BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0273.p (298 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2507 [GER] COG0697 Permeases of the drug/metabolite transport... 164 2e-40 VCA0090 [GER] COG0697 Permeases of the drug/metabolite transport... 162 1e-39 AGc3767 [GER] COG0697 Permeases of the drug/metabolite transport... 117 2e-26 BH0396 [GER] COG0697 Permeases of the drug/metabolite transporte... 107 4e-23 SMc01844 [GER] COG0697 Permeases of the drug/metabolite transpor... 88 3e-17 mlr1585 [GER] COG0697 Permeases of the drug/metabolite transport... 80 7e-15 AGl2619 [GER] COG0697 Permeases of the drug/metabolite transport... 78 2e-14 AF0266 [GER] COG0697 Permeases of the drug/metabolite transporte... 66 9e-11 BS_yvbV [GER] COG0697 Permeases of the drug/metabolite transport... 63 1e-09 AGc4240 [GER] COG0697 Permeases of the drug/metabolite transport... 61 3e-09 >RSc2507 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 310 Score = 164 bits (416), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 118/281 (41%), Positives = 169/281 (60%), Gaps = 2/281 (0%) Query: 1 MSSSNLCKLLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPMQW 60 M S+ +LL+LAA+WG SF+ MR+AAP FGP+ R ++A+ LL +RG Sbjct: 1 MRRSDAIELLILAALWGGSFLFMRVAAPPFGPVALIALRVAIASAFLLPVLAMRGGLGAL 60 Query: 61 RSNWLPYLVIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFLLMGERLSLV 120 R +W L +G+ N+A+PF L A++ L + + + + +N+ A +F A+ F +GER+S Sbjct: 61 RPHWPHLLAVGVLNSAVPFCLLAYAELTLTAGFTSVLNAAAPLFAAIVAFAWLGERMSAW 120 Query: 121 RCAAFVLGLVGVAVLVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIAL 180 R +G VGV VLVG A V AA+GA V YG A ++ + G+ P+A+ Sbjct: 121 RVLGLAIGFVGVIVLVGGSSALDARQGGLAVAAALGATVLYGLAGSYAKRYLTGVPPLAV 180 Query: 181 ATGSQFAAALCLLPLAAPSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQLIAAEGAT 240 ATGSQ AAA+ L PLA P G++ L V+ LG+ CTGIAY LFF+LIA G T Sbjct: 181 ATGSQIAAAVVLAPLAVWLWPAHTPTGSV--WLHVIGLGIACTGIAYILFFRLIAHVGPT 238 Query: 241 KAITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIVLVATA 281 +A++VTFLVP+ LW L L E +TL V G A++L+ T+ Sbjct: 239 RAVSVTFLVPVFGVLWGILFLGEQLTLNMVAGCAVILLGTS 279 >VCA0090 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Vch Vibrio cholerae Length = 297 Score = 162 bits (409), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 113/279 (40%), Positives = 164/279 (58%), Gaps = 25/279 (8%) Query: 13 AAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARV--RGVPMQWRSNWLPYLVI 70 AAIWG SF+ MRIAA FGP R A L+L A++ R +P+ R +W +L++ Sbjct: 13 AAIWGGSFLFMRIAAHSFGPAYLIEARVGFAALSLFLVAQLLRRSLPI--RQHWPHFLIL 70 Query: 71 GIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFLLMGERLSLVRCAAFVLGLV 130 G+ NTA+PF LFA++AL + + ++ +NS A ++ A+ GFL G LS A +LG+ Sbjct: 71 GLINTAVPFLLFAYAALTLNVSTLSILNSTAPIWGAVIGFLWHGTPLSRKAVAGLLLGVS 130 Query: 131 GVAVLVG-----IGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIALATGSQ 185 GVAV+VG IG A MV A + AA SYG A +T+ +A +S A GS Sbjct: 131 GVAVIVGWDMVAIGHHAALPMVCAAL-----AAASYGLATNYTK-QAPQLSAFENAHGSM 184 Query: 186 FAAALCLLPL----AAPSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQLIAAEGATK 241 +AA L + PL P +L+ G AV++LGV+CTG+AY ++F+L+ A GA Sbjct: 185 WAACLWVAPLMWFVPLRETPSSLEWG------AVILLGVICTGLAYLIYFRLVKAIGAAS 