BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0095.p (195 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Cj1424c [G] COG0279 Phosphoheptose isomerase Cje Campylobacter j... 190 2e-48 CAC3054 [G] COG0279 Phosphoheptose isomerase Cac Clostridium ace... 184 1e-46 aq_908 [G] COG0279 Phosphoheptose isomerase Aae Aquifex aeolicus 171 6e-43 HP0857 [G] COG0279 Phosphoheptose isomerase Hpy Helicobacter pyl... 159 4e-39 Cj1149c [G] COG0279 Phosphoheptose isomerase Cje Campylobacter j... 158 8e-39 jhp0791 [G] COG0279 Phosphoheptose isomerase jHp Helicobacter py... 156 3e-38 Rv0113 [G] COG0279 Phosphoheptose isomerase Mtu Mycobacterium tu... 152 5e-37 sll0083 [G] COG0279 Phosphoheptose isomerase Syn Synechocystis 150 1e-36 Ta0854 [G] COG0279 Phosphoheptose isomerase Tac Thermoplasma aci... 144 1e-34 TVN0956 [G] COG0279 Phosphoheptose isomerase Tvo Thermoplasma vo... 143 3e-34 >Cj1424c [G] COG0279 Phosphoheptose isomerase Cje Campylobacter jejuni Length = 201 Score = 190 bits (482), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 90/181 (49%), Positives = 121/181 (66%) Query: 15 SIRAKQQLMQESATLAVFDAAVAATIAAYRNGRRIYIAGNGGSAADAQHLAAEFVSKLAR 74 SI K+Q++++ + + A I AY+NG + +AGNGGSAADAQH+A EFVS+ Sbjct: 15 SILVKEQILKDENLITLIKNASLEVIKAYKNGNKTLLAGNGGSAADAQHIAGEFVSRFYF 74 Query: 75 DRAPLPAEALTTDSSILTAIGNDYGYEQVFSRQLAGKAVAGDIFLGITTSGRSPNILRAL 134 DR + + ALTTD+SILTAIGNDYGYE +F+RQ+ + V GD+F+GI+TSG S NIL+AL Sbjct: 75 DRPGIASIALTTDTSILTAIGNDYGYENLFARQVQAQGVKGDVFIGISTSGNSKNILKAL 134 Query: 135 EQCRAMGVPSILFTGRDGGPARPLADHAIVVPGEATSTIQELHIVLAHTLCESVEAALFG 194 E C+ + SI +G GG L D+ I VP T IQE HI++ H +C VE LFG Sbjct: 135 EFCKQKEIISIGLSGASGGAMNELCDYCIKVPSTCTPRIQEAHILIGHIICAIVEEELFG 194 Query: 195 E 195 + Sbjct: 195 K 195 >CAC3054 [G] COG0279 Phosphoheptose isomerase Cac Clostridium acetobutylicum Length = 196 Score = 184 bits (466), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 81/188 (43%), Positives = 125/188 (66%) Query: 8 LQRNLDASIRAKQQLMQESATLAVFDAAVAATIAAYRNGRRIYIAGNGGSAADAQHLAAE 67 ++ + +SI AK++++++ + + V I AY+ G+++ + GNGGSAAD+QH+AAE Sbjct: 5 IEAQIKSSIEAKEKILKDGQYIEQIQSIVEIVIQAYKLGKKVLLCGNGGSAADSQHIAAE 64 Query: 68 FVSKLARDRAPLPAEALTTDSSILTAIGNDYGYEQVFSRQLAGKAVAGDIFLGITTSGRS 