BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0031.p (1247 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0294 [E] COG1410 Methionine synthase I, cobalamin-binding dom... 1409 0.0 VC0390_2 [E] COG1410 Methionine synthase I, cobalamin-binding do... 1165 0.0 PA1843_2 [E] COG1410 Methionine synthase I, cobalamin-binding do... 1154 0.0 ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1144 0.0 ZmetH_2 [E] COG1410 Methionine synthase I, cobalamin-binding dom... 1144 0.0 metH_2 [E] COG1410 Methionine synthase I, cobalamin-binding doma... 1142 0.0 STM4188_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1138 0.0 YPO3722_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1122 0.0 AGc3907_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1119 0.0 BMEI1759_2 [E] COG1410 Methionine synthase I, cobalamin-binding ... 1103 0.0 >RSc0294 [E] COG1410 Methionine synthase I, cobalamin-binding domain Rso Ralstonia solanacearum Length = 905 Score = 1409 bits (3646), Expect = 0.0, Method: Compositional matrix adjust. Identities = 687/903 (76%), Positives = 775/903 (85%), Gaps = 4/903 (0%) Query: 348 HEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQI 407 H MRLSGLEPF I +D+L+VNVGERTNVTGSKAFAR+ILN Q+DEALAVARQQVENGAQ+ Sbjct: 4 HLMRLSGLEPFNIGEDTLFVNVGERTNVTGSKAFARMILNSQFDEALAVARQQVENGAQV 63 Query: 408 IDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSI 467 IDINMDEAMLDS AAM RFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGK+IVNSI Sbjct: 64 IDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKAIVNSI 123 Query: 468 SMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPE 527 S+KEGEE+F AKL +RYGAA +VMAFDE GQADTFARK EIC+R+Y LV+++ F PE Sbjct: 124 SLKEGEEQFAHHAKLIKRYGAAAVVMAFDEQGQADTFARKTEICKRSYDFLVNQVGFAPE 183 Query: 528 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPARE 587 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWI Q LP+AK+SGGVSNVSFSFRGND RE Sbjct: 184 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQKLPHAKVSGGVSNVSFSFRGNDVVRE 243 Query: 588 AIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAAT 647 AIHTVFLYHAI AGM MGIVNAG +GVY++L ELRERVEDVVLNRR DAT+R++E A Sbjct: 244 AIHTVFLYHAIGAGMDMGIVNAGQLGVYENLAPELRERVEDVVLNRRPDATDRLLEIADR 303 Query: 648 LKAGDKKEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGP 707 K G K E L WR PV KRL+HALVHGIT ++VEDTEEVRQ+I A GGRPI VIEGP Sbjct: 304 YKGGGAKREENLAWRQEPVEKRLAHALVHGITDYVVEDTEEVRQKIFAAGGRPIQVIEGP 363 Query: 708 LMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGK 767 LMDGMN+VGDLFG GKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQ+ A G+V + +GK Sbjct: 364 LMDGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQIAAAGGDV-RSRGK 422 Query: 768 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLIT 827 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPC EILAKAK E ADIIGLSGLIT Sbjct: 423 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCNEILAKAKVEGADIIGLSGLIT 482 Query: 828 PSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAV 887 PSLEEMAYVA EMQRD YF K+PL+IGGATTSR HTAVKIAPNYEGPVVYVPDASR+V Sbjct: 483 PSLEEMAYVASEMQRDEYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSV 542 Query: 888 SVAQSLLADEQKTQYVAELNADYERIREQHASKKAAPMLSLAAARANKTKLD---FAPVK 944 SVA SLL+DE +Y+ EL+ADY+RIR QHASKKA PM+SLAAARANKT++D + P K Sbjct: 543 SVASSLLSDEAAARYIEELHADYDRIRTQHASKKAMPMVSLAAARANKTRIDWSNYTPPK 602 Query: 945 PKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAML 1004 PKF+GRR+F+N DL LA YIDWGPFFQTWDLAG +P IL D +VGE+A +VF + ++ML Sbjct: 603 PKFVGRRVFRNYDLNELAQYIDWGPFFQTWDLAGKFPDILNDAIVGESARRVFSDGKSML 662 Query: 1005 KKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVAR 1064 ++I GRWLTANGVI+LLPANTVNDDDIEIYTD++RS+VA T+ +RQQ+E+P++DGV R Sbjct: 663 ARLIAGRWLTANGVIALLPANTVNDDDIEIYTDETRSEVALTWRNIRQQSERPIIDGVMR 722 Query: 1065 PNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEA 1124 PN+CL+DFIAPK++G+ DYIG+FAVT G+GI+K E FE HDDYS+IMLKALADR AEA Sbjct: 723 PNRCLADFIAPKDTGIADYIGLFAVTGGIGIDKREAAFEADHDDYSAIMLKALADRFAEA 782 Query: 1125 FAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKADVFRTMQCD 1184 FAE LH RVR+DLWGYA DE L + LI+E+Y GIRPAPGYPACPEHTVK D+FR + Sbjct: 783 FAECLHARVRRDLWGYAQDETLDNDALIREEYRGIRPAPGYPACPEHTVKRDLFRVLDAQ 842 Query: 1185 EIGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEELERWLA 1244 EIGM LTE+ AM P ASVSGF +HP S YF +GKIG+DQV DMA R + +ER LA Sbjct: 843 EIGMNLTEALAMTPAASVSGFQLSHPDSTYFTIGKIGQDQVDDMAARSGEDRRNVERALA 902 Query: 1245 PNL 1247 PNL Sbjct: 903 PNL 905 >VC0390_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Vch Vibrio cholerae Length = 899 Score = 1165 bits (3014), Expect = 0.0, Method: Compositional matrix adjust. Identities = 584/919 (63%), Positives = 709/919 (77%), Gaps = 32/919 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 + PR +P+ E RLSGLEP I ++L+VNVGERTNVTGS F RLI EQYDEAL VA Sbjct: 2 VKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNVTGSARFKRLIKEEQYDEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 R+QVENGAQIIDINMDE MLD+ A M RFLNL ASEP+I++VP+M+DSSKWEVIEAGLKC Sbjct: 62 REQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEISKVPVMVDSSKWEVIEAGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSIS+KEG+EKF+ +AKL RRYGAAVIVMAFDEVGQADT RK+EIC RAY + Sbjct: 122 IQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIVMAFDEVGQADTRERKLEICRRAYHI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 LVD++ FPPEDIIFDPNIFAVATGI+EHNNYA+DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINAVADIKRELPHAMISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGN+ REAIH VFLYH K GM MGIVNAG + +YD++P +LRE VEDV+LNRR D Sbjct: 242 SFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIYDNVPLKLREAVEDVILNRRSDG 301 Query: 638 TERMIEYAATLK---AGDKKEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIA 694 TER++E A + G +++ + LEWR PVAKRL HALV GIT++IV+DTEE RQQ Sbjct: 302 TERLLEIAEAYRENSVGKEEDASALEWRAWPVAKRLEHALVKGITEFIVQDTEEARQQ-- 359 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 +P+ VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFI +K Sbjct: 360 --ASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFINAQK--- 414 Query: 755 EIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 +G + GKI++ATVKGDVHDIGKNIV VVLQCNNFE++++GVMVPC +IL A+E Sbjct: 415 ---SGSTS--NGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVPCEQILKVARE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 + DIIGLSGLITPSL+EM +VAKEM+R G ++PL+IGGATTS+AHTAVKI NY Sbjct: 470 QNVDIIGLSGLITPSLDEMVHVAKEMERQ----GFELPLLIGGATTSKAHTAVKIEQNYH 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASK--KAAPMLSLAAAR 932 PVVYV +ASRAV V SLL+DEQ+ ++ L+ DYER R+QHA K K+ P ++L AR Sbjct: 526 APVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTPKSRP-VTLEQAR 584 Query: 933 ANKTKLDFA---PVKPKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVV 989 ANK LD+A P P G +F+N+ L L YIDW PFF TW L G YPAIL E V Sbjct: 585 ANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMGKYPAILEHEEV 644 Query: 990 GEAATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYG 1049 GE A ++F +A A+L K+ L A+G+ +L PA +V DDIE+Y+D+SR+QVA Y Sbjct: 645 GEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVG-DDIEVYSDESRTQVAHVLYN 703 Query: 1050 LRQQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDY 1109 LRQQTEKP N CLSD++APKESG +D+IG FAVT G+G ++ DDY Sbjct: 704 LRQQTEKP-----KGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDY 758 Query: 1110 SSIMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACP 1169 ++IM++A+ADRLAEAFAEYLHE+VRK++WGYA+DENLS+ DLI+E+Y GIRPAPGYPACP Sbjct: 759 NAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPGYPACP 818 Query: 1170 EHTVKADVFRTMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDM 1228 EHT KA +++ + +E IGM LT SYAM+PGASVSG+YF+HP S+YF V +I DQ+ Sbjct: 819 EHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPDQLHSY 878 Query: 1229 AERRHVPKEELERWLAPNL 1247 AER+ EE E+WLAPNL Sbjct: 879 AERKGWRLEEAEKWLAPNL 897 >PA1843_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Pae Pseudomonas aeruginosa Length = 898 Score = 1154 bits (2985), Expect = 0.0, Method: Compositional matrix adjust. Identities = 596/915 (65%), Positives = 691/915 (75%), Gaps = 28/915 (3%) Query: 340 PRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQ 399 PR +PE RLSGLEPFTI+ SL+VNVGERTN+TGS FARLI E Y EAL VA+Q Sbjct: 1 PRAIPEIPRACRLSGLEPFTIDRSSLFVNVGERTNITGSAKFARLIREENYAEALEVAQQ 60 Query: 400 QVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQ 459 QVE GAQ+IDINMDE MLDS AAM FLNLIASEPDI+RVPIMIDSSKWEVIEAGLKC+Q Sbjct: 61 QVEAGAQVIDINMDEGMLDSKAAMVTFLNLIASEPDISRVPIMIDSSKWEVIEAGLKCIQ 120 Query: 460 GKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLV 519 GK IVNSISMKEG E F A+LC+RYGAAV+VMAFDE GQADT ARK EIC+R+Y +LV Sbjct: 121 GKGIVNSISMKEGVEAFKHHARLCKRYGAAVVVMAFDEDGQADTQARKEEICKRSYDILV 180 Query: 520 DKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSF 579 D++ FPPEDIIFD NIFA+ATGIEEHNNYAVDFI A +I NLPYA SGGVSNVSFSF Sbjct: 181 DEVGFPPEDIIFDANIFAIATGIEEHNNYAVDFINACAYIRDNLPYALSSGGVSNVSFSF 240 Query: 580 RGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATE 639 RGN+P REAIH+VFLY+AI+ G+TMGIVNAG + +YD++P LR+RVEDVVLNR +ATE Sbjct: 241 RGNNPVREAIHSVFLYYAIRNGLTMGIVNAGQLEIYDEIPKALRDRVEDVVLNRTPEATE 300 Query: 640 RMIEYAATLKAGDK-KEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGG 698 ++ A K G KE EWR+ V KRL HALV GIT WIVEDTEE RQQ A Sbjct: 301 ALLAIADDYKGGGAVKEAEDEEWRSYSVEKRLEHALVKGITTWIVEDTEECRQQCA---- 356 Query: 699 RPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIAT 758 RPI VIEGPLM GMNVVGDLFG GKMFLPQVVKSARVMKQAVAHLIPFIE EK Sbjct: 357 RPIEVIEGPLMSGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEAEK------- 409 Query: 759 GEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKAD 818 G+ + KGKI++ATVKGDVHDIGKNIV VVL CN ++VV++GVMVP +IL A EK D Sbjct: 410 GDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNGYDVVDLGVMVPAEKILQTAIAEKCD 469 Query: 819 IIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEG-PV 877 IIGLSGLITPSL+EM +VAKEMQR + ++PLMIGGATTS+AHTAVKI P Y V Sbjct: 470 IIGLSGLITPSLDEMVHVAKEMQRQNF----QLPLMIGGATTSKAHTAVKIDPQYSNDAV 525 Query: 878 VYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKA-APMLSLAAARANKT 936 VYV DASRAV VA SLL+ E K YVA ADY +RE+ A++ A LS A ANK Sbjct: 526 VYVTDASRAVGVATSLLSKELKADYVARTRADYAVVRERTANRSARTERLSYEQAIANKP 585 Query: 937 KLDFAPVK---PKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAA 993 D+A + P F G R+ +DL +LA YIDW PFF +WDLAG YP ILTDEVVGEAA Sbjct: 586 AFDWAGYQAPTPSFTGVRVLDEIDLAVLAEYIDWTPFFISWDLAGKYPRILTDEVVGEAA 645 Query: 994 TKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQ 1053 T +F +AQAMLKK+ID + + A V PAN V DD+E+Y D + T + LRQQ Sbjct: 646 TSLFNDAQAMLKKLIDEKLIKARAVFGFWPANQVEHDDLEVYGADGETLA--TLHHLRQQ 703 Query: 1054 TEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIM 1113 T KP DG +PN L+DF+APKESGV+DYIG F TAG+G E+ K +E DDY+SIM Sbjct: 704 TIKP--DG--KPNLSLADFVAPKESGVRDYIGGFITTAGIGAEEVAKAYEAKGDDYNSIM 759 Query: 1114 LKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTV 1173 +KALADRLAEA AE+LHERVRK+ WGYA DE+L + LIKE+Y+GIRPAPGYPACP+HT Sbjct: 760 VKALADRLAEACAEWLHERVRKEYWGYARDEHLDNEALIKEQYVGIRPAPGYPACPDHTE 819 Query: 1174 KADVFRTMQCDEI-GMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERR 1232 K +F + + G+ LTE YAMFP A+VSG+YFAHPQ++YF VGKI +DQV ++R+ Sbjct: 820 KGTLFELLDPQGLSGVSLTEHYAMFPAAAVSGWYFAHPQAQYFAVGKIDKDQVERYSQRK 879 Query: 1233 HVPKEELERWLAPNL 1247 ERWLAPNL Sbjct: 880 GQEASVSERWLAPNL 894 >ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Ecs Escherichia coli O157:H7 Length = 901 Score = 1144 bits (2959), Expect = 0.0, Method: Compositional matrix adjust. Identities = 587/917 (64%), Positives = 684/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APRK+PE