BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0214.p (627 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2699 [R] COG1574 Predicted metal-dependent hydrolase with the ... 987 0.0 RSc0239 [R] COG1574 Predicted metal-dependent hydrolase with the... 956 0.0 SMa0380 [R] COG1574 Predicted metal-dependent hydrolase with the... 829 0.0 AGl1745 [R] COG1574 Predicted metal-dependent hydrolase with the... 827 0.0 SMa1819 [R] COG1574 Predicted metal-dependent hydrolase with the... 819 0.0 STM1472 [R] COG1574 Predicted metal-dependent hydrolase with the... 284 4e-76 SMa0101 [R] COG1574 Predicted metal-dependent hydrolase with the... 179 1e-44 BMEII0123 [R] COG1574 Predicted metal-dependent hydrolase with t... 154 6e-37 BS_ytcJ [R] COG1574 Predicted metal-dependent hydrolase with the... 147 9e-35 BH3200 [R] COG1574 Predicted metal-dependent hydrolase with the ... 129 2e-29 >PA2699 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Pae Pseudomonas aeruginosa Length = 612 Score = 987 bits (2552), Expect = 0.0, Method: Compositional matrix adjust. Identities = 485/621 (78%), Positives = 523/621 (84%), Gaps = 9/621 (1%) Query: 7 VTPDLILLNGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQAATQVIDLGGRTVI 66 +T DLIL NG+ HTVD+ NP A AVAI GKFL VG+ AE M + +ATQVIDL RTVI Sbjct: 1 MTADLILHNGRFHTVDRDNPTATAVAIKDGKFLAVGNDAEAMLHRGSATQVIDLQKRTVI 60 Query: 67 PGLNDSHLHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGWTEFQF 126 PGLNDSHLHLIRGGLNYNLELRWEGVPSLADALRML +QA RTP PQWVRVVGGW EFQF Sbjct: 61 PGLNDSHLHLIRGGLNYNLELRWEGVPSLADALRMLNNQAERTPSPQWVRVVGGWNEFQF 120 Query: 127 AEKRMPTLEELNAAAPDTPVFVLHLYDRALLNRAALQAVGYTKDTPNPPGGEIVRDASGN 186 AEKRMPTLEELN AAPDTPVFVLHLYDRALLNRAAL+ VGYTKDTPNPPGGEIVRD+SG Sbjct: 121 AEKRMPTLEELNKAAPDTPVFVLHLYDRALLNRAALRVVGYTKDTPNPPGGEIVRDSSGE 180 Query: 187 PTGMLIARPNAMILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSAIDAGGGFQNYPD 246 PTGMLIARPNAMILYATLAKGP LP EYQVNSTRQFMRELNRLG+TSAIDAGGGFQNYPD Sbjct: 181 PTGMLIARPNAMILYATLAKGPKLPLEYQVNSTRQFMRELNRLGLTSAIDAGGGFQNYPD 240 Query: 247 DYQIINKLAADGQLTIRIAYNLFTQNKGGELADFQKWTGMVKPGDGDDFLRHNGAGEMLV 306 DYQ+I +LA GQLT+RIAYNLFTQ ELADF+ WTG VK G G DF RHNGAGEMLV Sbjct: 241 DYQVIRELADQGQLTVRIAYNLFTQKPKEELADFKNWTGSVKYGQGSDFFRHNGAGEMLV 300 Query: 307 FSAADFEDFLEPRPDLAEGMEEELERVVRHLVSNRWPFRLHATYDESIARMLDVFEKVNR 366 FSAADFEDFLEPRPDL + ME+ELE VVRHLV RWPFRLHATYDESI+RMLDVFEKV+R Sbjct: 301 FSAADFEDFLEPRPDLPQTMEQELEPVVRHLVEQRWPFRLHATYDESISRMLDVFEKVDR 360 Query: 367 DIPFDGLHWMFDHAETITERNIERVKALGGGIAIQHRMAFQGEYFIDRYGSEAAEHTPPI 426 DIPF+GL W FDHAETIT RNIERV+ALGGGIAIQ RMAFQGEYF+DRYG++AAE TPPI Sbjct: 361 DIPFNGLPWFFDHAETITPRNIERVRALGGGIAIQDRMAFQGEYFVDRYGAKAAEATPPI 420 Query: 427 AKMLEMGVPVGAGTDATRVASYNPWTALYWLVSGRTVGGAKLYGAAGRLPRETALELWTA 486 +ML GVPVGAGTDATRV+SYNPWT+LYWLVSGRTVGG LY LPRETAL+L+T Sbjct: 421 QRMLAEGVPVGAGTDATRVSSYNPWTSLYWLVSGRTVGGMALYPQG--LPRETALQLFTH 478 Query: 487 GSAWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGKVVYGAGPFS 546 GSAWFSSEQ KKG+I+ GQLADLA LSADFF V E+ IK IES++TVVDGKVVY A F Sbjct: 479 GSAWFSSEQGKKGQIKVGQLADLAALSADFFGVEEEAIKWIESVLTVVDGKVVYAAAEFD 538 Query: 547 SHGPGEIPVLPEWSPVAKVPGHYRAVAKTDAARQKKATLPHACVGSCGVHGHAHDVARKS 606 GP PVLP+WSPVAKVPGH+R A A H CVG+C VH H H+ AR S Sbjct: 539 KLGPPAPPVLPDWSPVAKVPGHWRQGAPLTAQV-------HQCVGACAVHAHEHNRARHS 591 Query: 607 SVPVSHFAGFWGALGCSCFAF 627 +VPVS F GFWGA GCSCFAF Sbjct: 592 NVPVSDFQGFWGAFGCSCFAF 612 >RSc0239 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Rso Ralstonia solanacearum Length = 612 Score = 956 bits (2472), Expect = 0.0, Method: Compositional matrix adjust. Identities = 466/621 (75%), Positives = 520/621 (83%), Gaps = 9/621 (1%) Query: 7 VTPDLILLNGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQAATQVIDLGGRTVI 66 +T DLIL NG+IHTVD+ P A AVA+ G+F+ VG A M + AT+VIDL GRTVI Sbjct: 1 MTADLILHNGRIHTVDRDRPTASAVAVRDGRFVAVGDDATAMAQRGPATRVIDLRGRTVI 60 Query: 67 PGLNDSHLHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGWTEFQF 126 PGLNDSHLHLIRGGLNYNLEL WEGVPSLADALRML++QAARTP PQWVRVVGGWTEFQF Sbjct: 61 PGLNDSHLHLIRGGLNYNLELHWEGVPSLADALRMLREQAARTPSPQWVRVVGGWTEFQF 120 Query: 127 AEKRMPTLEELNAAAPDTPVFVLHLYDRALLNRAALQAVGYTKDTPNPPGGEIVRDASGN 186 AE+RMPTL+ELN AAPDTPVFVLHLYDRALLNRAAL+ VGYT+DTPNPPGGEI RDA G Sbjct: 121 AERRMPTLDELNQAAPDTPVFVLHLYDRALLNRAALRQVGYTRDTPNPPGGEIQRDAGGE 180 Query: 187 PTGMLIARPNAMILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSAIDAGGGFQNYPD 246 PTGMLIARPNAMILYATLAKGP LP EYQVNSTRQFMRELNRLGVTSAIDAGGGFQNYP+ Sbjct: 181 PTGMLIARPNAMILYATLAKGPKLPPEYQVNSTRQFMRELNRLGVTSAIDAGGGFQNYPE 240 Query: 247 DYQIINKLAADGQLTIRIAYNLFTQNKGGELADFQKWTGMVKPGDGDDFLRHNGAGEMLV 306 DY +I +LA + QLT+RIAYNLFTQ ELADF+ WTG V GDDFLRHNGAGEMLV Sbjct: 241 DYTVIRQLAQENQLTVRIAYNLFTQKPKEELADFKHWTGSVPYRQGDDFLRHNGAGEMLV 300 Query: 307 FSAADFEDFLEPRPDLAEGMEEELERVVRHLVSNRWPFRLHATYDESIARMLDVFEKVNR 366 FSAADFEDFL+PRPDL E ME ELE VVRHLV+ RWPFRLHATYDESI+RMLDVFE+V+R Sbjct: 301 FSAADFEDFLQPRPDLPETMEPELEGVVRHLVAQRWPFRLHATYDESISRMLDVFERVDR 360 Query: 367 DIPFDGLHWMFDHAETITERNIERVKALGGGIAIQHRMAFQGEYFIDRYGSEAAEHTPPI 426 +IPFDGL W FDHAETI+ +NIERV+ALGGGIAIQ RMAFQGEYF++RYG+ AA TPPI Sbjct: 361 EIPFDGLPWFFDHAETISPKNIERVRALGGGIAIQDRMAFQGEYFVERYGAAAAGQTPPI 420 Query: 427 AKMLEMGVPVGAGTDATRVASYNPWTALYWLVSGRTVGGAKLYGAAGRLPRETALELWTA 486 +ML GVPVGAGTDATRV+SYNPWT+LYWLVSGRTVGG LY LPR+ AL L+T Sbjct: 421 QRMLAEGVPVGAGTDATRVSSYNPWTSLYWLVSGRTVGGLPLYPQG--LPRDVALALYTH 478 Query: 487 GSAWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGKVVYGAGPFS 546 GSAWFS++Q KG+I+ GQLADLA LSADFFSV E IK IES++TVVDG+VVYGA F+ Sbjct: 479 GSAWFSADQGNKGQIKVGQLADLAALSADFFSVDEAGIKAIESVLTVVDGRVVYGAAEFT 538 Query: 547 SHGPGEIPVLPEWSPVAKVPGHYRAVAKTDAARQKKATLPHACVGSCGVHGHAHDVARKS 606 +GP IPVLPEWSPVA+VPGH+R A Q++ H C G+CGVHGHAH AR + Sbjct: 539 EYGPPPIPVLPEWSPVARVPGHWRPAAPL----QRQV---HHCAGACGVHGHAHQKARTA 591 Query: 607 SVPVSHFAGFWGALGCSCFAF 627 +VP + F FWGA GCSCFAF Sbjct: 592 NVPAADFRAFWGAFGCSCFAF 612 >SMa0380 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Sme