238 Query: 242 AITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIVLVAT 280 ++VTFL+P+ LW + +LDEP+ L T+ G +VL T Sbjct: 239 TLSVTFLIPVFGILWGYWILDEPIGLNTLFGTLLVLAGT 277 >AGc3767 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 329 Score = 117 bits (294), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 91/282 (32%), Positives = 150/282 (53%), Gaps = 9/282 (3%) Query: 1 MSSSNLCKLLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGV--PM 58 M + L+ L+ +WG SF + +A P+ R SLA +ALL R+ G+ P Sbjct: 27 MDAREWAMLIALSLLWGGSFFFIGVAVKELPPVTIVTLRVSLAAVALLVVCRIMGLRLPR 86 Query: 59 QWRSNWLPYLVIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFG-FLLMGERL 117 +W + W + +G+ N +PF L W I S + +N+ +FT + FL E++ Sbjct: 87 EW-AVWRAFFGMGLLNNIIPFCLIVWGQTQIASGLASILNATTPLFTVIVAHFLTADEKM 145 Query: 118 SLVRCAAFVLGLVGVAVLVGIGPAP-ADAMVIAGVLAAMGAAVSYGFAATF-TRLRAGGI 175 + + A ++G VGVA + IGPA + + G +A +GAA+SY FA F R +A G+ Sbjct: 146 TGNKLAGVLIGFVGVATM--IGPAAFGGSSGLWGQIAILGAAISYSFAGIFGRRFKAMGV 203 Query: 176 SPIALATGSQFAAALCLLPLAA-PSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQLI 234 P+ ATG ++ L L+P A P L L A++ + ++ T +AY +FF+++ Sbjct: 204 PPLMTATGQISSSTLMLIPAALLIDKPWTLAMPGLGTWGALIGIALLSTALAYLIFFRIL 263 Query: 235 AAEGATKAITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIV 276 A+ GAT VTFL+P++A L L+L E + + G+A++ Sbjct: 264 ASAGATNLALVTFLIPVSAILLGSLILGEQLEIKHFAGMAMI 305 >BH0396 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bha Bacillus halodurans Length = 305 Score = 107 bits (266), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 137/295 (46%), Gaps = 8/295 (2%) Query: 9 LLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPMQWRSNWLPYL 68 LL L+ IWG SF+ + + G T R + LL +R + W + Sbjct: 7 LLSLSLIWGFSFVFIEHLLGIVGVWGTVVVRCFAGAIILLPILLMRRKLFYRPAPWKALM 66 Query: 69 VIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFLLMGERLSLVRCAAFVLG 128 ++GIFN LP+ L A S I S+ A +N+L +FT + GFLL LS + VLG Sbjct: 67 IVGIFNAGLPWGLIALSQTEIYSSTAAVLNALTPLFTGLIGFLLYSNALSRQQWGGIVLG 126 Query: 129 LVGVAVLVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIALATGSQFAA 188 GV VL G GV + A + YGFA+ + + + + T S Sbjct: 127 FSGVVVLTGFQLQLLAPEHFVGVGTMILATICYGFASQYVKRHLHDTDVVLITTFSLLFG 186 Query: 189 ALCLLPLAAPSMPHALQAGTLP------ALLAVLVLGVVCTGIAYALFFQLIAAEGATKA 242 L+ L + +L +P +L++++ LG + +G+A+ L++ L+ G A Sbjct: 187 G--LVGLIGMWITDSLHVVRVPLTIDWLSLISIIGLGCLGSGMAHLLYYDLMKKGGPEFA 244 Query: 243 ITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIVLVATATALRAKPAVAARTKAT 297 TVT+L+PMTA +W L LDE +T V G+ ++L+ R + + + + Sbjct: 245 TTVTYLIPMTAIIWGKLFLDELITKNIVIGMLMILMGVYFTSRKRNVCSKANEDS 299 >SMc01844 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 314 Score = 87.8 bits (216), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 77/223 (34%), Positives = 116/223 (52%), Gaps = 12/223 (5%) Query: 63 NWLPYLVIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFL-LMGERLSLVR 121 W +L++G+ N A+P A HI + A +N+ V+T + + E+LS + Sbjct: 75 RWREFLLMGLINNAIPHAFIFLGQTHIGAGLAAILNATTPVWTVLIANVATEDEKLSTAK 134 Query: 122 CAAFVLGLVGVAVLVG-------IGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGG 174 + +LGL G VL+G G A D + A VL + AAVSYGF+AT+ + R Sbjct: 135 FSGCLLGLAGTVVLIGPSALAGLFGTA-GDVPLWALVLPVL-AAVSYGFSATYGK-RFRD 