RLSGLEP I DDSL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVPIMIDSSKWEVIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG + F+ AKL RRYGAAV+VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L +++ FPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDLPAELR+ VEDV+LNRR+D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIEYAATLKAGDKKEEAT---LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIA 694 TER++E A + + A EWR+ V KRL ++LV GIT++I +DTEE RQQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQAT 361 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Q Sbjct: 362 ----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQ- 416 Query: 755 EIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 417 -------GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 AD+IGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMERQ----GFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKA-APMLSLAAARA 933 GP VYV +ASR V V +LL+D Q+ +VA +YE +R QH KK P ++L AAR Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKTKLDFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVGE 991 N D+ P R + V+ + L NYIDW PFF TW LAG YP IL DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLR 1051 A ++F++A ML K+ + L GV+ L PAN V DDIEIY D++R+ V + LR Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSS 1111 QQTEK G A N CL+DF+APK SG DYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVRK WGYA +ENLS+ +LI+E Y GIRPAPGYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKADVFRTMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAE 1230 T KA ++ ++ ++ GM+LTES+AM+PGASVSG+YF+HP SKY+ V +I DQV D A Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRHVPKEELERWLAPNL 1247 R+ + ++ERWLAPNL Sbjct: 880 RKGMSVSDVERWLAPNL 896 >ZmetH_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain EcZ Escherichia coli O157:H7 EDL933 Length = 901 Score = 1144 bits (2959), Expect = 0.0, Method: Compositional matrix adjust. Identities = 587/917 (64%), Positives = 684/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APRK+PE RLSGLEP I DDSL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVPIMIDSSKWEVIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG + F+ AKL RRYGAAV+VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L +++ FPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDLPAELR+ VEDV+LNRR+D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIEYAATLKAGDKKEEAT---LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIA 694 TER++E A + + A EWR+ V KRL ++LV GIT++I +DTEE RQQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQAT 361 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Q Sbjct: 362 ----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQ- 416 Query: 755 EIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 417 -------GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 AD+IGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMERQ----GFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKA-APMLSLAAARA 933 GP VYV +ASR V V +LL+D Q+ +VA +YE +R QH KK P ++L AAR Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKTKLDFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVGE 991 N D+ P R + V+ + L NYIDW PFF TW LAG YP IL DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLR 1051 A ++F++A ML K+ + L GV+ L PAN V DDIEIY D++R+ V + LR Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSS 1111 QQTEK G A N CL+DF+APK SG DYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVRK WGYA +ENLS+ +LI+E Y GIRPAPGYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKADVFRTMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAE 1230 T KA ++ ++ ++ GM+LTES+AM+PGASVSG+YF+HP SKY+ V +I DQV D A Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRHVPKEELERWLAPNL 1247 R+ + ++ERWLAPNL Sbjct: 880 RKGMSVSDVERWLAPNL 896 >metH_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Eco Escherichia coli