Sinorhizobium meliloti Length = 660 Score = 829 bits (2141), Expect = 0.0, Method: Compositional matrix adjust. Identities = 402/632 (63%), Positives = 488/632 (77%), Gaps = 10/632 (1%) Query: 2 TTAASVTPDLILLNGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQAATQVIDLG 61 T ++ PDLIL NG++ T+D+ NP A A+AI G FLEVGS +EVM L + T+++DL Sbjct: 31 TGVDTMHPDLILHNGRVTTLDRTNPNATAIAIKDGLFLEVGSDSEVMALAGSGTKIVDLK 90 Query: 62 GRTVIPGLNDSHLHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGW 121 G+ V+PGL D+H H++RGGLNYN+ELRW+GV SLADA+ MLK Q A TP PQWVRVVGG+ Sbjct: 91 GKGVLPGLIDNHTHVVRGGLNYNMELRWDGVRSLADAMDMLKRQVAITPAPQWVRVVGGF 150 Query: 122 TEFQFAEKRMPTLEELNAAAPDTPVFVLHLYDRALLNRAALQAVGYTKDTPNPPGGEIVR 181 TE QFAEKR+PT+EE+NA APDTPVF+LHLYDRALLN AAL+AVGYT+DTPNPPGGEI R Sbjct: 151 TEHQFAEKRLPTIEEINAVAPDTPVFLLHLYDRALLNGAALRAVGYTRDTPNPPGGEITR 210 Query: 182 DASGNPTGMLIARPNAMILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSAIDAGGGF 241 DA+GNPTG+L+A+PNA ILY+TLAKGP LP +YQVNSTR FMRELNRLGVT IDAGGGF Sbjct: 211 DANGNPTGLLLAKPNAGILYSTLAKGPKLPLDYQVNSTRHFMRELNRLGVTGVIDAGGGF 270 Query: 242 QNYPDDYQIINKLAADGQLTIRIAYNLFTQNKGGELADFQKWTGMVKPGDGDDFLRHNGA 301 QNYPDDY++I KL+ + Q+T+R+AYNLFTQ E DF WT VK G+D+ RHNGA Sbjct: 271 QNYPDDYEVIQKLSDENQMTVRLAYNLFTQKPKEEKQDFLNWTQSVKYKQGNDYFRHNGA 330 Query: 302 GEMLVFSAADFEDFLEPRPDLAEGMEEELERVVRHLVSNRWPFRLHATYDESIARMLDVF 361 GEMLVFSAADFEDF +PRP++A ME ELE V+R L NRWP+RLHATYDE+I+R LDVF Sbjct: 331 GEMLVFSAADFEDFRQPRPEMAPEMEGELEEVLRVLAENRWPWRLHATYDETISRALDVF 390 Query: 362 EKVNRDIPFDGLHWMFDHAETITERNIERVKALGGGIAIQHRMAFQGEYFIDRYGSEAAE 421 EKVN+DIP +GL+W FDHAETI++R+I+R+ ALGGGIA QHRMA+QGEYF +RYG AE Sbjct: 391 EKVNKDIPLEGLNWFFDHAETISDRSIDRIAALGGGIATQHRMAYQGEYFAERYGHGVAE 450 Query: 422 HTPPIAKMLEMGVPVGAGTDATRVASYNPWTALYWLVSGRTVGGAKLYGAAGRLPRETAL 481 TPPI +ML+ GV V AGTDATRVASYNPW +L W+V+G+TVGG +LY A L RETAL Sbjct: 451 ATPPIRRMLDKGVNVSAGTDATRVASYNPWVSLSWMVTGKTVGGMQLYPRANCLDRETAL 510 Query: 482 ELWTAGSAWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGKVVYG 541 +WT WFS+E+ KKGRI+ GQ ADL V DFFS EDEI I S +T+V GK+VYG Sbjct: 511 RMWTEKVTWFSNEEGKKGRIEKGQFADLVVPDKDFFSCAEDEISFIVSELTMVGGKIVYG 570 Query: 542 AGPFSSHGPGEI-PVLPEWSPVAKVPGH------YRAVAKTDAARQKKATLPHACVGSCG 594 AG F + EI P +P+WSPV K G+ RA A++ ++ A C CG Sbjct: 571 AGDFKTLDENEIPPAMPDWSPVRKFGGYAAWGEPERAGARS---LRRTAISTCGCASDCG 627 Query: 595 VHGHAHDVARKSSVPVSHFAGFWGALGCSCFA 626 VHGH H A S +P++ GF+GALGCSC+A Sbjct: 628 VHGHDHAGAWTSKLPIADLKGFFGALGCSCWA 659 >AGl1745 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 625 Score = 827 bits (2137), Expect = 0.0, Method: Compositional matrix adjust. Identities = 402/623 (64%), Positives = 481/623 (77%), Gaps = 6/623 (0%) Query: 9 PDLILLNGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQAATQVIDLGGRTVIPG 68 PD IL NG++ T+D+ NP A AVAI G F+EVGS AEVM L + T++IDL G+ V+PG Sbjct: 3 PDTILHNGRVTTLDRGNPNATAVAIKDGLFVEVGSDAEVMALAGSETKIIDLKGKRVLPG 62 Query: 69 LNDSHLHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGWTEFQFAE 