219 AHEIRNPIGTMRMKA---ENALAAPPQMREARATGALEMVVAQTERLDALVGSLLALSQP 275 +HE+R P+ M+M L P + REA ++ V + RL L+ LL S+ Sbjct: 384 SHELRTPVTGMQMAFSLLRERLDFPAESREA---DLIQTVDEEMSRLVLLINDLLNFSR- 439 Query: 276 FQLQRQPL-----DLAQWLPQRRLAHLEMAERQGVRIQVTLPEQDDLVTHSLDPAQLARA 330 +Q Q L DL L Q + + E + V +Q+ L D+L LD Q+ R Sbjct: 440 YQTGMQKLELASCDLVDLLTQAQQRFIPKGEARRVSLQLELG--DELPRLQLDRLQIERV 497 Query: 331 LDNLLLNALAHCPAGGEIEIGARLRSPGRLLLWVADNGPGVPQDLRQSLFDPFVS--QRP 388 +DNLL NAL H GG+I + AR R R+L+ V DNG G+P + +F+PFV ++ Sbjct: 498 IDNLLENALRHSSEGGQIHLQAR-RQGDRVLIAVEDNGEGIPFSQQGRIFEPFVQVGRKK 556 Query: 389 GGTGLGLVLVREIIHAHGGEI-ILAPTAAGARFEMELP 425 GG GLGL L +EII HGG I + + GARF M LP Sbjct: 557 GGAGLGLALCKEIIQLHGGRIAVRSQPGQGARFYMLLP 594 >ECs4926 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 458 Score = 108 bits (270), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 80/261 (30%), Positives = 127/261 (48%), Gaps = 10/261 (3%) Query: 166 LLVAIGLLLAFVVITGLWLGATLTRWRSQSERLAAQLAHAERLATLGRVAAGMAHEIRNP 225 +L A+ +L V++ W R+ + L ++ E+L LG +AAG+AHEIRNP Sbjct: 197 ILFALATVLLASVLSFFWY----RRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNP 252 Query: 226 IGTMRMKAENALAAPPQMREARATGALEMVVAQTERLDALVGSLLALSQPFQLQRQPLDL 285 + +++ A+ P EA +++ + +RL+ +V LL L +P L Q +DL Sbjct: 253 LSSIKGLAKYFAERAPAGGEAHQLA--QVMAKEADRLNRVVSELLELVKPTHLALQAVDL 310 Query: 286 AQWLPQRRLAHLEMAERQGVRIQVTLPEQDDLVTHSLDPAQLARALDNLLLNALAHCPAG 345 + L + IQ+ D L DP +L + L NL LNA+ Sbjct: 311 NTLINHS--LQLVSQDANCREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQH 368 Query: 346 GEIEIGARLRSPGRLLLWVADNGPGVPQDLRQSLFDPFVSQRPGGTGLGLVLVREIIHAH 405 G I + A G + + V D+G G+ D +++F P+ + + GTGLGL +V I+ H Sbjct: 369 GVISVTASESGAG-VKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQH 427 Query: 406 GGEIILAP-TAAGARFEMELP 425 GG I +A GARF + LP Sbjct: 428 GGTIQVASLEGKGARFTLWLP 448 >ZhydH [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 458 Score = 108 bits (270), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 80/261 (30%), Positives = 127/261 (48%), Gaps = 10/261 (3%) Query: 166 LLVAIGLLLAFVVITGLWLGATLTRWRSQSERLAAQLAHAERLATLGRVAAGMAHEIRNP 225 +L A+ +L V++ W R+ + L ++ E+L LG +AAG+AHEIRNP Sbjct: 197 ILFALATVLLASVLSFFWY----RRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNP 252 Query: 226 IGTMRMKAENALAAPPQMREARATGALEMVVAQTERLDALVGSLLALSQPFQLQRQPLDL 285 + +++ A+ P EA +++ + +RL+ +V LL L +P L Q +DL Sbjct: 253 LSSIKGLAKYFAERAPAGGEAHQLA--QVMAKEADRLNRVVSELLELVKPTHLALQAVDL 310 Query: 286 AQWLPQRRLAHLEMAERQGVRIQVTLPEQDDLVTHSLDPAQLARALDNLLLNALAHCPAG 345 + L + IQ+ D L DP +L + L NL LNA+ Sbjct: 311 NTLINHS--LQLVSQDANCREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQH 368 Query: 346 GEIEIGARLRSPGRLLLWVADNGPGVPQDLRQSLFDPFVSQRPGGTGLGLVLVREIIHAH 405 G I + A G + + V D+G G+ D +++F P+ + + GTGLGL +V I+ H Sbjct: 369 GVISVTAXZSGAG-VKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQH 427 Query: 406 GGEIILAP-TAAGARFEMELP 425 GG I +A GARF + LP Sbjct: 428 GGTIQVASLEGKGARFTLWLP 448 >STM4173 [T] COG0642 Signal transduction histidine kinase Sty Salmonella typhimurium LT2 Length = 465 Score = 108 bits (269), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 74/235 (31%), Positives = 121/235 (51%), Gaps = 6/235 (2%) Query: 192 RSQSERLAAQLAHAERLATLGRVAAGMAHEIRNPIGTMRMKAENALAAPPQMREARATGA 251 RS E L A + E+L +G +AAG+AHEIRNP+ +++ A+ P E+ Sbjct: 229 RSHRELLDA-MKRKEKLVAMGHLAAGVAHEIRNPLSSIKGLAKYFAERTPAGGESHELA- 286 Query: 252 LEMVVAQTERLDALVGSLLALSQPFQLQRQPLDLAQWLPQRRLAHLEMAERQGVRIQVTL 311 +++ + +RL+ +V LL L +P L Q ++L + +L + Q IQ+ Sbjct: 287 -QVMAKEADRLNRVVSELLELVKPAHLTLQTVNLNDIITHS--LNLVSQDAQSREIQLRF 343 Query: 312 PEQDDLVTHSLDPAQLARALDNLLLNALAHCPAGGEIEIGARLRSPGRLLLWVADNGPGV 371 + L DP +L + L NL LNA+ G I + A+ R+++ V D+G G+ Sbjct: 344 TANETLKRIQADPDRLTQVLLNLYLNAIHAIGRQGTISVEAKESGTDRVIITVTDSGKGI 403 Query: 372 PQDLRQSLFDPFVSQRPGGTGLGLVLVREIIHAHGGEI-ILAPTAAGARFEMELP 425 D +++F P+ + + GTGLGL +V+ II HGG I + + GA F + LP Sbjct: 404 APDQLEAIFTPYFTTKADGTGLGLAVVQNIIEQHGGAIKVKSIEGKGAVFTIWLP 458 >AGl3043 [T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 633 Score = 107 bits (266), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 75/225 (33%), Positives = 115/225 (51%), Gaps = 3/225 (1%) Query: 201 QLAHAERLATLGRVAAGMAHEIRNPIGTMRMKAENALAAPPQMREARATGALEMVVAQTE 260 +L A RL+ LG+VAAG+AHEI P+ T+R A+NA + R A A LE + A TE Sbjct: 408 ELVQANRLSILGQVAAGVAHEINQPVATIRAFADNARTLLKRDRLAEANENLEDIAALTE 467 Query: 261 RLDALVGSLLALSQPFQLQRQPLDLAQWLPQRRLAHLEMAERQGVRIQVTLPEQDDLVTH 320 R+ + L L++ + +P+ + + Q + + LP+QD V Sbjct: 468 RIGTITTDLKILARKGRTAAEPVSARLVIEGAVVLLRSRFSGQMDALDIVLPDQDLKVLG 527 Query: 321 SLDPAQLARALDNLLLNALAHCPAGGEIEIGARLRSPGRL-LLWVADNGPGVPQDLRQSL 379 S +L + L NLL NAL + R+R G + ++ V+DNG G+P+ +R L Sbjct: 528 S--RIRLEQILINLLQNALEATETIETARVEVRVREEGDMVVISVSDNGAGIPEAIRAQL 585 Query: 380 FDPFVSQRPGGTGLGLVLVREIIHAHGGEIILAPTAAGARFEMEL 424 F PF + + G GLGLV+ +I +GG I + + AG F + L Sbjct: 586 FSPFNTSKESGLGLGLVISNDIASDYGGRIEVTSSGAGTSFSVYL 630 >BH1802 [T] COG0642 Signal transduction histidine kinase Bha Bacillus halodurans Length = 600 Score = 106 bits (265), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 73/277 (26%), Positives = 141/277 (50%), Gaps = 28/277 (10%) Query: 154 RVPVMSAAVLDQLLVAIGLLLAFVVITGLWLGATLTRWRSQSERLAAQLAHAERLATLGR 213 +V V + + + IG + F+ IT + E +A ++ +E+LA +G Sbjct: 342 QVLVSKTELFNDQQIVIGQIFYFIDIT-------------EVEEMAKRMHQSEKLALVGE 388 Query: 214 VAAGMAHEIRNPIGTMRMKAENALAAPPQMREARATGALEMVVAQTERLDALVGSLLALS 273 +AAG AHEIRNP+ + P E ++ + +++ + +R++ ++ +L L+ Sbjct: 389 MAAGAAHEIRNPLAVIHGFISLMKQTMPDSNENKS--YMPLLLQEIDRINGIIDEMLLLA 446 Query: 274 QPFQ--LQRQPL-DLAQWL-PQRRLAHLEMAERQGVRIQVTLPEQDDLVTHSLDPAQLAR 329 +P L+R + ++A+ L P R ++ ++I++ L D +D Q+ + Sbjct: 447 KPGAPILKRGDIKEMAEELIPLIRHSY----GHDDLKIEMKL----DSAVVMMDRKQMKQ 498 Query: 330 ALDNLLLNALAHCPAGGEIEIGARLRSPGRLLLWVADNGPGVPQDLRQSLFDPFVSQRPG 389 L NL+ N++ G + + +++ G L++ D G G+P L++++F+PF S + Sbjct: 499 VLHNLIKNSIDAVGGTGTVTLYSKVDESGWYHLFIRDTGKGIPSHLQETIFEPFSSSKES 558 Query: 390 GTGLGLVLVREIIHAHGGEIILAPTAA-GARFEMELP 425 GTGLGL +V+ II H G I L ++ G F++ LP Sbjct: 559 GTGLGLTIVQRIIENHHGSIRLVDSSENGTTFQISLP 595 >atoS_3 [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 278 Score = 105 bits (262), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 76/239 (31%), Positives = 129/239 (53%), Gaps = 17/239 (7%) Query: 192 RSQSERLAAQLAHAERLATLGRVAAGMAHEIRNPIGTMR--MKAENALAAPPQMREARAT 249 R +++R ++A AERLATLG + AG+AHE+RNP+ +R ++ + P +E Sbjct: 43 RKETQR---RMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEY--- 96 Query: 250 GALEMVVAQTERLDALVGSLLALSQPFQLQRQPLDLAQWLPQRRLAHLEMAERQGVRIQV 309 L +V+ + + ++ ++ LL S+P Q Q + L + + L + + GV+ +V Sbjct: 97 --LSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEET----LVLVQTAGVQARV 150 Query: 310 TLPEQ--DDLVTHSLDPAQLARALDNLLLNALAHCPAGGEIEIGARLRSPGRLLLWVADN 367 + ++L + D L + L N+L+NA+ A G+I I S + + + DN Sbjct: 151 DFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDN 210 Query: 368 GPGVPQDLRQSLFDPFVSQRPGGTGLGLVLVREIIHAHGGEIILAPT-AAGARFEMELP 425 G G+ L++ +FDPF + + GTGLGL L + II+AH G+I +A GA F + LP Sbjct: 211 GCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILP 269 >hydH [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 465 Score = 105 bits (261), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 79/262 (30%), Positives = 128/262 (48%), Gaps = 12/262 (4%) Query: 166 LLVAIGLLLAFVVITGLWLGATLTRWRSQSERLAAQLAHAERLATLGRVAAGMAHEIRNP 225 +L A+ +L V++ W R+ + L ++ E+L LG +AAG+AHEIRNP Sbjct: 204 ILFALATVLLASVLSFFWY----RRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNP 259 Query: 226 IGTMRMKAENALAAPPQMREARATGALEMVVAQTERLDALVGSLLALSQPFQLQRQPLDL 285 + +++ A+ P EA +++ + +RL+ +V LL L +P L Q +DL Sbjct: 260 LSSIKGLAKYFAERAPAGGEAHQLA--QVMAKEADRLNRVVSELLELVKPTHLALQAVDL 