K12 Length = 901 Score = 1142 bits (2953), Expect = 0.0, Method: Compositional matrix adjust. Identities = 586/917 (63%), Positives = 684/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APRK+PE RLSGLEP I +DSL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVPIMIDSSKW+VIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG + F+ AKL RRYGAAV+VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L +++ FPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDLPAELR+ VEDV+LNRR+D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIEYAATLKAGDKKEEAT---LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIA 694 TER++E A + + A EWR+ V KRL ++LV GIT++I +DTEE RQQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQAT 361 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Q Sbjct: 362 ----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQ- 416 Query: 755 EIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 417 -------GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 AD+IGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMERQ----GFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKA-APMLSLAAARA 933 GP VYV +ASR V V +LL+D Q+ +VA +YE +R QH KK P ++L AAR Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKTKLDFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVGE 991 N D+ P R + V+ + L NYIDW PFF TW LAG YP IL DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLR 1051 A ++F++A ML K+ + L GV+ L PAN V DDIEIY D++R+ V + LR Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSS 1111 QQTEK G A N CL+DF+APK SG DYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVRK WGYA +ENLS+ +LI+E Y GIRPAPGYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKADVFRTMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAE 1230 T KA ++ ++ ++ GM+LTES+AM+PGASVSG+YF+HP SKY+ V +I DQV D A Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRHVPKEELERWLAPNL 1247 R+ + E+ERWLAPNL Sbjct: 880 RKGMSVTEVERWLAPNL 896 >STM4188_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Sty Salmonella typhimurium LT2 Length = 901 Score = 1138 bits (2943), Expect = 0.0, Method: Compositional matrix adjust. Identities = 583/918 (63%), Positives = 688/918 (74%), Gaps = 31/918 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 + PR++P+ RLSGLEP I DDSL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LLPRQLPDIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVE+GAQIIDINMDE MLD+ AAM RFL+LIA EPDIARVPIMIDSSKWEVIE GLKC Sbjct: 62 RQQVESGAQIIDINMDEGMLDAEAAMVRFLSLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG E F+ AKL RRYGAAV+VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVEAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L +++ FPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDLPAELR+ VEDV+LNRR+D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIEYAATLKAGDKKEEAT----LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQI 693 TER+++ A + G K +EA EWR+ V KRL ++LV GIT++I +DTEE RQQ Sbjct: 302 TERLLDLAEKYR-GSKTDEAANAQQAEWRSWDVKKRLEYSLVKGITEFIEQDTEEARQQA 360 Query: 694 AADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQ 753 A RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE Sbjct: 361 A----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIE----- 411 Query: 754 LEIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAK 813 A+ E GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL A+ Sbjct: 412 ---ASKEKGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAR 468 Query: 814 EEKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNY 873 E AD+IGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY Sbjct: 469 EVNADLIGLSGLITPSLDEMVNVAKEMERQ----GFTIPLLIGGATTSKAHTAVKIEQNY 524 Query: 874 EGPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKA-APMLSLAAAR 932 GP VYV +ASR V V +LL+D Q+ +VA +YE +R QHA KK P ++L AAR Sbjct: 525 SGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHARKKPRTPPVTLEAAR 584 Query: 933 ANKTKLDFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVG 990 N D+ P R + V+ + L NYIDW PFF TW LAG YP IL DEVVG Sbjct: 585 DNDLAFDWERYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVG 644 Query: 991 EAATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGL 1050 A ++F++A ML K+ + L GV+ L PAN V DDIEIY D++R+ V + L Sbjct: 645 VEAQRLFKDANDMLDKLSAEKLLNPRGVVGLFPANRVG-DDIEIYRDETRTHVLTVSHHL 703 Query: 1051 RQQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYS 1110 RQQTEK V N CL+DF+APK SG DYIG FAVT GL + FE HDDY+ Sbjct: 704 RQQTEK-----VGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYN 758 Query: 1111 SIMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPE 1170 IM+KA+ADRLAEAFAEYLHERVRK WGYA +E+LS+ +LI+E Y GIRPAPGYPACPE Sbjct: 759 KIMVKAIADRLAEAFAEYLHERVRKVYWGYAPNESLSNDELIRENYQGIRPAPGYPACPE 818 Query: 1171 HTVKADVFRTMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMA 1229 HT K +++ + ++ GM+LTES+AM+PGASVSG+YF+HP+SKYF V +I DQV D A Sbjct: 819 HTEKGTIWQLLDVEKHTGMKLTESFAMWPGASVSGWYFSHPESKYFAVAQIQRDQVTDYA 878 Query: 1230 ERRHVPKEELERWLAPNL 1247 R+ + E++ERWLAPNL Sbjct: 879 FRKGMSVEDVERWLAPNL 896 >YPO3722_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Ype Yersinia pestis Length = 900 Score = 1122 bits (2901), Expect = 0.0, Method: Compositional matrix adjust. Identities = 572/916 (62%), Positives = 683/916 (74%), Gaps = 28/916 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 + PR +P+ RL+GLEP TI+ ++L+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 VPPRPLPDIPVACRLAGLEPLTIDANTLFVNVGERTNVTGSARFKRLIKEEKYGEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVE+GAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVPIMIDSS+W+VIE GLKC Sbjct: 62 RQQVESGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSRWDVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG + F+ AKL RRYGAA++VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLVRRYGAAMVVMAFDETGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L + + FPPEDIIFDPNIFAVATGIEEHNNYAVDFIEA I LP+A ISGGVSNVSF Sbjct: 182 LTETVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEACADIKAELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDL ELR+ VEDV+LNRR+D+ Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLSDELRDAVEDVILNRRDDS 301 Query: 638 TERMIEYAATLKAGDKKEEA--TLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAA 695 TER+++ A + E A EWR PV KRL ++LV GIT++I DTEE RQQ A Sbjct: 302 TERLLDLAEKYRDSKSGEVAIQQAEWRGWPVVKRLEYSLVKGITEFIELDTEEARQQ--A 359 Query: 696 DGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLE 755 D RPI VIEGPLM GMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L P+IE K++ Sbjct: 360 D--RPIEVIEGPLMSGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPYIEASKQKGT 417 Query: 756 IATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEE 815 A GKI++ATVKGDVHDIGKNIV VVLQCNN+E++++GVMVP +IL A+EE Sbjct: 418 TA--------GKILLATVKGDVHDIGKNIVGVVLQCNNYEIIDLGVMVPTEKILRTAREE 469 Query: 816 KADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEG 875 K DIIGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY G Sbjct: 470 KVDIIGLSGLITPSLDEMVNVAKEMERQ----GFTLPLLIGGATTSKAHTAVKIEQNYSG 525 Query: 876 PVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKA-APMLSLAAARAN 934 YV +ASR+V V +LL+D Q+ +VA+ +YE +R QHA KK P +SL AAR N Sbjct: 526 STTYVSNASRSVGVVSALLSDTQREAFVAKTRKEYETVRIQHARKKPRTPPVSLQAARNN 585 Query: 935 KTKLDFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVGEA 992 T +D+ P + + V+ + L NYIDW PFF TW LAG YP IL DEVVGE Sbjct: 586 PTVIDWENYTPPVAHKLGVQVVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGEE 645 Query: 993 ATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQ 1052 A ++ +A A+L K+ L GV+ L PAN+V DDIEIY D+ R +V Y LRQ Sbjct: 646 AKRLLADANALLDKLSAEDLLHPKGVVGLFPANSVG-DDIEIYRDERRDEVLAISYHLRQ 704 Query: 1053 QTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSI 1112 QTEK PN