128 L D+H H+IRGGLN+N+ELRW+GV SLADA+ MLK Q A TP PQWVRVVGG+TE QF E Sbjct: 63 LIDNHTHVIRGGLNFNMELRWDGVRSLADAMYMLKRQVAITPAPQWVRVVGGFTEHQFVE 122 Query: 129 KRMPTLEELNAAAPDTPVFVLHLYDRALLNRAALQAVGYTKDTPNPPGGEIVRDASGNPT 188 KR+PT+EE+NA APDTPVF+LHLYDRALLN AAL+AVGYTKDTPNPPGGEI RDA+GNPT Sbjct: 123 KRLPTIEEINAVAPDTPVFLLHLYDRALLNGAALRAVGYTKDTPNPPGGEITRDANGNPT 182 Query: 189 GMLIARPNAMILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSAIDAGGGFQNYPDDY 248 G+L+A+PNA ILY+TLAKGP LP +YQVNSTR FMRELNRLGVT IDAGGGFQNYPDDY Sbjct: 183 GLLLAKPNAGILYSTLAKGPKLPLDYQVNSTRHFMRELNRLGVTGVIDAGGGFQNYPDDY 242 Query: 249 QIINKLAADGQLTIRIAYNLFTQNKGGELADFQKWTGMVKPGDGDDFLRHNGAGEMLVFS 308 ++I KL+ + Q+T+R+AYNLFTQ E DF WT VK G+D+ RHNGAGEMLVFS Sbjct: 243 EVIQKLSDENQMTVRLAYNLFTQKPKQEKEDFLNWTSSVKYKQGNDYFRHNGAGEMLVFS 302 Query: 309 AADFEDFLEPRPDLAEGMEEELERVVRHLVSNRWPFRLHATYDESIARMLDVFEKVNRDI 368 AADFEDF +PRPD+ ME ELE VVR L NRWP+RLHATYDE+I+R LDVFEKVNRDI Sbjct: 303 AADFEDFRQPRPDMPPEMEGELEDVVRILAENRWPWRLHATYDETISRALDVFEKVNRDI 362 Query: 369 PFDGLHWMFDHAETITERNIERVKALGGGIAIQHRMAFQGEYFIDRYGSEAAEHTPPIAK 428 P +GL+W FDHAETI++R+I+R+ ALGGGIA QHRMA+QGEYF++RYG AE TPPIA+ Sbjct: 363 PLEGLNWFFDHAETISDRSIDRIAALGGGIATQHRMAYQGEYFVERYGQGVAEATPPIAR 422 Query: 429 MLEMGVPVGAGTDATRVASYNPWTALYWLVSGRTVGGAKLYGAAGRLPRETALELWTAGS 488 MLE GV V AGTDATRVASYNPW +L+W+V+G+TVGG +LY A L RETAL +WT Sbjct: 423 MLEKGVNVSAGTDATRVASYNPWVSLFWMVTGKTVGGMQLYPRANCLDRETALRMWTEKV 482 Query: 489 AWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGKVVYGAGPFSSH 548 WFS+E+ KKGRI+ GQ ADL V D+FS EDEI + S +T+V GK+VYGAG F Sbjct: 483 TWFSNEEGKKGRIEKGQFADLVVPDKDYFSCAEDEISFLTSELTMVGGKIVYGAGDFRVL 542 Query: 549 GPGEI-PVLPEWSPVAKVPGHYRAVAKTDAA----RQKKATLPHACVGSCGVHGHAHDVA 603 I P +P+WSPV + G Y A + A ++ A C CGVHGH H A Sbjct: 543 DESNIPPAMPDWSPV-RTFGGYAAWGEPQGAGKNSLRRAAITSCGCASDCGVHGHDHAGA 601 Query: 604 RKSSVPVSHFAGFWGALGCSCFA 626 S +P++ GF+GALGCSC+A Sbjct: 602 WTSKLPIADLKGFFGALGCSCWA 624 >SMa1819 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Sme Sinorhizobium meliloti Length = 661 Score = 819 bits (2116), Expect = 0.0, Method: Compositional matrix adjust. Identities = 397/625 (63%), Positives = 481/625 (76%), Gaps = 6/625 (0%) Query: 7 VTPDLILLNGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQAATQVIDLGGRTVI 66 ++ DLIL +G + T+D+ NP A A+AI KFL VG ++M L T+VIDL G+ V+ Sbjct: 37 MSADLILHHGLVTTLDRTNPNATAIAIRDSKFLAVGDDRDIMALAGPETKVIDLKGKRVL 96 Query: 67 PGLNDSHLHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGWTEFQF 126 PGL D+H H++RGGLNYN+ELRW+GV SLADA+ MLK Q A TP PQWVR VGG+TE QF Sbjct: 97 PGLIDNHTHVVRGGLNYNIELRWDGVRSLADAMDMLKRQVAITPPPQWVRAVGGFTEHQF 156 Query: 127 AEKRMPTLEELNAAAPDTPVFVLHLYDRALLNRAALQAVGYTKDTPNPPGGEIVRDASGN 186 EKR+PT++E+NA APDTPVF+LHLYDRALLN AAL+AVGYTKDTPNPPGGEI+RDASGN Sbjct: 157 VEKRLPTIDEINAVAPDTPVFLLHLYDRALLNGAALRAVGYTKDTPNPPGGEIIRDASGN 216 Query: 187 PTGMLIARPNAMILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSAIDAGGGFQNYPD 246 PTGML+A+PNA ILY+TLAKGP LP EYQVNSTR