127 FVSK DR LPA ALT ++S+LT+IGNDY Y+ +F RQ+ GD+ +GI+TSG S Sbjct: 65 FVSKFRLDRKALPAIALTVNTSVLTSIGNDYSYKNIFERQVEAFGKEGDVLIGISTSGNS 124 Query: 128 PNILRALEQCRAMGVPSILFTGRDGGPARPLADHAIVVPGEATSTIQELHIVLAHTLCES 187 NI A ++ + +G+ +I F G+DGG + D ++VP E T +QE HI++ H +C+ Sbjct: 125 ENITLAFKKAKEIGITTIGFLGKDGGENKNYCDFPLIVPSEDTPRVQEAHIMIGHIVCDI 184 Query: 188 VEAALFGE 195 VE LFGE Sbjct: 185 VEKELFGE 192 >aq_908 [G] COG0279 Phosphoheptose isomerase Aae Aquifex aeolicus Length = 191 Score = 171 bits (434), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 81/155 (52%), Positives = 108/155 (69%), Gaps = 1/155 (0%) Query: 36 VAATIA-AYRNGRRIYIAGNGGSAADAQHLAAEFVSKLARDRAPLPAEALTTDSSILTAI 94 VA IA A ++G ++ + GNGGSAADAQH+AAE V + ++R PLPA ALTTD+SILTA+ Sbjct: 30 VAGIIATALKDGNKVLLFGNGGSAADAQHIAAELVGRFKKERRPLPAIALTTDTSILTAL 89 Query: 95 GNDYGYEQVFSRQLAGKAVAGDIFLGITTSGRSPNILRALEQCRAMGVPSILFTGRDGGP 154 GNDYG+E +F RQ+ + GD+ +GITTSG S N++R L++ +G +I FTGR+GG Sbjct: 90 GNDYGFETIFERQVEALCMPGDVAIGITTSGNSENVIRGLKKAHDLGATTIAFTGRNGGK 149 Query: 155 ARPLADHAIVVPGEATSTIQELHIVLAHTLCESVE 189 +A + +VP T IQE HI L H LCE VE Sbjct: 150 VAQIAHYTFIVPSYETQRIQECHITLGHVLCELVE 184 >HP0857 [G] COG0279 Phosphoheptose isomerase Hpy Helicobacter pylori 26695 Length = 192 Score = 159 bits (402), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 76/178 (42%), Positives = 111/178 (62%), Gaps = 9/178 (5%) Query: 12 LDASIRAKQQLMQESATLAVFDAAVAATIAAYRNGRRIYIAGNGGSAADAQHLAAEFVSK 71 L+ S+ Q+ +++S L I N +I I GNGGSA+DAQH AAE + Sbjct: 17 LEKSLEGLQEALKQSVHL---------LIETLENQGKILICGNGGSASDAQHFAAELTGR 67 Query: 72 LARDRAPLPAEALTTDSSILTAIGNDYGYEQVFSRQLAGKAVAGDIFLGITTSGRSPNIL 131 +R L A +L TD S LTAI NDYGYE+VF+RQ+ V D+ +GI+TSG S N+L Sbjct: 68 YKLERKGLSAISLNTDISALTAIANDYGYEEVFARQVEALGVKNDVLIGISTSGNSKNVL 127 Query: 132 RALEQCRAMGVPSILFTGRDGGPARPLADHAIVVPGEATSTIQELHIVLAHTLCESVE 189 +A E+ + + + ++ GRDGG +PL+D A++VP + T IQE+HI++ H LC+ +E Sbjct: 128 KAYEKAKDLEMKTLSLAGRDGGKMKPLSDMALIVPSDDTPRIQEMHILMIHILCDCIE 185 >Cj1149c [G] COG0279 Phosphoheptose isomerase Cje Campylobacter jejuni Length = 186 Score = 158 bits (399), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 76/182 (41%), Positives = 115/182 (63%), Gaps = 1/182 (0%) Query: 12 