191 Query: 175 ISPIALATGSQFAAALCLLPLAA-PSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQL 233 ++P A G A+ L +LP+A MP + L +LA+L L +V T AY LFF++ Sbjct: 192 LAPPVTAAGQLTASTLIMLPVAVLVDMPWTMPMPPLTTVLAILGLALVSTAYAYILFFRI 251 Query: 234 IAAEGATKAITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIV 276 +A GAT VT LVP +A L +L L E + V G+ ++ Sbjct: 252 MAEAGATNTSLVTLLVPPSAILLGYLFLGEMLQATDVGGMLLI 294 >mlr1585 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 305 Score = 79.7 bits (195), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 86/284 (30%), Positives = 141/284 (49%), Gaps = 14/284 (4%) Query: 1 MSSSNLCKLLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPMQW 60 M+ ++ +LLLL AIWG SF RIA P++ R ++A +AL + +RG + Sbjct: 13 MTLTDWGQLLLLGAIWGGSFFFARIAVAELHPLVLVLFRVAIAAIALQIYLGLRGPSFR- 71 Query: 61 RSNWLPYLVIGIF------NTALPFALFAWSALHIPSAYMATMNSLALVFTAMF-GFLLM 113 L + G+F N +PF+L + + + +N+ +T + L Sbjct: 72 ----LAFPHAGLFFLLAFTNNVVPFSLIFAGQTELGAGVASVLNATTPFWTLILANALTS 127 Query: 114 GERLSLVRCAAFVLGLVGVAVLVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAG 173 E+LS + A LG+ G AV++G G + A +GA++SYG A R G Sbjct: 128 DEKLSWNKLAGIGLGVAGTAVMIGPGLLAGLGGPVWAKFALIGASLSYGVALMVARRFKG 187 Query: 174 GISPIALATGSQFAAALCLLPLAAPSM-PHALQAGTLPALLAVLVLGVVCTGIAYALFFQ 232 SP+ +ATG A+ + ++P+ + P L + + AVL L ++ T AY L+F Sbjct: 188 VPSPV-IATGQLTASTIIMIPIVLLTHGPADLFSASPSVWAAVLALALLSTAFAYILYFN 246 Query: 233 LIAAEGATKAITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIV 276 L+A+ GAT A VT +VP +A L +L L E + L + G+ ++ Sbjct: 247 LVASAGATNASLVTLIVPASAMLLGFLFLGERLELFEIGGVVLI 290 >AGl2619 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 297 Score = 78.2 bits (191), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 84/300 (28%), Positives = 139/300 (46%), Gaps = 18/300 (6%) Query: 1 MSSSNLCKLLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPMQW 60 M+ +L + LA WG SF+L+ FG + R+ + +AL AR + + Sbjct: 1 MAPRDLAAYIFLAITWGVSFLLLLHVVAAFGWIGAVTLRSLITAVALYLIARAARRKLAF 60 Query: 61 RSNWLPYLVIGIFNTALPFALFAWSALHIPSAY----MATMNSLALVFTAMFGFLLMGER 116 ++W + ++G A +++ I +A +AT+ +++ + M+G ER Sbjct: 61 SASWRAFAIVGATTVAGQLIGLSYATPQIGTAMAAILVATIPLFSMLISQMWGL----ER 116 Query: 117 LSLVRCAAFVLGLVGVAVLVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGIS 176 L+ A V+G G+ +LVG P + I G AA+ A + + + F L G+ Sbjct: 117 LTRQGIAGLVIGFAGIVLLVGFPAVPVTSGFIIGCAAAVAACICAAYGSNFASLHLKGVG 176 Query: 177 PIALATGSQFAAALCLLPL----AAPSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQ 232 + GS L LPL P P + G L L+ VV +G+ Y +F+ Sbjct: 177 SWEITIGSFLTGGLMTLPLLFAVPLPGTPDLVDYGYL------LIQAVVMSGLTYITYFK 230 Query: 233 LIAAEGATKAITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIVLVATATALRAKPAVAA 292 L+++ GATKAI+V F V + A L L+LDEP++L + G I++ A L P A Sbjct: 231 LVSSIGATKAISVEFAVTVVAVLVGALVLDEPLSLPQLFGAGIIIFGCALVLDLLPKKKA 290 >AF0266 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Afu Archaeoglobus fulgidus Length = 276 Score = 66.2 bits (160), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 65/275 (23%), Positives = 129/275 (46%), Gaps = 15/275 (5%) Query: 16 WGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPMQWRSNWLPYLV-IGIFN 74 WG +F ++ + P+ R ++A L A + G ++W+ LP + +GIF