FMRELNRLGVT IDAGGG+QNYPD Sbjct: 217 PTGMLLAKPNAAILYSTLAKGPKLPFEYQVNSTRHFMRELNRLGVTGVIDAGGGYQNYPD 276 Query: 247 DYQIINKLAADGQLTIRIAYNLFTQNKGGELADFQKWTGMVKPGDGDDFLRHNGAGEMLV 306 DY +I KLA DGQ+T+R+AYNLFTQ E DF WT VK GDD+ RHNGAGEMLV Sbjct: 277 DYAVIQKLADDGQMTVRLAYNLFTQKPKEEKQDFLNWTSSVKYKQGDDYFRHNGAGEMLV 336 Query: 307 FSAADFEDFLEPRPDLAEGMEEELERVVRHLVSNRWPFRLHATYDESIARMLDVFEKVNR 366 FSAADFEDF +PRPD+ ME +LE VVR L NRWP+R+HATYDE+I+R LDVFEKVN+ Sbjct: 337 FSAADFEDFRQPRPDMPPEMEGDLEEVVRVLAENRWPWRMHATYDETISRALDVFEKVNQ 396 Query: 367 DIPFDGLHWMFDHAETITERNIERVKALGGGIAIQHRMAFQGEYFIDRYGSEAAEHTPPI 426 D+P +GL+W FDHAETI+ER+I+R+ ALGGGIA QHRMA+QGEYF++RYG AAE TPPI Sbjct: 397 DMPLEGLNWFFDHAETISERSIDRIAALGGGIATQHRMAYQGEYFVERYGHGAAEATPPI 456 Query: 427 AKMLEMGVPVGAGTDATRVASYNPWTALYWLVSGRTVGGAKLYGAAGRLPRETALELWTA 486 AKMLE GV V AGTDATRVASYNPW +L W+++G+T+GG +LY A L RETAL +WT Sbjct: 457 AKMLEKGVHVSAGTDATRVASYNPWVSLSWMITGKTLGGMQLYPRANCLDRETALRMWTE 516 Query: 487 GSAWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGKVVYGAGPFS 546 WFS+E+ KKGRI+ GQ ADL V DFF+ EDEI I S +T+V GK+VYG G F+ Sbjct: 517 NVTWFSNEEGKKGRIEKGQFADLIVPDKDFFACPEDEISFITSELTMVGGKIVYGTGTFA 576 Query: 547 SHGPGEI-PVLPEWSPVAKVPGHYRAVAKTDAARQKK----ATLPHACVGSCGVHGHAHD 601 ++ P +P+WSPV ++ G Y A + + A ++ A C +C VHGH H Sbjct: 577 DFNENDVPPAMPDWSPV-RMFGGYAAWGEPEGAGKRSLRRTAMATCGCASNCNVHGHDHA 635 Query: 602 VARKSSVPVSHFAGFWGALGCSCFA 626 A S +P+S GF+GALGCSC+A Sbjct: 636 GAWTSKLPISDVKGFFGALGCSCWA 660 >STM1472 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Sty Salmonella typhimurium LT2 Length = 568 Score = 284 bits (727), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 185/539 (34%), Positives = 278/539 (51%), Gaps = 21/539 (3%) Query: 10 DLILLNGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQAATQVIDLGGRTVIPGL 69 D+IL NG I T++ P A A+AI G + + +G + T+ IDL G+TVIPGL Sbjct: 34 DIILHNGNIITLNDAQPQASALAISGSRIVAIGDDTATNEWRGDHTRTIDLQGKTVIPGL 93 Query: 70 NDSHLHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGWTEFQFAEK 129 D+H+H IRGG + E W PSL DAL L+ A R PH QWV VVG W QFAE Sbjct: 94 TDTHIHAIRGGQTWTFETYWYDSPSLKDALDKLRADANRRPHDQWVAVVGSWIPAQFAEN 153 Query: 130 RMPTLEELNAAAPDTPVFVLHLYDRALLNRAALQAVGYTKDTPNP--PGGEIVRDASGNP 187 R PT+ EL+ A PD P ++ +LYD AL+N+ + +G +TP P G + RDA G+ Sbjct: 154 RAPTVAELSHALPDHPAYIQYLYDYALVNQRGIDVLGL-NNTPPPDLAGIRVERDAKGSA 212 Query: 188 TGMLIARPNAM-ILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSAIDAGGGFQNYPD 246 TG L A L+A++++ + RQF ++N GVT ID G Sbjct: 213 TGKLFGDIAAFNQLFASISRNAD-----REGGLRQFFADMNARGVTGIIDPSAGPAAA-- 265 Query: 247 DYQIINKLAADGQLTIRIAYNLFTQ--NKGGELADFQKWTGMVKPGDGDD-FLRHNGAGE 303 Y+ + + G L +R+ Y + Q KG E F +P DD L G GE Sbjct: 266 -YEPLFAMRNQGDLPLRVGYRIPVQPEAKGHEAQWFSNLMAF-RPARADDGQLAFLGLGE 323 Query: 304 MLVFSAADFEDFLEPRPDLAEGMEEE--LERVVRHLVSNRWPFRLHATYDESIARMLDVF 361 LV A D + P + +++ L +V P +HA D+S +L +F Sbjct: 324 SLV---AGMNDGVRMAPGFSSSEQDKTALRQVATFAAKRGIPLEIHAYTDDSADAILTIF 380 Query: 362 EKVNRDIPFDGLHWMFDHAETITERNIERVKALGGGIAIQHRMAFQGEYFIDRYGSEAAE 