LDASIRAKQQLMQESATLAVFDAAVAATIA-AYRNGRRIYIAGNGGSAADAQHLAAEFVS 70 ++ + Q+++Q S L A V + + G +I I GNGGSAADAQH AAE Sbjct: 5 VEKEWQEHQKIVQASEILKGQIAKVGELLCECLKKGGKILICGNGGSAADAQHFAAELSG 64 Query: 71 KLARDRAPLPAEALTTDSSILTAIGNDYGYEQVFSRQLAGKAVAGDIFLGITTSGRSPNI 130 + ++R L ALTTD+S L+AIGNDYG+E VFSRQ+ D+ +GI+TSG+SPN+ Sbjct: 65 RYKKERKALAGIALTTDTSALSAIGNDYGFEFVFSRQVEALGNEKDVLIGISTSGKSPNV 124 Query: 131 LRALEQCRAMGVPSILFTGRDGGPARPLADHAIVVPGEATSTIQELHIVLAHTLCESVEA 190 L AL++ + + + + +G+ GG L DH +VVP + T+ IQE+HI++ HTLC+ ++ Sbjct: 125 LEALKKAKELNMLCLGLSGKGGGMMNKLCDHNLVVPSDDTARIQEMHILIIHTLCQIIDE 184 Query: 191 AL 192 + Sbjct: 185 SF 186 >jhp0791 [G] COG0279 Phosphoheptose isomerase jHp Helicobacter pylori J99 Length = 192 Score = 156 bits (394), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 76/178 (42%), Positives = 111/178 (62%), Gaps = 9/178 (5%) Query: 12 LDASIRAKQQLMQESATLAVFDAAVAATIAAYRNGRRIYIAGNGGSAADAQHLAAEFVSK 71 L+ S+ + Q +++S L I N +I I GNGGSA+DAQH AAE + Sbjct: 17 LEKSLESLQDALKQSVHL---------LIETLENQGKILICGNGGSASDAQHFAAELTGR 67 Query: 72 LARDRAPLPAEALTTDSSILTAIGNDYGYEQVFSRQLAGKAVAGDIFLGITTSGRSPNIL 131 +R L +L+TD+S LTAI NDYGYE+VF+RQ+ DI +GI+TSG S N+L Sbjct: 68 YKLERKGLSVISLSTDTSALTAIANDYGYEEVFARQVEALGNKEDILIGISTSGNSKNVL 127 Query: 132 RALEQCRAMGVPSILFTGRDGGPARPLADHAIVVPGEATSTIQELHIVLAHTLCESVE 189 +A E+ + +G+ ++ GRDGG +PL+D A++VP T IQE+HI++ H LC+ +E Sbjct: 128 KAYEKAKDLGMKTLSLAGRDGGKMKPLSDIALIVPSGDTPRIQEMHILMIHILCDCIE 185 >Rv0113 [G] COG0279 Phosphoheptose isomerase Mtu Mycobacterium tuberculosis H37Rv Length = 196 Score = 152 bits (383), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 84/179 (46%), Positives = 103/179 (57%) Query: 15 SIRAKQQLMQESATLAVFDAAVAATIAAYRNGRRIYIAGNGGSAADAQHLAAEFVSKLAR 74 +I K +++ + L A IA YR G R+++ GNGGSAADAQH AAE L Sbjct: 14 TIAVKTRILNDRVLLEAARAIGDRLIAGYRAGARVFMCGNGGSAADAQHFAAELTGHLIF 73 Query: 75 DRAPLPAEALTTDSSILTAIGNDYGYEQVFSRQLAGKAVAGDIFLGITTSGRSPNILRAL 134 DR PL AEAL +SS LTA+ NDY Y+ VF+R L G A GD I+TSG S ++LRA Sbjct: 74 DRPPLGAEALHANSSHLTAVANDYDYDTVFARALEGSARPGDTLFAISTSGNSMSVLRAA 133 Query: 135 EQCRAMGVPSILFTGRDGGPARPLADHAIVVPGEATSTIQELHIVLAHTLCESVEAALF 193 + R +GV + TG GG AD I VP T IQE HIV H + E VE ALF Sbjct: 134 KTARELGVTVVAMTGESGGQLAEFADFLINVPSRDTGRIQESHIVFIHAISEHVEHALF 