CL+D++APK SG DY G FAVT GL + ++ HDDY+ I Sbjct: 705 QTEK-----TDFPNYCLADYVAPKSSGKADYFGAFAVTGGLEEDALADAYDAQHDDYNKI 759 Query: 1113 MLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHT 1172 M+KAL+DRLAEAFAEYLHERVRK WG+A +ENLS+ +L++E Y GIRPAPGYPACPEHT Sbjct: 760 MIKALSDRLAEAFAEYLHERVRKVYWGFAPNENLSNEELVRENYQGIRPAPGYPACPEHT 819 Query: 1173 VKADVFRTMQCD-EIGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAER 1231 K +++ + + GM+LTESYAM+PGASVSG+YF+HP SKYF V +I DQV D A R Sbjct: 820 EKGQIWQLLDVETHTGMKLTESYAMWPGASVSGWYFSHPDSKYFAVAQIQRDQVEDYAAR 879 Query: 1232 RHVPKEELERWLAPNL 1247 + +P E+ERWLAPNL Sbjct: 880 KGMPTAEVERWLAPNL 895 >AGc3907_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 919 Score = 1119 bits (2894), Expect = 0.0, Method: Compositional matrix adjust. Identities = 565/916 (61%), Positives = 684/916 (74%), Gaps = 24/916 (2%) Query: 340 PRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQ 399 PR++PE M LSGLEPF + D +VNVGERTNVTGS F +LI Y ALAVAR Sbjct: 5 PREIPEHKPFMSLSGLEPFVLTKDIPFVNVGERTNVTGSARFRKLITAGDYTAALAVARD 64 Query: 400 QVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQ 459 QVENGAQIIDINMDE ++DS AM FLNLIA+EPDIARVP+MIDSSK+E+IEAGLKCVQ Sbjct: 65 QVENGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPVMIDSSKFEIIEAGLKCVQ 124 Query: 460 GKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLV 519 GKSIVNSIS+KEGEEKFL++A+L YGAAV+VMAFDEVGQADT+ RK+EIC RAY+LL Sbjct: 125 GKSIVNSISLKEGEEKFLQQARLVHNYGAAVVVMAFDEVGQADTYQRKVEICARAYKLLT 184 Query: 520 DKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSF 579 +K PEDIIFDPN+FAVATGIEEHNNY VDFIEAT+ I + +P ISGGVSN+SFSF Sbjct: 185 EKAGLSPEDIIFDPNVFAVATGIEEHNNYGVDFIEATKTIRETMPLTHISGGVSNLSFSF 244 Query: 580 RGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATE 639 RGN+P REA+H VFLYHAI+ GM MGIVNAG + VYD++ AELRE EDVVLNRR+DATE Sbjct: 245 RGNEPVREAMHAVFLYHAIQVGMDMGIVNAGQLAVYDNIDAELREACEDVVLNRRDDATE 304 Query: 640 RMIEYAATLKAGDKKEEAT--LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADG 697 R++E A + +K+ L WR PV KRL HALV+GIT +I DTEE RQQ A Sbjct: 305 RLLEVAERFRGTGEKQAKVQDLSWREYPVEKRLEHALVNGITDYIEADTEEARQQAA--- 361 Query: 698 GRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIA 757 RP+HVIEGPLM GMNVVGDLFG GKMFLPQVVKSARVMKQAVA L+P++EEEKR + Sbjct: 362 -RPLHVIEGPLMAGMNVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPYMEEEKR---LN 417 Query: 758 TGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKA 817 G GK+++ATVKGDVHDIGKNIV VVL CNN+E++++GVMVP +IL A EK Sbjct: 418 GGSERSAAGKVLMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPTTKILETAIAEKV 477 Query: 818 DIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE-GP 876 D+IGLSGLITPSL+EM +VA EM+R G +PL+IGGATTSR HTAVKI P YE G Sbjct: 478 DVIGLSGLITPSLDEMVHVAAEMERQ----GFDIPLLIGGATTSRVHTAVKIHPRYEQGQ 533 Query: 877 VVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHA-SKKAAPMLSLAAARANK 935 +YV DASRAV V +LL++EQK Y+ + A+Y ++ E HA +++ L L+ AR N Sbjct: 534 AIYVTDASRAVGVVSALLSEEQKPAYIDGIRAEYAKVAEAHARNEREKQRLPLSRARENA 593 Query: 936 TKLDFAP---VKPKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEA 992 K+D++ VKP+F G ++F+ DL L+ YIDW PFFQTW+L G +PAIL DE GEA Sbjct: 594 HKIDWSSYSVVKPQFFGTKVFETYDLEELSRYIDWTPFFQTWELKGRFPAILEDEKQGEA 653 Query: 993 ATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQ 1052 A +++ +AQAML KII+ +W VI PAN V DDI ++TD+ R + T++ LRQ Sbjct: 654 ARQLYADAQAMLAKIIEEKWFRPRAVIGFWPANAVG-DDIRLFTDEGRKEELATFFTLRQ 712 Query: 1053 QTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSI 1112 Q K DG RPN LSDF+AP +SGV DY+G F VTAG+ +RFE A+DDYSSI Sbjct: 713 QLSKR--DG--RPNVALSDFVAPVDSGVADYVGGFVVTAGIEEVAIAERFERANDDYSSI 768 Query: 1113 MLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHT 1172 ++KALADR AEAFAE +HERVRK+ WGYA DE L+ DLI E Y GIRPAPGYPA P+HT Sbjct: 769 LVKALADRFAEAFAERMHERVRKEFWGYAPDEALAGDDLIGEAYAGIRPAPGYPAQPDHT 828 Query: 1173 VKADVFRTMQC-DEIGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAER 1231 K +F + + G++LTESYAM+PG+SVSG Y HP+S YF V K+ DQV+D A R Sbjct: 829 EKKTLFALLDATNAAGVELTESYAMWPGSSVSGLYIGHPESYYFGVAKVERDQVLDYARR 888 Query: 1232 RHVPKEELERWLAPNL 1247 + +P E+ERWL P L Sbjct: 889 KDMPVTEVERWLGPVL 904 >BMEI1759_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Bme Brucella melitensis Length = 918 Score = 1103 bits (2852), Expect = 0.0, Method: Compositional matrix adjust. Identities = 568/920 (61%), Positives = 682/920 (74%), Gaps = 28/920 (3%) Query: 340 PRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQ 399 PRK + MRLSGLEPFT+ D +VN+GERTNVTGS F +L+ + AL VAR Sbjct: 3 PRKPAKVPPLMRLSGLEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAALDVARD 62 Query: 400 QVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQ 459 QV NGAQIIDINMDE ++DS AM FLNLIA+EPDIARVPIM+DSSKWEVIEAGLKCVQ Sbjct: 63 QVANGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLKCVQ 122 Query: 460 GKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLV 519 GK++VNSIS+KEGEE FL A+L R YGAAV++MAFDE GQADT ARKIEIC RAY++L Sbjct: 123 GKAVVNSISLKEGEEAFLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYKILT 182 Query: 520 DKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSF 579 +++ FPPEDIIFDPNIFAVATGIEEHNNY VDFIEATR I + LP+ ISGGVSN+SFSF Sbjct: 183 EQVGFPPEDIIFDPNIFAVATGIEEHNNYGVDFIEATREIVRTLPHVHISGGVSNLSFSF 242 Query: 580 RGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNR----RE 635 RGN+P REA+H VFLYHAI+AGM MGIVNAG + VYD + AELRE EDVVLNR E Sbjct: 243 RGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRPTKTGE 302 Query: 636 DATERMIEYAATLKAGDKKEEAT--LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQI 693 ATER++E A + +E T L WR PV KRL HALV+GIT++I DTEE R + Sbjct: 303 SATERLLEIAERFRDSGSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEAR--L 360 Query: 694 AADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQ 753 AA+ RP+HVIEGPLM GMNVVGDLFG GKMFLPQVVKSARVMKQAVA L+PF+EEEKR Sbjct: 361 AAE--RPLHVIEGPLMAGMNVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKR- 417 Query: 754 LEIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAK 813 + GE + GK+++ATVKGDVHDIGKNIV VVL CNN+E++++GVMVP +IL A+ Sbjct: 418 --LNGGEGRQSAGKVLMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPSQKILQVAR 475 Query: 814 EEKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNY 873 +EK DIIGLSGLITPSL+EMA+VA EM+R+ G +PL+IGGATTSR HTAVKI Y Sbjct: 476 DEKVDIIGLSGLITPSLDEMAHVAAEMERE----GFDIPLLIGGATTSRVHTAVKIHSRY 531 Query: 874 E-GPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYERIREQHASKKAAPM-LSLAAA 931 E G VYV DASRAV V +LL+ E K Y+ L +Y ++ HA +A L +A A Sbjct: 532 ERGQAVYVVDASRAVGVVSNLLSPEGKQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARA 591 Query: 932 RANKTKLD---FAPVKPKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEV 988 RAN +LD + PVKP F G ++F+ DL +A YIDW PFFQTW+L G YPAIL DE Sbjct: 592 RANPHQLDWENYEPVKPTFTGTKVFETYDLAEIARYIDWTPFFQTWELRGRYPAILEDEK 651 Query: 989 VGEAATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYY 1048 GEAA +++ +AQAML+KIID +W T V+ PAN V DDI ++TD+SR + T + Sbjct: 652 QGEAARQLWADAQAMLRKIIDEKWFTPRAVVGFWPANAVG-DDIRLFTDESRKEELATLF 710 Query: 1049 GLRQQTEKPVVDGVARPNQCLSDFIAPKESGVQDYIGMFAVTAGLGIEKYEKRFEDAHDD 1108 LRQQ K DG RPN ++DF+AP ESG QDY+G F VTAG+G +RFE A+DD Sbjct: 711 TLRQQLTKR--DG--RPNVAMADFVAPVESGKQDYVGGFVVTAGIGEIAIAERFERANDD 766 Query: 1109 YSSIMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPAC 1168 YS+I++KALADR AEAFAE +HERVRK+ W YA DE + +LI E Y GIRPAPGYPA Sbjct: 767 YSAILVKALADRFAEAFAELMHERVRKEFWAYAPDEAFTPEELISEPYKGIRPAPGYPAQ 826 Query: 1169 PEHTVKADVFRTMQCD-EIGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVD 1227 P+HT K +FR + G++LTESYAM+PG+SVSG Y HP+S YF V K+ DQV D Sbjct: 827 PDHTEKTTLFRLLDATANTGVELTESYAMWPGSSVSGLYIGHPESYYFGVAKVERDQVED 886 Query: 1228 MAERRHVPKEELERWLAPNL 1247 A R+ + E +ERWL P L Sbjct: 887 YARRKDMDVEAVERWLTPIL 906