421 E+V + L W H T + + +ER++ LG +Q F+G D A + Sbjct: 381 EQVAQQYDLRPLRWSIAHLNTGSPQTLERMRKLGLAYTVQMGPYFEGLAIRDANPPGATD 440 Query: 422 HTPPIAKMLEMGVPVGAGTDATRVASYNPWTALYWLVSGRTVGGAKLYGAAGRLPRETAL 481 ++PP+ L+ G+ V GTD+TR+ W A+ + ++G GG+ A+ RL R AL Sbjct: 441 NSPPVRLALDKGLVVAGGTDSTRIGIAGVWHAIEYHITGIASGGSVRKPASERLTRLEAL 500 Query: 482 ELWTAGSAWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGKVVY 540 L+T +AW + + +G+++ G+ ADLAVL+ F ++ ED I I +++T+VDG++V+ Sbjct: 501 ALYTRHAAWLAFAEQHRGQLRVGKQADLAVLNQPFMTMPEDRIDTIRAVLTLVDGRIVH 559 >SMa0101 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Sme Sinorhizobium meliloti Length = 541 Score = 179 bits (455), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 162/553 (29%), Positives = 255/553 (46%), Gaps = 28/553 (5%) Query: 4 AASVTPDLILLNGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQAATQVIDLGGR 63 A + DLIL+NG+I ++ I+EA+A+ GK L GS +++ LK T+VIDL GR Sbjct: 2 AFGIKADLILINGRIWR-GREEGISEALAVWQGKILATGSDTDILGLKGPRTEVIDLEGR 60 Query: 64 TVIPGLNDSHLHLIRGGLNYN-LELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGWT 122 PGL D+HLHLI G+ ++ P+LA + + D+AA TP WVR G+ Sbjct: 61 FATPGLIDNHLHLIATGMAMGWVDATPASAPTLAALMGRISDRAATTPKGGWVRAR-GYD 119 Query: 123 EFQFAEKRMPTLEELNAAAPDTPVFVLHLYDR-ALLNRAALQAVGYTKDTPNPPGGEIVR 181 + + R PT ++L+ APD PV + ++ N AL+ G T+ T P GG ++ Sbjct: 120 QVKLDTGRHPTRDDLDRVAPDHPVLLTRACGHVSIANSRALELAGITEATAVPEGG-VIG 178 Query: 182 DASGNPTGMLIARPNAMILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSAIDAGGGF 241 G G L ++ A P+ E ++ + R L G+TS +DA G Sbjct: 179 VTEGRLNGFLAENAQNLVKAAM----PSATTEDLIDGIERAGRYLLSFGITSCMDAAVGQ 234 Query: 242 QNYPDDYQIINKLAADGQLTIRIAYNLFTQNKGGELADFQKWTGMVKPGDGDDFLRHNGA 301 + + Q G+L +R+ L + D W + G GDD LR G Sbjct: 235 VSGFAEIQAYEMAKLSGRLPVRVWLTLLGDPGVSIVEDC--WRAGLLSGAGDDMLRVGGV 292 Query: 302 GEMLVFSAADFEDFLEPRPDLAE----GME----EELERVVRHLVSNRWPFRLHATYDES 353 L SA ++ RP E G++ E+E VV+ + HA D + Sbjct: 293 KVFLDGSAGGRTAWMT-RPYRGEPDNIGVQMLPDAEVEAVVKACHDRGYQMVCHAIGDGA 351 Query: 354 IARMLDVFEKVNRDIPFDGLHWMFDHAETITERNIERVKALGGGIAIQHRMAFQ---GEY 410 I +++ +EK P +H T R+KA GI +MAF G+ Sbjct: 352 IEQLITAYEKALAANPDPDRRHRVEHCGFSTPDQNARMKA--AGILPAPQMAFIHDFGDS 409 Query: 411 FIDRYGSEAAEHTPPIAKMLEMGVPVGAGTDATRVASYNPWTALYWLVSGRTVGGAKLYG 470 +I G E + PI + MG+ G+D+ V S +P+ L+ +++ R G + Sbjct: 410 YISVLGEERGRLSYPIGTWMRMGLKPSTGSDSP-VCSPDPFPNLHAMLT-RQTGKGTVME 467 Query: 471 AAGRLPRETALELWTAGSAWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEI-KGIES 529 A+ RL R+ AL+ +T A+ + KGR+ GQ AD+AV D + + I Sbjct: 468 ASERLSRQEALQTYTEYGAYSQKAEGVKGRLVPGQWADIAVFDNDLLAAPPETILSDTSC 527 Query: 530 LMTVVDGKVVYGA 542 ++T++ G+VV+ A Sbjct: 528 VLTLLAGRVVHDA 540 >BMEII0123 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Bme Brucella melitensis Length = 560 Score = 154 bits (389), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 159/584 (27%), Positives = 248/584 (42%), Gaps = 78/584 (13%) Query: 1 MTTAASVTPDLILLNGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQAATQVIDL 60 MT+A DLIL NG+I+TVD P A+AVAI GG+ L VGS AE+ + T+V+DL Sbjct: 9 MTSATHA--DLILTNGRIYTVDTARPWAQAVAISGGRILAVGSTAEIEAYRTGETEVVDL 66 Query: 61 GGRTVIPGLNDSHLHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGG 120 GGR +PG D H H++ GG E + S+ D ++ QA QW+ + Sbjct: 67 GGRMAMPGFVDVHNHIMMGGQADLFETQLPAGASVDDICAHVRRQAEAAVPGQWI-IANQ 125 Query: 121 W-TEFQFAEKRMPTLEELNAAAPDTPVFVLHLYDRALLNR----AALQAVGYTKDTPNPP 175 W + A +L +L+AA+ PV L D + NR ALQ G D P+PP Sbjct: 126 WGADMITALNSEASLAKLDAASLGHPVL---LRDETMHNRWVNSVALQMCGIANDQPDPP 182 Query: 176 GGEIVRD-ASGNPTGMLIARPNAMILY------------ATLAKGPTLPQEYQVNSTRQF 222 G RD A+G TG+L+ ++ A +A+ + Y V + + Sbjct: 183 AGSFGRDPATGRLTGLLVESAAGIVERVAADHFTEAMGEAAIARAVEIVNSYGVTAFQDA 242 Query: 223 MRELNRLGVTSAIDAGGGFQNYP------DDYQIINKLAADGQLTIRIAYNLFTQNKGGE 276 L + + +D G + + + L+ D L +R Y Sbjct: 243 ASVLPIMKALTGLDNKGKLTAWAVTSLPLIEPSFMFGLSGDELLALRDEYR--------- 293 Query: 277 LADFQKWTGMVKPGDGDDFLRHNGAGEMLVFSAADFEDFLEPR----------PDLAEGM 326 T V+P FL F A +D + PR PDL + + Sbjct: 294 -------TRHVRPNFTKIFLDGVPGARTSAFHDAYLDDGVHPRGYRGETLVTYPDLVQHI 346 Query: 327 EEELERVVRHLVSNRWPFRLHATYDESIARMLDVFEKVNR-DIPFDGLHWMFDHAETITE 385 ++ E++ L ++H T D ++ MLD E V + P +H + HA + Sbjct: 347 DKS-EKLGMGL-------KIHCTGDYAVTEMLDAVEAVRHFNGPAKVMHHIA-HASYVRP 397 Query: 386 RNIERVKALGGGIAIQHRMAFQGEYFIDRY----GSEAAEHTPPIAKMLEMGVPVGAGTD 441 +++ER L +A M + F++ + G E A PIA + + G + G+D Sbjct: 398 QDVERFAKLSV-VADLSPMIWYPTTFLEGHKEAMGDERATRFWPIADLHKSGALLAGGSD 456 Query: 442 ATRVASYNPWTALYWLVSGRTVGGAKLYGAAGRLPRE-----TALELWTAGSAWFSSEQA 496 + +PWT + +V+ + GA + P + TA+ ++T SA A Sbjct: 457 WPVIPVPDPWTGIEGMVTRQNPSGA--FPGVALWPEQAIDLATAIRIFTLNSAIAMGIGA 514 Query: 497 KKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGKVVY 540 + G I+ G+ AD+ VL F V D I + L T G+ VY Sbjct: 515 ETGSIEPGKSADIIVLDQQVFDVAPDRIADTKVLTTYFAGRAVY 558 >BS_ytcJ [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Bsu Bacillus subtilis Length = 529 Score = 147 bits (370), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 145/540 (26%), Positives = 239/540 (44%), Gaps = 36/540 (6%) Query: 16 GKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEVMRLKQA----ATQVIDLGGRTVIPGLND 71 G I+T+ ++ EAV + G GS RLK+ T+ I L G + PG D Sbjct: 8 GFIYTMLEEGDRTEAVYVEDGVIKGTGSYE---RLKEKYGSPETEEISLNGAVMFPGFVD 64 Query: 72 SHLHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGWTEFQFAEKRM 131 SHLHLI G L+L + S L+ K++ + P W+ + GW E QF Sbjct: 65 SHLHLIGHG-EKQLQLDLSALTSKDSILQAAKERERQLPKNDWL-IGEGWNENQFETPDY 122 Query: 132 PTLEELNAAAPDTPVFVLHLYDRAL-LNRAALQAVGYTKDTPNPPGGEIVRDASGNPTGM 190 T +L+ PD PV + + A+ +N AALQA G +++TP+P GG IV+DA+G PTG+ Sbjct: 123 LTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGISRNTPDPDGGVIVKDANGEPTGL 182 Query: 191 LIARPNAMILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSAIDAGGGFQN--YPDDY 248 L + +IL A P + Q Y + +++ G+T GG ++ Y D Sbjct: 183 LFDKAQDLILKAV----PPVSQHYVDEALTAAIKDCWTKGLT-----GGHSEDLSYYGDV 233 Query: 249 