192 >sll0083 [G] COG0279 Phosphoheptose isomerase Syn Synechocystis Length = 194 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 74/163 (45%), Positives = 105/163 (64%) Query: 33 DAAVAATIAAYRNGRRIYIAGNGGSAADAQHLAAEFVSKLARDRAPLPAEALTTDSSILT 92 +A V ++ G ++ I GNGGSAADAQHLAAEFV + +R LPA ALT +SSILT Sbjct: 25 EAVVDLICQRFQAGNKLLICGNGGSAADAQHLAAEFVGRFHFNRQALPAIALTANSSILT 84 Query: 93 AIGNDYGYEQVFSRQLAGKAVAGDIFLGITTSGRSPNILRALEQCRAMGVPSILFTGRDG 152 ++ NDY Y+ VFSRQ+ GDI G++TSG+S N+L AL+ + G+ +I G +G Sbjct: 85 SVSNDYTYDIVFSRQVEALGQPGDILWGLSTSGKSTNVLHALKCAKDKGLHTIGMAGNNG 144 Query: 153 GPARPLADHAIVVPGEATSTIQELHIVLAHTLCESVEAALFGE 195 G + AD+ + V + T IQE+H++ H +CE VE+ LF + Sbjct: 145 GLFQEFADYPLFVADKNTPCIQEVHLMTYHHICEQVESRLFAQ 187 >Ta0854 [G] COG0279 Phosphoheptose isomerase Tac Thermoplasma acidophilum Length = 182 Score = 144 bits (364), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 66/149 (44%), Positives = 97/149 (65%) Query: 41 AAYRNGRRIYIAGNGGSAADAQHLAAEFVSKLARDRAPLPAEALTTDSSILTAIGNDYGY 100 +A +G ++ + GNGGSAADAQH AE ++R PL A ALTT++S +TAI NDY Y Sbjct: 31 SAISSGNKLIVFGNGGSAADAQHFVAELTGHFMKERKPLAAIALTTNTSSITAIANDYSY 90 Query: 101 EQVFSRQLAGKAVAGDIFLGITTSGRSPNILRALEQCRAMGVPSILFTGRDGGPARPLAD 160 + VFSRQ+ A GD+ +GI+TSG S N++ ++ + +G +I FTGR GG + +AD Sbjct: 91 DVVFSRQVEALAKPGDVVVGISTSGNSKNVIEGIKSAKRIGCHTIAFTGRSGGQLKGVAD 150 Query: 161 HAIVVPGEATSTIQELHIVLAHTLCESVE 189 + V + TS IQE+HI + H +C ++ Sbjct: 151 ETLNVDSDLTSIIQEMHITVIHMICAMID 179 >TVN0956 [G] COG0279 Phosphoheptose isomerase Tvo Thermoplasma volcanium Length = 182 Score = 143 bits (360), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 66/151 (43%), Positives = 97/151 (64%) Query: 40 IAAYRNGRRIYIAGNGGSAADAQHLAAEFVSKLARDRAPLPAEALTTDSSILTAIGNDYG 99 + + +G ++ + GNGGSAAD+QH AE +++R LPA ALT ++S LTAI NDY Sbjct: 30 VNVFNSGGKLIVFGNGGSAADSQHFVAELSGHFSKERKALPAMALTVNTSALTAISNDYS 89 Query: 100 YEQVFSRQLAGKAVAGDIFLGITTSGRSPNILRALEQCRAMGVPSILFTGRDGGPARPLA 159 Y+ VFSRQL A GD +GI+TSG S N+++ LE+ + +G ++ TGR GG +A Sbjct: 90 YDVVFSRQLEAFAKPGDYVVGISTSGNSVNVVKGLERAKELGCKTLAMTGRSGGKIAKVA 149 Query: 160 DHAIVVPGEATSTIQELHIVLAHTLCESVEA 190 + AI++ E TS IQE HI H +C +++ Sbjct: 150 EEAIMIDSEVTSIIQEAHIAAIHMICSVIDS 180