317 Query: 286 AQWLPQR-RLAHLEMAERQGVRIQVTLPEQDDLVTHSLDPAQLARALDNLLLNALAHCPA 344 + +L + R+ IQ+ D L DP +L + L NL LNA+ Sbjct: 318 NTLINHSLQLVSQDANSRE---IQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQ 374 Query: 345 GGEIEIGARLRSPGRLLLWVADNGPGVPQDLRQSLFDPFVSQRPGGTGLGLVLVREIIHA 404 G I + A G + + V D+G G+ D ++F P+ + + GTGLGL +V I+ Sbjct: 375 HGVISVTASESGAG-VKISVTDSGKGIAADQLDAIFTPYFTTKAEGTGLGLAVVHNIVEQ 433 Query: 405 HGGEIILAP-TAAGARFEMELP 425 HGG I +A G+ F + LP Sbjct: 434 HGGTIQVASQEGKGSTFTLWLP 455 >BS_yycG [T] COG5002 Signal transduction histidine kinase Bsu Bacillus subtilis Length = 611 Score = 103 bits (257), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 66/206 (32%), Positives = 108/206 (52%), Gaps = 15/206 (7%) Query: 215 AAGMAHEIRNPIGTMRMKAENALAAPPQMREARATGALEMVVAQTERLDALVGSLLALSQ 274 A ++HE+R P+ TMR E ALA + A L + +TER+ LV LL LS+ Sbjct: 381 VANVSHELRTPLTTMRSYLE-ALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSK 439 Query: 275 ----PFQLQRQPLDLAQWLPQRRLAHLEMAERQGVRIQVTLPEQDDLVTHSLDPAQLARA 330 +Q R+ + + +++ + EM + Q V LP++D V +D ++ + Sbjct: 440 FDSKDYQFNREWIQIVRFMS-LIIDRFEMTKEQHVEFIRNLPDRDLYV--EIDQDKITQV 496 Query: 331 LDNLLLNALAHCPAGGEIEIGARLRSPGRLL-LWVADNGPGVPQDLRQSLFDPFV----- 384 LDN++ NAL + P GG + + LL + V D G G+P+ + +FD F Sbjct: 497 LDNIISNALKYSPEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKA 556 Query: 385 -SQRPGGTGLGLVLVREIIHAHGGEI 409 +++ GGTGLGL + +E++ AHGG+I Sbjct: 557 RTRKLGGTGLGLAIAKEMVQAHGGDI 582 >BH1920 [T] COG0642 Signal transduction histidine kinase Bha Bacillus halodurans Length = 548 Score = 102 bits (253), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 80/256 (31%), Positives = 134/256 (52%), Gaps = 22/256 (8%) Query: 183 WLGATLTRWRSQSER--LAAQLAHAERLATLGRVAAGMAHEIRNPIGTMRMKAENALAAP 240 ++GA ++R ++R L Q+ E+ + +GR++AG+AHEIRNP+ T + N L Sbjct: 295 FIGA-YGQFRDITDRVELEQQVIQNEKFSAIGRLSAGLAHEIRNPL-TPIIGFVNLLKNE 352 Query: 241 PQMREARATGALEMVVAQTERLDALVGSLLALSQPFQLQRQPLDLAQWLPQRRLAHLEMA 300 + E +A L ++ + ER+ LV + +S+P + + L + Q + Sbjct: 353 SHLDE-KAKQYLRIMSDELERVRKLVNDFVIVSKPEPPELKKTSLHTLVEQV----IRFM 407 Query: 301 ERQG----VRIQV--TLPEQDDLVTHSLDPAQLARALDNLLLNALAHCPAGGEI--EIGA 352 E QG V+++V ++ E D+L+ +D +Q+ + L NLL NA+ GG I E G Sbjct: 408 ESQGSLHNVQMEVNHSIDETDELL---VDASQMKQVLINLLTNAMDAMERGGTIRVETGK 464 Query: 353 RLRSPGRLLLWVADNGPGVPQDLRQSLFDPFVSQRPGGTGLGLVLVREIIHAHGGEI-IL 411 L + G + V D G G+ +D LF+PF + + G GLGL + II HGG I ++ Sbjct: 465 DLGN-GMFSIKVQDEGCGMSEDQLNQLFNPFFTTKDDGLGLGLSICYRIIKNHGGTINVV 523 Query: 412 APTAAGARFEMELPWR 427 + G+ FE+ LP + Sbjct: 524 SQQGEGSTFEILLPVK 539