QI----INKLAADGQLTIRIAYNLFTQNKGGELADFQKWTGMVKPGDGDDFLRHNGAGEM 304 + K AA G+ R + L +K +G G Sbjct: 234 SVPMKAYEKAAAGGKYPFR-CHLLVHHEAVDRWEQLEKLSGPYVEFGAMKIFADGALGGR 292 Query: 305 LVFSAADFEDFLEPRPDLAEGMEEE-LERVVRHLVSNRWPFRLHATYDESIARMLDVFEK 363 ++D +P + + ++E L R++R +HA D + ++L+ EK Sbjct: 293 TALLKEPYQD--DPSTNGVQVHDDETLGRLIRKAREKGMEVAVHAIGDLAFEKVLNAIEK 350 Query: 364 VNRDIPFDGLHWMFDHAETITERNIERVKALGGGIAIQ-HRMAFQGEYFIDRYGSEAAEH 422 P +G H HA+ + IER + + +Q H +A + IDR G + + Sbjct: 351 ---HPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASDFPWVIDRLGKDRMKT 407 Query: 423 TPPIAKMLEMGVPVGAGTDATRVASYNPWTALYWLVSGRTV--GGAKLYGAAGRLPRETA 480 ++ G+ G+DA + +P + V ++ Y + LP A Sbjct: 408 AFAWKTLISKGILCAGGSDAP-IEPVDPLLGIQSAVLRKSSHEQNGPSYNESECLPVYEA 466 Query: 481 LELWTAGSAWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGKVVY 540 ++L+T GSA ++ +G+I G AD VLS D F++ ++ +E TV++G++VY Sbjct: 467 IKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPAQLHLLEIKKTVINGQIVY 526 >BH3200 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold Bha Bacillus halodurans Length = 529 Score = 129 bits (324), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 140/545 (25%), Positives = 234/545 (42%), Gaps = 39/545 (7%) Query: 15 NGKIHTVDKQNPIAEAVAIGGGKFLEVGSAAEV-MRLKQAATQVIDLGGRTVIPGLNDSH 73 NG T+ + EAV GK + +G+A E+ R Q ++ G V PG DSH Sbjct: 7 NGTFFTMVHEGDQVEAVFTEDGKIVAIGTAEELRQRYSTRINQEMNCDGAYVYPGFVDSH 66 Query: 74 LHLIRGGLNYNLELRWEGVPSLADALRMLKDQAARTPHPQWVRVVGGWTEFQFAEKRMPT 133 LH+I G L L V + D L ++ A T WV GW E F ++++ Sbjct: 67 LHMIGHGEKL-LRLDLSTVMNAEDMREKLMERVALTEEGDWV-TAEGWNENNFPDQKIFH 124 Query: 134 LEELNAAAPDTPVFVLHLYDRALL-NRAALQAVGYTKDTPNPPGGEIVRDASGNPTGMLI 192 EL+ AP+ P+ + + A+L N ALQ G +KDT +PPGG IVRD G PTG L+ Sbjct: 125 RNELDEIAPNHPMILTRVCRHAILVNSKALQLAGISKDTTDPPGGRIVRDELGEPTGYLL 184 Query: 193 ARPNAMILYATLAKGPTLPQEYQVNSTRQFMRELNRLGVTSA-IDAGGGFQNYPDDYQII 251 ++ P++ Y + + ++ G+ + G + + + Sbjct: 185 DTAQELVKRV----APSVSAAYLERALAAAVDDMVAKGLVGGHTEDLGYYLGFNQTFATF 240 Query: 252 NKLAADGQLTIRIAYNLFTQNKGGELADFQKWTGMVKPGDGDDFLRHNGAGEMLVFSAAD 311 ++ DG T R +L + E+ D G K G ++L G M +F+ Sbjct: 241 QRV-IDGN-TRRFRAHLLVHH---EVIDDMIKAGYCK-GPVGEWLEF---GAMKIFADGA 291 Query: 312 FED----FLEPRPD------LAEGMEEELERVVRHLVSNRWPFRLHATYDESIARMLDVF 361 F EP D +A +E+L +++ + P +H DE++ + Sbjct: 292 FGGRTALLSEPYCDAPTTSGVAIHTQEQLTNLIKKARQYKLPVAIHTIGDEALRMAITSI 351 Query: 362 EKVNRDIPFDGLHWMFDHAETITERNIERVKALGGGIAIQHRMAFQGEYF---IDRYGSE 418 E P H + +ER+K L + IQ AF F +R G+E Sbjct: 352 EAH----PVTEGRDRLIHTQVTPPSLVERMKKLKVILDIQP--AFVPADFPWVEERLGNE 405 Query: 419 AAEHTPPIAKMLEMGVPVGAGTDATRVASYNPWTALYWLVSGRT-VGGAKLYGAAGRLPR 477 ++ +L G+ + G+DA + +P +Y V+ + + Y +L R Sbjct: 406 RLSYSFAWKTLLRSGMALAGGSDAP-IEEVDPLYGIYAAVARKKPTDQHEGYLPEEKLTR 464 Query: 478 ETALELWTAGSAWFSSEQAKKGRIQAGQLADLAVLSADFFSVHEDEIKGIESLMTVVDGK 537 AL+L+T GSA+ + ++G I+ G +AD +L+ + F+ E+E+ TV+ Sbjct: 465 YEALQLYTTGSAYAIEREHERGNIRPGYVADFTMLNRNLFTCREEELLTTRVEKTVIGEA 524 Query: 538 VVYGA 542 +V+ A Sbjct: 525 IVFQA 529