Sbjct: 14 WGLAFTAIKYSVRFLSPIAIASLRFAIAN-TLFAVIIILGKRIKWKD--LPKVFALGIFG 70 Query: 75 TALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFLLMGERLSLVRCAAFVLGLVGVAV 134 ++ ++I S + + SLA +F + + + ER++ + ++ +GV V Sbjct: 71 VSVYHVFLNLGEVYISSGVASVVISLAPIFVLILSAIFLRERITYSKVVGIIIAFLGVVV 130 Query: 135 LVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIALATGSQFAAALCLLP 194 + P+ A+ IA V+ + AA Y TF + +PI L + + ++ L P Sbjct: 131 ISE--PSYANIYGIALVMVSTVAAAIY---TTFGKSLLSKYNPITLTSNAMVLGSIPLYP 185 Query: 195 LAAPSMPHALQA--GTLPALLAVLVLGVVCTGIAYALFFQLIAAEGATKAITVTFLVPMT 252 +P ++++ G L + +++ LG+ T Y ++ + E A++A +P+ Sbjct: 186 F----LPDSIRSLGGDLNLIGSIVFLGIFSTFFGYLGWYYFLEKEEASRASVFLLAIPVV 241 Query: 253 ASLWAWLLLDEPVTLGTVTGIAIVLVATATALRAK 287 + L +LL EP+TL TV G +VL+ +R + Sbjct: 242 SLLAGNILLAEPLTLRTVAGSGLVLLGIYIVVRKR 276 >BS_yvbV [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 305 Score = 62.8 bits (151), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 70/293 (23%), Positives = 134/293 (45%), Gaps = 7/293 (2%) Query: 9 LLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPMQWRSNWLPYL 68 L L +WG ++ L + A P+L R + L L+ A R ++ + W YL Sbjct: 13 LAFLVIMWGVNWPLSKAALAYSPPLLFAGIRTLIGGLLLVIVALPRIHKLRLKETWPIYL 72 Query: 69 VIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFLLMGERLSLVRCAAFVLG 128 V + N L + L ++P+ + + V +F +L +GE + +++ +LG Sbjct: 73 VSALLNITLFYGLQTIGLNYLPAGLFSAIVFFQPVLMGVFSWLWLGESMFVMKVIGLILG 132 Query: 129 LVGVAVLVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIALATGSQFAA 188 GVAV+ G +++ GVL A+G+AVS+ + + + I + Sbjct: 133 FAGVAVISAAGFGGHISVI--GVLLALGSAVSWALGTVYMKKTGSRVDSIWMVALQLTIG 190 Query: 189 ALCLLPLAAPSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQLIAAEGATKAITVTFL 248 ++ LL + + T P + ++L + V + + +FF L+ + A+K + TFL Sbjct: 191 SVFLLISGFWTESFSAIQWTAPFITSLLFISVFVIALGWLVFFTLVGSGEASKVASYTFL 250 Query: 249 VPMTASLWAWLLLDEPVTLGTVTGI-----AIVLVATATALRAKPAVAARTKA 296 +P+ + + + + L EP+TL + G+ +I LV T + + A+ KA Sbjct: 251 IPLISIVASSIFLHEPLTLSLLAGLLLIVTSICLVNTKSKAQKAAAIGINEKA 303 >AGc4240 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 302 Score = 61.2 bits (147), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 76/282 (26%), Positives = 134/282 (47%), Gaps = 10/282 (3%) Query: 15 IWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPM-QWRSNWLPYLVIGIF 73 +W S+ ++I P+ R +A L LL R+RG+ + + + W + V Sbjct: 20 LWAASYTFIKIGVETIPPLTFIAARTLIAGLLLLVVIRLRGLRLPRDPATWRLFFVQACI 79 Query: 74 NTALPFALFAWSALHIPSAYMATMNSLALVFTAMF-GFLLMGERLSLVRCAAFVLGLVGV 132 N+ LPF L AW+ I + +N+ +FT + ++ E +S + + G+ GV Sbjct: 80 NSVLPFTLIAWAEQSIDAGLAVILNATTPIFTFLLTALVIRHETVSGRKLFGTIAGMTGV 139 Query: 133 AVLVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIALATGSQFAAALCL 192 +++G+ I LA + AA SY AA F++ G+ P+ A GS A+ L Sbjct: 140 CLIIGVEALGGAGEAIWSQLAVLTAAFSYACAAIFSK-NFKGLDPVMPAAGSLICGAVLL 198 Query: 193 LPLA-APSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQLIAAEGATKAITVTFL-VP 250 LP++ P L + +L A++ L V T +A+ ++F+L+ G+ + +L VP Sbjct: 199 LPVSLIVDRPWTLSP-SAASLTALVCLSVFSTALAFMIYFRLMQTLGSVGTTSQAYLRVP 257 Query: 251 MTASLWAWLLLDEPVT---LGTVTGIAIVLVATATALRAKPA 289 + ++ L + P + +G V IA VL T + R +PA Sbjct: 258 VGVAIGMVFLGEVPTSAMWVGLVCVIAGVLAMTLPS-RRRPA 298